Click here to switch to the map view.

The map label for this gene is ezrA

Identifier: 49187541

GI number: 49187541

Start: 4453512

End: 4455224

Strand: Reverse

Name: ezrA

Synonym: BAS4547

Alternate gene names: 49187541

Gene position: 4455224-4453512 (Counterclockwise)

Preceding gene: 49187542

Following gene: 49187540

Centisome position: 85.21

GC content: 36.37

Gene sequence:

>1713_bases
ATGGATTCTATCCTGACGATCGTTATCATTGTAGTAAGCTCTATTCTAGTGCTGCTCATGATAGAGCTTGTGATAAGAAA
TCGTTCATATAAAGATATTGAAGCACTTGAGCAGTGGAAACAAGAGATAAAAGATAAACCTGTGGCAGATGAGCTAAAAC
GGGTGAAAGATTTAAATATGACGGGCCAAACAGAAGAACTGTTTGGTAAATGGCGTGAAGAATGGGATGAAATTGTATCA
ACAACGATTCCGAAAGCTGACAAAGATTTAGCGCAAGCGCGAAAATTCGCCTCGCAATTCTCCTTCCGAAAAGCAAAGCA
TGCGATGAATGAATCCATAAGTGGTTTAGATGACGCTGATAATCGTATTACAGACATTTTAAATGAATTACAGCAATTGT
TAGAAAGCCATGAAAAAAATAGCTCAGAAATTGAAGGGTTACGTGATACATATCGTAGTATGAAGAAGAGTGTTCTTGCT
CATAGACATATGTATGGAGCAGCAGAGCAGAAAATCGAAGAGATGCTAGACGCTGAATCTGAGAAATTTAAAACCTTTGA
AGAAGCAACAAACAATGGCGACTATTTAAAAGCGAGAGAAATTGTTATTAGTTTGGAAGAAGGTTTAGCAGATTTAGAAA
TCATTATTCACCAAATTCCAGATTTATTGGTAGAGTGTCAAGCGACGTTACCAGTTCAGCTGGAAGATTTATTACACGGA
CATAATGATATGGTAAGACAAGGCTATGTATTAGATTATTTGGAAGTCCCTAAAGAAGTTCGCGATATGACGAAACAACT
ACAAACATGTTTAATAGATATACAAGAGCTTCACATAACGGAAGCGGCTGAAAAAGTAGAAAACTTGAAAACACGTTTAG
ATGGCTTCTACGATCAACTGGAACAAGAAGTACATGCGAGACATTATGTGGAGCAAAAAACACTTTCTGTTTATGAAGAC
TTAGAAGAAATTCGCACGGAAACGATTGAAACAAAAGCAGAAACACAACTTGTGAAACAAAGTTATCAGTTACAAGATAA
GGACATTGAGTCTCAAAAAGTAATTGAAAAGCAAATGCACATTTTAACGAAACGTTTTGAAATGTTGCAATTACGCGTTG
CGGAACAAGATATTGCCTTCTCTATTATTCGTGAGGAACTAGAAGAGATTTATGAGCAATGTGAAACATTAAAAGTACTT
CATGCAGAATATAAAGAAATGCTGCAAACGATGCGTAAAGAAGAATTTGAAGCGCGTGAGAAGTTACAAGAAATGCGAAA
TACTATTTTTGAAACGAAACGCTTTATGCAAAAGTCGAATTTGCCAGGTCTTCCAGAGAGTATTATGGAAGATTTAAAAA
GAGGACAAATGGCAATGCAAGCTGTATATGAACAATTAGAAGTGAAGCCGTTAAATATGAATGCTGTAAATAGCAGTTTA
GAAGAAGCTTACACAACTGTTAATGGTGTAGCTGAAATGACAGAAGAGTTAATTGGACAGGCGTATTTAGTTGAAAAATT
AATTCAATACGGTAATCGTTACCGCAGTCATGATGAGAACCTTGCAGAGAGCTTAAATTATGCGGAGAAATTATTCCGTG
AATATCAATACGATGCGGCTTTAGAACAAGCGGCTTCTGTACTAGAGCAACTTGAGCCTGGCGTTGTTCAAAAAATAGCT
GAATATGTAGACAATGAACAAACCCTTTCATAA

Upstream 100 bases:

>100_bases
TAGTTGTTAAATATAGGGGAATTCCCTTTTTATACATAATGCCTTCCATTTCATAAACGGAACGGACAAAAAAAGAGATA
TAACTAGGAGGCTTTTTTGC

Downstream 100 bases:

>100_bases
GGGTTTGTTTTTTTGTGTAATTTTGCAGGCGATGTTGCTATAATGAATAGCGGAATACAGTAAGGTTATTCGTTTCAAAA
TATAACGGAACCTTTGAGTA

Product: septation ring formation regulator EzrA

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 570; Mature: 570

Protein sequence:

>570_residues
MDSILTIVIIVVSSILVLLMIELVIRNRSYKDIEALEQWKQEIKDKPVADELKRVKDLNMTGQTEELFGKWREEWDEIVS
TTIPKADKDLAQARKFASQFSFRKAKHAMNESISGLDDADNRITDILNELQQLLESHEKNSSEIEGLRDTYRSMKKSVLA
HRHMYGAAEQKIEEMLDAESEKFKTFEEATNNGDYLKAREIVISLEEGLADLEIIIHQIPDLLVECQATLPVQLEDLLHG
HNDMVRQGYVLDYLEVPKEVRDMTKQLQTCLIDIQELHITEAAEKVENLKTRLDGFYDQLEQEVHARHYVEQKTLSVYED
LEEIRTETIETKAETQLVKQSYQLQDKDIESQKVIEKQMHILTKRFEMLQLRVAEQDIAFSIIREELEEIYEQCETLKVL
HAEYKEMLQTMRKEEFEAREKLQEMRNTIFETKRFMQKSNLPGLPESIMEDLKRGQMAMQAVYEQLEVKPLNMNAVNSSL
EEAYTTVNGVAEMTEELIGQAYLVEKLIQYGNRYRSHDENLAESLNYAEKLFREYQYDAALEQAASVLEQLEPGVVQKIA
EYVDNEQTLS

Sequences:

>Translated_570_residues
MDSILTIVIIVVSSILVLLMIELVIRNRSYKDIEALEQWKQEIKDKPVADELKRVKDLNMTGQTEELFGKWREEWDEIVS
TTIPKADKDLAQARKFASQFSFRKAKHAMNESISGLDDADNRITDILNELQQLLESHEKNSSEIEGLRDTYRSMKKSVLA
HRHMYGAAEQKIEEMLDAESEKFKTFEEATNNGDYLKAREIVISLEEGLADLEIIIHQIPDLLVECQATLPVQLEDLLHG
HNDMVRQGYVLDYLEVPKEVRDMTKQLQTCLIDIQELHITEAAEKVENLKTRLDGFYDQLEQEVHARHYVEQKTLSVYED
LEEIRTETIETKAETQLVKQSYQLQDKDIESQKVIEKQMHILTKRFEMLQLRVAEQDIAFSIIREELEEIYEQCETLKVL
HAEYKEMLQTMRKEEFEAREKLQEMRNTIFETKRFMQKSNLPGLPESIMEDLKRGQMAMQAVYEQLEVKPLNMNAVNSSL
EEAYTTVNGVAEMTEELIGQAYLVEKLIQYGNRYRSHDENLAESLNYAEKLFREYQYDAALEQAASVLEQLEPGVVQKIA
EYVDNEQTLS
>Mature_570_residues
MDSILTIVIIVVSSILVLLMIELVIRNRSYKDIEALEQWKQEIKDKPVADELKRVKDLNMTGQTEELFGKWREEWDEIVS
TTIPKADKDLAQARKFASQFSFRKAKHAMNESISGLDDADNRITDILNELQQLLESHEKNSSEIEGLRDTYRSMKKSVLA
HRHMYGAAEQKIEEMLDAESEKFKTFEEATNNGDYLKAREIVISLEEGLADLEIIIHQIPDLLVECQATLPVQLEDLLHG
HNDMVRQGYVLDYLEVPKEVRDMTKQLQTCLIDIQELHITEAAEKVENLKTRLDGFYDQLEQEVHARHYVEQKTLSVYED
LEEIRTETIETKAETQLVKQSYQLQDKDIESQKVIEKQMHILTKRFEMLQLRVAEQDIAFSIIREELEEIYEQCETLKVL
HAEYKEMLQTMRKEEFEAREKLQEMRNTIFETKRFMQKSNLPGLPESIMEDLKRGQMAMQAVYEQLEVKPLNMNAVNSSL
EEAYTTVNGVAEMTEELIGQAYLVEKLIQYGNRYRSHDENLAESLNYAEKLFREYQYDAALEQAASVLEQLEPGVVQKIA
EYVDNEQTLS

Specific function: Negative regulator of ftsZ ring formation; modulates the frequency and position of ftsZ ring formation. Inhibits ftsZ ring formation at polar sites. Interacts either with ftsZ or with one of its binding partners to promote depolymerization

COG id: COG4477

COG function: function code D; Negative regulator of septation ring formation

Gene ontology:

Cell location: Cell membrane; Single-pass membrane protein. Note=Colocalized with ftsZ to the nascent septal site (By similarity)

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ezrA family

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): EZRA_BACAA (C3PBB5)

Other databases:

- EMBL:   CP001598
- RefSeq:   YP_002868931.1
- ProteinModelPortal:   C3PBB5
- EnsemblBacteria:   EBBACT00000127076
- GeneID:   7853070
- GenomeReviews:   CP001598_GR
- KEGG:   bai:BAA_4911
- GeneTree:   EBGT00050000000289
- ProtClustDB:   PRK04778
- HAMAP:   MF_00728
- InterPro:   IPR010379

Pfam domain/function: PF06160 EzrA

EC number: NA

Molecular weight: Translated: 66437; Mature: 66437

Theoretical pI: Translated: 4.45; Mature: 4.45

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

HASH(0x163754e0)-;

Cys/Met content:

0.5 %Cys     (Translated Protein)
3.5 %Met     (Translated Protein)
4.0 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
3.5 %Met     (Mature Protein)
4.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MDSILTIVIIVVSSILVLLMIELVIRNRSYKDIEALEQWKQEIKDKPVADELKRVKDLNM
CCHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHCCCCCHHHHHHHHHCCC
TGQTEELFGKWREEWDEIVSTTIPKADKDLAQARKFASQFSFRKAKHAMNESISGLDDAD
CCCHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCH
NRITDILNELQQLLESHEKNSSEIEGLRDTYRSMKKSVLAHRHMYGAAEQKIEEMLDAES
HHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCH
EKFKTFEEATNNGDYLKAREIVISLEEGLADLEIIIHQIPDLLVECQATLPVQLEDLLHG
HHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHCC
HNDMVRQGYVLDYLEVPKEVRDMTKQLQTCLIDIQELHITEAAEKVENLKTRLDGFYDQL
CHHHHHCCCHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
EQEVHARHYVEQKTLSVYEDLEEIRTETIETKAETQLVKQSYQLQDKDIESQKVIEKQMH
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHH
ILTKRFEMLQLRVAEQDIAFSIIREELEEIYEQCETLKVLHAEYKEMLQTMRKEEFEARE
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
KLQEMRNTIFETKRFMQKSNLPGLPESIMEDLKRGQMAMQAVYEQLEVKPLNMNAVNSSL
HHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHH
EEAYTTVNGVAEMTEELIGQAYLVEKLIQYGNRYRSHDENLAESLNYAEKLFREYQYDAA
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHH
LEQAASVLEQLEPGVVQKIAEYVDNEQTLS
HHHHHHHHHHHCCHHHHHHHHHHCCCCCCH
>Mature Secondary Structure
MDSILTIVIIVVSSILVLLMIELVIRNRSYKDIEALEQWKQEIKDKPVADELKRVKDLNM
CCHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHCCCCCHHHHHHHHHCCC
TGQTEELFGKWREEWDEIVSTTIPKADKDLAQARKFASQFSFRKAKHAMNESISGLDDAD
CCCHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCH
NRITDILNELQQLLESHEKNSSEIEGLRDTYRSMKKSVLAHRHMYGAAEQKIEEMLDAES
HHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCH
EKFKTFEEATNNGDYLKAREIVISLEEGLADLEIIIHQIPDLLVECQATLPVQLEDLLHG
HHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHCC
HNDMVRQGYVLDYLEVPKEVRDMTKQLQTCLIDIQELHITEAAEKVENLKTRLDGFYDQL
CHHHHHCCCHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
EQEVHARHYVEQKTLSVYEDLEEIRTETIETKAETQLVKQSYQLQDKDIESQKVIEKQMH
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHH
ILTKRFEMLQLRVAEQDIAFSIIREELEEIYEQCETLKVLHAEYKEMLQTMRKEEFEARE
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
KLQEMRNTIFETKRFMQKSNLPGLPESIMEDLKRGQMAMQAVYEQLEVKPLNMNAVNSSL
HHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHH
EEAYTTVNGVAEMTEELIGQAYLVEKLIQYGNRYRSHDENLAESLNYAEKLFREYQYDAA
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHH
LEQAASVLEQLEPGVVQKIAEYVDNEQTLS
HHHHHHHHHHHCCHHHHHHHHHHCCCCCCH

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: NA