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The map label for this gene is trxA [H]

Identifier: 49187412

GI number: 49187412

Start: 4326853

End: 4327167

Strand: Reverse

Name: trxA [H]

Synonym: BAS4417

Alternate gene names: 49187412

Gene position: 4327167-4326853 (Counterclockwise)

Preceding gene: 49187413

Following gene: 49187411

Centisome position: 82.76

GC content: 38.73

Gene sequence:

>315_bases
ATGGCAATTGTAAACGCAAATGACCAAAGCTTCGCAGCAGAAACTAGCGAAGGTGTTGTATTATTAGATTTCTGGGCACC
TTGGTGTGGACCTTGTAAAATGATCGCTCCTGTATTAGAGGAAATTGATGCAGAACTAGGCGAAAAAGTAAAAGTAGTAA
AAGTAGACGTGGATGAAAACCAAGAAACTGCTCGTCAATTCGAAGTAATGAGCATTCCAGCTCTTTTCGTATTAAAAGAC
GGTAAAGTAGTTGATCAAGCGTTGGGTTACAAACCGAAAGAAGCGTTAGTAGAATTAGTTTCTAAACACTTCTAA

Upstream 100 bases:

>100_bases
GAACACTTTTTTGTTACAATACATAACGATACATATTATTCGCCACGTATATAAGTTAATGATATACTCTTGGTAGAATA
TACTTGAAGGAGGAAATAAA

Downstream 100 bases:

>100_bases
AATAAAGGAGCTACCATTTGGTAGCTTTTTTTATTTTCCTTTTTTACACCTTTCCGTTACAATAAAAGAACGTATGTTGG
GTGTTTTGGCATAGTATGTT

Product: thioredoxin

Products: NA

Alternate protein names: Trx [H]

Number of amino acids: Translated: 104; Mature: 103

Protein sequence:

>104_residues
MAIVNANDQSFAAETSEGVVLLDFWAPWCGPCKMIAPVLEEIDAELGEKVKVVKVDVDENQETARQFEVMSIPALFVLKD
GKVVDQALGYKPKEALVELVSKHF

Sequences:

>Translated_104_residues
MAIVNANDQSFAAETSEGVVLLDFWAPWCGPCKMIAPVLEEIDAELGEKVKVVKVDVDENQETARQFEVMSIPALFVLKD
GKVVDQALGYKPKEALVELVSKHF
>Mature_103_residues
AIVNANDQSFAAETSEGVVLLDFWAPWCGPCKMIAPVLEEIDAELGEKVKVVKVDVDENQETARQFEVMSIPALFVLKDG
KVVDQALGYKPKEALVELVSKHF

Specific function: Participates in various redox reactions through the reversible oxidation of its active center dithiol to a disulfide and catalyzes dithiol-disulfide exchange reactions [H]

COG id: COG0526

COG function: function code OC; Thiol-disulfide isomerase and thioredoxins

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 thioredoxin domain [H]

Homologues:

Organism=Homo sapiens, GI21361403, Length=87, Percent_Identity=40.2298850574713, Blast_Score=74, Evalue=2e-14,
Organism=Homo sapiens, GI224493972, Length=93, Percent_Identity=37.6344086021505, Blast_Score=66, Evalue=5e-12,
Organism=Homo sapiens, GI42794771, Length=97, Percent_Identity=36.0824742268041, Blast_Score=64, Evalue=2e-11,
Organism=Homo sapiens, GI38505222, Length=98, Percent_Identity=32.6530612244898, Blast_Score=62, Evalue=8e-11,
Organism=Escherichia coli, GI87082331, Length=104, Percent_Identity=39.4230769230769, Blast_Score=89, Evalue=8e-20,
Organism=Escherichia coli, GI1788936, Length=74, Percent_Identity=44.5945945945946, Blast_Score=81, Evalue=1e-17,
Organism=Caenorhabditis elegans, GI17509965, Length=92, Percent_Identity=38.0434782608696, Blast_Score=69, Evalue=5e-13,
Organism=Caenorhabditis elegans, GI17507705, Length=86, Percent_Identity=31.3953488372093, Blast_Score=66, Evalue=3e-12,
Organism=Caenorhabditis elegans, GI71980562, Length=73, Percent_Identity=36.986301369863, Blast_Score=62, Evalue=6e-11,
Organism=Caenorhabditis elegans, GI71980565, Length=73, Percent_Identity=36.986301369863, Blast_Score=62, Evalue=8e-11,
Organism=Saccharomyces cerevisiae, GI6321648, Length=88, Percent_Identity=40.9090909090909, Blast_Score=71, Evalue=3e-14,
Organism=Saccharomyces cerevisiae, GI6323072, Length=81, Percent_Identity=40.7407407407407, Blast_Score=69, Evalue=2e-13,
Organism=Saccharomyces cerevisiae, GI6319925, Length=73, Percent_Identity=38.3561643835616, Blast_Score=65, Evalue=3e-12,
Organism=Drosophila melanogaster, GI24639826, Length=87, Percent_Identity=39.0804597701149, Blast_Score=75, Evalue=6e-15,
Organism=Drosophila melanogaster, GI28573567, Length=88, Percent_Identity=39.7727272727273, Blast_Score=75, Evalue=6e-15,
Organism=Drosophila melanogaster, GI17648013, Length=82, Percent_Identity=41.4634146341463, Blast_Score=74, Evalue=1e-14,
Organism=Drosophila melanogaster, GI24583090, Length=82, Percent_Identity=41.4634146341463, Blast_Score=74, Evalue=1e-14,
Organism=Drosophila melanogaster, GI24664269, Length=70, Percent_Identity=42.8571428571429, Blast_Score=72, Evalue=8e-14,

Paralogues:

None

Copy number: 3,500 Molecules/Cell In: Glucose minimal media [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005746
- InterPro:   IPR017936
- InterPro:   IPR012336
- InterPro:   IPR017937
- InterPro:   IPR013766
- InterPro:   IPR012335 [H]

Pfam domain/function: PF00085 Thioredoxin [H]

EC number: NA

Molecular weight: Translated: 11478; Mature: 11347

Theoretical pI: Translated: 4.24; Mature: 4.24

Prosite motif: PS00194 THIOREDOXIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.9 %Cys     (Translated Protein)
2.9 %Met     (Translated Protein)
4.8 %Cys+Met (Translated Protein)
1.9 %Cys     (Mature Protein)
1.9 %Met     (Mature Protein)
3.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAIVNANDQSFAAETSEGVVLLDFWAPWCGPCKMIAPVLEEIDAELGEKVKVVKVDVDEN
CEEECCCCCCCCCCCCCCEEEEECCCCCCCHHHHHHHHHHHHHHHCCCCEEEEEEECCCC
QETARQFEVMSIPALFVLKDGKVVDQALGYKPKEALVELVSKHF
HHHHHHHHHHCCCEEEEEECCCHHHHHHCCCCHHHHHHHHHHCC
>Mature Secondary Structure 
AIVNANDQSFAAETSEGVVLLDFWAPWCGPCKMIAPVLEEIDAELGEKVKVVKVDVDEN
EEECCCCCCCCCCCCCCEEEEECCCCCCCHHHHHHHHHHHHHHHCCCCEEEEEEECCCC
QETARQFEVMSIPALFVLKDGKVVDQALGYKPKEALVELVSKHF
HHHHHHHHHHCCCEEEEEECCCHHHHHHCCCCHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: Reduction reactions; participates in dithiol-disulfide exchange reactions [C]

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 2559145; 8969504; 9384377; 8755892 [H]