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The map label for this gene is mtnA [H]

Identifier: 49186940

GI number: 49186940

Start: 3888773

End: 3889828

Strand: Reverse

Name: mtnA [H]

Synonym: BAS3942

Alternate gene names: 49186940

Gene position: 3889828-3888773 (Counterclockwise)

Preceding gene: 49186941

Following gene: 49186938

Centisome position: 74.39

GC content: 36.74

Gene sequence:

>1056_bases
ATGAGTACAGTTGTTAGGATTCCGAGGTCTGTCAGTTGGAAAGGTGATGCCATTGCAGTATTAAATCAAACAAAGTTGCC
GCATAGCACAGAATACAAAACATTAACGACGATTGAAGAGGTATGGAAAAGTATTGTCATGCTAGAAGTAAGAGGAGCAC
CTGCAATTGGAATTGTAGCTGCATTTGGCTTGGCGCTTGCATCAAAAAAATATACTACTTTACATATTGAAGAATTTCAA
AAGAAGTTTAATAGAGATTGTAATTATTTAGGGACGTCACGCCCGACAGCAGTCAATTTATTTTGGGCAATCGATCGTAT
GAGAGAATCTATTCAAGAAATTACTACAATAAAAGAAGCGCAAAAAATATTAGAAGAAGAAGCACTTCGTATTCAGCAAG
AAGATGAAGCGGTATGCCGGAGTATTGGAGAACATGCATTAACATGCTTTAAAGACGGTGATAACATTTTAACAATTTGT
AACGCTGGCAGTATTGCAACTGCTAGATATGGTACTGCATTAGCACCGTTTTATATTGGGAAAGAAAAAGGGGTACGGTT
ACATGCGTATGCGTGTGAAACGAGACCGGTTTTACAAGGCGGACGTTTAACGACCTGGGAATTAAAACAGGCAGGTATTG
ATGTAACACTTATTACAGATAATACGGCAGCTCATGCTATTCAAACGAAAGAAATAAGCGCGATTATTGTAGGAGCGGAC
CGAATTGTTGCAAATGGAGACACCGCAAATAAAATTGGAACAATGAATTTAGCTATATTAGCAAAGTATTTTGATATTCC
GTTTTACGTTGCAGCTCCACTATCGACATTTGATATTACGAAACAAACAGGTGCAGAAATTGTTATTGAAGAAAGAGATG
AAACAGAAGTTACGAAAATTTTTGGGAAACAAGTGGCACCAGTTGGAACTACTGTTTATAATCCTGCATTTGATGTAACA
CCGAATGAATTAATTACAGGTATTATTACTGAGAAAGGTATTATACGTGGAGATTATAAGCGAGAAATTGCATCATTGTT
TAAAAAAACAAGCTAA

Upstream 100 bases:

>100_bases
TATCCTTAGGGAAAGAACTAATAAAATATGAGTCTAAGAACGCCGATATTCAACTGTTCCGAACATTATTTCAACAGACA
GTTTCTGGAGGGATAAAAGC

Downstream 100 bases:

>100_bases
TACATAATAGCTTGTTTTTTTATGCCTAAATGTGTTCTTTTTTCTTATTTATATAATGAAAGGAGGAGAAAAAGATGGAA
GAGTGGATCAAGATGATAGG

Product: methylthioribose-1-phosphate isomerase

Products: NA

Alternate protein names: M1Pi 2; MTR-1-P isomerase 2; S-methyl-5-thioribose-1-phosphate isomerase 2 [H]

Number of amino acids: Translated: 351; Mature: 350

Protein sequence:

>351_residues
MSTVVRIPRSVSWKGDAIAVLNQTKLPHSTEYKTLTTIEEVWKSIVMLEVRGAPAIGIVAAFGLALASKKYTTLHIEEFQ
KKFNRDCNYLGTSRPTAVNLFWAIDRMRESIQEITTIKEAQKILEEEALRIQQEDEAVCRSIGEHALTCFKDGDNILTIC
NAGSIATARYGTALAPFYIGKEKGVRLHAYACETRPVLQGGRLTTWELKQAGIDVTLITDNTAAHAIQTKEISAIIVGAD
RIVANGDTANKIGTMNLAILAKYFDIPFYVAAPLSTFDITKQTGAEIVIEERDETEVTKIFGKQVAPVGTTVYNPAFDVT
PNELITGIITEKGIIRGDYKREIASLFKKTS

Sequences:

>Translated_351_residues
MSTVVRIPRSVSWKGDAIAVLNQTKLPHSTEYKTLTTIEEVWKSIVMLEVRGAPAIGIVAAFGLALASKKYTTLHIEEFQ
KKFNRDCNYLGTSRPTAVNLFWAIDRMRESIQEITTIKEAQKILEEEALRIQQEDEAVCRSIGEHALTCFKDGDNILTIC
NAGSIATARYGTALAPFYIGKEKGVRLHAYACETRPVLQGGRLTTWELKQAGIDVTLITDNTAAHAIQTKEISAIIVGAD
RIVANGDTANKIGTMNLAILAKYFDIPFYVAAPLSTFDITKQTGAEIVIEERDETEVTKIFGKQVAPVGTTVYNPAFDVT
PNELITGIITEKGIIRGDYKREIASLFKKTS
>Mature_350_residues
STVVRIPRSVSWKGDAIAVLNQTKLPHSTEYKTLTTIEEVWKSIVMLEVRGAPAIGIVAAFGLALASKKYTTLHIEEFQK
KFNRDCNYLGTSRPTAVNLFWAIDRMRESIQEITTIKEAQKILEEEALRIQQEDEAVCRSIGEHALTCFKDGDNILTICN
AGSIATARYGTALAPFYIGKEKGVRLHAYACETRPVLQGGRLTTWELKQAGIDVTLITDNTAAHAIQTKEISAIIVGADR
IVANGDTANKIGTMNLAILAKYFDIPFYVAAPLSTFDITKQTGAEIVIEERDETEVTKIFGKQVAPVGTTVYNPAFDVTP
NELITGIITEKGIIRGDYKREIASLFKKTS

Specific function: Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1-P) [H]

COG id: COG0182

COG function: function code J; Predicted translation initiation factor 2B subunit, eIF-2B alpha/beta/delta family

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the eIF-2B alpha/beta/delta subunits family. MtnA subfamily [H]

Homologues:

Organism=Homo sapiens, GI72534748, Length=342, Percent_Identity=41.5204678362573, Blast_Score=233, Evalue=2e-61,
Organism=Homo sapiens, GI23943880, Length=329, Percent_Identity=37.6899696048632, Blast_Score=201, Evalue=6e-52,
Organism=Homo sapiens, GI78000156, Length=346, Percent_Identity=25.7225433526012, Blast_Score=78, Evalue=1e-14,
Organism=Homo sapiens, GI78000158, Length=346, Percent_Identity=25.7225433526012, Blast_Score=78, Evalue=1e-14,
Organism=Homo sapiens, GI187607323, Length=346, Percent_Identity=25.7225433526012, Blast_Score=78, Evalue=2e-14,
Organism=Caenorhabditis elegans, GI17557462, Length=332, Percent_Identity=35.2409638554217, Blast_Score=195, Evalue=3e-50,
Organism=Caenorhabditis elegans, GI17557123, Length=166, Percent_Identity=29.5180722891566, Blast_Score=73, Evalue=2e-13,
Organism=Saccharomyces cerevisiae, GI6325375, Length=406, Percent_Identity=35.7142857142857, Blast_Score=210, Evalue=3e-55,
Organism=Drosophila melanogaster, GI21357667, Length=369, Percent_Identity=36.8563685636856, Blast_Score=233, Evalue=1e-61,
Organism=Drosophila melanogaster, GI24651647, Length=369, Percent_Identity=36.8563685636856, Blast_Score=233, Evalue=1e-61,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000649
- InterPro:   IPR005251
- InterPro:   IPR011559 [H]

Pfam domain/function: PF01008 IF-2B [H]

EC number: =5.3.1.23 [H]

Molecular weight: Translated: 38676; Mature: 38545

Theoretical pI: Translated: 7.02; Mature: 7.02

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.4 %Cys     (Translated Protein)
1.1 %Met     (Translated Protein)
2.6 %Cys+Met (Translated Protein)
1.4 %Cys     (Mature Protein)
0.9 %Met     (Mature Protein)
2.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSTVVRIPRSVSWKGDAIAVLNQTKLPHSTEYKTLTTIEEVWKSIVMLEVRGAPAIGIVA
CCCEEECCCCCCCCCCEEEEEECCCCCCCCCCHHHHHHHHHHHHEEEEEECCCCHHHHHH
AFGLALASKKYTTLHIEEFQKKFNRDCNYLGTSRPTAVNLFWAIDRMRESIQEITTIKEA
HHHHHHHCCCCEEEEHHHHHHHHCCCCCCCCCCCCCEEEHHHHHHHHHHHHHHHHHHHHH
QKILEEEALRIQQEDEAVCRSIGEHALTCFKDGDNILTICNAGSIATARYGTALAPFYIG
HHHHHHHHHHCCCHHHHHHHHHHHHHEEEEECCCCEEEEECCCCEEECCCCCEECCEEEC
KEKGVRLHAYACETRPVLQGGRLTTWELKQAGIDVTLITDNTAAHAIQTKEISAIIVGAD
CCCCEEEEEEEECCCCCCCCCCEEEEEHHHCCEEEEEEECCCHHHEEEECCEEEEEEECC
RIVANGDTANKIGTMNLAILAKYFDIPFYVAAPLSTFDITKQTGAEIVIEERDETEVTKI
EEEECCCCCCCCCCHHHHHHHHHHCCCEEEECCCCCEECCCCCCCEEEEECCCCHHHHHH
FGKQVAPVGTTVYNPAFDVTPNELITGIITEKGIIRGDYKREIASLFKKTS
HCCCCCCCCCEEECCCCCCCHHHHHHHHHHCCCCCCCHHHHHHHHHHHCCC
>Mature Secondary Structure 
STVVRIPRSVSWKGDAIAVLNQTKLPHSTEYKTLTTIEEVWKSIVMLEVRGAPAIGIVA
CCEEECCCCCCCCCCEEEEEECCCCCCCCCCHHHHHHHHHHHHEEEEEECCCCHHHHHH
AFGLALASKKYTTLHIEEFQKKFNRDCNYLGTSRPTAVNLFWAIDRMRESIQEITTIKEA
HHHHHHHCCCCEEEEHHHHHHHHCCCCCCCCCCCCCEEEHHHHHHHHHHHHHHHHHHHHH
QKILEEEALRIQQEDEAVCRSIGEHALTCFKDGDNILTICNAGSIATARYGTALAPFYIG
HHHHHHHHHHCCCHHHHHHHHHHHHHEEEEECCCCEEEEECCCCEEECCCCCEECCEEEC
KEKGVRLHAYACETRPVLQGGRLTTWELKQAGIDVTLITDNTAAHAIQTKEISAIIVGAD
CCCCEEEEEEEECCCCCCCCCCEEEEEHHHCCEEEEEEECCCHHHEEEECCEEEEEEECC
RIVANGDTANKIGTMNLAILAKYFDIPFYVAAPLSTFDITKQTGAEIVIEERDETEVTKI
EEEECCCCCCCCCCHHHHHHHHHHCCCEEEECCCCCEECCCCCCCEEEEECCCCHHHHHH
FGKQVAPVGTTVYNPAFDVTPNELITGIITEKGIIRGDYKREIASLFKKTS
HCCCCCCCCCEEECCCCCCCHHHHHHHHHHCCCCCCCHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 12721630 [H]