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The map label for this gene is kinB [H]

Identifier: 49186914

GI number: 49186914

Start: 3864265

End: 3865539

Strand: Reverse

Name: kinB [H]

Synonym: BAS3916

Alternate gene names: 49186914

Gene position: 3865539-3864265 (Counterclockwise)

Preceding gene: 49186917

Following gene: 49186912

Centisome position: 73.93

GC content: 35.06

Gene sequence:

>1275_bases
ATGGAGCTTATCCGTGATTTAATGATCCAAATTGCCATCATTATTTTGCCACTATTTTTATACGAAGCGATTCGTTTAAA
TCGTTATCAAGAAATGCCTCCGAAGCCGAACCGCTACTTTATTATGTTTTTATCTAGCATTACACTCGTTCTCTCTATGA
CATACTCTATTTGTTTTGGGGACGTTTGTGGGTATAACTTTCACCCAATCCCGATTGTTAGTGGTTTTCTATATGGTGGG
ATTGTTGGTTTAGTCCCGGCTGCTATTTTTGTTGCATATGAATGGGTGCTAAAGGGAATAAACCTTCTTCCAGTTATAGA
AGTAATATTCCTATCGATAGTTCCATTATTTTTATCAAAGAAATGGTCTCTATTTTCAAGGGATAAGAAGCTAATTTTGG
CCTTTATGATTTCATCATTGTACGTACTCGTTTCTTTAGTGATTGGCATGATTAATGTTCTGCTAGAAACGGGGTTTACA
CCATATGTTTCGCACTTATATAGCGGATACATATTCGCTTCGCTTATTATGGTTATGACAATGGTATTTCAGGTGTACTT
AACAGAATATTTAAATGAAAATGCAATACTACGTACAGAGATGCAAAAGTCAGAGAAACTTAATATAGTAAGTGAGTTAG
CTGCAAGTGTTGCACATGAGGTTCGAAATCCGCTCACTGTTGTTCGTGGTTTTATTCAATTGCTTGAAAGTACGGAAGAT
GTGAAGAATAAGGATTATATGCGTCTCGTATTAGCCGAATTAGACCGGGCAGAACAAATTATTTCAGATTATTTGAATTT
AGCAAGGCCACAAATTGAGAAGAAAGAACATATTTGCTTATCAGCCCAATTAATAGAAATGACAACCCTTATGTCATCAT
TTGCAGCGATGCAAGGTGTATATTTGCAAGTTGAGATTTCTGAAAGCCTTTATACGATTGGTGATAAGACGAAATTAAAA
CAAGCTATTATGAATGTTGTTAAAAATGGTATTGAAGCAATTCAAGGAAATAAAGGATATTTAAAGGTAACGGCTATGCA
AAAAGATGAAACGATTGTAATAAGAGTTAAAGATAGTGGTGTTGGTATGACGAAAGAACAGTTAGCCAGGCTCGGACAAC
CGTATTATTCTTTAAAAGAAAAAGGAACAGGATTAGGTCTTATGGTAACATTTAGTATTTTACAAGCACATAATGGTACG
CTGGAATATAAAAGCGAAAGTGGGAAAGGCACGGAAGCAATTATTATATTACCAGCTGTAAGAAATAAGGAATAA

Upstream 100 bases:

>100_bases
AAAGAATTAACAAATATATTAAGAAAAATCAAAATCTTACAACAAATACGTCTATAAAATGATATAATCATATCAAAATA
CATATAGGGGATGAGAGGCT

Downstream 100 bases:

>100_bases
AAGTTACCGATGGAAGGTAACTTTTTATTTTATATAGGAAAAAATATATTATTTTATTCAGTTGTTTTTTCTTGTTTTGT
TCGGCTAAATAAACTTCTAA

Product: sporulation kinase B

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 424; Mature: 424

Protein sequence:

>424_residues
MELIRDLMIQIAIIILPLFLYEAIRLNRYQEMPPKPNRYFIMFLSSITLVLSMTYSICFGDVCGYNFHPIPIVSGFLYGG
IVGLVPAAIFVAYEWVLKGINLLPVIEVIFLSIVPLFLSKKWSLFSRDKKLILAFMISSLYVLVSLVIGMINVLLETGFT
PYVSHLYSGYIFASLIMVMTMVFQVYLTEYLNENAILRTEMQKSEKLNIVSELAASVAHEVRNPLTVVRGFIQLLESTED
VKNKDYMRLVLAELDRAEQIISDYLNLARPQIEKKEHICLSAQLIEMTTLMSSFAAMQGVYLQVEISESLYTIGDKTKLK
QAIMNVVKNGIEAIQGNKGYLKVTAMQKDETIVIRVKDSGVGMTKEQLARLGQPYYSLKEKGTGLGLMVTFSILQAHNGT
LEYKSESGKGTEAIIILPAVRNKE

Sequences:

>Translated_424_residues
MELIRDLMIQIAIIILPLFLYEAIRLNRYQEMPPKPNRYFIMFLSSITLVLSMTYSICFGDVCGYNFHPIPIVSGFLYGG
IVGLVPAAIFVAYEWVLKGINLLPVIEVIFLSIVPLFLSKKWSLFSRDKKLILAFMISSLYVLVSLVIGMINVLLETGFT
PYVSHLYSGYIFASLIMVMTMVFQVYLTEYLNENAILRTEMQKSEKLNIVSELAASVAHEVRNPLTVVRGFIQLLESTED
VKNKDYMRLVLAELDRAEQIISDYLNLARPQIEKKEHICLSAQLIEMTTLMSSFAAMQGVYLQVEISESLYTIGDKTKLK
QAIMNVVKNGIEAIQGNKGYLKVTAMQKDETIVIRVKDSGVGMTKEQLARLGQPYYSLKEKGTGLGLMVTFSILQAHNGT
LEYKSESGKGTEAIIILPAVRNKE
>Mature_424_residues
MELIRDLMIQIAIIILPLFLYEAIRLNRYQEMPPKPNRYFIMFLSSITLVLSMTYSICFGDVCGYNFHPIPIVSGFLYGG
IVGLVPAAIFVAYEWVLKGINLLPVIEVIFLSIVPLFLSKKWSLFSRDKKLILAFMISSLYVLVSLVIGMINVLLETGFT
PYVSHLYSGYIFASLIMVMTMVFQVYLTEYLNENAILRTEMQKSEKLNIVSELAASVAHEVRNPLTVVRGFIQLLESTED
VKNKDYMRLVLAELDRAEQIISDYLNLARPQIEKKEHICLSAQLIEMTTLMSSFAAMQGVYLQVEISESLYTIGDKTKLK
QAIMNVVKNGIEAIQGNKGYLKVTAMQKDETIVIRVKDSGVGMTKEQLARLGQPYYSLKEKGTGLGLMVTFSILQAHNGT
LEYKSESGKGTEAIIILPAVRNKE

Specific function: Phosphorylates the sporulation-regulatory proteins spo0A and spo0F. Spo0F is required for the kinB activity [H]

COG id: COG0642

COG function: function code T; Signal transduction histidine kinase

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 histidine kinase domain [H]

Homologues:

Organism=Escherichia coli, GI1790436, Length=259, Percent_Identity=30.8880308880309, Blast_Score=129, Evalue=3e-31,
Organism=Escherichia coli, GI1788549, Length=222, Percent_Identity=33.7837837837838, Blast_Score=127, Evalue=1e-30,
Organism=Escherichia coli, GI1786783, Length=221, Percent_Identity=27.6018099547511, Blast_Score=79, Evalue=7e-16,
Organism=Escherichia coli, GI1789149, Length=230, Percent_Identity=28.695652173913, Blast_Score=78, Evalue=9e-16,
Organism=Escherichia coli, GI1788393, Length=239, Percent_Identity=23.0125523012552, Blast_Score=77, Evalue=1e-15,
Organism=Escherichia coli, GI145693157, Length=291, Percent_Identity=24.7422680412371, Blast_Score=77, Evalue=3e-15,
Organism=Escherichia coli, GI1790300, Length=239, Percent_Identity=26.7782426778243, Blast_Score=72, Evalue=7e-14,
Organism=Escherichia coli, GI87081816, Length=244, Percent_Identity=27.0491803278689, Blast_Score=70, Evalue=3e-13,
Organism=Escherichia coli, GI48994928, Length=214, Percent_Identity=23.8317757009346, Blast_Score=67, Evalue=2e-12,
Organism=Escherichia coli, GI1790551, Length=217, Percent_Identity=29.9539170506912, Blast_Score=67, Evalue=3e-12,
Organism=Escherichia coli, GI1786600, Length=218, Percent_Identity=23.8532110091743, Blast_Score=66, Evalue=4e-12,
Organism=Escherichia coli, GI1789808, Length=219, Percent_Identity=26.4840182648402, Blast_Score=64, Evalue=2e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003594
- InterPro:   IPR004358
- InterPro:   IPR003661
- InterPro:   IPR005467
- InterPro:   IPR009082 [H]

Pfam domain/function: PF02518 HATPase_c; PF00512 HisKA [H]

EC number: =2.7.13.3 [H]

Molecular weight: Translated: 47783; Mature: 47783

Theoretical pI: Translated: 8.01; Mature: 8.01

Prosite motif: PS50109 HIS_KIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
4.5 %Met     (Translated Protein)
5.2 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
4.5 %Met     (Mature Protein)
5.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MELIRDLMIQIAIIILPLFLYEAIRLNRYQEMPPKPNRYFIMFLSSITLVLSMTYSICFG
CHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCEEEHHHHHHHHHHHHHHHHHHH
DVCGYNFHPIPIVSGFLYGGIVGLVPAAIFVAYEWVLKGINLLPVIEVIFLSIVPLFLSK
HHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHCC
KWSLFSRDKKLILAFMISSLYVLVSLVIGMINVLLETGFTPYVSHLYSGYIFASLIMVMT
CHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHH
MVFQVYLTEYLNENAILRTEMQKSEKLNIVSELAASVAHEVRNPLTVVRGFIQLLESTED
HHHHHHHHHHHCCCCEEHHHHHHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHHHH
VKNKDYMRLVLAELDRAEQIISDYLNLARPQIEKKEHICLSAQLIEMTTLMSSFAAMQGV
HCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCE
YLQVEISESLYTIGDKTKLKQAIMNVVKNGIEAIQGNKGYLKVTAMQKDETIVIRVKDSG
EEEEEECCHHHHCCCHHHHHHHHHHHHHHHHHHHCCCCCEEEEEEECCCCEEEEEEECCC
VGMTKEQLARLGQPYYSLKEKGTGLGLMVTFSILQAHNGTLEYKSESGKGTEAIIILPAV
CCCCHHHHHHCCCCHHHHHHCCCCCHHHHHHHHHHHCCCCEEEECCCCCCCEEEEEEECC
RNKE
CCCC
>Mature Secondary Structure
MELIRDLMIQIAIIILPLFLYEAIRLNRYQEMPPKPNRYFIMFLSSITLVLSMTYSICFG
CHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCEEEHHHHHHHHHHHHHHHHHHH
DVCGYNFHPIPIVSGFLYGGIVGLVPAAIFVAYEWVLKGINLLPVIEVIFLSIVPLFLSK
HHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHCC
KWSLFSRDKKLILAFMISSLYVLVSLVIGMINVLLETGFTPYVSHLYSGYIFASLIMVMT
CHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHH
MVFQVYLTEYLNENAILRTEMQKSEKLNIVSELAASVAHEVRNPLTVVRGFIQLLESTED
HHHHHHHHHHHCCCCEEHHHHHHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHHHH
VKNKDYMRLVLAELDRAEQIISDYLNLARPQIEKKEHICLSAQLIEMTTLMSSFAAMQGV
HCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCE
YLQVEISESLYTIGDKTKLKQAIMNVVKNGIEAIQGNKGYLKVTAMQKDETIVIRVKDSG
EEEEEECCHHHHCCCHHHHHHHHHHHHHHHHHHHCCCCCEEEEEEECCCCEEEEEEECCC
VGMTKEQLARLGQPYYSLKEKGTGLGLMVTFSILQAHNGTLEYKSESGKGTEAIIILPAV
CCCCHHHHHHCCCCHHHHHHCCCCCHHHHHHHHHHHCCCCEEEECCCCCCCEEEEEEECC
RNKE
CCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 8497199; 9274030; 9384377 [H]