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The map label for this gene is ilvD

Identifier: 49184730

GI number: 49184730

Start: 1735056

End: 1736729

Strand: Direct

Name: ilvD

Synonym: BAS1717

Alternate gene names: 49184730

Gene position: 1735056-1736729 (Clockwise)

Preceding gene: 49184729

Following gene: 49184731

Centisome position: 33.18

GC content: 40.74

Gene sequence:

>1674_bases
ATGAGAAGTGACATGATTAAAAAAGGTTTTGATAAAGCGCCGCATCGTAGTTTATTAAAAGCAACTGGTTTGAAAGATGA
AGACTTTGATAAACCGTTTATAGCGATCTGTAATTCTTTTATTGAAATTATTCCAGGTCATAAGCACTTAAATGAGTTTG
GGAAGCTTGTTAAAGAAGCAGTACGTGCAGCAGGTATGGTTCCATTTGAATTTAATACAATTGGAGTAGATGACGGTATT
GCGATGGGGCATATCGGTATGCGCTATTCGCTTCCGAGTCGAGAAATTATTGCAGATTCAGTAGAAACGGTTGTAAATGC
CCATTGGTTTGATGGCATGATTTGCATTCCAAACTGTGACAAAATCACACCCGGTATGATGATGGCTGCACTTCGTATTA
ACATTCCAACTGTTTTTGTTTCAGGTGGTCCGATGGCGGCTGGAAAAACATCTAAAGGAGACGTTGTTGATTTAAGTTCT
GTTTTCGAAGGAGTAGGGGCTTATCAATCTGGGAAAATTTCAGAAGAAGAATTAAAGGATATTGAAGATCATGGCTGTCC
ATCTTGTGGTTCTTGTTCTGGTATGTTTACAGCGAACTCTATGAACTGTTTATGTGAAGTGTTAGGTTTAGCTCTTCCTG
GTAACGGAAGTATTTTGGCTATTGATCCAAGACGCGAAGAATTAATTAAACAAGCAGCAGAAAAATTAAAGATTTTAATT
GAAAGAGATATTAAACCGAGAGACATTGTAACGGAAGAAGCAATTGATGATGCGTTCGCGCTTGATATGGCAATGGGCGG
TTCAACAAATACAGTGTTGCATACATTGGCGCTCGCGCAAGAGGCTGGATTAGATTACGATATGAACCGTATTGATGCCG
TTTCAAGACGTGTACCACATTTATGTAAAGTAAGCCCTGCTTCCAATTGGCATATGGAAGACATTGATCGTGCAGGCGGG
ATTAGTGCAATTTTGAAAGAGATGAGCCGAAAAGAAGGGGTACTTCATTTAGACCGTATTACTGCTACGGGGCAAACATT
AAGAGAAAATATTGCTCATGCAGAGATTAAAGATAAGGAAGTGATTCATTCTCTTGAAAATCCTCATAGTGAAGAAGGTG
GATTACGTATATTAAAAGGAAACCTTGCGAAAGACGGAGCAGTTATTAAAAGCGGGGCAACTGAAGTAAAACGATTTGAA
GGACCTTGTGTTATTTTTAATTCACAAGATGAGGCGCTTGCCGGCATTATGCTTGGGAAGGTTAAGAAAGGAGATGTAGT
TGTTATTCGTTATGAAGGACCAAGAGGCGGTCCTGGTATGCCGGAAATGTTAGCACCAACGTCAGCGATTGCTGGCATGG
GATTAGGTGCAGATGTTGCGTTATTAACCGATGGTCGTTTCTCTGGTGCTTCACGTGGTATTTCAGTAGGTCATATTTCG
CCAGAAGCAGCTGCGGGCGGAACGATTGCACTTCTTGAACAAGGGGATATCGTTTGTATCGATGTTGAGGAAAGGTTGTT
AGAAGTAAGAGTTAGTGACGAAGAATTAGGTAAGCGTAAAAAAGAATGGAAACGACCAGAACCGAAAGTGAAAACGGGCT
GGCTTGGACGTTATGCACAAATGGTAACATCGGCGAATACAGGTGCAGTCCTAAAAATCCCGAATTTTGATTGA

Upstream 100 bases:

>100_bases
CTTCGTGAAATGATGAGCTGGATTCATGCACCGAAAGAATTAGTGAAGAAATAGAGTAATAGATTGCAAGTGAAAAATAC
GTAAGAGGGGATTTGACAAG

Downstream 100 bases:

>100_bases
GTCAATATAAAAGAGATAAGGATGATATGAAATGGTGCAAAAGGTAAAGGAGAGAGTGAAAATTGAAGATATCTTAATGG
CCCATACTTGTATGAAAGAT

Product: dihydroxy-acid dehydratase

Products: NA

Alternate protein names: DAD

Number of amino acids: Translated: 557; Mature: 557

Protein sequence:

>557_residues
MRSDMIKKGFDKAPHRSLLKATGLKDEDFDKPFIAICNSFIEIIPGHKHLNEFGKLVKEAVRAAGMVPFEFNTIGVDDGI
AMGHIGMRYSLPSREIIADSVETVVNAHWFDGMICIPNCDKITPGMMMAALRINIPTVFVSGGPMAAGKTSKGDVVDLSS
VFEGVGAYQSGKISEEELKDIEDHGCPSCGSCSGMFTANSMNCLCEVLGLALPGNGSILAIDPRREELIKQAAEKLKILI
ERDIKPRDIVTEEAIDDAFALDMAMGGSTNTVLHTLALAQEAGLDYDMNRIDAVSRRVPHLCKVSPASNWHMEDIDRAGG
ISAILKEMSRKEGVLHLDRITATGQTLRENIAHAEIKDKEVIHSLENPHSEEGGLRILKGNLAKDGAVIKSGATEVKRFE
GPCVIFNSQDEALAGIMLGKVKKGDVVVIRYEGPRGGPGMPEMLAPTSAIAGMGLGADVALLTDGRFSGASRGISVGHIS
PEAAAGGTIALLEQGDIVCIDVEERLLEVRVSDEELGKRKKEWKRPEPKVKTGWLGRYAQMVTSANTGAVLKIPNFD

Sequences:

>Translated_557_residues
MRSDMIKKGFDKAPHRSLLKATGLKDEDFDKPFIAICNSFIEIIPGHKHLNEFGKLVKEAVRAAGMVPFEFNTIGVDDGI
AMGHIGMRYSLPSREIIADSVETVVNAHWFDGMICIPNCDKITPGMMMAALRINIPTVFVSGGPMAAGKTSKGDVVDLSS
VFEGVGAYQSGKISEEELKDIEDHGCPSCGSCSGMFTANSMNCLCEVLGLALPGNGSILAIDPRREELIKQAAEKLKILI
ERDIKPRDIVTEEAIDDAFALDMAMGGSTNTVLHTLALAQEAGLDYDMNRIDAVSRRVPHLCKVSPASNWHMEDIDRAGG
ISAILKEMSRKEGVLHLDRITATGQTLRENIAHAEIKDKEVIHSLENPHSEEGGLRILKGNLAKDGAVIKSGATEVKRFE
GPCVIFNSQDEALAGIMLGKVKKGDVVVIRYEGPRGGPGMPEMLAPTSAIAGMGLGADVALLTDGRFSGASRGISVGHIS
PEAAAGGTIALLEQGDIVCIDVEERLLEVRVSDEELGKRKKEWKRPEPKVKTGWLGRYAQMVTSANTGAVLKIPNFD
>Mature_557_residues
MRSDMIKKGFDKAPHRSLLKATGLKDEDFDKPFIAICNSFIEIIPGHKHLNEFGKLVKEAVRAAGMVPFEFNTIGVDDGI
AMGHIGMRYSLPSREIIADSVETVVNAHWFDGMICIPNCDKITPGMMMAALRINIPTVFVSGGPMAAGKTSKGDVVDLSS
VFEGVGAYQSGKISEEELKDIEDHGCPSCGSCSGMFTANSMNCLCEVLGLALPGNGSILAIDPRREELIKQAAEKLKILI
ERDIKPRDIVTEEAIDDAFALDMAMGGSTNTVLHTLALAQEAGLDYDMNRIDAVSRRVPHLCKVSPASNWHMEDIDRAGG
ISAILKEMSRKEGVLHLDRITATGQTLRENIAHAEIKDKEVIHSLENPHSEEGGLRILKGNLAKDGAVIKSGATEVKRFE
GPCVIFNSQDEALAGIMLGKVKKGDVVVIRYEGPRGGPGMPEMLAPTSAIAGMGLGADVALLTDGRFSGASRGISVGHIS
PEAAAGGTIALLEQGDIVCIDVEERLLEVRVSDEELGKRKKEWKRPEPKVKTGWLGRYAQMVTSANTGAVLKIPNFD

Specific function: Valine and isoleucine biosynthesis; fourth step. [C]

COG id: COG0129

COG function: function code EG; Dihydroxyacid dehydratase/phosphogluconate dehydratase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ilvD/edd family

Homologues:

Organism=Escherichia coli, GI48994964, Length=606, Percent_Identity=48.019801980198, Blast_Score=546, Evalue=1e-156,
Organism=Escherichia coli, GI1788157, Length=540, Percent_Identity=30.7407407407407, Blast_Score=218, Evalue=6e-58,
Organism=Escherichia coli, GI2367371, Length=525, Percent_Identity=31.6190476190476, Blast_Score=194, Evalue=1e-50,
Organism=Escherichia coli, GI1786464, Length=489, Percent_Identity=31.2883435582822, Blast_Score=176, Evalue=5e-45,
Organism=Saccharomyces cerevisiae, GI6322476, Length=545, Percent_Identity=42.2018348623853, Blast_Score=426, Evalue=1e-120,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): ILVD_BACAA (C3P6S2)

Other databases:

- EMBL:   CP001598
- RefSeq:   YP_002866269.1
- EnsemblBacteria:   EBBACT00000128702
- GeneID:   7849139
- GenomeReviews:   CP001598_GR
- KEGG:   bai:BAA_1922
- GeneTree:   EBGT00050000001430
- ProtClustDB:   PRK00911
- HAMAP:   MF_00012
- InterPro:   IPR015928
- InterPro:   IPR004404
- InterPro:   IPR000581
- InterPro:   IPR020558
- PANTHER:   PTHR21000
- TIGRFAMs:   TIGR00110

Pfam domain/function: PF00920 ILVD_EDD; SSF52016 Aconitase/3IPM_dehydase_swvl

EC number: =4.2.1.9

Molecular weight: Translated: 59935; Mature: 59935

Theoretical pI: Translated: 5.66; Mature: 5.66

Prosite motif: PS00886 ILVD_EDD_1; PS00887 ILVD_EDD_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.0 %Cys     (Translated Protein)
3.9 %Met     (Translated Protein)
5.9 %Cys+Met (Translated Protein)
2.0 %Cys     (Mature Protein)
3.9 %Met     (Mature Protein)
5.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRSDMIKKGFDKAPHRSLLKATGLKDEDFDKPFIAICNSFIEIIPGHKHLNEFGKLVKEA
CCCHHHHHCCCCCCHHHHHHHCCCCCCCCCCHHHHHHHHHHHHCCCHHHHHHHHHHHHHH
VRAAGMVPFEFNTIGVDDGIAMGHIGMRYSLPSREIIADSVETVVNAHWFDGMICIPNCD
HHHCCCCCEEEEEECCCCCCEECCCCEEECCCCHHHHHHHHHHHHHHHHCCCEEECCCCC
KITPGMMMAALRINIPTVFVSGGPMAAGKTSKGDVVDLSSVFEGVGAYQSGKISEEELKD
CCCHHHHHHHEEEECCEEEECCCCCCCCCCCCCCEEEHHHHHHHHCCCCCCCCCHHHHHH
IEDHGCPSCGSCSGMFTANSMNCLCEVLGLALPGNGSILAIDPRREELIKQAAEKLKILI
HHHCCCCCCCCCCCCEECCHHHHHHHHHHEECCCCCCEEEECCHHHHHHHHHHHHHHHHH
ERDIKPRDIVTEEAIDDAFALDMAMGGSTNTVLHTLALAQEAGLDYDMNRIDAVSRRVPH
HCCCCCHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHCCCCCCHHHHHHHHHHCCC
LCKVSPASNWHMEDIDRAGGISAILKEMSRKEGVLHLDRITATGQTLRENIAHAEIKDKE
CEECCCCCCCCHHHHHHCCCHHHHHHHHHHHCCCEEEEHHHHCHHHHHHHHHHHHCHHHH
VIHSLENPHSEEGGLRILKGNLAKDGAVIKSGATEVKRFEGPCVIFNSQDEALAGIMLGK
HHHHHCCCCCCCCCEEEEECCCCCCCCEEECCCHHHHHCCCCEEEECCCCHHHHHHHHCC
VKKGDVVVIRYEGPRGGPGMPEMLAPTSAIAGMGLGADVALLTDGRFSGASRGISVGHIS
CCCCCEEEEEECCCCCCCCCCHHHCCHHHHHCCCCCCCEEEEECCCCCCCCCCEEEECCC
PEAAAGGTIALLEQGDIVCIDVEERLLEVRVSDEELGKRKKEWKRPEPKVKTGWLGRYAQ
CCCCCCCEEEEEECCCEEEEEHHHHEEEEECCHHHHHHHHHHHCCCCCCCCCCHHHHHHH
MVTSANTGAVLKIPNFD
HHHCCCCCEEEECCCCC
>Mature Secondary Structure
MRSDMIKKGFDKAPHRSLLKATGLKDEDFDKPFIAICNSFIEIIPGHKHLNEFGKLVKEA
CCCHHHHHCCCCCCHHHHHHHCCCCCCCCCCHHHHHHHHHHHHCCCHHHHHHHHHHHHHH
VRAAGMVPFEFNTIGVDDGIAMGHIGMRYSLPSREIIADSVETVVNAHWFDGMICIPNCD
HHHCCCCCEEEEEECCCCCCEECCCCEEECCCCHHHHHHHHHHHHHHHHCCCEEECCCCC
KITPGMMMAALRINIPTVFVSGGPMAAGKTSKGDVVDLSSVFEGVGAYQSGKISEEELKD
CCCHHHHHHHEEEECCEEEECCCCCCCCCCCCCCEEEHHHHHHHHCCCCCCCCCHHHHHH
IEDHGCPSCGSCSGMFTANSMNCLCEVLGLALPGNGSILAIDPRREELIKQAAEKLKILI
HHHCCCCCCCCCCCCEECCHHHHHHHHHHEECCCCCCEEEECCHHHHHHHHHHHHHHHHH
ERDIKPRDIVTEEAIDDAFALDMAMGGSTNTVLHTLALAQEAGLDYDMNRIDAVSRRVPH
HCCCCCHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHCCCCCCHHHHHHHHHHCCC
LCKVSPASNWHMEDIDRAGGISAILKEMSRKEGVLHLDRITATGQTLRENIAHAEIKDKE
CEECCCCCCCCHHHHHHCCCHHHHHHHHHHHCCCEEEEHHHHCHHHHHHHHHHHHCHHHH
VIHSLENPHSEEGGLRILKGNLAKDGAVIKSGATEVKRFEGPCVIFNSQDEALAGIMLGK
HHHHHCCCCCCCCCEEEEECCCCCCCCEEECCCHHHHHCCCCEEEECCCCHHHHHHHHCC
VKKGDVVVIRYEGPRGGPGMPEMLAPTSAIAGMGLGADVALLTDGRFSGASRGISVGHIS
CCCCCEEEEEECCCCCCCCCCHHHCCHHHHHCCCCCCCEEEEECCCCCCCCCCEEEECCC
PEAAAGGTIALLEQGDIVCIDVEERLLEVRVSDEELGKRKKEWKRPEPKVKTGWLGRYAQ
CCCCCCCEEEEEECCCEEEEEHHHHEEEEECCHHHHHHHHHHHCCCCCCCCCCHHHHHHH
MVTSANTGAVLKIPNFD
HHHCCCCCEEEECCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA