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The map label for this gene is hpd [H]

Identifier: 49183259

GI number: 49183259

Start: 226839

End: 227957

Strand: Direct

Name: hpd [H]

Synonym: BAS0226

Alternate gene names: 49183259

Gene position: 226839-227957 (Clockwise)

Preceding gene: 49183258

Following gene: 49183260

Centisome position: 4.34

GC content: 36.46

Gene sequence:

>1119_bases
ATGAAACAAAAATCTATGGATACGCTAGCTGCACAAATGGAGGACTTTTTTCCAGTACGTGATGTAGATCATTTGGAATT
TTACGTAGGAAATGCAAAGCAATCAAGTTATTATCTTGCGAGAGCATTCGGATTCAAAATTGTGGCTTACTCTGGATTAG
AAACTGGTAATCGTGAAAAAGTATCTTATGTTCTTGTGCAAAAAAACATGCGTTTTGTTGTGTCTGGGGCTTTAAGTAGT
GACAATCGTATTGCAGAGTTTGTAAAGACTCATGGTGATGGCGTGAAAGATGTAGCATTACTTGTTGACGATGTTGATAA
AGCATACTCAGAAGCAGTGAAACGTGGTGCCGTCGCAATTGCTCCGCCTGTAGAGTTAACAGATGAGAACGGTACATTGA
AAAAAGCAGTTATTGGTACGTATGGTGATACAATTCATACGCTTGTAGAGCGTAAAAATTATAAAGGGACATTTATGCCA
GGATTCCAAAAGGCTGAGTTTGATATTCCATTTGAAGAGTCAGGTTTAATTGCTGTAGACCATGTAGTTGGTAATGTTGA
AAAGATGGAAGAGTGGGTTAGTTATTACGAGAACGTTATGGGCTTTAAACAAATGATCCATTTTGATGATGATGATATTA
GTACAGAGTATTCAGCATTAATGTCGAAGGTTATGACAAATGGAAGTCGTATTAAGTTCCCTATTAACGAGCCAGCAGAT
GGAAAGAGAAAATCACAAATTCAAGAATATCTAGAGTTCTATAATGGAGCAGGTGTACAGCATCTTGCTTTACTAACAAA
TGACATTGTTAAAACAGTAGAAGCGCTACGTGCAAATGGTGTGGAGTTTTTAGATACACCAGATACTTATTATGATGAGT
TAACTGCACGAGTTGGAAAAATTGATGAGGAAATTGATAAGTTGAAAGAATTAAAGATTTTAGTAGATCGCGATGATGAA
GGATACTTACTACAAATCTTTACGAAACCAATTGTAGATCGTCCAACTTTATTTATTGAAATCATTCAGCGTAAAGGTTC
TCGTGGATTTGGAGAAGGAAACTTTAAAGCGTTATTCGAATCAATTGAAAGAGAACAAGAGCGTCGCGGGAATTTATAA

Upstream 100 bases:

>100_bases
GTTAGCTTGCTAACTAATTTCTATTAATTGATGTTGGAAGCGTTTTCGATTGGTTTTAAGTATGAACCATTTAATCTATT
TACAGAGGGATGAGGATTTT

Downstream 100 bases:

>100_bases
AATTTATATCCACCAGCAATAATTCTTTTGCTGGTGGAAATTTCATTTTCATAGGGAGGAATCATGATGAAATTTGTTAC
ATTTCGTCTTCCTTCAAAAG

Product: 4-hydroxyphenylpyruvate dioxygenase

Products: NA

Alternate protein names: 4HPPD; HPD; HPPDase [H]

Number of amino acids: Translated: 372; Mature: 372

Protein sequence:

>372_residues
MKQKSMDTLAAQMEDFFPVRDVDHLEFYVGNAKQSSYYLARAFGFKIVAYSGLETGNREKVSYVLVQKNMRFVVSGALSS
DNRIAEFVKTHGDGVKDVALLVDDVDKAYSEAVKRGAVAIAPPVELTDENGTLKKAVIGTYGDTIHTLVERKNYKGTFMP
GFQKAEFDIPFEESGLIAVDHVVGNVEKMEEWVSYYENVMGFKQMIHFDDDDISTEYSALMSKVMTNGSRIKFPINEPAD
GKRKSQIQEYLEFYNGAGVQHLALLTNDIVKTVEALRANGVEFLDTPDTYYDELTARVGKIDEEIDKLKELKILVDRDDE
GYLLQIFTKPIVDRPTLFIEIIQRKGSRGFGEGNFKALFESIEREQERRGNL

Sequences:

>Translated_372_residues
MKQKSMDTLAAQMEDFFPVRDVDHLEFYVGNAKQSSYYLARAFGFKIVAYSGLETGNREKVSYVLVQKNMRFVVSGALSS
DNRIAEFVKTHGDGVKDVALLVDDVDKAYSEAVKRGAVAIAPPVELTDENGTLKKAVIGTYGDTIHTLVERKNYKGTFMP
GFQKAEFDIPFEESGLIAVDHVVGNVEKMEEWVSYYENVMGFKQMIHFDDDDISTEYSALMSKVMTNGSRIKFPINEPAD
GKRKSQIQEYLEFYNGAGVQHLALLTNDIVKTVEALRANGVEFLDTPDTYYDELTARVGKIDEEIDKLKELKILVDRDDE
GYLLQIFTKPIVDRPTLFIEIIQRKGSRGFGEGNFKALFESIEREQERRGNL
>Mature_372_residues
MKQKSMDTLAAQMEDFFPVRDVDHLEFYVGNAKQSSYYLARAFGFKIVAYSGLETGNREKVSYVLVQKNMRFVVSGALSS
DNRIAEFVKTHGDGVKDVALLVDDVDKAYSEAVKRGAVAIAPPVELTDENGTLKKAVIGTYGDTIHTLVERKNYKGTFMP
GFQKAEFDIPFEESGLIAVDHVVGNVEKMEEWVSYYENVMGFKQMIHFDDDDISTEYSALMSKVMTNGSRIKFPINEPAD
GKRKSQIQEYLEFYNGAGVQHLALLTNDIVKTVEALRANGVEFLDTPDTYYDELTARVGKIDEEIDKLKELKILVDRDDE
GYLLQIFTKPIVDRPTLFIEIIQRKGSRGFGEGNFKALFESIEREQERRGNL

Specific function: Unknown

COG id: COG3185

COG function: function code ER; 4-hydroxyphenylpyruvate dioxygenase and related hemolysins

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the 4HPPD family [H]

Homologues:

Organism=Homo sapiens, GI4504477, Length=359, Percent_Identity=48.7465181058496, Blast_Score=328, Evalue=7e-90,
Organism=Homo sapiens, GI285002264, Length=344, Percent_Identity=49.4186046511628, Blast_Score=311, Evalue=8e-85,
Organism=Homo sapiens, GI14249394, Length=374, Percent_Identity=26.7379679144385, Blast_Score=137, Evalue=1e-32,
Organism=Caenorhabditis elegans, GI17555220, Length=364, Percent_Identity=49.7252747252747, Blast_Score=340, Evalue=5e-94,
Organism=Caenorhabditis elegans, GI17550752, Length=366, Percent_Identity=37.7049180327869, Blast_Score=241, Evalue=5e-64,
Organism=Drosophila melanogaster, GI24667510, Length=361, Percent_Identity=49.0304709141274, Blast_Score=330, Evalue=1e-90,
Organism=Drosophila melanogaster, GI21356105, Length=292, Percent_Identity=51.3698630136986, Blast_Score=286, Evalue=1e-77,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005956
- InterPro:   IPR004360 [H]

Pfam domain/function: PF00903 Glyoxalase [H]

EC number: =1.13.11.27 [H]

Molecular weight: Translated: 42079; Mature: 42079

Theoretical pI: Translated: 4.78; Mature: 4.78

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
2.7 %Met     (Translated Protein)
2.7 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
2.7 %Met     (Mature Protein)
2.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKQKSMDTLAAQMEDFFPVRDVDHLEFYVGNAKQSSYYLARAFGFKIVAYSGLETGNREK
CCCHHHHHHHHHHHHCCCCCCCCHHHEEECCCCCCHHHHHHHHCEEEEEECCCCCCCCCC
VSYVLVQKNMRFVVSGALSSDNRIAEFVKTHGDGVKDVALLVDDVDKAYSEAVKRGAVAI
EEEEEEECCCEEEEEECCCCCHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHCCCEEE
APPVELTDENGTLKKAVIGTYGDTIHTLVERKNYKGTFMPGFQKAEFDIPFEESGLIAVD
CCCCEEECCCCCCHHHHHHCCCHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCEEEH
HVVGNVEKMEEWVSYYENVMGFKQMIHFDDDDISTEYSALMSKVMTNGSRIKFPINEPAD
HHHCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHCCCCEEEECCCCCCC
GKRKSQIQEYLEFYNGAGVQHLALLTNDIVKTVEALRANGVEFLDTPDTYYDELTARVGK
CHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHCCCEEECCCHHHHHHHHHHHHH
IDEEIDKLKELKILVDRDDEGYLLQIFTKPIVDRPTLFIEIIQRKGSRGFGEGNFKALFE
HHHHHHHHHHHEEEEECCCCCCEEEEECCCCCCCCHHHHHHHHHCCCCCCCCCHHHHHHH
SIEREQERRGNL
HHHHHHHHCCCC
>Mature Secondary Structure
MKQKSMDTLAAQMEDFFPVRDVDHLEFYVGNAKQSSYYLARAFGFKIVAYSGLETGNREK
CCCHHHHHHHHHHHHCCCCCCCCHHHEEECCCCCCHHHHHHHHCEEEEEECCCCCCCCCC
VSYVLVQKNMRFVVSGALSSDNRIAEFVKTHGDGVKDVALLVDDVDKAYSEAVKRGAVAI
EEEEEEECCCEEEEEECCCCCHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHCCCEEE
APPVELTDENGTLKKAVIGTYGDTIHTLVERKNYKGTFMPGFQKAEFDIPFEESGLIAVD
CCCCEEECCCCCCHHHHHHCCCHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCEEEH
HVVGNVEKMEEWVSYYENVMGFKQMIHFDDDDISTEYSALMSKVMTNGSRIKFPINEPAD
HHHCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHCCCCEEEECCCCCCC
GKRKSQIQEYLEFYNGAGVQHLALLTNDIVKTVEALRANGVEFLDTPDTYYDELTARVGK
CHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHCCCEEECCCHHHHHHHHHHHHH
IDEEIDKLKELKILVDRDDEGYLLQIFTKPIVDRPTLFIEIIQRKGSRGFGEGNFKALFE
HHHHHHHHHHHEEEEECCCCCCEEEEECCCCCCCCHHHHHHHHHCCCCCCCCCHHHHHHH
SIEREQERRGNL
HHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8071207; 11572948; 12692562 [H]