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The map label for this gene is sdhA [H]

Identifier: 46447476

GI number: 46447476

Start: 2201436

End: 2203319

Strand: Reverse

Name: sdhA [H]

Synonym: pc1842

Alternate gene names: 46447476

Gene position: 2203319-2201436 (Counterclockwise)

Preceding gene: 46447477

Following gene: 46447475

Centisome position: 91.25

GC content: 38.69

Gene sequence:

>1884_bases
ATGTCTAAAGCTAAAGAAGTAATCGTGGTTGGAGGGGGATTATCAGGGCTTTCTACGGCTATGAAACTCGCAGAAAATGG
TTGCAATGTCAAAATCGTCTCAGTCACAAAAGTGAAACGCTCTCATTCTGTATGTGCTCAAGGAGGAATTAACGCAGCGA
TGAATTTAAAAGGAGAAGATGATTCTCCTTTGATTCATGCCTATGACACGATTAAAGGAGGTGACTTTTTAGCTAACCAA
CCTCCTGTTTTAGAAATGTGTTTAGCAGCTCCAGCAATTATTCAGATGATGGCACGGTTTGGGTGTCCTTTCAATCGAAC
TTCGGAAGGAAATTTAGATTTTAGACGCTTTGGAGGCACGCTTTATAATCGAACCGCTTTTTGTGGTGCTTCTACTGGAC
AGCAGCTGCTTTATGCTCTAGATGAGCAAGTTAGAAAATACGAAGTGATGGGGAGAGTTGAAAAATTTGAATCTCATGAA
TTTATGCGTCTGATCTTAGATGAACAAGGACTCGCTAGAGGTATTGTCATGATGGATCTTTTTAACATGAAGTTAGATGT
GCTAAAAGCCGATGCTGTTGTGATAGCAACGGGAGGAATTGGAATGATTTTTAAAAAATCGACAAATTCCACGTTTTGTA
CTGGAGCTGCTAATGGTCGTTTATTTAAACAAGGCATGATTTATGCGAATGGAGAATTTATCCAAATTCATCCAACAGCT
ATTCCGGGGCATGATAAACTCCGATTAATGTCAGAATCTGCCCGTGGGGAAGGAGGACGCATTTGGGTTTATGGAGATTC
TTCTAAACAGATAAAAAAAGCGGATGGAACTGAAATTCCATGTGGAAAAACAGGAGAGCCTTGGTATTTTCTTGAAGAGT
TATATCCAGCATTTGGAAATTTGGTTCCCCGCGATATTGGTGCAAGAGAAGTTTTACGTATTTGCGAAATGGGATTAGGG
ATCAATGGGGAAATGCAGGTTTATCTCGACGTATCCCATCTATCGGATGAGAAAAAACAAAAGCTTAAAGCGATTTTGGA
AATTTATCAAAAATTTACTGGTGATGATCCAAAAAAGGTTCCTATGCGAATTTTCCCTGCTATGCATTATACAATGGGGG
GGGCGTGGGTTGATTGGCCAGCTGCGGATGATCACGATCGGTTTGATCGTTTTAGACAAATGACTAATTTACATGGATGT
TTTAATGTTGGCGAATCAGATTACCAATATCATGGAGCTAATCGATTAGGAGCCAACGCGCTACTCTCTTGTATTTTCAG
TGGGCTTGTTGCCGGGCAAGAAGTACCTAGATATTTAGATCAATTAACCCATTCTTATCGAGAAACTCCATCTTCAGTTT
TTGAATCAGCTTTAAATGCCGAACAAGACATAAAAAAAGATTTATTATCGAGGAAGGGTATTGAAAATATTCATCGTTTA
CATGACGAATTATCTGATTGGATGCTTACAAATGTAACAGTTAAACGAAATAATGCCGACCTACTAAAAACCCTTAATAA
ATTGAAGGAACTGAGAGAGCGATATCAACACATTTCGCTAGATGATCGAACGCAATTTGCTAATCAAACATATGCTGTCG
CCAATCAGTTTGGGCCTATGCTCGAGATTGCTATGGTAATTACTAAAGGTGCTCTTTTACGGAATGAATTTAGAGGAGCT
CACTATAAACCAGAGTTTCCAGAGCGAAATGATAAAGAGTGGTTAAAAACAACTTTAGCAACTTATCAGGTAGATGAACC
GCGCATTGAATATGCAGAAGTAGATTTACGCCATCTCCAACCTATTCAAAGAGATTATACACAGGCTAAAAAAATTAAAC
CCAAATTAGAAAATATCCCTGCCAATCTTATTTTACCTATTTAA

Upstream 100 bases:

>100_bases
AAATGGCTACTTTACTGATGATCATGATTGCTTTTTTGGGGTTTGCGGCGATTTGGGGCACATATTGGTTTAATCTCTCA
CATTAATAGGAATTGGTAAG

Downstream 100 bases:

>100_bases
TACCTAGGAGATTTTTGATGGTTCGAACATACATTTTAAAAATATATCGGGGAGAACCGGGATCTCAATATTGGGAAGAA
TTTGAACTTGCTTTAATTCC

Product: succinate dehydrogenase flavoprotein subunit

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 627; Mature: 626

Protein sequence:

>627_residues
MSKAKEVIVVGGGLSGLSTAMKLAENGCNVKIVSVTKVKRSHSVCAQGGINAAMNLKGEDDSPLIHAYDTIKGGDFLANQ
PPVLEMCLAAPAIIQMMARFGCPFNRTSEGNLDFRRFGGTLYNRTAFCGASTGQQLLYALDEQVRKYEVMGRVEKFESHE
FMRLILDEQGLARGIVMMDLFNMKLDVLKADAVVIATGGIGMIFKKSTNSTFCTGAANGRLFKQGMIYANGEFIQIHPTA
IPGHDKLRLMSESARGEGGRIWVYGDSSKQIKKADGTEIPCGKTGEPWYFLEELYPAFGNLVPRDIGAREVLRICEMGLG
INGEMQVYLDVSHLSDEKKQKLKAILEIYQKFTGDDPKKVPMRIFPAMHYTMGGAWVDWPAADDHDRFDRFRQMTNLHGC
FNVGESDYQYHGANRLGANALLSCIFSGLVAGQEVPRYLDQLTHSYRETPSSVFESALNAEQDIKKDLLSRKGIENIHRL
HDELSDWMLTNVTVKRNNADLLKTLNKLKELRERYQHISLDDRTQFANQTYAVANQFGPMLEIAMVITKGALLRNEFRGA
HYKPEFPERNDKEWLKTTLATYQVDEPRIEYAEVDLRHLQPIQRDYTQAKKIKPKLENIPANLILPI

Sequences:

>Translated_627_residues
MSKAKEVIVVGGGLSGLSTAMKLAENGCNVKIVSVTKVKRSHSVCAQGGINAAMNLKGEDDSPLIHAYDTIKGGDFLANQ
PPVLEMCLAAPAIIQMMARFGCPFNRTSEGNLDFRRFGGTLYNRTAFCGASTGQQLLYALDEQVRKYEVMGRVEKFESHE
FMRLILDEQGLARGIVMMDLFNMKLDVLKADAVVIATGGIGMIFKKSTNSTFCTGAANGRLFKQGMIYANGEFIQIHPTA
IPGHDKLRLMSESARGEGGRIWVYGDSSKQIKKADGTEIPCGKTGEPWYFLEELYPAFGNLVPRDIGAREVLRICEMGLG
INGEMQVYLDVSHLSDEKKQKLKAILEIYQKFTGDDPKKVPMRIFPAMHYTMGGAWVDWPAADDHDRFDRFRQMTNLHGC
FNVGESDYQYHGANRLGANALLSCIFSGLVAGQEVPRYLDQLTHSYRETPSSVFESALNAEQDIKKDLLSRKGIENIHRL
HDELSDWMLTNVTVKRNNADLLKTLNKLKELRERYQHISLDDRTQFANQTYAVANQFGPMLEIAMVITKGALLRNEFRGA
HYKPEFPERNDKEWLKTTLATYQVDEPRIEYAEVDLRHLQPIQRDYTQAKKIKPKLENIPANLILPI
>Mature_626_residues
SKAKEVIVVGGGLSGLSTAMKLAENGCNVKIVSVTKVKRSHSVCAQGGINAAMNLKGEDDSPLIHAYDTIKGGDFLANQP
PVLEMCLAAPAIIQMMARFGCPFNRTSEGNLDFRRFGGTLYNRTAFCGASTGQQLLYALDEQVRKYEVMGRVEKFESHEF
MRLILDEQGLARGIVMMDLFNMKLDVLKADAVVIATGGIGMIFKKSTNSTFCTGAANGRLFKQGMIYANGEFIQIHPTAI
PGHDKLRLMSESARGEGGRIWVYGDSSKQIKKADGTEIPCGKTGEPWYFLEELYPAFGNLVPRDIGAREVLRICEMGLGI
NGEMQVYLDVSHLSDEKKQKLKAILEIYQKFTGDDPKKVPMRIFPAMHYTMGGAWVDWPAADDHDRFDRFRQMTNLHGCF
NVGESDYQYHGANRLGANALLSCIFSGLVAGQEVPRYLDQLTHSYRETPSSVFESALNAEQDIKKDLLSRKGIENIHRLH
DELSDWMLTNVTVKRNNADLLKTLNKLKELRERYQHISLDDRTQFANQTYAVANQFGPMLEIAMVITKGALLRNEFRGAH
YKPEFPERNDKEWLKTTLATYQVDEPRIEYAEVDLRHLQPIQRDYTQAKKIKPKLENIPANLILPI

Specific function: Two Distinct, Membrane-Bound, FAD-Containing Enzymes Are Responsible For The Catalysis Of Fumarate And Succinate Interconversion; The Fumarate Reductase Is Used In Anaerobic Growth, And The Succinate Dehydrogenase Is Used In Aerobic Growth. [C]

COG id: COG1053

COG function: function code C; Succinate dehydrogenase/fumarate reductase, flavoprotein subunit

Gene ontology:

Cell location: Cell membrane; Peripheral membrane protein; Cytoplasmic side [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the FAD-dependent oxidoreductase 2 family. FRD/SDH subfamily [H]

Homologues:

Organism=Homo sapiens, GI156416003, Length=561, Percent_Identity=28.5204991087344, Blast_Score=186, Evalue=5e-47,
Organism=Escherichia coli, GI1790597, Length=587, Percent_Identity=31.8568994889268, Blast_Score=257, Evalue=1e-69,
Organism=Escherichia coli, GI1786942, Length=588, Percent_Identity=29.421768707483, Blast_Score=207, Evalue=1e-54,
Organism=Escherichia coli, GI1788928, Length=584, Percent_Identity=27.2260273972603, Blast_Score=159, Evalue=5e-40,
Organism=Caenorhabditis elegans, GI17550100, Length=621, Percent_Identity=27.8582930756844, Blast_Score=190, Evalue=2e-48,
Organism=Caenorhabditis elegans, GI17505833, Length=574, Percent_Identity=28.7456445993031, Blast_Score=181, Evalue=7e-46,
Organism=Saccharomyces cerevisiae, GI6322701, Length=610, Percent_Identity=29.016393442623, Blast_Score=208, Evalue=2e-54,
Organism=Saccharomyces cerevisiae, GI6322416, Length=591, Percent_Identity=28.2571912013536, Blast_Score=196, Evalue=9e-51,
Organism=Drosophila melanogaster, GI17137288, Length=583, Percent_Identity=29.8456260720412, Blast_Score=202, Evalue=7e-52,
Organism=Drosophila melanogaster, GI24655642, Length=583, Percent_Identity=29.8456260720412, Blast_Score=202, Evalue=7e-52,
Organism=Drosophila melanogaster, GI24655647, Length=583, Percent_Identity=29.8456260720412, Blast_Score=202, Evalue=7e-52,
Organism=Drosophila melanogaster, GI24663005, Length=579, Percent_Identity=30.0518134715026, Blast_Score=193, Evalue=3e-49,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003953
- InterPro:   IPR013027
- InterPro:   IPR003952
- InterPro:   IPR015939
- InterPro:   IPR004112
- InterPro:   IPR011280 [H]

Pfam domain/function: PF00890 FAD_binding_2; PF02910 Succ_DH_flav_C [H]

EC number: =1.3.99.1 [H]

Molecular weight: Translated: 70439; Mature: 70308

Theoretical pI: Translated: 7.77; Mature: 7.77

Prosite motif: PS00504 FRD_SDH_FAD_BINDING

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.6 %Cys     (Translated Protein)
3.7 %Met     (Translated Protein)
5.3 %Cys+Met (Translated Protein)
1.6 %Cys     (Mature Protein)
3.5 %Met     (Mature Protein)
5.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSKAKEVIVVGGGLSGLSTAMKLAENGCNVKIVSVTKVKRSHSVCAQGGINAAMNLKGED
CCCCCEEEEECCCHHHHHHHHHHHHCCCCEEEEEEEHHHHHHHHHHCCCCCEEEECCCCC
DSPLIHAYDTIKGGDFLANQPPVLEMCLAAPAIIQMMARFGCPFNRTSEGNLDFRRFGGT
CCCEEEEEECCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCHHHHCCH
LYNRTAFCGASTGQQLLYALDEQVRKYEVMGRVEKFESHEFMRLILDEQGLARGIVMMDL
HHCCEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHH
FNMKLDVLKADAVVIATGGIGMIFKKSTNSTFCTGAANGRLFKQGMIYANGEFIQIHPTA
HHHHHEEEECCEEEEEECCCEEEEEECCCCEEEECCCCCCEEECCEEEECCEEEEEECCC
IPGHDKLRLMSESARGEGGRIWVYGDSSKQIKKADGTEIPCGKTGEPWYFLEELYPAFGN
CCCCHHHHEEHHHCCCCCCEEEEEECCCCHHHCCCCCCCCCCCCCCCCHHHHHHHHHHCC
LVPRDIGAREVLRICEMGLGINGEMQVYLDVSHLSDEKKQKLKAILEIYQKFTGDDPKKV
CCCCCCCHHHHHHHHHHCCCCCCCEEEEEEHHHCCHHHHHHHHHHHHHHHHHCCCCCCCC
PMRIFPAMHYTMGGAWVDWPAADDHDRFDRFRQMTNLHGCFNVGESDYQYHGANRLGANA
CHHHHHHHHHHCCCCEEECCCCCCHHHHHHHHHHHHHHHHHCCCCCCCEECCCCCCCHHH
LLSCIFSGLVAGQEVPRYLDQLTHSYRETPSSVFESALNAEQDIKKDLLSRKGIENIHRL
HHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHCHHHHHHHHHHHHCCHHHHHHH
HDELSDWMLTNVTVKRNNADLLKTLNKLKELRERYQHISLDDRTQFANQTYAVANQFGPM
HHHHHHHEEEEEEEECCCHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHCCHH
LEIAMVITKGALLRNEFRGAHYKPEFPERNDKEWLKTTLATYQVDEPRIEYAEVDLRHLQ
HHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCHHHHHHHHHHEECCCCCCHHHHCCHHHHC
PIQRDYTQAKKIKPKLENIPANLILPI
HHHHHHHHHHHCCCHHHCCCCCEEECC
>Mature Secondary Structure 
SKAKEVIVVGGGLSGLSTAMKLAENGCNVKIVSVTKVKRSHSVCAQGGINAAMNLKGED
CCCCEEEEECCCHHHHHHHHHHHHCCCCEEEEEEEHHHHHHHHHHCCCCCEEEECCCCC
DSPLIHAYDTIKGGDFLANQPPVLEMCLAAPAIIQMMARFGCPFNRTSEGNLDFRRFGGT
CCCEEEEEECCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCHHHHCCH
LYNRTAFCGASTGQQLLYALDEQVRKYEVMGRVEKFESHEFMRLILDEQGLARGIVMMDL
HHCCEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHH
FNMKLDVLKADAVVIATGGIGMIFKKSTNSTFCTGAANGRLFKQGMIYANGEFIQIHPTA
HHHHHEEEECCEEEEEECCCEEEEEECCCCEEEECCCCCCEEECCEEEECCEEEEEECCC
IPGHDKLRLMSESARGEGGRIWVYGDSSKQIKKADGTEIPCGKTGEPWYFLEELYPAFGN
CCCCHHHHEEHHHCCCCCCEEEEEECCCCHHHCCCCCCCCCCCCCCCCHHHHHHHHHHCC
LVPRDIGAREVLRICEMGLGINGEMQVYLDVSHLSDEKKQKLKAILEIYQKFTGDDPKKV
CCCCCCCHHHHHHHHHHCCCCCCCEEEEEEHHHCCHHHHHHHHHHHHHHHHHCCCCCCCC
PMRIFPAMHYTMGGAWVDWPAADDHDRFDRFRQMTNLHGCFNVGESDYQYHGANRLGANA
CHHHHHHHHHHCCCCEEECCCCCCHHHHHHHHHHHHHHHHHCCCCCCCEECCCCCCCHHH
LLSCIFSGLVAGQEVPRYLDQLTHSYRETPSSVFESALNAEQDIKKDLLSRKGIENIHRL
HHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHCHHHHHHHHHHHHCCHHHHHHH
HDELSDWMLTNVTVKRNNADLLKTLNKLKELRERYQHISLDDRTQFANQTYAVANQFGPM
HHHHHHHEEEEEEEECCCHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHCCHH
LEIAMVITKGALLRNEFRGAHYKPEFPERNDKEWLKTTLATYQVDEPRIEYAEVDLRHLQ
HHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCHHHHHHHHHHEECCCCCCHHHHCCHHHHC
PIQRDYTQAKKIKPKLENIPANLILPI
HHHHHHHHHHHCCCHHHCCCCCEEECC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 3027051; 8969504; 9384377; 3086287; 3021212 [H]