Click here to switch to the map view.

The map label for this gene is fumC [H]

Identifier: 46447294

GI number: 46447294

Start: 1998054

End: 1999445

Strand: Reverse

Name: fumC [H]

Synonym: pc1660

Alternate gene names: 46447294

Gene position: 1999445-1998054 (Counterclockwise)

Preceding gene: 46447295

Following gene: 46447291

Centisome position: 82.81

GC content: 38.15

Gene sequence:

>1392_bases
ATGGACTATCGAACAGAAAAAGACACCTTAGGAGAAGTTAGAGTTTCTGCAGACTGTTATTATGGAGCTCAAACGAAGCG
TTCCTACGATAATTTTTCGATTGGAATAGAAAAAATGCCTAAGGAAGTAATTCATGCGCTTGCTCTAATCAAGAAAGCGG
CCGCCTTAACTAACGAACAGCTTGGTTTATTACCAAAAAATAAACAACTCGTGATTTGTGAAGTTTGCGACGAAATTTTA
TCTGGCTGCTTAGATGATCAATTTCCGTTATCTGTTTGGCAGACAGGGTCTGGAACGCAAACAAACATGAACCTCAATGA
AGTGATTAGTAATAGGGCCATTGAAAAGCTGGGTGGGGTGCTTGGTTCTAAATATCCGATCCATCCCAATGATGATGTCA
ACTTATCTCAATCGTCTAATGATGTGTTTCCTTCAGCCATGCATATTGCGGTGATGTTTGATATATCTAAGAAGTTGTTA
CCAAGTTTAAGAGAACTAAAAGAAACTTTAGAAGCGAAAGTTGAAGCTTTTAAAGATATTGTAAAAATTGGGCGTACGCA
TTTAATGGATGCGACCCCTTTAACACTTGGACAAGAATTTTCGGGGTATGTCAGCCAAATAGAGCATGGAATACAAGCTC
TAAAAAATACGTTTGCGCATCTTTCTGAATTGGCCTTGGGAGCAACTGCTGTGGGAACGGGAATGAATACGCATCCCAAC
TACGCAAAATTAGTGGCTGAAAAAATTAGTGAGTTGTCCGGATTTAATTTTGTTTCTGCCAGGAATAAATTTGAGTCGCT
CGCGACTAATGACGCTCTTGTAGAAGTTAGCGGGGCTTTAAAAAGGGTGGCCGTTTCAGTGTTTAAAATTGCCAATGATA
TTCGGTGGCTTTCTTCAGGCCCTAGATGTGCCATAGGAGAAATCGTTATTCCTGCTAATGAACCAGGCTCATCGATTATG
CCAGGAAAAGTTAATCCTACACAAAGTGAAGCCTTAATGATGATTGCCATTCAAGTAATGGGGAATGATGGGATCATTGG
TTTTGCAGGTTCGCAAGGCAATCTAGAATTGAATGTTTTTCGCCCTCTTATTATTTATAACTTAATTCAATCTATTCGAT
TATTGAGCGATGCTATTTCTAATTTTAACCAAAAATGTGTTGTCGGAATAGAGGCTAACCAAACAAGAATTGCAGAACAT
CTGAATCGTTCCTTAATGTTAGCAACTGCTCTTAATCATGCAATTGGTTATGATCGTGCAAGTCAAATTGTAAAAAAAGC
ATACTTAGAAAATATAACATTAAAAGAAGCTGCACTAGCTTTAGCCTTTTTAACCGAAGATGAATTTGATCAGATTATGG
ATCCTAAAAAAATGATTGGGCCAATGACTTAA

Upstream 100 bases:

>100_bases
TTTAGGATATTTAGGATCTAAAATTTACCTTGATAAAATTCTCAGTTATGAGAATAGACTGAGAATATATCATTATTGGA
ATATGAGAGAATAAGATTAA

Downstream 100 bases:

>100_bases
TATTTTGCTGATTTTGATTTGTTAAATGTTTCTTGTTCTTTTTTTGTGTTTTCAGTGGAAAAATCAAAAGAGATTAAGTC
TACCCATAGGGGATGCGTCC

Product: fumarate hydratase

Products: NA

Alternate protein names: Fumarase C [H]

Number of amino acids: Translated: 463; Mature: 463

Protein sequence:

>463_residues
MDYRTEKDTLGEVRVSADCYYGAQTKRSYDNFSIGIEKMPKEVIHALALIKKAAALTNEQLGLLPKNKQLVICEVCDEIL
SGCLDDQFPLSVWQTGSGTQTNMNLNEVISNRAIEKLGGVLGSKYPIHPNDDVNLSQSSNDVFPSAMHIAVMFDISKKLL
PSLRELKETLEAKVEAFKDIVKIGRTHLMDATPLTLGQEFSGYVSQIEHGIQALKNTFAHLSELALGATAVGTGMNTHPN
YAKLVAEKISELSGFNFVSARNKFESLATNDALVEVSGALKRVAVSVFKIANDIRWLSSGPRCAIGEIVIPANEPGSSIM
PGKVNPTQSEALMMIAIQVMGNDGIIGFAGSQGNLELNVFRPLIIYNLIQSIRLLSDAISNFNQKCVVGIEANQTRIAEH
LNRSLMLATALNHAIGYDRASQIVKKAYLENITLKEAALALAFLTEDEFDQIMDPKKMIGPMT

Sequences:

>Translated_463_residues
MDYRTEKDTLGEVRVSADCYYGAQTKRSYDNFSIGIEKMPKEVIHALALIKKAAALTNEQLGLLPKNKQLVICEVCDEIL
SGCLDDQFPLSVWQTGSGTQTNMNLNEVISNRAIEKLGGVLGSKYPIHPNDDVNLSQSSNDVFPSAMHIAVMFDISKKLL
PSLRELKETLEAKVEAFKDIVKIGRTHLMDATPLTLGQEFSGYVSQIEHGIQALKNTFAHLSELALGATAVGTGMNTHPN
YAKLVAEKISELSGFNFVSARNKFESLATNDALVEVSGALKRVAVSVFKIANDIRWLSSGPRCAIGEIVIPANEPGSSIM
PGKVNPTQSEALMMIAIQVMGNDGIIGFAGSQGNLELNVFRPLIIYNLIQSIRLLSDAISNFNQKCVVGIEANQTRIAEH
LNRSLMLATALNHAIGYDRASQIVKKAYLENITLKEAALALAFLTEDEFDQIMDPKKMIGPMT
>Mature_463_residues
MDYRTEKDTLGEVRVSADCYYGAQTKRSYDNFSIGIEKMPKEVIHALALIKKAAALTNEQLGLLPKNKQLVICEVCDEIL
SGCLDDQFPLSVWQTGSGTQTNMNLNEVISNRAIEKLGGVLGSKYPIHPNDDVNLSQSSNDVFPSAMHIAVMFDISKKLL
PSLRELKETLEAKVEAFKDIVKIGRTHLMDATPLTLGQEFSGYVSQIEHGIQALKNTFAHLSELALGATAVGTGMNTHPN
YAKLVAEKISELSGFNFVSARNKFESLATNDALVEVSGALKRVAVSVFKIANDIRWLSSGPRCAIGEIVIPANEPGSSIM
PGKVNPTQSEALMMIAIQVMGNDGIIGFAGSQGNLELNVFRPLIIYNLIQSIRLLSDAISNFNQKCVVGIEANQTRIAEH
LNRSLMLATALNHAIGYDRASQIVKKAYLENITLKEAALALAFLTEDEFDQIMDPKKMIGPMT

Specific function: Tricarboxylic acid cycle [C]

COG id: COG0114

COG function: function code C; Fumarase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-II fumarase/aspartase family. Fumarase subfamily [H]

Homologues:

Organism=Homo sapiens, GI19743875, Length=461, Percent_Identity=56.8329718004338, Blast_Score=525, Evalue=1e-149,
Organism=Escherichia coli, GI1787896, Length=459, Percent_Identity=60.1307189542484, Blast_Score=573, Evalue=1e-164,
Organism=Escherichia coli, GI87082375, Length=461, Percent_Identity=39.6963123644252, Blast_Score=327, Evalue=1e-90,
Organism=Caenorhabditis elegans, GI17553882, Length=462, Percent_Identity=58.008658008658, Blast_Score=543, Evalue=1e-155,
Organism=Caenorhabditis elegans, GI32565146, Length=327, Percent_Identity=56.5749235474006, Blast_Score=382, Evalue=1e-106,
Organism=Saccharomyces cerevisiae, GI6324993, Length=461, Percent_Identity=58.7852494577007, Blast_Score=546, Evalue=1e-156,
Organism=Drosophila melanogaster, GI24640177, Length=463, Percent_Identity=56.5874730021598, Blast_Score=537, Evalue=1e-153,
Organism=Drosophila melanogaster, GI24640179, Length=463, Percent_Identity=56.5874730021598, Blast_Score=537, Evalue=1e-153,
Organism=Drosophila melanogaster, GI78710009, Length=463, Percent_Identity=56.1555075593952, Blast_Score=527, Evalue=1e-150,
Organism=Drosophila melanogaster, GI24662684, Length=465, Percent_Identity=53.9784946236559, Blast_Score=503, Evalue=1e-143,
Organism=Drosophila melanogaster, GI24583245, Length=464, Percent_Identity=47.4137931034483, Blast_Score=428, Evalue=1e-120,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003031
- InterPro:   IPR005677
- InterPro:   IPR018951
- InterPro:   IPR000362
- InterPro:   IPR020557
- InterPro:   IPR008948
- InterPro:   IPR022761 [H]

Pfam domain/function: PF10415 FumaraseC_C; PF00206 Lyase_1 [H]

EC number: =4.2.1.2 [H]

Molecular weight: Translated: 50545; Mature: 50545

Theoretical pI: Translated: 6.07; Mature: 6.07

Prosite motif: PS00163 FUMARATE_LYASES

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
3.2 %Met     (Translated Protein)
4.5 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
3.2 %Met     (Mature Protein)
4.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MDYRTEKDTLGEVRVSADCYYGAQTKRSYDNFSIGIEKMPKEVIHALALIKKAAALTNEQ
CCCCCCCCCCCCEEEECCEEECCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCC
LGLLPKNKQLVICEVCDEILSGCLDDQFPLSVWQTGSGTQTNMNLNEVISNRAIEKLGGV
CCCCCCCCCEEEHHHHHHHHHHHCCCCCCCCEEECCCCCCCCCCHHHHHHHHHHHHHHHH
LGSKYPIHPNDDVNLSQSSNDVFPSAMHIAVMFDISKKLLPSLRELKETLEAKVEAFKDI
HCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
VKIGRTHLMDATPLTLGQEFSGYVSQIEHGIQALKNTFAHLSELALGATAVGTGMNTHPN
HHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCH
YAKLVAEKISELSGFNFVSARNKFESLATNDALVEVSGALKRVAVSVFKIANDIRWLSSG
HHHHHHHHHHHHCCCCCHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCC
PRCAIGEIVIPANEPGSSIMPGKVNPTQSEALMMIAIQVMGNDGIIGFAGSQGNLELNVF
CCEEECCEEEECCCCCCCCCCCCCCCCHHHHHEEEEEEEECCCCEEEEECCCCCEEEEHH
RPLIIYNLIQSIRLLSDAISNFNQKCVVGIEANQTRIAEHLNRSLMLATALNHAIGYDRA
HHHHHHHHHHHHHHHHHHHHCCCCEEEEEECCCHHHHHHHHCHHHHHHHHHHHHHCHHHH
SQIVKKAYLENITLKEAALALAFLTEDEFDQIMDPKKMIGPMT
HHHHHHHHHHCCHHHHHHHHHHHHCHHHHHHHCCCHHHCCCCC
>Mature Secondary Structure
MDYRTEKDTLGEVRVSADCYYGAQTKRSYDNFSIGIEKMPKEVIHALALIKKAAALTNEQ
CCCCCCCCCCCCEEEECCEEECCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCC
LGLLPKNKQLVICEVCDEILSGCLDDQFPLSVWQTGSGTQTNMNLNEVISNRAIEKLGGV
CCCCCCCCCEEEHHHHHHHHHHHCCCCCCCCEEECCCCCCCCCCHHHHHHHHHHHHHHHH
LGSKYPIHPNDDVNLSQSSNDVFPSAMHIAVMFDISKKLLPSLRELKETLEAKVEAFKDI
HCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
VKIGRTHLMDATPLTLGQEFSGYVSQIEHGIQALKNTFAHLSELALGATAVGTGMNTHPN
HHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCH
YAKLVAEKISELSGFNFVSARNKFESLATNDALVEVSGALKRVAVSVFKIANDIRWLSSG
HHHHHHHHHHHHCCCCCHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCC
PRCAIGEIVIPANEPGSSIMPGKVNPTQSEALMMIAIQVMGNDGIIGFAGSQGNLELNVF
CCEEECCEEEECCCCCCCCCCCCCCCCHHHHHEEEEEEEECCCCEEEEECCCCCEEEEHH
RPLIIYNLIQSIRLLSDAISNFNQKCVVGIEANQTRIAEHLNRSLMLATALNHAIGYDRA
HHHHHHHHHHHHHHHHHHHHCCCCEEEEEECCCHHHHHHHHCHHHHHHHHHHHHHCHHHH
SQIVKKAYLENITLKEAALALAFLTEDEFDQIMDPKKMIGPMT
HHHHHHHHHHCCHHHHHHHHHHHHCHHHHHHHCCCHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 12704232 [H]