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The map label for this gene is hldD [H]

Identifier: 46447222

GI number: 46447222

Start: 1904621

End: 1905607

Strand: Reverse

Name: hldD [H]

Synonym: pc1588

Alternate gene names: 46447222

Gene position: 1905607-1904621 (Counterclockwise)

Preceding gene: 46447223

Following gene: 46447221

Centisome position: 78.92

GC content: 34.75

Gene sequence:

>987_bases
ATGAAAATATATGATGATCAATTAATAGTAATCACAGGTGGAGCTGGATTTATTGGCTCTTGTCTTGTTCGCTATTTGAA
TAACAAAGGAATGACGAATCTCTTGATTGTTGATGAACTTGGGCACAGTGAAAAATGGAAAAATCTTGTTGGTAAAAAAT
TTGCCGACATCATTCCTAAACATCAATTATTTAATTGGTTAAATGGAAAAGAATCCTTGATTGAAGCGTTCGTTCATTTA
GGAGCTTGTTCAAATACATTAGAGAAAGATGCTAGTTACCTTTTAGAAAATAATTACCGCTATACAGTTCAATTAGCTGA
GTATGCGTTAAAACATGAGCATCGCTTTATTTACGCTTCTTCAGCAGCCACTTACGGGGATGGCTTAAAGGGATTTCAAG
ATAAAGAAAACGAGTTGTACTCGCTTGAACCTTTAAATATGTACGGCTTTTCTAAACAGCTTTTTGATCAATGGGCTTAT
ACAGAAGGAGCCTTAGAAAAAATTGTGGGATTAAAATACTTTAATGTATTTGGTCCTAATGAATATCACAAAGGGCGAAT
GGCCTCAGCTGTGAATAAAATGGTACCAGAAATTTTAAAGGGTGAAACAGTCAAACTTTTTAAATCGAGCGAGCCTCATC
TTTATGCAGACGGAGAGCAAAAAAGAGATTTTATTTATGTCAAAGATGTTGTTAGAATCACGTGTGCATTTTTAGAAAAC
GACGTTGGAGGTTTATATAATGTTGGTAGCGGGGAAGCTTCTACATGGAATTCCTTAACACATGCTGTTTTTAAAGCTCT
CGATTGTCCTGTCAAAATTGAATATGTTGACATGCCAAAAGAATTGGTTGGGAAATATCAAAATTACAGTCGTGCAGATA
CAAAAAAGCTTGAAACGATACTAAAAGATCAATCTCATCCCATGCTTTTGGAAGCTGCTATTGAAGATTATGTAAAAAAC
TATTTGGTGACGAAGAAAATATGGTAG

Upstream 100 bases:

>100_bases
GAATGCCAAATTTATTTTTCCAAAATTTAATTTTTAGTTCTTTCTTGTCTTATTTATGATAGACTATAGATTTATTTATT
TTTTTTGATGAGTTCGAATA

Downstream 100 bases:

>100_bases
CGTTAGCAAATACATTGCGAGATTTAAAACCTGTTAAGGTAGCAGTAATTGGAGATTTCTTATTAGACACTTATACTATA
GGAAAGGCTAAAAGAATTTC

Product: putative ADP-D-beta-heptose epimerase, hldD

Products: NA

Alternate protein names: ADP-L-glycero-beta-D-manno-heptose-6-epimerase; ADP-glyceromanno-heptose 6-epimerase; ADP-hep 6-epimerase; AGME [H]

Number of amino acids: Translated: 328; Mature: 328

Protein sequence:

>328_residues
MKIYDDQLIVITGGAGFIGSCLVRYLNNKGMTNLLIVDELGHSEKWKNLVGKKFADIIPKHQLFNWLNGKESLIEAFVHL
GACSNTLEKDASYLLENNYRYTVQLAEYALKHEHRFIYASSAATYGDGLKGFQDKENELYSLEPLNMYGFSKQLFDQWAY
TEGALEKIVGLKYFNVFGPNEYHKGRMASAVNKMVPEILKGETVKLFKSSEPHLYADGEQKRDFIYVKDVVRITCAFLEN
DVGGLYNVGSGEASTWNSLTHAVFKALDCPVKIEYVDMPKELVGKYQNYSRADTKKLETILKDQSHPMLLEAAIEDYVKN
YLVTKKIW

Sequences:

>Translated_328_residues
MKIYDDQLIVITGGAGFIGSCLVRYLNNKGMTNLLIVDELGHSEKWKNLVGKKFADIIPKHQLFNWLNGKESLIEAFVHL
GACSNTLEKDASYLLENNYRYTVQLAEYALKHEHRFIYASSAATYGDGLKGFQDKENELYSLEPLNMYGFSKQLFDQWAY
TEGALEKIVGLKYFNVFGPNEYHKGRMASAVNKMVPEILKGETVKLFKSSEPHLYADGEQKRDFIYVKDVVRITCAFLEN
DVGGLYNVGSGEASTWNSLTHAVFKALDCPVKIEYVDMPKELVGKYQNYSRADTKKLETILKDQSHPMLLEAAIEDYVKN
YLVTKKIW
>Mature_328_residues
MKIYDDQLIVITGGAGFIGSCLVRYLNNKGMTNLLIVDELGHSEKWKNLVGKKFADIIPKHQLFNWLNGKESLIEAFVHL
GACSNTLEKDASYLLENNYRYTVQLAEYALKHEHRFIYASSAATYGDGLKGFQDKENELYSLEPLNMYGFSKQLFDQWAY
TEGALEKIVGLKYFNVFGPNEYHKGRMASAVNKMVPEILKGETVKLFKSSEPHLYADGEQKRDFIYVKDVVRITCAFLEN
DVGGLYNVGSGEASTWNSLTHAVFKALDCPVKIEYVDMPKELVGKYQNYSRADTKKLETILKDQSHPMLLEAAIEDYVKN
YLVTKKIW

Specific function: Catalyzes the interconversion between ADP-D-glycero- beta-D-manno-heptose and ADP-L-glycero-beta-D-manno-heptose via an epimerization at carbon 6 of the heptose [H]

COG id: COG0451

COG function: function code MG; Nucleoside-diphosphate-sugar epimerases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the sugar epimerase family. HldD subfamily [H]

Homologues:

Organism=Escherichia coli, GI1790049, Length=313, Percent_Identity=40.8945686900958, Blast_Score=224, Evalue=6e-60,

Paralogues:

None

Copy number: 220 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001509
- InterPro:   IPR011912
- InterPro:   IPR016040 [H]

Pfam domain/function: PF01370 Epimerase [H]

EC number: =5.1.3.20 [H]

Molecular weight: Translated: 37385; Mature: 37385

Theoretical pI: Translated: 6.79; Mature: 6.79

Prosite motif: PS00013 PROKAR_LIPOPROTEIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
2.1 %Met     (Translated Protein)
3.4 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
2.1 %Met     (Mature Protein)
3.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKIYDDQLIVITGGAGFIGSCLVRYLNNKGMTNLLIVDELGHSEKWKNLVGKKFADIIPK
CCEECCEEEEEECCCCHHHHHHHHHHCCCCCEEEEEEECCCCCHHHHHHHHHHHHHHCCH
HQLFNWLNGKESLIEAFVHLGACSNTLEKDASYLLENNYRYTVQLAEYALKHEHRFIYAS
HHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEHHHHHHHHHCCEEEEEC
SAATYGDGLKGFQDKENELYSLEPLNMYGFSKQLFDQWAYTEGALEKIVGLKYFNVFGPN
CCCCCCCCCCCCCCCCCCEEEECCCCHHCCHHHHHHHHHHHHHHHHHHHHHHHEECCCCC
EYHKGRMASAVNKMVPEILKGETVKLFKSSEPHLYADGEQKRDFIYVKDVVRITCAFLEN
HHHCCHHHHHHHHHHHHHHCCCEEEEEECCCCCEEECCCCCCCEEHHHHHHHHHHHHHHC
DVGGLYNVGSGEASTWNSLTHAVFKALDCPVKIEYVDMPKELVGKYQNYSRADTKKLETI
CCCCCEECCCCCCCHHHHHHHHHHHHHCCCEEEEEECCCHHHHHHHHCCCHHHHHHHHHH
LKDQSHPMLLEAAIEDYVKNYLVTKKIW
HHCCCCCHHHHHHHHHHHHHHHHHHCCC
>Mature Secondary Structure
MKIYDDQLIVITGGAGFIGSCLVRYLNNKGMTNLLIVDELGHSEKWKNLVGKKFADIIPK
CCEECCEEEEEECCCCHHHHHHHHHHCCCCCEEEEEEECCCCCHHHHHHHHHHHHHHCCH
HQLFNWLNGKESLIEAFVHLGACSNTLEKDASYLLENNYRYTVQLAEYALKHEHRFIYAS
HHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEHHHHHHHHHCCEEEEEC
SAATYGDGLKGFQDKENELYSLEPLNMYGFSKQLFDQWAYTEGALEKIVGLKYFNVFGPN
CCCCCCCCCCCCCCCCCCEEEECCCCHHCCHHHHHHHHHHHHHHHHHHHHHHHEECCCCC
EYHKGRMASAVNKMVPEILKGETVKLFKSSEPHLYADGEQKRDFIYVKDVVRITCAFLEN
HHHCCHHHHHHHHHHHHHHCCCEEEEEECCCCCEEECCCCCCCEEHHHHHHHHHHHHHHC
DVGGLYNVGSGEASTWNSLTHAVFKALDCPVKIEYVDMPKELVGKYQNYSRADTKKLETI
CCCCCEECCCCCCCHHHHHHHHHHHHHCCCEEEEEECCCHHHHHHHHCCCHHHHHHHHHH
LKDQSHPMLLEAAIEDYVKNYLVTKKIW
HHCCCCCHHHHHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA