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The map label for this gene is hldE [H]

Identifier: 46447221

GI number: 46447221

Start: 1903266

End: 1904627

Strand: Reverse

Name: hldE [H]

Synonym: pc1587

Alternate gene names: 46447221

Gene position: 1904627-1903266 (Counterclockwise)

Preceding gene: 46447222

Following gene: 46447219

Centisome position: 78.88

GC content: 38.62

Gene sequence:

>1362_bases
ATGGTAGCGTTAGCAAATACATTGCGAGATTTAAAACCTGTTAAGGTAGCAGTAATTGGAGATTTCTTATTAGACACTTA
TACTATAGGAAAGGCTAAAAGAATTTCTCCTGAAGCTCCTGTTGCTGTCATTCATGTTCACCATGAAGAGCATAAACCAG
GAGGAGCCGGGAATGTTGTGCTCAATTTAATTTCGTTAGGTGCACAGGTAACAGCGATAGGTAGAACAGGTAAGGATTGG
GGGGGCGATGTTCTTTGCAATGTCTTAAGTCAAGAAGGAGTTGATACGTCAGCTATTTTCAACCAACAAAGATACAGAAC
GCCTGTCAAAAACCGCGTTATTGCAGAAAATCAACAAATTGTCCGCATAGATTTTGAAGAAATTGTCTCCCTTGATGCCC
AATTAGAGCAAGAAATCATTCTTGCTATCCCAACCTTTATGCATGATGTTCAAGCGATCGCGATTTCCGATTATGGTAAA
GGTTTTCTAACAGATCAGCTCCTTAAAGCTATCATTGATTATGCTAATAAAAATGCCATTTTGGTTGTAACAGATCCAAA
AGGACACGACTTTTCTAAATATACTCAAACAACTTTAATTAAACCTAACCTTTCGGAAGCTTATGCAGCAGTTGGGTTAC
CGCCTTCAGCACCACTTGATTTAGTTGCCCAAAAAATCTTGCATATCACTCAAGCACGCTTGTTAATGATTACTCGTTCA
GAAGCTGGTATTTCCCTTTTTGAACCGTCGGGAACTCGGCAGGATTTCCCTGTTCACGCAAAAGAAGTTAAAGATGTTAC
GGGTGCTGGCGATACCGTGTTGGCTATGCTCACTTATGCTTTGGCGAATAAAACTACTTATTCAGTAGCAGCTCAACTTT
GCAATGTCGCAGCTGGAATTGCCATTGAGCAAGTGGGATGCGCAAGAGTCACTTTATCAGATGTTGCTTACAGATTATTT
CAACATGATATGAAACATAAAGTCTTTGATCATGAGCAAGTGTTTGTACTTCGAGAAGTCCTGAAAAAAAATCCTTTCAA
TCTGCTAATTGTACAATGCATTGAAAGCATCTCTTTATCTCTTTTTCAATCGATTCAAGAGTTGACAGTTGGTGAGCAAC
CTCTTTTAATCTATGTAATAGATTCCGAGCCTTCTCGATTGGGAATAGATATGCTTGCCTCTTTAAAAGAGGTCAGTTTT
ATACTTATCCAGCAAGATAATCTAAAGTTTTTATGCAGCGATGTAAAACCTGCTAAATCATATGCCTATGATGGTCATCA
CCTTCAATGTGTGGATCCTGAATCTTATCTTTTAAATGTTTGGCTGCATGACGATTTAAAACTTCCAGTCACTTTGAATT
AA

Upstream 100 bases:

>100_bases
CAAAAAAGCTTGAAACGATACTAAAAGATCAATCTCATCCCATGCTTTTGGAAGCTGCTATTGAAGATTATGTAAAAAAC
TATTTGGTGACGAAGAAAAT

Downstream 100 bases:

>100_bases
CAAGATTTAGGAATTTCTATGTTTTTTAATTTTTGATTTCATGTTTTGATAAATATGAGTGATGGTTTTGTAAACAATCC
TATATTCAAATAAACGCTAT

Product: putative bifunctional protein involved in LPS core biosynthesis, hdlE

Products: NA

Alternate protein names: D-beta-D-heptose 7-phosphate kinase; D-beta-D-heptose 7-phosphotransferase; D-beta-D-heptose 1-phosphate adenosyltransferase [H]

Number of amino acids: Translated: 453; Mature: 453

Protein sequence:

>453_residues
MVALANTLRDLKPVKVAVIGDFLLDTYTIGKAKRISPEAPVAVIHVHHEEHKPGGAGNVVLNLISLGAQVTAIGRTGKDW
GGDVLCNVLSQEGVDTSAIFNQQRYRTPVKNRVIAENQQIVRIDFEEIVSLDAQLEQEIILAIPTFMHDVQAIAISDYGK
GFLTDQLLKAIIDYANKNAILVVTDPKGHDFSKYTQTTLIKPNLSEAYAAVGLPPSAPLDLVAQKILHITQARLLMITRS
EAGISLFEPSGTRQDFPVHAKEVKDVTGAGDTVLAMLTYALANKTTYSVAAQLCNVAAGIAIEQVGCARVTLSDVAYRLF
QHDMKHKVFDHEQVFVLREVLKKNPFNLLIVQCIESISLSLFQSIQELTVGEQPLLIYVIDSEPSRLGIDMLASLKEVSF
ILIQQDNLKFLCSDVKPAKSYAYDGHHLQCVDPESYLLNVWLHDDLKLPVTLN

Sequences:

>Translated_453_residues
MVALANTLRDLKPVKVAVIGDFLLDTYTIGKAKRISPEAPVAVIHVHHEEHKPGGAGNVVLNLISLGAQVTAIGRTGKDW
GGDVLCNVLSQEGVDTSAIFNQQRYRTPVKNRVIAENQQIVRIDFEEIVSLDAQLEQEIILAIPTFMHDVQAIAISDYGK
GFLTDQLLKAIIDYANKNAILVVTDPKGHDFSKYTQTTLIKPNLSEAYAAVGLPPSAPLDLVAQKILHITQARLLMITRS
EAGISLFEPSGTRQDFPVHAKEVKDVTGAGDTVLAMLTYALANKTTYSVAAQLCNVAAGIAIEQVGCARVTLSDVAYRLF
QHDMKHKVFDHEQVFVLREVLKKNPFNLLIVQCIESISLSLFQSIQELTVGEQPLLIYVIDSEPSRLGIDMLASLKEVSF
ILIQQDNLKFLCSDVKPAKSYAYDGHHLQCVDPESYLLNVWLHDDLKLPVTLN
>Mature_453_residues
MVALANTLRDLKPVKVAVIGDFLLDTYTIGKAKRISPEAPVAVIHVHHEEHKPGGAGNVVLNLISLGAQVTAIGRTGKDW
GGDVLCNVLSQEGVDTSAIFNQQRYRTPVKNRVIAENQQIVRIDFEEIVSLDAQLEQEIILAIPTFMHDVQAIAISDYGK
GFLTDQLLKAIIDYANKNAILVVTDPKGHDFSKYTQTTLIKPNLSEAYAAVGLPPSAPLDLVAQKILHITQARLLMITRS
EAGISLFEPSGTRQDFPVHAKEVKDVTGAGDTVLAMLTYALANKTTYSVAAQLCNVAAGIAIEQVGCARVTLSDVAYRLF
QHDMKHKVFDHEQVFVLREVLKKNPFNLLIVQCIESISLSLFQSIQELTVGEQPLLIYVIDSEPSRLGIDMLASLKEVSF
ILIQQDNLKFLCSDVKPAKSYAYDGHHLQCVDPESYLLNVWLHDDLKLPVTLN

Specific function: Catalyzes the ADP transfer to D-glycero-D-manno-heptose 1-phosphate, yielding ADP-D,D-heptose [H]

COG id: COG2870

COG function: function code M; ADP-heptose synthase, bifunctional sugar kinase/adenylyltransferase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: In the C-terminal section; belongs to the cytidylyltransferase family [H]

Homologues:

Organism=Escherichia coli, GI1789432, Length=308, Percent_Identity=38.3116883116883, Blast_Score=184, Evalue=8e-48,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR023030
- InterPro:   IPR011611
- InterPro:   IPR002173
- InterPro:   IPR004821
- InterPro:   IPR004820
- InterPro:   IPR011913
- InterPro:   IPR011914
- InterPro:   IPR014729 [H]

Pfam domain/function: PF01467 CTP_transf_2; PF00294 PfkB [H]

EC number: 2.7.-.-

Molecular weight: Translated: 49881; Mature: 49881

Theoretical pI: Translated: 6.02; Mature: 6.02

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
1.3 %Met     (Translated Protein)
2.6 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
1.3 %Met     (Mature Protein)
2.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MVALANTLRDLKPVKVAVIGDFLLDTYTIGKAKRISPEAPVAVIHVHHEEHKPGGAGNVV
CCCHHHHHHCCCCEEEEEEHHHHHHHHCCCCCCCCCCCCCEEEEEEECCCCCCCCCHHHH
LNLISLGAQVTAIGRTGKDWGGDVLCNVLSQEGVDTSAIFNQQRYRTPVKNRVIAENQQI
HHHHHCCCEEEEECCCCCCCCHHHHHHHHHHCCCCHHHHHHHHHHCCCHHHCEEECCCEE
VRIDFEEIVSLDAQLEQEIILAIPTFMHDVQAIAISDYGKGFLTDQLLKAIIDYANKNAI
EEECHHHHHHHHHHHHHHHHHHHHHHHHHHHEEEEECCCCCHHHHHHHHHHHHHCCCCEE
LVVTDPKGHDFSKYTQTTLIKPNLSEAYAAVGLPPSAPLDLVAQKILHITQARLLMITRS
EEEECCCCCCCHHHHHHEEECCCHHHHHHCCCCCCCCCHHHHHHHHHHHHHCEEEEEEEC
EAGISLFEPSGTRQDFPVHAKEVKDVTGAGDTVLAMLTYALANKTTYSVAAQLCNVAAGI
CCCEEEECCCCCCCCCCCCHHHHHHHCCCCHHHHHHHHHHHHCCHHHHHHHHHHHHHHCC
AIEQVGCARVTLSDVAYRLFQHDMKHKVFDHEQVFVLREVLKKNPFNLLIVQCIESISLS
HHHCCCCCEEHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHCCCCHHHHHHHHHHHHHH
LFQSIQELTVGEQPLLIYVIDSEPSRLGIDMLASLKEVSFILIQQDNLKFLCSDVKPAKS
HHHHHHHHHCCCCCEEEEEECCCCCCCCHHHHHHHHHCEEEEEECCCCEEEECCCCCHHH
YAYDGHHLQCVDPESYLLNVWLHDDLKLPVTLN
HCCCCCEEEEECCCCEEEEEEEECCCEECEEEC
>Mature Secondary Structure
MVALANTLRDLKPVKVAVIGDFLLDTYTIGKAKRISPEAPVAVIHVHHEEHKPGGAGNVV
CCCHHHHHHCCCCEEEEEEHHHHHHHHCCCCCCCCCCCCCEEEEEEECCCCCCCCCHHHH
LNLISLGAQVTAIGRTGKDWGGDVLCNVLSQEGVDTSAIFNQQRYRTPVKNRVIAENQQI
HHHHHCCCEEEEECCCCCCCCHHHHHHHHHHCCCCHHHHHHHHHHCCCHHHCEEECCCEE
VRIDFEEIVSLDAQLEQEIILAIPTFMHDVQAIAISDYGKGFLTDQLLKAIIDYANKNAI
EEECHHHHHHHHHHHHHHHHHHHHHHHHHHHEEEEECCCCCHHHHHHHHHHHHHCCCCEE
LVVTDPKGHDFSKYTQTTLIKPNLSEAYAAVGLPPSAPLDLVAQKILHITQARLLMITRS
EEEECCCCCCCHHHHHHEEECCCHHHHHHCCCCCCCCCHHHHHHHHHHHHHCEEEEEEEC
EAGISLFEPSGTRQDFPVHAKEVKDVTGAGDTVLAMLTYALANKTTYSVAAQLCNVAAGI
CCCEEEECCCCCCCCCCCCHHHHHHHCCCCHHHHHHHHHHHHCCHHHHHHHHHHHHHHCC
AIEQVGCARVTLSDVAYRLFQHDMKHKVFDHEQVFVLREVLKKNPFNLLIVQCIESISLS
HHHCCCCCEEHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHCCCCHHHHHHHHHHHHHH
LFQSIQELTVGEQPLLIYVIDSEPSRLGIDMLASLKEVSFILIQQDNLKFLCSDVKPAKS
HHHHHHHHHCCCCCEEEEEECCCCCCCCHHHHHHHHHCEEEEEECCCCEEEECCCCCHHH
YAYDGHHLQCVDPESYLLNVWLHDDLKLPVTLN
HCCCCCEEEEECCCCEEEEEEEECCCEECEEEC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA