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The map label for this gene is hemE

Identifier: 46447147

GI number: 46447147

Start: 1809242

End: 1810336

Strand: Reverse

Name: hemE

Synonym: pc1513

Alternate gene names: 46447147

Gene position: 1810336-1809242 (Counterclockwise)

Preceding gene: 46447148

Following gene: 46447146

Centisome position: 74.98

GC content: 37.35

Gene sequence:

>1095_bases
TTGAGGCTATACTTGAACGTATTTTATAGTCAAAAAAACGCACCTAATTCTGTTGTTTCAAATATCATTAGTAGTTCATT
TAATGATCGACTACTTCAAGCCCTGCAATGTCGCAATAATTCCAGACCTCCCGTCTGGCTTATGCGACAAGCCGGGCGCC
ATTTAGCTTCTTATCGAGCATTAAGAGAAAAATATTCTTTTTTAGATATGTGTCACAATCCAGAATTGATTGCTGAAGTT
ACCTTATTGCCTATCGAAGCTTATCAAGTCGATGCAGCTATTTTATTTTCAGACATTTTAGTCATTCCCGAAGCCTTAAA
AGTAGGAGTTCGCTTTGAAGATAAGGTAGGACCTATTATAGAAAAACCTATCACTAACCTTCACGATATTGAAAAACTTG
CGATGCCCGAGGATCTTACTTCTCTTGAATTTGTCAAGGAAGGAATTAGATGTTTACAACCCCGATTAAATGTTCCTTTA
ATTGGTTTTTGTGGAGCACCCTTTACTGTGGCAAGTTATATGATCGAAGGAAAAACTAGCCGAGACTTCAAAAAAATTAA
ACATTGGATGTATCATGAGCCGCAAGGATTTCATACTTTACTTCGGAAAATAGCAGATTGGTCGATTGCTTATCTCAATA
TGCAAATTGATGCGGGGGTACATGCTTTACAGATTTTTGATTCTTGGGCAAATACTCTTTCTTATCGTCAATTTCAAGAG
TTTTCTTTAAATTATTTAAAGTACATTTTAAAAGGATTAAAAAAAGATATCCCTCTCATTTTATTTTGCCGAGGATCCTC
GGTTTTTGGCCCAGATTTAGCTTCCATTAAACCCGCAGCTGTTGGATTAGATTGGAATTGTCGGGTAAAACGGATGCGTG
ATGTCATTCCTTATCCCATTGCTTTGCAAGGAAATTTAGATCCTGATTTGCTTTATGCACCTTTGCCCAAAATCAGGGAA
GAGGTAAATGCTTTATTAGATGAAATGGAAGGAGATCGAGGGTTTATTTTAAACTTAGGGCATGGCATCTTTCCTGATGT
TTCTGAAGAGGCAGTTCGCACTTTAGTTGAAACTGTGAGGGAAAGGCGTGGTTAA

Upstream 100 bases:

>100_bases
TGGCATAAATACATTGGCCGTGATGGTATTGCAATTTGTATGGAACATTTTGGAGCCTCAGCTCCTGCGGGTGTATTAGC
AAAAGAATTTGGTTTTACCG

Downstream 100 bases:

>100_bases
ACATATCGTGATCTTAGGTGCTGGAATTAGCGGACTTGCAACAGCATGGTTTTTGAAAAAACTATTAGGATCTTCCGTTC
AACTTACTTTGTTAGAAGCA

Product: uroporphyrinogen decarboxylase

Products: NA

Alternate protein names: UPD; URO-D

Number of amino acids: Translated: 364; Mature: 364

Protein sequence:

>364_residues
MRLYLNVFYSQKNAPNSVVSNIISSSFNDRLLQALQCRNNSRPPVWLMRQAGRHLASYRALREKYSFLDMCHNPELIAEV
TLLPIEAYQVDAAILFSDILVIPEALKVGVRFEDKVGPIIEKPITNLHDIEKLAMPEDLTSLEFVKEGIRCLQPRLNVPL
IGFCGAPFTVASYMIEGKTSRDFKKIKHWMYHEPQGFHTLLRKIADWSIAYLNMQIDAGVHALQIFDSWANTLSYRQFQE
FSLNYLKYILKGLKKDIPLILFCRGSSVFGPDLASIKPAAVGLDWNCRVKRMRDVIPYPIALQGNLDPDLLYAPLPKIRE
EVNALLDEMEGDRGFILNLGHGIFPDVSEEAVRTLVETVRERRG

Sequences:

>Translated_364_residues
MRLYLNVFYSQKNAPNSVVSNIISSSFNDRLLQALQCRNNSRPPVWLMRQAGRHLASYRALREKYSFLDMCHNPELIAEV
TLLPIEAYQVDAAILFSDILVIPEALKVGVRFEDKVGPIIEKPITNLHDIEKLAMPEDLTSLEFVKEGIRCLQPRLNVPL
IGFCGAPFTVASYMIEGKTSRDFKKIKHWMYHEPQGFHTLLRKIADWSIAYLNMQIDAGVHALQIFDSWANTLSYRQFQE
FSLNYLKYILKGLKKDIPLILFCRGSSVFGPDLASIKPAAVGLDWNCRVKRMRDVIPYPIALQGNLDPDLLYAPLPKIRE
EVNALLDEMEGDRGFILNLGHGIFPDVSEEAVRTLVETVRERRG
>Mature_364_residues
MRLYLNVFYSQKNAPNSVVSNIISSSFNDRLLQALQCRNNSRPPVWLMRQAGRHLASYRALREKYSFLDMCHNPELIAEV
TLLPIEAYQVDAAILFSDILVIPEALKVGVRFEDKVGPIIEKPITNLHDIEKLAMPEDLTSLEFVKEGIRCLQPRLNVPL
IGFCGAPFTVASYMIEGKTSRDFKKIKHWMYHEPQGFHTLLRKIADWSIAYLNMQIDAGVHALQIFDSWANTLSYRQFQE
FSLNYLKYILKGLKKDIPLILFCRGSSVFGPDLASIKPAAVGLDWNCRVKRMRDVIPYPIALQGNLDPDLLYAPLPKIRE
EVNALLDEMEGDRGFILNLGHGIFPDVSEEAVRTLVETVRERRG

Specific function: Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III

COG id: COG0407

COG function: function code H; Uroporphyrinogen-III decarboxylase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the uroporphyrinogen decarboxylase family

Homologues:

Organism=Homo sapiens, GI71051616, Length=345, Percent_Identity=38.8405797101449, Blast_Score=240, Evalue=1e-63,
Organism=Escherichia coli, GI2367337, Length=340, Percent_Identity=42.9411764705882, Blast_Score=280, Evalue=1e-76,
Organism=Saccharomyces cerevisiae, GI6320252, Length=346, Percent_Identity=34.6820809248555, Blast_Score=217, Evalue=3e-57,
Organism=Drosophila melanogaster, GI19921920, Length=344, Percent_Identity=37.7906976744186, Blast_Score=230, Evalue=1e-60,
Organism=Drosophila melanogaster, GI221330099, Length=344, Percent_Identity=37.7906976744186, Blast_Score=230, Evalue=1e-60,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): DCUP_PARUW (Q6MB12)

Other databases:

- EMBL:   BX908798
- RefSeq:   YP_008512.1
- HSSP:   P06132
- ProteinModelPortal:   Q6MB12
- SMR:   Q6MB12
- STRING:   Q6MB12
- GeneID:   2781261
- GenomeReviews:   BX908798_GR
- KEGG:   pcu:pc1513
- NMPDR:   fig|264201.1.peg.1513
- eggNOG:   COG0407
- HOGENOM:   HBG628392
- OMA:   AVQLFDS
- PhylomeDB:   Q6MB12
- ProtClustDB:   CLSK2762412
- BioCyc:   CPRO264201:PC1513-MONOMER
- GO:   GO:0005737
- HAMAP:   MF_00218
- InterPro:   IPR006361
- InterPro:   IPR000257
- PANTHER:   PTHR21091:SF2
- TIGRFAMs:   TIGR01464

Pfam domain/function: PF01208 URO-D

EC number: =4.1.1.37

Molecular weight: Translated: 41550; Mature: 41550

Theoretical pI: Translated: 7.85; Mature: 7.85

Prosite motif: PS00906 UROD_1; PS00907 UROD_2

Important sites: BINDING 98-98 BINDING 173-173 BINDING 228-228 BINDING 341-341

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.6 %Cys     (Translated Protein)
2.5 %Met     (Translated Protein)
4.1 %Cys+Met (Translated Protein)
1.6 %Cys     (Mature Protein)
2.5 %Met     (Mature Protein)
4.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRLYLNVFYSQKNAPNSVVSNIISSSFNDRLLQALQCRNNSRPPVWLMRQAGRHLASYRA
CEEEEEEEECCCCCCHHHHHHHHHCCHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHH
LREKYSFLDMCHNPELIAEVTLLPIEAYQVDAAILFSDILVIPEALKVGVRFEDKVGPII
HHHHHHHHHHCCCCCHHHEEEEEEEHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCHH
EKPITNLHDIEKLAMPEDLTSLEFVKEGIRCLQPRLNVPLIGFCGAPFTVASYMIEGKTS
HHHCCHHHHHHHHCCCCCHHHHHHHHHHHHHHCCCCCCCEEEECCCHHHHHHHHHCCCCC
RDFKKIKHWMYHEPQGFHTLLRKIADWSIAYLNMQIDAGVHALQIFDSWANTLSYRQFQE
HHHHHHHHHHCCCCCHHHHHHHHHHCCEEEEEEEEECCCHHHHHHHHHHHHHHHHHHHHH
FSLNYLKYILKGLKKDIPLILFCRGSSVFGPDLASIKPAAVGLDWNCRVKRMRDVIPYPI
HHHHHHHHHHHHHCCCCCEEEEECCCCCCCCCCCCCCCHHCCCCCCCHHHHHHCCCCCCE
ALQGNLDPDLLYAPLPKIREEVNALLDEMEGDRGFILNLGHGIFPDVSEEAVRTLVETVR
EEECCCCCCHHHCCCHHHHHHHHHHHHHCCCCCCEEEECCCCCCCCCHHHHHHHHHHHHH
ERRG
HHCC
>Mature Secondary Structure
MRLYLNVFYSQKNAPNSVVSNIISSSFNDRLLQALQCRNNSRPPVWLMRQAGRHLASYRA
CEEEEEEEECCCCCCHHHHHHHHHCCHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHH
LREKYSFLDMCHNPELIAEVTLLPIEAYQVDAAILFSDILVIPEALKVGVRFEDKVGPII
HHHHHHHHHHCCCCCHHHEEEEEEEHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCHH
EKPITNLHDIEKLAMPEDLTSLEFVKEGIRCLQPRLNVPLIGFCGAPFTVASYMIEGKTS
HHHCCHHHHHHHHCCCCCHHHHHHHHHHHHHHCCCCCCCEEEECCCHHHHHHHHHCCCCC
RDFKKIKHWMYHEPQGFHTLLRKIADWSIAYLNMQIDAGVHALQIFDSWANTLSYRQFQE
HHHHHHHHHHCCCCCHHHHHHHHHHCCEEEEEEEEECCCHHHHHHHHHHHHHHHHHHHHH
FSLNYLKYILKGLKKDIPLILFCRGSSVFGPDLASIKPAAVGLDWNCRVKRMRDVIPYPI
HHHHHHHHHHHHHCCCCCEEEEECCCCCCCCCCCCCCCHHCCCCCCCHHHHHHCCCCCCE
ALQGNLDPDLLYAPLPKIREEVNALLDEMEGDRGFILNLGHGIFPDVSEEAVRTLVETVR
EEECCCCCCHHHCCCHHHHHHHHHHHHHCCCCCCEEEECCCCCCCCCHHHHHHHHHHHHH
ERRG
HHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA