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The map label for this gene is hemG [H]

Identifier: 46447146

GI number: 46447146

Start: 1807876

End: 1809249

Strand: Reverse

Name: hemG [H]

Synonym: pc1512

Alternate gene names: 46447146

Gene position: 1809249-1807876 (Counterclockwise)

Preceding gene: 46447147

Following gene: 46447145

Centisome position: 74.93

GC content: 36.24

Gene sequence:

>1374_bases
GTGGTTAAACATATCGTGATCTTAGGTGCTGGAATTAGCGGACTTGCAACAGCATGGTTTTTGAAAAAACTATTAGGATC
TTCCGTTCAACTTACTTTGTTAGAAGCAAATTCAAGAGCCGGAGGATGGATTCAAACGATTCATTCTCAAGATTTTTTGT
TTGAGACAGGTCCACGCAGTTGCCGTTCGAAAGGCTCTGGAAGAGAAATGCTTCAACTCATTGAAGAATTAGGATTATGT
GATGAAATCATTGGGGCACATTCTTCTGCGAACCTTCGTTTTCTTTATTTTCAAAAAAAATTACAGCCTTTACCCAGTTC
CTTTTTTCATATTCTTTTTAACCCTCTTGTTAAAGGATGGCTCAAAGCGGTTTATCGGGATTTAAATTCTCCAAGGTCGT
TAAAAGAAGATGAATCTATAGAAGAATTTTTTAGCCGACGTATTGGAAAAGAATGGACCTCCCGTTTAATTGATCCATTT
GTTTCAGGAATTTATGCTGGAGATTGCAAAAAATTATCCATGAAAAGCTGTTTTCCTCTTTTTTGGAAGTGGGAACAAGA
AAACGGATCTTTAATTAAAGGGATATGGAATCAAAAAAAAGAAAAAAAATCCTCTAGCGCTTTTGTTTCATATTGGATGA
AACAACCTCTTTTTTCCTTTAAGCAAGGAATGGGATATTTAATACAATCTTTCGTGCATCAATTAGATGCTAATATTCAT
TTTTCTTCTACTGTGAAAACGATTGAAATGGAAAAAGAGGGGGCCACAGTTGTTTTAGATAACGGAAAAGTTTTTAAAGC
TGATCATTTGATTTCTACTTTGCCAGCTTCAAAATTGGCTCCTTTACTTGGTTCAGAGTTTAGTGAAACGGCTTCACTGC
TACAGTCTATGGAATCAACCTCTGTGATGGTTGTCAATTGTGGTTATCGTCGACCTGTTTTAAAAAAATCTGGCTTTGGT
TATTTAATTCCCTTTCAAGAAAAAGAATCAATTTTGGGATGTGTATGGGATTCAGCAGTGTTTCCTAAGCAAAATTTTTC
TCCTGAACACACTCGCTTAACAGTTATGATGGGGGGAACTCAGCACCCTCAGATAGATGATAGGCAAAAAGGATTAGCCC
TTGCATTATCTTCTATCGAAAGGCATTTGGCGATTGATTCTGTGCCAGATGAAGTTTATGTTTCTTTAGCCAAACAGGCG
ATCCCTCAATATCAAATTGGACATTACCTAACTTTAATCAATTTATCTCAATCCTTATCTCTTTATCCCCAATTCACTTT
TACAGGTCATTCTTTTGACGGGGTTTCTGTGAATGATAGAGTTTTGCAAGCCCGTTTATTAGCCGTTAAAATTGCAAAAG
GTTTTAACATTTAG

Upstream 100 bases:

>100_bases
GAAGGAGATCGAGGGTTTATTTTAAACTTAGGGCATGGCATCTTTCCTGATGTTTCTGAAGAGGCAGTTCGCACTTTAGT
TGAAACTGTGAGGGAAAGGC

Downstream 100 bases:

>100_bases
CAGTTGCTTTATGTGATTGCTAAAAAATAAATGAAAGCTTATTATTAAAAATAATAAAAATCCATTATTTCCAATTTCCT
AGAAGTTAATAATTTATAAT

Product: putative protoporphyrinogen oxidase

Products: NA

Alternate protein names: PPO [H]

Number of amino acids: Translated: 457; Mature: 457

Protein sequence:

>457_residues
MVKHIVILGAGISGLATAWFLKKLLGSSVQLTLLEANSRAGGWIQTIHSQDFLFETGPRSCRSKGSGREMLQLIEELGLC
DEIIGAHSSANLRFLYFQKKLQPLPSSFFHILFNPLVKGWLKAVYRDLNSPRSLKEDESIEEFFSRRIGKEWTSRLIDPF
VSGIYAGDCKKLSMKSCFPLFWKWEQENGSLIKGIWNQKKEKKSSSAFVSYWMKQPLFSFKQGMGYLIQSFVHQLDANIH
FSSTVKTIEMEKEGATVVLDNGKVFKADHLISTLPASKLAPLLGSEFSETASLLQSMESTSVMVVNCGYRRPVLKKSGFG
YLIPFQEKESILGCVWDSAVFPKQNFSPEHTRLTVMMGGTQHPQIDDRQKGLALALSSIERHLAIDSVPDEVYVSLAKQA
IPQYQIGHYLTLINLSQSLSLYPQFTFTGHSFDGVSVNDRVLQARLLAVKIAKGFNI

Sequences:

>Translated_457_residues
MVKHIVILGAGISGLATAWFLKKLLGSSVQLTLLEANSRAGGWIQTIHSQDFLFETGPRSCRSKGSGREMLQLIEELGLC
DEIIGAHSSANLRFLYFQKKLQPLPSSFFHILFNPLVKGWLKAVYRDLNSPRSLKEDESIEEFFSRRIGKEWTSRLIDPF
VSGIYAGDCKKLSMKSCFPLFWKWEQENGSLIKGIWNQKKEKKSSSAFVSYWMKQPLFSFKQGMGYLIQSFVHQLDANIH
FSSTVKTIEMEKEGATVVLDNGKVFKADHLISTLPASKLAPLLGSEFSETASLLQSMESTSVMVVNCGYRRPVLKKSGFG
YLIPFQEKESILGCVWDSAVFPKQNFSPEHTRLTVMMGGTQHPQIDDRQKGLALALSSIERHLAIDSVPDEVYVSLAKQA
IPQYQIGHYLTLINLSQSLSLYPQFTFTGHSFDGVSVNDRVLQARLLAVKIAKGFNI
>Mature_457_residues
MVKHIVILGAGISGLATAWFLKKLLGSSVQLTLLEANSRAGGWIQTIHSQDFLFETGPRSCRSKGSGREMLQLIEELGLC
DEIIGAHSSANLRFLYFQKKLQPLPSSFFHILFNPLVKGWLKAVYRDLNSPRSLKEDESIEEFFSRRIGKEWTSRLIDPF
VSGIYAGDCKKLSMKSCFPLFWKWEQENGSLIKGIWNQKKEKKSSSAFVSYWMKQPLFSFKQGMGYLIQSFVHQLDANIH
FSSTVKTIEMEKEGATVVLDNGKVFKADHLISTLPASKLAPLLGSEFSETASLLQSMESTSVMVVNCGYRRPVLKKSGFG
YLIPFQEKESILGCVWDSAVFPKQNFSPEHTRLTVMMGGTQHPQIDDRQKGLALALSSIERHLAIDSVPDEVYVSLAKQA
IPQYQIGHYLTLINLSQSLSLYPQFTFTGHSFDGVSVNDRVLQARLLAVKIAKGFNI

Specific function: Catalyzes the 6-electron oxidation of protoporphyrinogen-IX to form protoporphyrin-IX. Also oxidizes the pathway intermediate coproporphyrinogen-III [H]

COG id: COG1232

COG function: function code H; Protoporphyrinogen oxidase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the protoporphyrinogen oxidase family [H]

Homologues:

Organism=Homo sapiens, GI170650615, Length=474, Percent_Identity=32.7004219409283, Blast_Score=233, Evalue=3e-61,
Organism=Homo sapiens, GI4506001, Length=474, Percent_Identity=32.7004219409283, Blast_Score=233, Evalue=3e-61,
Organism=Saccharomyces cerevisiae, GI6320851, Length=474, Percent_Identity=25.7383966244726, Blast_Score=105, Evalue=2e-23,
Organism=Drosophila melanogaster, GI24649745, Length=458, Percent_Identity=32.5327510917031, Blast_Score=204, Evalue=1e-52,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002937
- InterPro:   IPR016040
- InterPro:   IPR004572 [H]

Pfam domain/function: PF01593 Amino_oxidase [H]

EC number: =1.3.3.4 [H]

Molecular weight: Translated: 51278; Mature: 51278

Theoretical pI: Translated: 9.48; Mature: 9.48

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
2.2 %Met     (Translated Protein)
3.5 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
2.2 %Met     (Mature Protein)
3.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MVKHIVILGAGISGLATAWFLKKLLGSSVQLTLLEANSRAGGWIQTIHSQDFLFETGPRS
CCEEEEEEECCHHHHHHHHHHHHHHCCCEEEEEEECCCCCCCHHEECCCCCCEECCCCHH
CRSKGSGREMLQLIEELGLCDEIIGAHSSANLRFLYFQKKLQPLPSSFFHILFNPLVKGW
HHCCCCHHHHHHHHHHHCCHHHHHCCCCCCCEEEEEEHHHHCCCHHHHHHHHHHHHHHHH
LKAVYRDLNSPRSLKEDESIEEFFSRRIGKEWTSRLIDPFVSGIYAGDCKKLSMKSCFPL
HHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCEECCCCCCCCHHCCCCE
FWKWEQENGSLIKGIWNQKKEKKSSSAFVSYWMKQPLFSFKQGMGYLIQSFVHQLDANIH
EEEEECCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCE
FSSTVKTIEMEKEGATVVLDNGKVFKADHLISTLPASKLAPLLGSEFSETASLLQSMEST
ECCCEEEEEEECCCCEEEECCCCEEEHHHHHHHCCHHHHHHHHCCHHHHHHHHHHHHCCC
SVMVVNCGYRRPVLKKSGFGYLIPFQEKESILGCVWDSAVFPKQNFSPEHTRLTVMMGGT
CEEEEECCCCCCCCCCCCCEEEEECCCCCCHHHHHHCCCCCCCCCCCCCCEEEEEEECCC
QHPQIDDRQKGLALALSSIERHLAIDSVPDEVYVSLAKQAIPQYQIGHYLTLINLSQSLS
CCCCCCCHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHCCCHHHCCEEEEEECCCCCC
LYPQFTFTGHSFDGVSVNDRVLQARLLAVKIAKGFNI
CCEEEEECCCCCCCCCCHHHHHHHHHHHHHHHCCCCC
>Mature Secondary Structure
MVKHIVILGAGISGLATAWFLKKLLGSSVQLTLLEANSRAGGWIQTIHSQDFLFETGPRS
CCEEEEEEECCHHHHHHHHHHHHHHCCCEEEEEEECCCCCCCHHEECCCCCCEECCCCHH
CRSKGSGREMLQLIEELGLCDEIIGAHSSANLRFLYFQKKLQPLPSSFFHILFNPLVKGW
HHCCCCHHHHHHHHHHHCCHHHHHCCCCCCCEEEEEEHHHHCCCHHHHHHHHHHHHHHHH
LKAVYRDLNSPRSLKEDESIEEFFSRRIGKEWTSRLIDPFVSGIYAGDCKKLSMKSCFPL
HHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCEECCCCCCCCHHCCCCE
FWKWEQENGSLIKGIWNQKKEKKSSSAFVSYWMKQPLFSFKQGMGYLIQSFVHQLDANIH
EEEEECCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCE
FSSTVKTIEMEKEGATVVLDNGKVFKADHLISTLPASKLAPLLGSEFSETASLLQSMEST
ECCCEEEEEEECCCCEEEECCCCEEEHHHHHHHCCHHHHHHHHCCHHHHHHHHHHHHCCC
SVMVVNCGYRRPVLKKSGFGYLIPFQEKESILGCVWDSAVFPKQNFSPEHTRLTVMMGGT
CEEEEECCCCCCCCCCCCCEEEEECCCCCCHHHHHHCCCCCCCCCCCCCCEEEEEEECCC
QHPQIDDRQKGLALALSSIERHLAIDSVPDEVYVSLAKQAIPQYQIGHYLTLINLSQSLS
CCCCCCCHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHCCCHHHCCEEEEEECCCCCC
LYPQFTFTGHSFDGVSVNDRVLQARLLAVKIAKGFNI
CCEEEEECCCCCCCCCCHHHHHHHHHHHHHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 1459957; 9579061; 9384377; 8288631 [H]