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The map label for this gene is sucC

Identifier: 46446932

GI number: 46446932

Start: 1554249

End: 1555418

Strand: Reverse

Name: sucC

Synonym: pc1298

Alternate gene names: 46446932

Gene position: 1555418-1554249 (Counterclockwise)

Preceding gene: 46446935

Following gene: 46446931

Centisome position: 64.42

GC content: 37.69

Gene sequence:

>1170_bases
ATGAATACACACGAGTTTCAAGCCAAGCAGATTTTACGTAAGTATGGCATTCCCGTTCCTGATTTTTATATCGCTTCTTC
TTCGAAAGAAGTGGAAGAGATCATTAAGCAATACCAATTGCAAAGTGCTATCATCAAAGTACAGGTGCATGCCGGAGGAC
GTGGAAAAGCCGGTGGAGTCAAGTTAGCGACAAATCCGCAAGAAATCTTAGAATTTTCCCAAGAACTCATCGGAAAAAAA
ATCATTAATGAACAGACAGGCCCTAGCGGAATGATTTCTCATCAAGTTTTGATTTCCCCTGCTATTTTGATTAAAAAAGA
ATTCTATTTAGGAATCACTATTAATCGTGAATTGGCAAGCCGTGTTTTAATCGCTTCTCCTATTGGAGGAGTAAACATTG
AAAAAATTGCTCACGAACAACCTAATCAATTGTTAATGCTTCCAATTCCTTTGGAGGAAACATTTAGATCTTATCATTTA
ATTCGCATTGCAAGCTTTATGGGATGGAAGGGAAAACAAATTCAAGAGGGGGTTGCAATTATTCAATCTCTTGTGAAAGC
TTTTAAAGAAACGGATGCTTCTCTACTTGAAATTAACCCTCTTGTGGAAACAAAGGAAGGCCATTTATTAGCGCTGGACG
CGAAGTTATCAATTGATGACAATGCTCTTTTTAAACATGAGGACTTGAAAACCTTATTCGATCCTTCACAAATGTCTAAT
AATGAAGCAAGAGCTCAGCAATTTGAACTTGCCTATGTTGCTTTAGAAGGGGAAATTGGTTGTATGGTCAATGGAGCTGG
ATTAGCCATGGCTACAATGGACCTTATTCAATACCATGGAGGACGTCCTGCTAACTTTTTGGATGTAGGAGGTGGGGCAT
CGCAAGTTAAAGTGGCAGAAGGATTTAGAATTATTCTATCGGATTCTAATGTGAAAGCCATTTTAATTAACATCTTTGGG
GGAATTATGAATTGTGAAACGTTAGCCTCAGGAATTATCGAAGCAGCTAAAGGATTACAAATTCATATTCCCTTAATTGT
AAGAATGGAGGGAACAAATGTCGAAAAAGGGAAGCAACTTCTTCAACAATCAGGCTTAAAGATTTTAATTACAGAAAATT
TGACAGAAGCAGCTCAACAAGCAGTTCAATTAGCACAATCAGTAAGGTGA

Upstream 100 bases:

>100_bases
AGCATATAAAAAAGAAAAAGGTGAAGATCTTAATTTGGCTTGCCCTATCAATTCTATACATAAAACCACTAATTAGCTTT
TAGAATAATGAAGGTCCATC

Downstream 100 bases:

>100_bases
TCCATGGCTATTTTGGTTAATAAACAGACACGAGTGATTACGCAAGGAATAACTGGAAAAGCTGGTCGTTTTCACACAGA
GCAAAGCATGCTTTATGCAC

Product: succinate-CoA ligase (ADP-forming) beta chain

Products: NA

Alternate protein names: Succinyl-CoA synthetase subunit beta; SCS-beta

Number of amino acids: Translated: 389; Mature: 389

Protein sequence:

>389_residues
MNTHEFQAKQILRKYGIPVPDFYIASSSKEVEEIIKQYQLQSAIIKVQVHAGGRGKAGGVKLATNPQEILEFSQELIGKK
IINEQTGPSGMISHQVLISPAILIKKEFYLGITINRELASRVLIASPIGGVNIEKIAHEQPNQLLMLPIPLEETFRSYHL
IRIASFMGWKGKQIQEGVAIIQSLVKAFKETDASLLEINPLVETKEGHLLALDAKLSIDDNALFKHEDLKTLFDPSQMSN
NEARAQQFELAYVALEGEIGCMVNGAGLAMATMDLIQYHGGRPANFLDVGGGASQVKVAEGFRIILSDSNVKAILINIFG
GIMNCETLASGIIEAAKGLQIHIPLIVRMEGTNVEKGKQLLQQSGLKILITENLTEAAQQAVQLAQSVR

Sequences:

>Translated_389_residues
MNTHEFQAKQILRKYGIPVPDFYIASSSKEVEEIIKQYQLQSAIIKVQVHAGGRGKAGGVKLATNPQEILEFSQELIGKK
IINEQTGPSGMISHQVLISPAILIKKEFYLGITINRELASRVLIASPIGGVNIEKIAHEQPNQLLMLPIPLEETFRSYHL
IRIASFMGWKGKQIQEGVAIIQSLVKAFKETDASLLEINPLVETKEGHLLALDAKLSIDDNALFKHEDLKTLFDPSQMSN
NEARAQQFELAYVALEGEIGCMVNGAGLAMATMDLIQYHGGRPANFLDVGGGASQVKVAEGFRIILSDSNVKAILINIFG
GIMNCETLASGIIEAAKGLQIHIPLIVRMEGTNVEKGKQLLQQSGLKILITENLTEAAQQAVQLAQSVR
>Mature_389_residues
MNTHEFQAKQILRKYGIPVPDFYIASSSKEVEEIIKQYQLQSAIIKVQVHAGGRGKAGGVKLATNPQEILEFSQELIGKK
IINEQTGPSGMISHQVLISPAILIKKEFYLGITINRELASRVLIASPIGGVNIEKIAHEQPNQLLMLPIPLEETFRSYHL
IRIASFMGWKGKQIQEGVAIIQSLVKAFKETDASLLEINPLVETKEGHLLALDAKLSIDDNALFKHEDLKTLFDPSQMSN
NEARAQQFELAYVALEGEIGCMVNGAGLAMATMDLIQYHGGRPANFLDVGGGASQVKVAEGFRIILSDSNVKAILINIFG
GIMNCETLASGIIEAAKGLQIHIPLIVRMEGTNVEKGKQLLQQSGLKILITENLTEAAQQAVQLAQSVR

Specific function: Tricarboxylic acid cycle. [C]

COG id: COG0045

COG function: function code C; Succinyl-CoA synthetase, beta subunit

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 ATP-grasp domain

Homologues:

Organism=Homo sapiens, GI11321583, Length=395, Percent_Identity=42.5316455696203, Blast_Score=333, Evalue=2e-91,
Organism=Homo sapiens, GI157779135, Length=375, Percent_Identity=37.8666666666667, Blast_Score=290, Evalue=2e-78,
Organism=Homo sapiens, GI294862256, Length=363, Percent_Identity=37.7410468319559, Blast_Score=278, Evalue=6e-75,
Organism=Escherichia coli, GI1786948, Length=389, Percent_Identity=47.0437017994859, Blast_Score=348, Evalue=3e-97,
Organism=Caenorhabditis elegans, GI17539378, Length=391, Percent_Identity=41.6879795396419, Blast_Score=324, Evalue=4e-89,
Organism=Caenorhabditis elegans, GI17567829, Length=393, Percent_Identity=41.9847328244275, Blast_Score=307, Evalue=7e-84,
Organism=Saccharomyces cerevisiae, GI6321683, Length=397, Percent_Identity=37.7833753148615, Blast_Score=293, Evalue=2e-80,
Organism=Drosophila melanogaster, GI21356231, Length=390, Percent_Identity=43.3333333333333, Blast_Score=351, Evalue=5e-97,
Organism=Drosophila melanogaster, GI161078106, Length=396, Percent_Identity=41.9191919191919, Blast_Score=317, Evalue=9e-87,
Organism=Drosophila melanogaster, GI24645208, Length=396, Percent_Identity=41.9191919191919, Blast_Score=317, Evalue=9e-87,
Organism=Drosophila melanogaster, GI281361397, Length=397, Percent_Identity=42.0654911838791, Blast_Score=316, Evalue=2e-86,
Organism=Drosophila melanogaster, GI281361395, Length=397, Percent_Identity=42.0654911838791, Blast_Score=316, Evalue=2e-86,

Paralogues:

None

Copy number: 340 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 2361 Molecules/Cell In: Growth Phase, Glucose-minimal MOPS Media. 3,000 Molecules/Cell In: Glucose minimal media [C]

Swissprot (AC and ID): SUCC_PARUW (Q6MBM7)

Other databases:

- EMBL:   BX908798
- RefSeq:   YP_008297.1
- HSSP:   P0A836
- ProteinModelPortal:   Q6MBM7
- SMR:   Q6MBM7
- STRING:   Q6MBM7
- GeneID:   2780242
- GenomeReviews:   BX908798_GR
- KEGG:   pcu:pc1298
- NMPDR:   fig|264201.1.peg.1298
- eggNOG:   COG0045
- HOGENOM:   HBG315432
- OMA:   LPIVVRM
- PhylomeDB:   Q6MBM7
- ProtClustDB:   CLSK2762375
- BioCyc:   CPRO264201:PC1298-MONOMER
- HAMAP:   MF_00558
- InterPro:   IPR011761
- InterPro:   IPR013650
- InterPro:   IPR013815
- InterPro:   IPR013816
- InterPro:   IPR005811
- InterPro:   IPR017866
- InterPro:   IPR005809
- InterPro:   IPR016102
- Gene3D:   G3DSA:3.30.1490.20
- Gene3D:   G3DSA:3.30.470.20
- Gene3D:   G3DSA:3.40.50.261
- PANTHER:   PTHR11815
- TIGRFAMs:   TIGR01016

Pfam domain/function: PF08442 ATP-grasp_2; PF00549 Ligase_CoA; SSF52210 CoA_ligase

EC number: =6.2.1.5

Molecular weight: Translated: 42508; Mature: 42508

Theoretical pI: Translated: 6.61; Mature: 6.61

Prosite motif: PS50975 ATP_GRASP; PS01217 SUCCINYL_COA_LIG_3

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
2.6 %Met     (Translated Protein)
3.1 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
2.6 %Met     (Mature Protein)
3.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNTHEFQAKQILRKYGIPVPDFYIASSSKEVEEIIKQYQLQSAIIKVQVHAGGRGKAGGV
CCCHHHHHHHHHHHCCCCCCCEEEECCCHHHHHHHHHHHHHEEEEEEEEECCCCCCCCCE
KLATNPQEILEFSQELIGKKIINEQTGPSGMISHQVLISPAILIKKEFYLGITINRELAS
EEECCHHHHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHCCCEEEEEEEEEEEEECHHHHC
RVLIASPIGGVNIEKIAHEQPNQLLMLPIPLEETFRSYHLIRIASFMGWKGKQIQEGVAI
CEEEECCCCCCCHHHHHCCCCCCEEEEECCHHHHHHHHHHHHHHHHHCCCCCHHHHHHHH
IQSLVKAFKETDASLLEINPLVETKEGHLLALDAKLSIDDNALFKHEDLKTLFDPSQMSN
HHHHHHHHHHCCCCEEEECCCEECCCCCEEEEEEEEECCCCCEEECCCHHHHCCCHHCCC
NEARAQQFELAYVALEGEIGCMVNGAGLAMATMDLIQYHGGRPANFLDVGGGASQVKVAE
CHHHHHHEEEEEEEEECCEEEEEECCCHHHHHHHHHHHCCCCCCCEEECCCCCCEEEEEC
GFRIILSDSNVKAILINIFGGIMNCETLASGIIEAAKGLQIHIPLIVRMEGTNVEKGKQL
CEEEEEECCCCEEEEEEHHCCHHHHHHHHHHHHHHHCCCEEEEEEEEEECCCCHHHHHHH
LQQSGLKILITENLTEAAQQAVQLAQSVR
HHHCCCEEEEECCHHHHHHHHHHHHHHCC
>Mature Secondary Structure
MNTHEFQAKQILRKYGIPVPDFYIASSSKEVEEIIKQYQLQSAIIKVQVHAGGRGKAGGV
CCCHHHHHHHHHHHCCCCCCCEEEECCCHHHHHHHHHHHHHEEEEEEEEECCCCCCCCCE
KLATNPQEILEFSQELIGKKIINEQTGPSGMISHQVLISPAILIKKEFYLGITINRELAS
EEECCHHHHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHCCCEEEEEEEEEEEEECHHHHC
RVLIASPIGGVNIEKIAHEQPNQLLMLPIPLEETFRSYHLIRIASFMGWKGKQIQEGVAI
CEEEECCCCCCCHHHHHCCCCCCEEEEECCHHHHHHHHHHHHHHHHHCCCCCHHHHHHHH
IQSLVKAFKETDASLLEINPLVETKEGHLLALDAKLSIDDNALFKHEDLKTLFDPSQMSN
HHHHHHHHHHCCCCEEEECCCEECCCCCEEEEEEEEECCCCCEEECCCHHHHCCCHHCCC
NEARAQQFELAYVALEGEIGCMVNGAGLAMATMDLIQYHGGRPANFLDVGGGASQVKVAE
CHHHHHHEEEEEEEEECCEEEEEECCCHHHHHHHHHHHCCCCCCCEEECCCCCCEEEEEC
GFRIILSDSNVKAILINIFGGIMNCETLASGIIEAAKGLQIHIPLIVRMEGTNVEKGKQL
CEEEEEECCCCEEEEEEHHCCHHHHHHHHHHHHHHHCCCEEEEEEEEEECCCCHHHHHHH
LQQSGLKILITENLTEAAQQAVQLAQSVR
HHHCCCEEEEECCHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA