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The map label for this gene is murC

Identifier: 46446881

GI number: 46446881

Start: 1487532

End: 1488896

Strand: Reverse

Name: murC

Synonym: pc1247

Alternate gene names: 46446881

Gene position: 1488896-1487532 (Counterclockwise)

Preceding gene: 46446882

Following gene: 46446880

Centisome position: 61.67

GC content: 35.38

Gene sequence:

>1365_bases
ATGAGAGGGCATTATCATTTCATTGGAATCGGTGGAATAGGAATGAGCGGGCTTGCGCGAATTCTACTTCAACAAAATCT
GAGTGTGTCAGGTAGTGATATTGCTTTTAACTACACTATTGAAGGATTAATTAAATCTGGTGCGACTATTTATAAAGGAC
ATTCTCCTTCTTATATTACTTCAGGGTCTACTGTGATTTACAGTAGTGATATAAAAACTGATAATCCTGAATACCTTGCA
GCAAAAAATTTGCAATGTTCTTTACTTCATCGTGCTGAATTATTAGCCCTTTTAACAAGACAAAAAAAATCATTAGCTGT
TACTGGAACTCATGGTAAAACGACAACATCCTCTCTTTTAGCAACAACTCTTTTAGAAGCAAATTGCGATTCTTCTTTTG
CCGTTGGTGGGATAATCCCTCAATTTCAAAGTAATGCAAAACATGGTTTAGGTGATTTATTTGTTTTTGAGGCCGACGAA
AGTGATCGAAGCTTTTTAAAGTATTTTCCCTACGGAGCTATTGTGACCAATATCGATAACGATCATTTAAACTCCTATGA
AAATTCTGAAGATGTATTAATACAATCTTTTCAGCAGTTTACTTCCCAAATTTCTTCCCCCAATCACCTTTTTTGGTGTG
GAGATGATACTCATTTAAAATTTCTCAATGGTATTGGGCAAAGTTATGGCTTTGGAGAGCATTGCAATTGGAGAATTTCT
AATGTTTTTCAAAAAGATTTCAATCTTGAATTTGATTTAGAAGGCAATGAAAAAAAGTATCCATCCATTAAATTAAATTT
AATTGGCCGACATAATCTTCTCAATGGTGCTGCAGTATTTGGATTAGCAATGTCTTTAAATATTTCTGAAGCTTCGATTA
GGCACACATTTGAAAGATTTTGTGGGGTATTAAGGCGATGTGAGTATAAGGGAGAGTTTGAAAACACTATTTTTTTAGAT
GATTATGCACACCATCCAACAGAAATTCAAACCACCTTAGAGGGAATTCGAAAAGCTATTAAATCGAAAAGGCTGATTGC
TGTTTTTCAACCTCATCGCTTTTCTCGTATAAAGGATTGTTTAGGAATGTATGGAAAAATTTTTAATAATGCCGATGAAG
TGTTTGTAACAGATGTTTATGGGGCAGGAGAAACGCCTATTGAGGGAATATCTCAACAACAAATTATCCAGGAAATTTCT
GAGAACTCTAGTGTTCCAGTCAAATATGTTCCTCGAACGGCGTTAGGACATAAACTTAGTGAATTTATTCAACCTCTCGA
TGTCATTGTGACTCTCGGGGCTGGAGATGTCACAAAAGTGGCTAGCGAAACACTAAGCTTGCTTGAAAATGGAAAGCGCT
TTTAA

Upstream 100 bases:

>100_bases
CTTATAAATGTAGGCCAGATCGTACAACGCTTTGCGAGCTTGTTTTAGACACAAGCGAATTAAAAAGTTTACATAAAGCA
CCACAGAAAAGGAAATAACC

Downstream 100 bases:

>100_bases
CTTTGTTACGCTTGAAAATAACCTCTTTTAATCAGAAAATCTATGGTTTCTAAATCTTACCCTAACCCAGAAATTCCTTT
TAAACGAGCCTGTTTATGGA

Product: putative UDP-N-acetylmuramate-alanine ligase murC

Products: NA

Alternate protein names: UDP-N-acetylmuramoyl-L-alanine synthetase

Number of amino acids: Translated: 454; Mature: 454

Protein sequence:

>454_residues
MRGHYHFIGIGGIGMSGLARILLQQNLSVSGSDIAFNYTIEGLIKSGATIYKGHSPSYITSGSTVIYSSDIKTDNPEYLA
AKNLQCSLLHRAELLALLTRQKKSLAVTGTHGKTTTSSLLATTLLEANCDSSFAVGGIIPQFQSNAKHGLGDLFVFEADE
SDRSFLKYFPYGAIVTNIDNDHLNSYENSEDVLIQSFQQFTSQISSPNHLFWCGDDTHLKFLNGIGQSYGFGEHCNWRIS
NVFQKDFNLEFDLEGNEKKYPSIKLNLIGRHNLLNGAAVFGLAMSLNISEASIRHTFERFCGVLRRCEYKGEFENTIFLD
DYAHHPTEIQTTLEGIRKAIKSKRLIAVFQPHRFSRIKDCLGMYGKIFNNADEVFVTDVYGAGETPIEGISQQQIIQEIS
ENSSVPVKYVPRTALGHKLSEFIQPLDVIVTLGAGDVTKVASETLSLLENGKRF

Sequences:

>Translated_454_residues
MRGHYHFIGIGGIGMSGLARILLQQNLSVSGSDIAFNYTIEGLIKSGATIYKGHSPSYITSGSTVIYSSDIKTDNPEYLA
AKNLQCSLLHRAELLALLTRQKKSLAVTGTHGKTTTSSLLATTLLEANCDSSFAVGGIIPQFQSNAKHGLGDLFVFEADE
SDRSFLKYFPYGAIVTNIDNDHLNSYENSEDVLIQSFQQFTSQISSPNHLFWCGDDTHLKFLNGIGQSYGFGEHCNWRIS
NVFQKDFNLEFDLEGNEKKYPSIKLNLIGRHNLLNGAAVFGLAMSLNISEASIRHTFERFCGVLRRCEYKGEFENTIFLD
DYAHHPTEIQTTLEGIRKAIKSKRLIAVFQPHRFSRIKDCLGMYGKIFNNADEVFVTDVYGAGETPIEGISQQQIIQEIS
ENSSVPVKYVPRTALGHKLSEFIQPLDVIVTLGAGDVTKVASETLSLLENGKRF
>Mature_454_residues
MRGHYHFIGIGGIGMSGLARILLQQNLSVSGSDIAFNYTIEGLIKSGATIYKGHSPSYITSGSTVIYSSDIKTDNPEYLA
AKNLQCSLLHRAELLALLTRQKKSLAVTGTHGKTTTSSLLATTLLEANCDSSFAVGGIIPQFQSNAKHGLGDLFVFEADE
SDRSFLKYFPYGAIVTNIDNDHLNSYENSEDVLIQSFQQFTSQISSPNHLFWCGDDTHLKFLNGIGQSYGFGEHCNWRIS
NVFQKDFNLEFDLEGNEKKYPSIKLNLIGRHNLLNGAAVFGLAMSLNISEASIRHTFERFCGVLRRCEYKGEFENTIFLD
DYAHHPTEIQTTLEGIRKAIKSKRLIAVFQPHRFSRIKDCLGMYGKIFNNADEVFVTDVYGAGETPIEGISQQQIIQEIS
ENSSVPVKYVPRTALGHKLSEFIQPLDVIVTLGAGDVTKVASETLSLLENGKRF

Specific function: Cell wall formation

COG id: COG0773

COG function: function code M; UDP-N-acetylmuramate-alanine ligase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the MurCDEF family

Homologues:

Organism=Escherichia coli, GI1786279, Length=455, Percent_Identity=35.6043956043956, Blast_Score=247, Evalue=1e-66,
Organism=Escherichia coli, GI1790680, Length=387, Percent_Identity=29.4573643410853, Blast_Score=148, Evalue=6e-37,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): MURC_PARUW (Q6MBS8)

Other databases:

- EMBL:   BX908798
- RefSeq:   YP_008246.1
- ProteinModelPortal:   Q6MBS8
- SMR:   Q6MBS8
- STRING:   Q6MBS8
- GeneID:   2780006
- GenomeReviews:   BX908798_GR
- KEGG:   pcu:pc1247
- NMPDR:   fig|264201.1.peg.1247
- eggNOG:   COG0773
- HOGENOM:   HBG476594
- OMA:   YQPHRYS
- PhylomeDB:   Q6MBS8
- ProtClustDB:   CLSK2762357
- BioCyc:   CPRO264201:PC1247-MONOMER
- GO:   GO:0005737
- HAMAP:   MF_00046
- InterPro:   IPR004101
- InterPro:   IPR013221
- InterPro:   IPR000713
- InterPro:   IPR016040
- InterPro:   IPR005758
- Gene3D:   G3DSA:3.90.190.20
- Gene3D:   G3DSA:3.40.1190.10
- Gene3D:   G3DSA:3.40.50.720
- TIGRFAMs:   TIGR01082

Pfam domain/function: PF01225 Mur_ligase; PF02875 Mur_ligase_C; PF08245 Mur_ligase_M; SSF53244 Mur_ligase_C; SSF53623 Mur_ligase_cen

EC number: =6.3.2.8

Molecular weight: Translated: 50351; Mature: 50351

Theoretical pI: Translated: 6.61; Mature: 6.61

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.5 %Cys     (Translated Protein)
0.9 %Met     (Translated Protein)
2.4 %Cys+Met (Translated Protein)
1.5 %Cys     (Mature Protein)
0.9 %Met     (Mature Protein)
2.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRGHYHFIGIGGIGMSGLARILLQQNLSVSGSDIAFNYTIEGLIKSGATIYKGHSPSYIT
CCCCEEEEEECCCCHHHHHHHHHHHCCCCCCCCEEEEEEEEHHHHCCCEEEECCCCCEEE
SGSTVIYSSDIKTDNPEYLAAKNLQCSLLHRAELLALLTRQKKSLAVTGTHGKTTTSSLL
CCCEEEEECCCCCCCCCEEEECCCCHHHHHHHHHHHHHHHCCCCEEEECCCCCCHHHHHH
ATTLLEANCDSSFAVGGIIPQFQSNAKHGLGDLFVFEADESDRSFLKYFPYGAIVTNIDN
HHHHHHCCCCCCEEECCCCHHHHCCCCCCCCEEEEEECCCCCCHHHHHCCCCEEEECCCC
DHLNSYENSEDVLIQSFQQFTSQISSPNHLFWCGDDTHLKFLNGIGQSYGFGEHCNWRIS
HHCCCCCCCHHHHHHHHHHHHHHCCCCCEEEEECCCCHHHHHHHCCCCCCCCCCCCCHHH
NVFQKDFNLEFDLEGNEKKYPSIKLNLIGRHNLLNGAAVFGLAMSLNISEASIRHTFERF
HHHHHCCCEEEEECCCCCCCCEEEEEEEECCCCCCHHHHHHHHEEECCCHHHHHHHHHHH
CGVLRRCEYKGEFENTIFLDDYAHHPTEIQTTLEGIRKAIKSKRLIAVFQPHRFSRIKDC
HHHHHHCCCCCCCCCEEEEECCCCCCHHHHHHHHHHHHHHHCCCEEEEECCCHHHHHHHH
LGMYGKIFNNADEVFVTDVYGAGETPIEGISQQQIIQEISENSSVPVKYVPRTALGHKLS
HHHHHHHHCCCCCEEEEEECCCCCCCCCCCCHHHHHHHHHCCCCCCEEECCCHHHHHHHH
EFIQPLDVIVTLGAGDVTKVASETLSLLENGKRF
HHHCHHEEEEECCCCCHHHHHHHHHHHHHCCCCC
>Mature Secondary Structure
MRGHYHFIGIGGIGMSGLARILLQQNLSVSGSDIAFNYTIEGLIKSGATIYKGHSPSYIT
CCCCEEEEEECCCCHHHHHHHHHHHCCCCCCCCEEEEEEEEHHHHCCCEEEECCCCCEEE
SGSTVIYSSDIKTDNPEYLAAKNLQCSLLHRAELLALLTRQKKSLAVTGTHGKTTTSSLL
CCCEEEEECCCCCCCCCEEEECCCCHHHHHHHHHHHHHHHCCCCEEEECCCCCCHHHHHH
ATTLLEANCDSSFAVGGIIPQFQSNAKHGLGDLFVFEADESDRSFLKYFPYGAIVTNIDN
HHHHHHCCCCCCEEECCCCHHHHCCCCCCCCEEEEEECCCCCCHHHHHCCCCEEEECCCC
DHLNSYENSEDVLIQSFQQFTSQISSPNHLFWCGDDTHLKFLNGIGQSYGFGEHCNWRIS
HHCCCCCCCHHHHHHHHHHHHHHCCCCCEEEEECCCCHHHHHHHCCCCCCCCCCCCCHHH
NVFQKDFNLEFDLEGNEKKYPSIKLNLIGRHNLLNGAAVFGLAMSLNISEASIRHTFERF
HHHHHCCCEEEEECCCCCCCCEEEEEEEECCCCCCHHHHHHHHEEECCCHHHHHHHHHHH
CGVLRRCEYKGEFENTIFLDDYAHHPTEIQTTLEGIRKAIKSKRLIAVFQPHRFSRIKDC
HHHHHHCCCCCCCCCEEEEECCCCCCHHHHHHHHHHHHHHHCCCEEEEECCCHHHHHHHH
LGMYGKIFNNADEVFVTDVYGAGETPIEGISQQQIIQEISENSSVPVKYVPRTALGHKLS
HHHHHHHHCCCCCEEEEEECCCCCCCCCCCCHHHHHHHHHCCCCCCEEECCCHHHHHHHH
EFIQPLDVIVTLGAGDVTKVASETLSLLENGKRF
HHHCHHEEEEECCCCCHHHHHHHHHHHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA