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The map label for this gene is nuoH

Identifier: 46446200

GI number: 46446200

Start: 700466

End: 701443

Strand: Direct

Name: nuoH

Synonym: pc0566

Alternate gene names: 46446200

Gene position: 700466-701443 (Clockwise)

Preceding gene: 46446199

Following gene: 46446201

Centisome position: 29.01

GC content: 37.93

Gene sequence:

>978_bases
ATGATTGACGACTTAATCATCATTCTTATTAAAAGTGCTGTTGTCATTCTTTTATTATTTACAGCAGCTGCCTATATGAC
ATTTTTAGAACGTATTGTCATGGCTCGTCTTCAACTAAGAATGGGACCTGTGAGAGTAGGTCCTTTTGGCCTTTTTCAGC
CCCTCGCTGATGGAATCAAATTATTATGCAAAGAACGTTTTCAACCAGCTAATGTAGAAACATTTGTTTATTGGCTTGCT
CCCGGCATCTCCTTATTTACAGCATTGTTTATTTTTGTATTGATTCCATTTGGGGGTGTAGTAGAAATTGCAGGTCGGCT
TATTTATTTACAAATTGCCGACATAAACGTTGGAGTTGTTTTTTTGTTAGCTTTTTCTTCTTTAGCCGTCTACGGAGTTG
TTTTAGCTGGCTGGGCTTCGAATAATCGTTATTCACTCATTGGAGGATTAAGAGGAACTGCTCAAATGATCAGTTACGAA
ATTCCAATGGGGCTTTCTTTGCTAACTGTTGTTTTATCAACTGGTACATTGAGTTTACGAGAAATTGTTGAATTGCAACA
AAATCATTGGTTGATTTGGACAAATCCGATTAGTTTTATCATTTATTTTATTACTTCCTTCGCTGAAACCAATCGGGCTC
CATTTGATCTTCCTGAGGCTGAGCAAGAATTAACAGCAGGTTATCATACAGAATATGGGGGAATGAAATTTGCCGCTTTT
TTTCTTGGAGAATACATCAATATTTTAGCCGTATCGGCTATTGCAACGACCCTCTTTTTTGGAGGATGGCATGGACCTGG
AGATATTCCTATTCTTTGGTTTGGGTTAAAAGTCGCTATTTTTGTTTTTATTTTCATGTGGGTGCGAGCGACGATGCCTC
GTTTTCGCTATGATCAACTCATGAGCTTTGGGTGGAAGGTGTTGATTCCCATTGCCATCTTAAATCTAATTATAACAGCA
TACTTTACGTTGGTGTAG

Upstream 100 bases:

>100_bases
TAGGATTTGACCTTATTTCCGCTCATGATTTAGATAGTAACCTCATCAATGGATTGCCAATCGATATTCAACTAATTGAA
TCACAAAAAGAAGAGTCTCT

Downstream 100 bases:

>100_bases
CATGAGAACAACTATACACAAAGTTATCACAATGATGAAAGGGTTGATTATCGTTTTAAAACACGCTTTTCAAACTCCGG
TCACACTGCGTTATCCTGAA

Product: NADH-ubiquinone oxidoreductase chain H

Products: NA

Alternate protein names: NADH dehydrogenase I subunit H; NDH-1 subunit H

Number of amino acids: Translated: 325; Mature: 325

Protein sequence:

>325_residues
MIDDLIIILIKSAVVILLLFTAAAYMTFLERIVMARLQLRMGPVRVGPFGLFQPLADGIKLLCKERFQPANVETFVYWLA
PGISLFTALFIFVLIPFGGVVEIAGRLIYLQIADINVGVVFLLAFSSLAVYGVVLAGWASNNRYSLIGGLRGTAQMISYE
IPMGLSLLTVVLSTGTLSLREIVELQQNHWLIWTNPISFIIYFITSFAETNRAPFDLPEAEQELTAGYHTEYGGMKFAAF
FLGEYINILAVSAIATTLFFGGWHGPGDIPILWFGLKVAIFVFIFMWVRATMPRFRYDQLMSFGWKVLIPIAILNLIITA
YFTLV

Sequences:

>Translated_325_residues
MIDDLIIILIKSAVVILLLFTAAAYMTFLERIVMARLQLRMGPVRVGPFGLFQPLADGIKLLCKERFQPANVETFVYWLA
PGISLFTALFIFVLIPFGGVVEIAGRLIYLQIADINVGVVFLLAFSSLAVYGVVLAGWASNNRYSLIGGLRGTAQMISYE
IPMGLSLLTVVLSTGTLSLREIVELQQNHWLIWTNPISFIIYFITSFAETNRAPFDLPEAEQELTAGYHTEYGGMKFAAF
FLGEYINILAVSAIATTLFFGGWHGPGDIPILWFGLKVAIFVFIFMWVRATMPRFRYDQLMSFGWKVLIPIAILNLIITA
YFTLV
>Mature_325_residues
MIDDLIIILIKSAVVILLLFTAAAYMTFLERIVMARLQLRMGPVRVGPFGLFQPLADGIKLLCKERFQPANVETFVYWLA
PGISLFTALFIFVLIPFGGVVEIAGRLIYLQIADINVGVVFLLAFSSLAVYGVVLAGWASNNRYSLIGGLRGTAQMISYE
IPMGLSLLTVVLSTGTLSLREIVELQQNHWLIWTNPISFIIYFITSFAETNRAPFDLPEAEQELTAGYHTEYGGMKFAAF
FLGEYINILAVSAIATTLFFGGWHGPGDIPILWFGLKVAIFVFIFMWVRATMPRFRYDQLMSFGWKVLIPIAILNLIITA
YFTLV

Specific function: NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocat

COG id: COG1005

COG function: function code C; NADH:ubiquinone oxidoreductase subunit 1 (chain H)

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein (Potential)

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the complex I subunit 1 family

Homologues:

Organism=Homo sapiens, GI251831107, Length=294, Percent_Identity=38.7755102040816, Blast_Score=216, Evalue=2e-56,
Organism=Escherichia coli, GI1788618, Length=318, Percent_Identity=44.3396226415094, Blast_Score=280, Evalue=1e-76,
Organism=Escherichia coli, GI1789077, Length=239, Percent_Identity=27.1966527196653, Blast_Score=62, Evalue=5e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NUOH_PARUW (Q6MDQ9)

Other databases:

- EMBL:   BX908798
- RefSeq:   YP_007565.1
- STRING:   Q6MDQ9
- GeneID:   2781137
- GenomeReviews:   BX908798_GR
- KEGG:   pcu:pc0566
- NMPDR:   fig|264201.1.peg.566
- eggNOG:   COG1005
- HOGENOM:   HBG727670
- OMA:   QLMNLGW
- PhylomeDB:   Q6MDQ9
- BioCyc:   CPRO264201:PC0566-MONOMER
- HAMAP:   MF_01350
- InterPro:   IPR023020
- InterPro:   IPR001694
- InterPro:   IPR018086
- PANTHER:   PTHR11432

Pfam domain/function: PF00146 NADHdh

EC number: =1.6.99.5

Molecular weight: Translated: 36352; Mature: 36352

Theoretical pI: Translated: 6.80; Mature: 6.80

Prosite motif: PS00667 COMPLEX1_ND1_1; PS00668 COMPLEX1_ND1_2

Important sites: NA

Signals:

None

Transmembrane regions:

HASH(0xcd64630)-; HASH(0xce8cc88)-; HASH(0xc3625b4)-; HASH(0xb461568)-; HASH(0xb50c14c)-; HASH(0xbeec17c)-; HASH(0xbf2a678)-; HASH(0xb53cf40)-;

Cys/Met content:

0.3 %Cys     (Translated Protein)
3.1 %Met     (Translated Protein)
3.4 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
3.1 %Met     (Mature Protein)
3.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MIDDLIIILIKSAVVILLLFTAAAYMTFLERIVMARLQLRMGPVRVGPFGLFQPLADGIK
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEECCHHHHHHHHHHHH
LLCKERFQPANVETFVYWLAPGISLFTALFIFVLIPFGGVVEIAGRLIYLQIADINVGVV
HHHHHCCCCCCHHHHHHHHHCHHHHHHHHHHHHHHCCCHHHHHHCEEEEEEEECCCHHHH
FLLAFSSLAVYGVVLAGWASNNRYSLIGGLRGTAQMISYEIPMGLSLLTVVLSTGTLSLR
HHHHHHHHHHHHHHHHHCCCCCCEEEEECCCHHHHHHHCCCCCHHHHHHHHHHCCCHHHH
EIVELQQNHWLIWTNPISFIIYFITSFAETNRAPFDLPEAEQELTAGYHTEYGGMKFAAF
HHHHHHHCCEEEEECHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHCCCCCCCCCHHHHHH
FLGEYINILAVSAIATTLFFGGWHGPGDIPILWFGLKVAIFVFIFMWVRATMPRFRYDQL
HHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHH
MSFGWKVLIPIAILNLIITAYFTLV
HHCCHHHHHHHHHHHHHHHHHHHCH
>Mature Secondary Structure
MIDDLIIILIKSAVVILLLFTAAAYMTFLERIVMARLQLRMGPVRVGPFGLFQPLADGIK
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEECCHHHHHHHHHHHH
LLCKERFQPANVETFVYWLAPGISLFTALFIFVLIPFGGVVEIAGRLIYLQIADINVGVV
HHHHHCCCCCCHHHHHHHHHCHHHHHHHHHHHHHHCCCHHHHHHCEEEEEEEECCCHHHH
FLLAFSSLAVYGVVLAGWASNNRYSLIGGLRGTAQMISYEIPMGLSLLTVVLSTGTLSLR
HHHHHHHHHHHHHHHHHCCCCCCEEEEECCCHHHHHHHCCCCCHHHHHHHHHHCCCHHHH
EIVELQQNHWLIWTNPISFIIYFITSFAETNRAPFDLPEAEQELTAGYHTEYGGMKFAAF
HHHHHHHCCEEEEECHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHCCCCCCCCCHHHHHH
FLGEYINILAVSAIATTLFFGGWHGPGDIPILWFGLKVAIFVFIFMWVRATMPRFRYDQL
HHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHH
MSFGWKVLIPIAILNLIITAYFTLV
HHCCHHHHHHHHHHHHHHHHHHHCH

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: NA