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The map label for this gene is nuoD

Identifier: 46446196

GI number: 46446196

Start: 695130

End: 696338

Strand: Direct

Name: nuoD

Synonym: pc0562

Alternate gene names: 46446196

Gene position: 695130-696338 (Clockwise)

Preceding gene: 46446195

Following gene: 46446197

Centisome position: 28.79

GC content: 39.04

Gene sequence:

>1209_bases
ATGACAAAAGTAAGTAAAGAGCGCCTTAAAGAACTTGAGGAGTCCGGTGATGTCATGGAGCTCAATTTGGGCCCGCAACA
TCCTTCTACTCACGGTGTATTGCGTTTAAAATTGCGCCTTGAAGGAGAGGTTGTATTATCTTGTGATCCTGTGATTGGCT
ATTTACATACCGGAGTGGAAAAAGAGTGTGAAAGTCGCACCTATCATCAGGTTTTTACTTTAGTTGATCGTTTAGACTAT
TTGTCAGGCCCAGCTGAAGAACAAGCTTTTGCAGGTGCCCTCGAACGTTTAATGAATATTGAGGTTCCAGAACGTGCACA
AACGATTCGCATTATTCTTTTAGAATTATCGCGAATAGCAAGTCATCTTTTATGGGCTGGAACAAGTGCTTTAGAATTAA
ATATGTCTTCAGTTTTTATGTATAGCTTTGCAGAAAGGGAAAAAATTTTAGACCTATTTGAACAAGTCTCTGGTGCCAGA
ATGTTTCCTTCCTTGTGGAGAATCGGCGGATTAGCAAAAGACTTAAATTCTGATTTTATCTCTCATTTAAAAGAATTTAT
CTCTGGTTTTCAAAAAATTTGGAAAGAGTTGGATAGGCTTTTAACAGATAATTTTGTTTGGTGTAAACGCTTACAAGGTG
TTGCTGTCATTGATCAAGAAATCTGTAAGCAATACATGTGTACAGGTCCTGTACTTCGCGCATCCGGTATTTCTTATGAT
ATCCGCAAAGCTTATCCTTATTTAGGATATGAAAATTACAATTTCGATATACCAACGCATATCGATGGAGATTCTTATGC
ACGTTACCTTGTTCGTATGGAAGAGATGTTACAAAGTATTTCTATCATTGAACAAGCTATTGCACGCTTAAAACCAGGTG
TTGTGTTAACAAATGATCGCAAAGTTGCCTTGCCCCCTCGAAAGGAGTTAGCCCGAAGCATGGAAGCTGTCATTCATCAA
TTTAAATTGATTTCCGAAGGCCTTCATCCTCCTGTTGGTTCAGTTTATAATTGTGTAGAATCTGCTAGAGGAGAACTGGG
TCATTATGTGATTAGCGACGGGACACCTAAACCGTATCGGTTAAGAGTTCGCTCACCTTCATTTTCTCACGTTGAAGTGT
TAAAAAAGGTTTTACGAGGCCATGTCATTTCAGATGTTGTTGTTGCTATTGCTAGTGTTGACCCTATACTTGGAGACGTA
GATCGCTAA

Upstream 100 bases:

>100_bases
TGGTTAGGACATCCAATGTTACGTGACTATGCATTAACTGAAGAAGTTGTTCAATTTAAAAATAATGTAAAACCGAAAGT
ACCTTCACAGATTATTTCTT

Downstream 100 bases:

>100_bases
TGCTTACCGAAGAAACAAAACAGGCTATCTTAAAATTGCAGAATCTATATCCAAATAAACGCTCAGCTCTTATTCCAGCC
CTTCATTTAGCACAAGCTGA

Product: putative NADH-ubiquinone oxidoreductase chain C/D

Products: NA

Alternate protein names: NADH dehydrogenase I subunit D; NDH-1 subunit D

Number of amino acids: Translated: 402; Mature: 401

Protein sequence:

>402_residues
MTKVSKERLKELEESGDVMELNLGPQHPSTHGVLRLKLRLEGEVVLSCDPVIGYLHTGVEKECESRTYHQVFTLVDRLDY
LSGPAEEQAFAGALERLMNIEVPERAQTIRIILLELSRIASHLLWAGTSALELNMSSVFMYSFAEREKILDLFEQVSGAR
MFPSLWRIGGLAKDLNSDFISHLKEFISGFQKIWKELDRLLTDNFVWCKRLQGVAVIDQEICKQYMCTGPVLRASGISYD
IRKAYPYLGYENYNFDIPTHIDGDSYARYLVRMEEMLQSISIIEQAIARLKPGVVLTNDRKVALPPRKELARSMEAVIHQ
FKLISEGLHPPVGSVYNCVESARGELGHYVISDGTPKPYRLRVRSPSFSHVEVLKKVLRGHVISDVVVAIASVDPILGDV
DR

Sequences:

>Translated_402_residues
MTKVSKERLKELEESGDVMELNLGPQHPSTHGVLRLKLRLEGEVVLSCDPVIGYLHTGVEKECESRTYHQVFTLVDRLDY
LSGPAEEQAFAGALERLMNIEVPERAQTIRIILLELSRIASHLLWAGTSALELNMSSVFMYSFAEREKILDLFEQVSGAR
MFPSLWRIGGLAKDLNSDFISHLKEFISGFQKIWKELDRLLTDNFVWCKRLQGVAVIDQEICKQYMCTGPVLRASGISYD
IRKAYPYLGYENYNFDIPTHIDGDSYARYLVRMEEMLQSISIIEQAIARLKPGVVLTNDRKVALPPRKELARSMEAVIHQ
FKLISEGLHPPVGSVYNCVESARGELGHYVISDGTPKPYRLRVRSPSFSHVEVLKKVLRGHVISDVVVAIASVDPILGDV
DR
>Mature_401_residues
TKVSKERLKELEESGDVMELNLGPQHPSTHGVLRLKLRLEGEVVLSCDPVIGYLHTGVEKECESRTYHQVFTLVDRLDYL
SGPAEEQAFAGALERLMNIEVPERAQTIRIILLELSRIASHLLWAGTSALELNMSSVFMYSFAEREKILDLFEQVSGARM
FPSLWRIGGLAKDLNSDFISHLKEFISGFQKIWKELDRLLTDNFVWCKRLQGVAVIDQEICKQYMCTGPVLRASGISYDI
RKAYPYLGYENYNFDIPTHIDGDSYARYLVRMEEMLQSISIIEQAIARLKPGVVLTNDRKVALPPRKELARSMEAVIHQF
KLISEGLHPPVGSVYNCVESARGELGHYVISDGTPKPYRLRVRSPSFSHVEVLKKVLRGHVISDVVVAIASVDPILGDVD
R

Specific function: NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocat

COG id: COG0649

COG function: function code C; NADH:ubiquinone oxidoreductase 49 kD subunit 7

Gene ontology:

Cell location: Cell inner membrane; Peripheral membrane protein; Cytoplasmic side

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the complex I 49 kDa subunit family

Homologues:

Organism=Homo sapiens, GI4758786, Length=384, Percent_Identity=43.4895833333333, Blast_Score=338, Evalue=5e-93,
Organism=Homo sapiens, GI260898743, Length=379, Percent_Identity=43.5356200527704, Blast_Score=328, Evalue=7e-90,
Organism=Escherichia coli, GI145693162, Length=397, Percent_Identity=37.5314861460957, Blast_Score=292, Evalue=3e-80,
Organism=Escherichia coli, GI1789076, Length=381, Percent_Identity=29.6587926509186, Blast_Score=168, Evalue=7e-43,
Organism=Escherichia coli, GI1788832, Length=392, Percent_Identity=28.0612244897959, Blast_Score=151, Evalue=8e-38,
Organism=Caenorhabditis elegans, GI17555284, Length=398, Percent_Identity=41.2060301507538, Blast_Score=328, Evalue=4e-90,
Organism=Caenorhabditis elegans, GI17568379, Length=398, Percent_Identity=40.4522613065327, Blast_Score=324, Evalue=5e-89,
Organism=Drosophila melanogaster, GI24638644, Length=395, Percent_Identity=42.5316455696203, Blast_Score=355, Evalue=2e-98,
Organism=Drosophila melanogaster, GI221459469, Length=382, Percent_Identity=42.1465968586387, Blast_Score=336, Evalue=2e-92,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NUOD_PARUW (Q6MDR3)

Other databases:

- EMBL:   BX908798
- RefSeq:   YP_007561.1
- HSSP:   Q56220
- ProteinModelPortal:   Q6MDR3
- SMR:   Q6MDR3
- STRING:   Q6MDR3
- GeneID:   2779448
- GenomeReviews:   BX908798_GR
- KEGG:   pcu:pc0562
- NMPDR:   fig|264201.1.peg.562
- eggNOG:   COG0649
- HOGENOM:   HBG459705
- OMA:   GVFIQGN
- PhylomeDB:   Q6MDR3
- BioCyc:   CPRO264201:PC0562-MONOMER
- GO:   GO:0006810
- HAMAP:   MF_01358
- InterPro:   IPR010219
- InterPro:   IPR001135
- InterPro:   IPR022885
- TIGRFAMs:   TIGR01962

Pfam domain/function: PF00346 Complex1_49kDa

EC number: =1.6.99.5

Molecular weight: Translated: 45474; Mature: 45343

Theoretical pI: Translated: 6.65; Mature: 6.65

Prosite motif: PS00535 COMPLEX1_49K

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.5 %Cys     (Translated Protein)
2.5 %Met     (Translated Protein)
4.0 %Cys+Met (Translated Protein)
1.5 %Cys     (Mature Protein)
2.2 %Met     (Mature Protein)
3.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTKVSKERLKELEESGDVMELNLGPQHPSTHGVLRLKLRLEGEVVLSCDPVIGYLHTGVE
CCCCCHHHHHHHHHCCCEEEEECCCCCCCCCCEEEEEEEECCCEEEECCHHHHHHHCCHH
KECESRTYHQVFTLVDRLDYLSGPAEEQAFAGALERLMNIEVPERAQTIRIILLELSRIA
HHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHH
SHLLWAGTSALELNMSSVFMYSFAEREKILDLFEQVSGARMFPSLWRIGGLAKDLNSDFI
HHHHHCCCCCEEECHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHCCHHHHHHHHHH
SHLKEFISGFQKIWKELDRLLTDNFVWCKRLQGVAVIDQEICKQYMCTGPVLRASGISYD
HHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHCCHHHHHHHHHHHHHCCCCCEECCCCCCH
IRKAYPYLGYENYNFDIPTHIDGDSYARYLVRMEEMLQSISIIEQAIARLKPGVVLTNDR
HHHHCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEECCC
KVALPPRKELARSMEAVIHQFKLISEGLHPPVGSVYNCVESARGELGHYVISDGTPKPYR
EEECCCHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHCCEEEECCCCCCEE
LRVRSPSFSHVEVLKKVLRGHVISDVVVAIASVDPILGDVDR
EEECCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCHHHCCCCC
>Mature Secondary Structure 
TKVSKERLKELEESGDVMELNLGPQHPSTHGVLRLKLRLEGEVVLSCDPVIGYLHTGVE
CCCCHHHHHHHHHCCCEEEEECCCCCCCCCCEEEEEEEECCCEEEECCHHHHHHHCCHH
KECESRTYHQVFTLVDRLDYLSGPAEEQAFAGALERLMNIEVPERAQTIRIILLELSRIA
HHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHH
SHLLWAGTSALELNMSSVFMYSFAEREKILDLFEQVSGARMFPSLWRIGGLAKDLNSDFI
HHHHHCCCCCEEECHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHCCHHHHHHHHHH
SHLKEFISGFQKIWKELDRLLTDNFVWCKRLQGVAVIDQEICKQYMCTGPVLRASGISYD
HHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHCCHHHHHHHHHHHHHCCCCCEECCCCCCH
IRKAYPYLGYENYNFDIPTHIDGDSYARYLVRMEEMLQSISIIEQAIARLKPGVVLTNDR
HHHHCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEECCC
KVALPPRKELARSMEAVIHQFKLISEGLHPPVGSVYNCVESARGELGHYVISDGTPKPYR
EEECCCHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHCCEEEECCCCCCEE
LRVRSPSFSHVEVLKKVLRGHVISDVVVAIASVDPILGDVDR
EEECCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: NA