Click here to switch to the map view.

The map label for this gene is mutS [H]

Identifier: 45659206

GI number: 45659206

Start: 4153049

End: 4154881

Strand: Reverse

Name: mutS [H]

Synonym: LIC13389

Alternate gene names: 45659206

Gene position: 4154881-4153049 (Counterclockwise)

Preceding gene: 45659207

Following gene: 45659195

Centisome position: 97.14

GC content: 33.06

Gene sequence:

>1833_bases
ATGACTTCTTTTACTCGGATCGATCGGCTTAAACGCAGAGCTGAAAAGTTAAATAAACTTCACGATAAAATTTCCGTTCT
TCTTTCTAGGCTTTCGTTATTTCGTCTTATTTTTTTTTCCGTCTTTTTACTTTGGATTTCTATTTTCTACTATTTACATT
CTTCAATTTTTTATCATCTTCCTTCTCTGGTTTTTCTTTTTCTTTTTTTCTTTTTTGTTCGAAGATATAAAAAAACTCTT
TTAACTCGGAAAAAAATTCAACTTTGGATTTTCGTTTTGGAGAGGGAATCCGCAAGAATTTCAATCAAAGGTTTTGGTAA
AAAATTTGGAACTCAAATCGTTTTAGAAAAAGTTTCTCCTTTAGCCAGAGATTTGGATCTATTTCGAGAAAACGGTTTAT
TTTCCTGGTTAGATACTACCTTTACCTCCAATGCCGAACAAAAGTTGATTGCTCTTTTAGATTTGGAAGATTCTTCTTCA
TATAATAATAGAGAGAATGTGCTTTTACGCCAGTCTATTGTTCGATCGATTTCTGAAAAAACATTAGCAATTCCTAAAAT
ACTTAGACTCGCCTCTTATCTAAAAGAAAATCAGGACGTTTTTCAAGCTCGTACTAAAACCGAAACAAAGTCGATCCGGG
ATGAAAATACATCCAAATTTTGGGAAAGTTACCCTTGGTTGAAAAAGATATATAGACCGATTACGATTTTGGTGCTTGCA
TTCATTCCTGCAAACGTGTTTTTGGGAGTTCCTTTTCCTGCTTCCGTTTTGTTTTTAAATTTGATCCTATTTGGATTGTA
CCGTTCTCGTTCTTTGGATATTTTTAGACAGTATTACTCTATTTCCGGAAGTATTTCAGGACTTCAGAAAATTCTAATAT
ATTTAAAGGGATTGAAAATTAAAGATAAAAACGGTAGATTTCTTTTAGAGGATACTTCCAAGGATGAATTAAGATCTGCT
TATAAGGATTTGGATCTGATTTTAAAACGTGTTTCTCTAACTGAAGCTCCTCTCTTACACCTGATCTTAAATAATTTGTT
TCTTTACGATCTTTGGGTTTTACAGAAAATTTCGAAATGGAAAGAAAAACATTCTGTACTGTTGGAAAAATCGATCGAGG
ATCTGACCTTATTCGATTCTCTATTTTCCTTTGCGAATTTGAAATGGATGTTTCCCGATTATTGTTTTCCGGAAATTCTT
TCTGAAAATTCTAAAGAAGGAATTTCAGGTAAGGGTCTTTTTCATCCTTTGATTCCTTCTGACTCCAGAGTTTCTAATCC
ATTAGATTTTATTGAAGAACAAAATGTAGTTCTGATTACGGGTTCGAATATGTCTGGAAAAACCACTTATCTACGTACGA
TCGGTGTAGCTTCTATTCTTTCTATGGCGGGTGGTCCGGTTCCCGCGTCCAAATTTTCATTACCTGTTTTAAAAATTCAT
ACGAGTATGAGAAATGAAGATAACTTAGAAGAAGGAATTTCTTTCTTTTATGCAGAAGTGAGAAGACTTTCTGAAATTGT
AAAAAAAATCAGGGATAAAAATTCATCTCATCTTGTTTTACTCGATGAGATTTTAAAAGGAACTAATACAAGAGAGCGTT
CTCTTGCTTGTAAGGGAATTTTAAAAGAGCTCAAAAAAAATCGTACAATCGTTTTTGTAACGAGTCATGATCTTGAACTT
GCGAAAGTGGAAGGTGTTATCTTAAAACATTTTCAAGAGGAAGTTTTAGATGGAACCATGTATTTCGATTATAAAATCCG
AGAAGGACTAGTAGAAACTAGCAATGCTCTTCGTATTTTAGTTCAAGAAGGATTGGATCTAGATTTCACGTAA

Upstream 100 bases:

>100_bases
GTTGGGTAATGCCGGACCTAGGATCATTAGTTCGTTTGTTGGATTTTGAAATTTATAAACGAGAGAATGAACACTACGAA
AATATAAGTTCCGTTATTGG

Downstream 100 bases:

>100_bases
AAAATTTGATACTGCCAATGATGATCGCGTAATATTTCAATTCCTGTAGTATTTCCACTACAATCACTTTATATTGGTTA
TACCAAATTCACGACCTTAA

Product: DNA mismatch repair protein

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 610; Mature: 609

Protein sequence:

>610_residues
MTSFTRIDRLKRRAEKLNKLHDKISVLLSRLSLFRLIFFSVFLLWISIFYYLHSSIFYHLPSLVFLFLFFFFVRRYKKTL
LTRKKIQLWIFVLERESARISIKGFGKKFGTQIVLEKVSPLARDLDLFRENGLFSWLDTTFTSNAEQKLIALLDLEDSSS
YNNRENVLLRQSIVRSISEKTLAIPKILRLASYLKENQDVFQARTKTETKSIRDENTSKFWESYPWLKKIYRPITILVLA
FIPANVFLGVPFPASVLFLNLILFGLYRSRSLDIFRQYYSISGSISGLQKILIYLKGLKIKDKNGRFLLEDTSKDELRSA
YKDLDLILKRVSLTEAPLLHLILNNLFLYDLWVLQKISKWKEKHSVLLEKSIEDLTLFDSLFSFANLKWMFPDYCFPEIL
SENSKEGISGKGLFHPLIPSDSRVSNPLDFIEEQNVVLITGSNMSGKTTYLRTIGVASILSMAGGPVPASKFSLPVLKIH
TSMRNEDNLEEGISFFYAEVRRLSEIVKKIRDKNSSHLVLLDEILKGTNTRERSLACKGILKELKKNRTIVFVTSHDLEL
AKVEGVILKHFQEEVLDGTMYFDYKIREGLVETSNALRILVQEGLDLDFT

Sequences:

>Translated_610_residues
MTSFTRIDRLKRRAEKLNKLHDKISVLLSRLSLFRLIFFSVFLLWISIFYYLHSSIFYHLPSLVFLFLFFFFVRRYKKTL
LTRKKIQLWIFVLERESARISIKGFGKKFGTQIVLEKVSPLARDLDLFRENGLFSWLDTTFTSNAEQKLIALLDLEDSSS
YNNRENVLLRQSIVRSISEKTLAIPKILRLASYLKENQDVFQARTKTETKSIRDENTSKFWESYPWLKKIYRPITILVLA
FIPANVFLGVPFPASVLFLNLILFGLYRSRSLDIFRQYYSISGSISGLQKILIYLKGLKIKDKNGRFLLEDTSKDELRSA
YKDLDLILKRVSLTEAPLLHLILNNLFLYDLWVLQKISKWKEKHSVLLEKSIEDLTLFDSLFSFANLKWMFPDYCFPEIL
SENSKEGISGKGLFHPLIPSDSRVSNPLDFIEEQNVVLITGSNMSGKTTYLRTIGVASILSMAGGPVPASKFSLPVLKIH
TSMRNEDNLEEGISFFYAEVRRLSEIVKKIRDKNSSHLVLLDEILKGTNTRERSLACKGILKELKKNRTIVFVTSHDLEL
AKVEGVILKHFQEEVLDGTMYFDYKIREGLVETSNALRILVQEGLDLDFT
>Mature_609_residues
TSFTRIDRLKRRAEKLNKLHDKISVLLSRLSLFRLIFFSVFLLWISIFYYLHSSIFYHLPSLVFLFLFFFFVRRYKKTLL
TRKKIQLWIFVLERESARISIKGFGKKFGTQIVLEKVSPLARDLDLFRENGLFSWLDTTFTSNAEQKLIALLDLEDSSSY
NNRENVLLRQSIVRSISEKTLAIPKILRLASYLKENQDVFQARTKTETKSIRDENTSKFWESYPWLKKIYRPITILVLAF
IPANVFLGVPFPASVLFLNLILFGLYRSRSLDIFRQYYSISGSISGLQKILIYLKGLKIKDKNGRFLLEDTSKDELRSAY
KDLDLILKRVSLTEAPLLHLILNNLFLYDLWVLQKISKWKEKHSVLLEKSIEDLTLFDSLFSFANLKWMFPDYCFPEILS
ENSKEGISGKGLFHPLIPSDSRVSNPLDFIEEQNVVLITGSNMSGKTTYLRTIGVASILSMAGGPVPASKFSLPVLKIHT
SMRNEDNLEEGISFFYAEVRRLSEIVKKIRDKNSSHLVLLDEILKGTNTRERSLACKGILKELKKNRTIVFVTSHDLELA
KVEGVILKHFQEEVLDGTMYFDYKIREGLVETSNALRILVQEGLDLDFT

Specific function: This protein is involved in the repair of mismatches in DNA. It is possible that it carries out the mismatch recognition step. This protein has a weak ATPase activity [H]

COG id: COG0249

COG function: function code L; Mismatch repair ATPase (MutS family)

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the DNA mismatch repair mutS family [H]

Homologues:

Organism=Homo sapiens, GI36949366, Length=374, Percent_Identity=27.0053475935829, Blast_Score=100, Evalue=7e-21,
Organism=Homo sapiens, GI284813531, Length=177, Percent_Identity=32.7683615819209, Blast_Score=86, Evalue=9e-17,
Organism=Homo sapiens, GI26638666, Length=204, Percent_Identity=28.921568627451, Blast_Score=74, Evalue=5e-13,
Organism=Homo sapiens, GI4505253, Length=204, Percent_Identity=28.921568627451, Blast_Score=74, Evalue=5e-13,
Organism=Homo sapiens, GI26638664, Length=204, Percent_Identity=28.4313725490196, Blast_Score=73, Evalue=8e-13,
Organism=Homo sapiens, GI4504191, Length=261, Percent_Identity=28.3524904214559, Blast_Score=72, Evalue=2e-12,
Organism=Escherichia coli, GI1789089, Length=251, Percent_Identity=27.4900398406374, Blast_Score=87, Evalue=4e-18,
Organism=Caenorhabditis elegans, GI17508445, Length=242, Percent_Identity=28.5123966942149, Blast_Score=78, Evalue=1e-14,
Organism=Caenorhabditis elegans, GI17534743, Length=151, Percent_Identity=31.7880794701987, Blast_Score=72, Evalue=9e-13,
Organism=Caenorhabditis elegans, GI17508447, Length=274, Percent_Identity=27.007299270073, Blast_Score=67, Evalue=3e-11,
Organism=Saccharomyces cerevisiae, GI6319935, Length=254, Percent_Identity=26.3779527559055, Blast_Score=74, Evalue=9e-14,
Organism=Saccharomyces cerevisiae, GI6321912, Length=252, Percent_Identity=26.5873015873016, Blast_Score=65, Evalue=3e-11,
Organism=Drosophila melanogaster, GI24584320, Length=237, Percent_Identity=29.1139240506329, Blast_Score=86, Evalue=1e-16,
Organism=Drosophila melanogaster, GI24664545, Length=221, Percent_Identity=27.1493212669683, Blast_Score=72, Evalue=8e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005748
- InterPro:   IPR007695
- InterPro:   IPR000432
- InterPro:   IPR007861
- InterPro:   IPR007860
- InterPro:   IPR007696
- InterPro:   IPR016151 [H]

Pfam domain/function: PF01624 MutS_I; PF05188 MutS_II; PF05192 MutS_III; PF05190 MutS_IV; PF00488 MutS_V [H]

EC number: NA

Molecular weight: Translated: 70700; Mature: 70568

Theoretical pI: Translated: 10.06; Mature: 10.06

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
1.0 %Met     (Translated Protein)
1.3 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
0.8 %Met     (Mature Protein)
1.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTSFTRIDRLKRRAEKLNKLHDKISVLLSRLSLFRLIFFSVFLLWISIFYYLHSSIFYHL
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
PSLVFLFLFFFFVRRYKKTLLTRKKIQLWIFVLERESARISIKGFGKKFGTQIVLEKVSP
HHHHHHHHHHHHHHHHHHHHHHHHHHEEEEEEEECCCCEEEEEECCHHHHHHHHHHHHHH
LARDLDLFRENGLFSWLDTTFTSNAEQKLIALLDLEDSSSYNNRENVLLRQSIVRSISEK
HHHHHHHHHHCCCHHHHHHHHCCCCHHHEEEEEECCCCCCCCCHHHHHHHHHHHHHHHHH
TLAIPKILRLASYLKENQDVFQARTKTETKSIRDENTSKFWESYPWLKKIYRPITILVLA
HHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHCCCCHHHHHHCCHHHHHHHHHHHHHHHH
FIPANVFLGVPFPASVLFLNLILFGLYRSRSLDIFRQYYSISGSISGLQKILIYLKGLKI
HHHHHHEECCCCHHHHHHHHHHHHHHHHCCHHHHHHHHHHHCCCHHHHHHHHHHHHCCEE
KDKNGRFLLEDTSKDELRSAYKDLDLILKRVSLTEAPLLHLILNNLFLYDLWVLQKISKW
ECCCCCEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
KEKHSVLLEKSIEDLTLFDSLFSFANLKWMFPDYCFPEILSENSKEGISGKGLFHPLIPS
HHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCHHHHCCCCCCCCCCCCCCCCCCCC
DSRVSNPLDFIEEQNVVLITGSNMSGKTTYLRTIGVASILSMAGGPVPASKFSLPVLKIH
CCCCCCCHHHHCCCCEEEEECCCCCCCHHHHHHHHHHHHHHHCCCCCCCCCCCCHHHHHH
TSMRNEDNLEEGISFFYAEVRRLSEIVKKIRDKNSSHLVLLDEILKGTNTRERSLACKGI
HHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEHHHHHCCCCCHHHHHHHHHH
LKELKKNRTIVFVTSHDLELAKVEGVILKHFQEEVLDGTMYFDYKIREGLVETSNALRIL
HHHHHCCCEEEEEECCCCHHHHHHHHHHHHHHHHHHCCCEEEEHHHHHHHHHHHHHHHHH
VQEGLDLDFT
HHCCCCCCCC
>Mature Secondary Structure 
TSFTRIDRLKRRAEKLNKLHDKISVLLSRLSLFRLIFFSVFLLWISIFYYLHSSIFYHL
CCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
PSLVFLFLFFFFVRRYKKTLLTRKKIQLWIFVLERESARISIKGFGKKFGTQIVLEKVSP
HHHHHHHHHHHHHHHHHHHHHHHHHHEEEEEEEECCCCEEEEEECCHHHHHHHHHHHHHH
LARDLDLFRENGLFSWLDTTFTSNAEQKLIALLDLEDSSSYNNRENVLLRQSIVRSISEK
HHHHHHHHHHCCCHHHHHHHHCCCCHHHEEEEEECCCCCCCCCHHHHHHHHHHHHHHHHH
TLAIPKILRLASYLKENQDVFQARTKTETKSIRDENTSKFWESYPWLKKIYRPITILVLA
HHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHCCCCHHHHHHCCHHHHHHHHHHHHHHHH
FIPANVFLGVPFPASVLFLNLILFGLYRSRSLDIFRQYYSISGSISGLQKILIYLKGLKI
HHHHHHEECCCCHHHHHHHHHHHHHHHHCCHHHHHHHHHHHCCCHHHHHHHHHHHHCCEE
KDKNGRFLLEDTSKDELRSAYKDLDLILKRVSLTEAPLLHLILNNLFLYDLWVLQKISKW
ECCCCCEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
KEKHSVLLEKSIEDLTLFDSLFSFANLKWMFPDYCFPEILSENSKEGISGKGLFHPLIPS
HHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCHHHHCCCCCCCCCCCCCCCCCCCC
DSRVSNPLDFIEEQNVVLITGSNMSGKTTYLRTIGVASILSMAGGPVPASKFSLPVLKIH
CCCCCCCHHHHCCCCEEEEECCCCCCCHHHHHHHHHHHHHHHCCCCCCCCCCCCHHHHHH
TSMRNEDNLEEGISFFYAEVRRLSEIVKKIRDKNSSHLVLLDEILKGTNTRERSLACKGI
HHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEHHHHHCCCCCHHHHHHHHHH
LKELKKNRTIVFVTSHDLELAKVEGVILKHFQEEVLDGTMYFDYKIREGLVETSNALRIL
HHHHHCCCEEEEEECCCCHHHHHHHHHHHHHHHHHHCCCEEEEHHHHHHHHHHHHHHHHH
VQEGLDLDFT
HHCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 10360571 [H]