| Definition | Leptospira interrogans serovar Copenhageni str. Fiocruz L1-130 chromosome chromosome I, complete sequence. |
|---|---|
| Accession | NC_005823 |
| Length | 4,277,185 |
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The map label for this gene is nprS [H]
Identifier: 45659140
GI number: 45659140
Start: 4073098
End: 4075476
Strand: Reverse
Name: nprS [H]
Synonym: LIC13321
Alternate gene names: 45659140
Gene position: 4075476-4073098 (Counterclockwise)
Preceding gene: 45659141
Following gene: 45659139
Centisome position: 95.28
GC content: 36.95
Gene sequence:
>2379_bases ATGAGACTTTTAAAGTTATTAAAGATCAATTCGAATATAAAGATACTCTTAAGTATGTTTATGATTTCGATATTATTTTC TTGTAAGGATAAACAGGGCCCGGGAATAGAATCTTGGTTGTGGGTTTTAAATCCTGTTCAATTGGATAGTAAGGCGCTTT CTGAAAGGACGTATACGTCAGATGGTAGGATAACATTTGCGAAGTTCAATTCGGATCTAGTTCCTTATTCACGTAAACAA GCACCTGAAGTTCTTAAGACGTATTTGCAATTACCCTTAAGTTCTGAAGCTACATTCTTGCGTTCGGCTCGTGTAGGTAA TTATGATCAGGATCGGTTCCAGCAGAGATATAAAGGTATTAGAGTAGAGAATGGAATTTATACAGTGGTCTCAAAAGAGA ATACGATAGAATTGATGATGGGTGAATTTCACCAAGTTCCAGAGAATTTTAATTCCTCTCCTAAGCTATCCGAGTCAGAA GCACTTTCAAAGACTTTAAAACATATCGGAGCTAAGAAGTATATTTGGGAATCTGTTGAACGAGAAGCAGCATTGAAACG TAAGAAAAATGATCCAAATGCAAGTTATTTTCCGAAGGGAGAACTATTAGTTTATGAACATTCATTAGGAAAATCCAATA CTAAAAAAGAGTTTCGATTGGCTTATAAATTTGGTATAGCCTCGATAGATCCACCAATATCGAGATACGTGTATGTGGAT TCTAACTCTGGGGAAATTCTATCCAGTAAAGATGCTAGAAGATACGAGGGAGTTCAATTTCCAAGTCCAAAACCTCCTAT AGAAATAGATATTGATTATAGTCGTTGTATAATAGACAGAGAATATTGTATCGAACAGGGAACGGCAATGACCCGTTTTA GCGGATTACAATCGATTACAACTTGGACGGCAGGAAAAACGAACCATTTTGAACTGAAAGATAATTCGAGAGGCGGTGGA ATTTATACTTACTCTTGGGAATTTGTAAAAGATCCTTTGGAAGATATTCAACTTTTGAATATTCCAATGATTGATACTAA TAACTCATGGTCGCAATCTGAATATCATGACGATTATAATCATGATGCGTTATTGGATGCACATTGGGGAATTGAAATGA CTTATGACTATTTCAAATCCATTCATAATCGGTTGAGTTATGATGGTGATAATAGTAGAATATTTAATAACGTGCACTAT TTTAATGCGTTTGTAGCGAATAACGCGTATTGGGATCCTGTTACGGAAGAAATATATTACGTTTACTGTCCTCATAAAAA TAGTATATGCAAGGGTTTTAATCTACCGATTCTCTTAGACCCTAAATATGAAGATTTTACTTCTTTGGATATTGTATCTC ATGAATTTGGGCATGGTATCAACGGGGATCTTGCGGGTTTTAATCTTGATATGGAGCCAGGCGCTCTCGATGAAGGTTTT AGCGATATTTGGAATGTTGGTGTAAATAACTACGTAAATAAAGTTTTAGGAATGCAAAAGAATATTTGGTTAGTAGGAGA TGAAACGGTTCCGGGAGGAGGAATGCGTTCTGTGTCAAATCCAAAATCTACTACAGTAATGTCCCCTGGGCCAAATACGT ATCATGGAGATCTTTGGGATTTTGAAGATAACGAAGCACATACGAATAGTCTTGTTTTGAGTCACTGGTTCTATACTTTA TCCAAAGGAAAATTAGGATTTAACGATTATGAATGCACGTATAACGTTTCTGGAATTGGCATTGAAAAAGCCGAAAGAAT TGCTTATGTTGCCCTTCTTTTTCTTTCTTCTACGTCCGGTTATACTTCTGCAAGGACTTATGCGATTATTGCGGCTAAAC TATTGTATGGTTTGTTTTCTTCGGAAGTAAAAAGTACAATTGATGCTTGGGATGCAGTAGCTGTTCCGGCTGAGACGACT TCTCGCGGAGGACAAGGTATGGTAAGGCCTCGACATTATATCGCTTCTGTAAAACTTTCTAATGTAACGAACGATTCCGG AAACGATTGTGGGTACAAGGATAATTCATACTTACTTCCAACGGTCTTGAGAGGAGTGACGTATAACATGGTGTTATTGA GTCAGGGTTCGGCAAGTAATCCGTCAAAAGTTCACAAATGGAGAGTATGGATCGATTTTAATCAAAACGGTAGTTTTGAA TCGTCGGAAATGGTAGTTCAGGATACTGTTAATTCTTCGTTTGGAGGAACATTACAAAAATCGATTAAGATCCCAACGAA TGCACTTACTGGATATGCGAAGATGAGAGTTTCTATGAAGGCGGCTCAAAGTGGAGAAGCTTATCAAGGTTCGAGTGAAA GCTTTGTAGAAGGAGAAGTGGAGGATTATATTGTTTCGATTCTAGATTTCAGTTTATAG
Upstream 100 bases:
>100_bases TTATTACATATTTTTTTGTAAATTTGAAATAATTTAACCTAACGCGTTATAGTTGGTGAGTGAGGGTTTACTAAATTTAA AATTAAAACAGAGGGATTGA
Downstream 100 bases:
>100_bases AAATCTTTAAGGGAATTTCTATAAAATGAATTTTAAAAGGAACTGATCACTAAACACCAGTGTTATGTAGAAGTTCTTTA TGAAATTTTGTCGTCTTGAA
Product: thermolysin homolog precursor
Products: NA
Alternate protein names: Neutral protease [H]
Number of amino acids: Translated: 792; Mature: 792
Protein sequence:
>792_residues MRLLKLLKINSNIKILLSMFMISILFSCKDKQGPGIESWLWVLNPVQLDSKALSERTYTSDGRITFAKFNSDLVPYSRKQ APEVLKTYLQLPLSSEATFLRSARVGNYDQDRFQQRYKGIRVENGIYTVVSKENTIELMMGEFHQVPENFNSSPKLSESE ALSKTLKHIGAKKYIWESVEREAALKRKKNDPNASYFPKGELLVYEHSLGKSNTKKEFRLAYKFGIASIDPPISRYVYVD SNSGEILSSKDARRYEGVQFPSPKPPIEIDIDYSRCIIDREYCIEQGTAMTRFSGLQSITTWTAGKTNHFELKDNSRGGG IYTYSWEFVKDPLEDIQLLNIPMIDTNNSWSQSEYHDDYNHDALLDAHWGIEMTYDYFKSIHNRLSYDGDNSRIFNNVHY FNAFVANNAYWDPVTEEIYYVYCPHKNSICKGFNLPILLDPKYEDFTSLDIVSHEFGHGINGDLAGFNLDMEPGALDEGF SDIWNVGVNNYVNKVLGMQKNIWLVGDETVPGGGMRSVSNPKSTTVMSPGPNTYHGDLWDFEDNEAHTNSLVLSHWFYTL SKGKLGFNDYECTYNVSGIGIEKAERIAYVALLFLSSTSGYTSARTYAIIAAKLLYGLFSSEVKSTIDAWDAVAVPAETT SRGGQGMVRPRHYIASVKLSNVTNDSGNDCGYKDNSYLLPTVLRGVTYNMVLLSQGSASNPSKVHKWRVWIDFNQNGSFE SSEMVVQDTVNSSFGGTLQKSIKIPTNALTGYAKMRVSMKAAQSGEAYQGSSESFVEGEVEDYIVSILDFSL
Sequences:
>Translated_792_residues MRLLKLLKINSNIKILLSMFMISILFSCKDKQGPGIESWLWVLNPVQLDSKALSERTYTSDGRITFAKFNSDLVPYSRKQ APEVLKTYLQLPLSSEATFLRSARVGNYDQDRFQQRYKGIRVENGIYTVVSKENTIELMMGEFHQVPENFNSSPKLSESE ALSKTLKHIGAKKYIWESVEREAALKRKKNDPNASYFPKGELLVYEHSLGKSNTKKEFRLAYKFGIASIDPPISRYVYVD SNSGEILSSKDARRYEGVQFPSPKPPIEIDIDYSRCIIDREYCIEQGTAMTRFSGLQSITTWTAGKTNHFELKDNSRGGG IYTYSWEFVKDPLEDIQLLNIPMIDTNNSWSQSEYHDDYNHDALLDAHWGIEMTYDYFKSIHNRLSYDGDNSRIFNNVHY FNAFVANNAYWDPVTEEIYYVYCPHKNSICKGFNLPILLDPKYEDFTSLDIVSHEFGHGINGDLAGFNLDMEPGALDEGF SDIWNVGVNNYVNKVLGMQKNIWLVGDETVPGGGMRSVSNPKSTTVMSPGPNTYHGDLWDFEDNEAHTNSLVLSHWFYTL SKGKLGFNDYECTYNVSGIGIEKAERIAYVALLFLSSTSGYTSARTYAIIAAKLLYGLFSSEVKSTIDAWDAVAVPAETT SRGGQGMVRPRHYIASVKLSNVTNDSGNDCGYKDNSYLLPTVLRGVTYNMVLLSQGSASNPSKVHKWRVWIDFNQNGSFE SSEMVVQDTVNSSFGGTLQKSIKIPTNALTGYAKMRVSMKAAQSGEAYQGSSESFVEGEVEDYIVSILDFSL >Mature_792_residues MRLLKLLKINSNIKILLSMFMISILFSCKDKQGPGIESWLWVLNPVQLDSKALSERTYTSDGRITFAKFNSDLVPYSRKQ APEVLKTYLQLPLSSEATFLRSARVGNYDQDRFQQRYKGIRVENGIYTVVSKENTIELMMGEFHQVPENFNSSPKLSESE ALSKTLKHIGAKKYIWESVEREAALKRKKNDPNASYFPKGELLVYEHSLGKSNTKKEFRLAYKFGIASIDPPISRYVYVD SNSGEILSSKDARRYEGVQFPSPKPPIEIDIDYSRCIIDREYCIEQGTAMTRFSGLQSITTWTAGKTNHFELKDNSRGGG IYTYSWEFVKDPLEDIQLLNIPMIDTNNSWSQSEYHDDYNHDALLDAHWGIEMTYDYFKSIHNRLSYDGDNSRIFNNVHY FNAFVANNAYWDPVTEEIYYVYCPHKNSICKGFNLPILLDPKYEDFTSLDIVSHEFGHGINGDLAGFNLDMEPGALDEGF SDIWNVGVNNYVNKVLGMQKNIWLVGDETVPGGGMRSVSNPKSTTVMSPGPNTYHGDLWDFEDNEAHTNSLVLSHWFYTL SKGKLGFNDYECTYNVSGIGIEKAERIAYVALLFLSSTSGYTSARTYAIIAAKLLYGLFSSEVKSTIDAWDAVAVPAETT SRGGQGMVRPRHYIASVKLSNVTNDSGNDCGYKDNSYLLPTVLRGVTYNMVLLSQGSASNPSKVHKWRVWIDFNQNGSFE SSEMVVQDTVNSSFGGTLQKSIKIPTNALTGYAKMRVSMKAAQSGEAYQGSSESFVEGEVEDYIVSILDFSL
Specific function: Extracellular zinc metalloprotease [H]
COG id: COG3227
COG function: function code E; Zinc metalloprotease (elastase)
Gene ontology:
Cell location: Secreted [H]
Metaboloic importance: NA
Operon status: Not Known
Operon components: None
Similarity: Belongs to the peptidase M4 family [H]
Homologues:
None
Paralogues:
None
Copy number: NA
Swissprot (AC and ID): NA
Other databases:
- InterPro: IPR005075 - InterPro: IPR013856 - InterPro: IPR001570 - InterPro: IPR011096 [H]
Pfam domain/function: PF07504 FTP; PF03413 PepSY; PF01447 Peptidase_M4; PF02868 Peptidase_M4_C [H]
EC number: =3.4.24.28 [H]
Molecular weight: Translated: 89309; Mature: 89309
Theoretical pI: Translated: 5.88; Mature: 5.88
Prosite motif: PS00013 PROKAR_LIPOPROTEIN ; PS00142 ZINC_PROTEASE
Important sites: NA
Signals:
None
Transmembrane regions:
None
Cys/Met content:
0.9 %Cys (Translated Protein) 2.1 %Met (Translated Protein) 3.0 %Cys+Met (Translated Protein) 0.9 %Cys (Mature Protein) 2.1 %Met (Mature Protein) 3.0 %Cys+Met (Mature Protein)
Secondary structure:
>Translated Secondary Structure MRLLKLLKINSNIKILLSMFMISILFSCKDKQGPGIESWLWVLNPVQLDSKALSERTYTS CCCEEEEECCCCHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHCCCEECCHHHHHCCCCCC DGRITFAKFNSDLVPYSRKQAPEVLKTYLQLPLSSEATFLRSARVGNYDQDRFQQRYKGI CCCEEEEECCCCCCCCCHHCCHHHHHHHHCCCCCCCHHHHHHCCCCCCCHHHHHHHHCCE RVENGIYTVVSKENTIELMMGEFHQVPENFNSSPKLSESEALSKTLKHIGAKKYIWESVE EECCCEEEEEECCCEEEHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHCCCHHHHHHHHH REAALKRKKNDPNASYFPKGELLVYEHSLGKSNTKKEFRLAYKFGIASIDPPISRYVYVD HHHHHHHCCCCCCCCCCCCCCEEEEEECCCCCCCCHHEEEEEEECCCCCCCCCCEEEEEE SNSGEILSSKDARRYEGVQFPSPKPPIEIDIDYSRCIIDREYCIEQGTAMTRFSGLQSIT CCCCCEECCCCCHHHCCCCCCCCCCCEEEEECHHHEEECHHHHHHCCCHHHHHHCCHHHE TWTAGKTNHFELKDNSRGGGIYTYSWEFVKDPLEDIQLLNIPMIDTNNSWSQSEYHDDYN EECCCCCCEEEECCCCCCCCEEEEEHHHHHCCHHHCEEEECEEEECCCCCCCCCCCCCCC HDALLDAHWGIEMTYDYFKSIHNRLSYDGDNSRIFNNVHYFNAFVANNAYWDPVTEEIYY CCEEEEECCCEEEEHHHHHHHHHHCCCCCCCCEEECCEEEEEEEEECCCCCCCCCCCEEE VYCPHKNSICKGFNLPILLDPKYEDFTSLDIVSHEFGHGINGDLAGFNLDMEPGALDEGF EECCCCCCCCCCCCCCEEECCCCCCCCHHHHHHHHHCCCCCCCCEEEEECCCCCCCCCCH SDIWNVGVNNYVNKVLGMQKNIWLVGDETVPGGGMRSVSNPKSTTVMSPGPNTYHGDLWD HHHHHCCHHHHHHHHHCCCCCEEEEECCCCCCCCCCCCCCCCCCEEECCCCCCCCCCCCC FEDNEAHTNSLVLSHWFYTLSKGKLGFNDYECTYNVSGIGIEKAERIAYVALLFLSSTSG CCCCCCCCHHEEEEHHHHHHCCCCCCCCCCEEEEEECCCCHHHHHHHHHHHHHHHCCCCC YTSARTYAIIAAKLLYGLFSSEVKSTIDAWDAVAVPAETTSRGGQGMVRPRHYIASVKLS CCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCEEECCCCCCCCCCCCCCCCCCEEEEEEEE NVTNDSGNDCGYKDNSYLLPTVLRGVTYNMVLLSQGSASNPSKVHKWRVWIDFNQNGSFE CCCCCCCCCCCCCCCCEEHHHHHCCCEEEEEEEECCCCCCCCCEEEEEEEEEECCCCCCC SSEMVVQDTVNSSFGGTLQKSIKIPTNALTGYAKMRVSMKAAQSGEAYQGSSESFVEGEV CCCEEEEECCCCCCCCCCHHEEECCCHHHCCHHHEEEEEHHHCCCCCCCCCCCCCCCCCH EDYIVSILDFSL HHHHHHHHHCCC >Mature Secondary Structure MRLLKLLKINSNIKILLSMFMISILFSCKDKQGPGIESWLWVLNPVQLDSKALSERTYTS CCCEEEEECCCCHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHCCCEECCHHHHHCCCCCC DGRITFAKFNSDLVPYSRKQAPEVLKTYLQLPLSSEATFLRSARVGNYDQDRFQQRYKGI CCCEEEEECCCCCCCCCHHCCHHHHHHHHCCCCCCCHHHHHHCCCCCCCHHHHHHHHCCE RVENGIYTVVSKENTIELMMGEFHQVPENFNSSPKLSESEALSKTLKHIGAKKYIWESVE EECCCEEEEEECCCEEEHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHCCCHHHHHHHHH REAALKRKKNDPNASYFPKGELLVYEHSLGKSNTKKEFRLAYKFGIASIDPPISRYVYVD HHHHHHHCCCCCCCCCCCCCCEEEEEECCCCCCCCHHEEEEEEECCCCCCCCCCEEEEEE SNSGEILSSKDARRYEGVQFPSPKPPIEIDIDYSRCIIDREYCIEQGTAMTRFSGLQSIT CCCCCEECCCCCHHHCCCCCCCCCCCEEEEECHHHEEECHHHHHHCCCHHHHHHCCHHHE TWTAGKTNHFELKDNSRGGGIYTYSWEFVKDPLEDIQLLNIPMIDTNNSWSQSEYHDDYN EECCCCCCEEEECCCCCCCCEEEEEHHHHHCCHHHCEEEECEEEECCCCCCCCCCCCCCC HDALLDAHWGIEMTYDYFKSIHNRLSYDGDNSRIFNNVHYFNAFVANNAYWDPVTEEIYY CCEEEEECCCEEEEHHHHHHHHHHCCCCCCCCEEECCEEEEEEEEECCCCCCCCCCCEEE VYCPHKNSICKGFNLPILLDPKYEDFTSLDIVSHEFGHGINGDLAGFNLDMEPGALDEGF EECCCCCCCCCCCCCCEEECCCCCCCCHHHHHHHHHCCCCCCCCEEEEECCCCCCCCCCH SDIWNVGVNNYVNKVLGMQKNIWLVGDETVPGGGMRSVSNPKSTTVMSPGPNTYHGDLWD HHHHHCCHHHHHHHHHCCCCCEEEEECCCCCCCCCCCCCCCCCCEEECCCCCCCCCCCCC FEDNEAHTNSLVLSHWFYTLSKGKLGFNDYECTYNVSGIGIEKAERIAYVALLFLSSTSG CCCCCCCCHHEEEEHHHHHHCCCCCCCCCCEEEEEECCCCHHHHHHHHHHHHHHHCCCCC YTSARTYAIIAAKLLYGLFSSEVKSTIDAWDAVAVPAETTSRGGQGMVRPRHYIASVKLS CCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCEEECCCCCCCCCCCCCCCCCCEEEEEEEE NVTNDSGNDCGYKDNSYLLPTVLRGVTYNMVLLSQGSASNPSKVHKWRVWIDFNQNGSFE CCCCCCCCCCCCCCCCEEHHHHHCCCEEEEEEEECCCCCCCCCEEEEEEEEEECCCCCCC SSEMVVQDTVNSSFGGTLQKSIKIPTNALTGYAKMRVSMKAAQSGEAYQGSSESFVEGEV CCCEEEEECCCCCCCCCCHHEEECCCHHHCCHHHEEEEEHHHCCCCCCCCCCCCCCCCCH EDYIVSILDFSL HHHHHHHHHCCC
PDB accession: NA
Resolution: NA
Structure class: Alpha Beta
Cofactors: NA
Metal ions: NA
Kcat value (1/min): NA
Specific activity: NA
Km value (mM): NA
Substrates: NA
Specific reaction: NA
General reaction: NA
Inhibitor: NA
Structure determination priority: 9.0
TargetDB status: NA
Availability: NA
References: 2203733; 3149972 [H]