| Definition | Leptospira interrogans serovar Copenhageni str. Fiocruz L1-130 chromosome chromosome I, complete sequence. |
|---|---|
| Accession | NC_005823 |
| Length | 4,277,185 |
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The map label for this gene is nprS [H]
Identifier: 45659139
GI number: 45659139
Start: 4069685
End: 4072060
Strand: Reverse
Name: nprS [H]
Synonym: LIC13320
Alternate gene names: 45659139
Gene position: 4072060-4069685 (Counterclockwise)
Preceding gene: 45659140
Following gene: 45659136
Centisome position: 95.2
GC content: 37.58
Gene sequence:
>2376_bases ATGGAAAATTTTAAGTGGTTAGGTATCGATTTGAGGTTAAAAATACTCATTTGTATTTTTTCGATTTTATTTTCTTGTAA GGATAACAAACAAGAATTTGGAGAATCTTGGATAAGTCTTTTCAATAATGTGAAAATGGATGAAAAGGCAATTTCAGATC GTCATTATTCATCAGATGGAACACTTACGTTTGCCACGTTCAATTCGGATCTTGTTCCCTATAATCGCAAACAAGCACCT GAAGTTTTGAAAACGTATTTACAGTTAACTTTAAATTCGGAGCCAGTTTTTTTACGTTCGAATCATATTGGAGATTATGA TCATGATCGATTCCAACAGAGATACAAAGGAATTAAAGTCGAAAATGGAACGTACACGGTAGTCTCAAAAAGAAACACCA TCGAATTTATGATGGGTGAATTTTATCAAGTTCCGGAGAATTTTAATTCTTCTCCTAAATTGTCAGAATCAGAAGCGTTT TCAAAAGCGTTAAAACATTTTGGAGCTAAAAAATATATTTGGGAATCTCCGGAAAGAGAAGAAGCTTTCAAGAAAAAGCA AGATGATCCTAGTGCGACTAATTTTCCAAAAGGTGAACTTTTAGTTTATCAACATTCATTAGGTAAATTGAATTCTCAAA AAGAATTTCGATTGGTTTACAAATTTGGAATTGTATCAATTGAACCTTCTTTTTCGAGATATGTGTACGTAGATTCCCAT TCTGGTGAGATTTTAGCAAATATGGATGCTAATCGTTATGAAGCTGGTGGTGGAGATACGACTCCAACAACTCCACAAAC TCCGCCAGATACGCATTACGGAATTTGTTTTCCTGACAAAACTCCTTGTATTAAACAAGGTACGGCTGCGACACGTTTTA GCGGAATTCAGTCGATTATAACTTGGACTACAGAGGCAGATTATTTCGAACTCAAAGATTATTCAAGAGGTAAGGGAATC GTTAGTTATTCTTGGGAATTCGTGAGAGTTGCCCCATCGGCATTGGAAACTGTAAAAATTCCTCTGATCGATACTGATAA TAATTGGACGAAGGCTGAATATCACGATGATTACAATCACGATGCAGTTTTGGATGCGCATTGGGGAATTGAACATACGT ACGACTATTTTAAATCCGTTCACAATCGTTCTAGCTTTGATGGAGAAGATGCCAAGATAGTAAATAATGTACACTATACA AAGGTGCTTAATTTTAATAATGCACACTGGAATCCTATTACAGAAGAATTAGAATACACGTACTGTCCTCACGATAGTAG TCTTTGTCATGGTATTAATGATGAGATTCTTTTAGATCCAAGATTTGAAGATTTTACGTCTCTGGATATTGCATCTCATG AATTTGGGCATGCGATAAATGCATACGCTGCTGGTTTCGATTATAACGCAGAATCTGCTGCTCTCGATGAAGGATTTGGT GATATTTGGAATGTTGGTGTGAATCACTATGTGAATAAAATTTTAGGAATGCACAAGAATGTCTGGAGATTTGGCGACGA AACCGTTCTCAATGGAGGAATGCGTTCTCTACAATATCCGAATTCTGCTACGCCGGTTACTTTGGGAGGAGCGGATACGT ATTACGGAGACCTTTGGGATTTTACCAATAAGAAGACTCATGAAAACGGTCTGGTTCTCGGTCATTGGTTTTATATTCTT TCCAATGGGAAGAGTGGGATCAATGATCATTCGTGTGAATACAATACAACTGGAATCAGTATCGAAAAAGCGGAGAAAAT AGCTTATTCTACCATCCATTATCTTTCTCCAACTTCTGGATATGTAGCAACAAGGAGTGCGGCTATTCTTGCCGCTAAAA ATCTGTATGGGAAGTTTTCATCAGAAGTAAAAAGTACGATCGATGCTTGGGACGCGGTAGGTGTTCCTGCGGAAACAACT TCTCGTGGAGGAGATGGAATGAGAAAGGTTGGAAATTATATCACTTCTGTAAAACTTTCGGGCATGGAAAATAATTCCGG AAACGATTGTGGATACAAAGATAACACGTATCTTCATCCTTGGGTATTGAAAGGGGGAACGTATCAGTTGGTGTTATCAA GTGAAGGTTCCCAGCTTCCTTTGAAATCTCATAAATGGAGTGTGTGGATCGACTTAAATCGAAATGGGATTTTTGATTCT TCTGAGATAATACTTCAAACTTCAAATCAACTTTGGGGAGAAGGAACTCTTCAAAGATCGATCGTAATTCCAACGACCGC TTTGACTGGAGATACGAAGATGAGAGTTTCTATGAAGGCTGCGGATTCTTGGGAAGCATATCCGCGTGCTGACGAAAAGT TTTACGATGGGGAAGTGGAGGACTATACAATAAGTATTAATAGTTTCCGTCTCTAA
Upstream 100 bases:
>100_bases ATTCTTTGTTTGGAAGAATTTTAAGTTATGGTTTGTTGAAGTTGTTAGTTTTTGATTTAGCAAAAGTAAATTTAAAAATT GGGTTAGAAGGAGAAATTGA
Downstream 100 bases:
>100_bases AAATCTATAAAACTATACGACTAGTATCTAAATCGGCTCGATGTAAAAACGTTGAGTCGATTTTTGCAAACTTGTCTGTC TTTTGCACATACAAAAATTT
Product: thermolysin precursor
Products: NA
Alternate protein names: Neutral protease [H]
Number of amino acids: Translated: 791; Mature: 791
Protein sequence:
>791_residues MENFKWLGIDLRLKILICIFSILFSCKDNKQEFGESWISLFNNVKMDEKAISDRHYSSDGTLTFATFNSDLVPYNRKQAP EVLKTYLQLTLNSEPVFLRSNHIGDYDHDRFQQRYKGIKVENGTYTVVSKRNTIEFMMGEFYQVPENFNSSPKLSESEAF SKALKHFGAKKYIWESPEREEAFKKKQDDPSATNFPKGELLVYQHSLGKLNSQKEFRLVYKFGIVSIEPSFSRYVYVDSH SGEILANMDANRYEAGGGDTTPTTPQTPPDTHYGICFPDKTPCIKQGTAATRFSGIQSIITWTTEADYFELKDYSRGKGI VSYSWEFVRVAPSALETVKIPLIDTDNNWTKAEYHDDYNHDAVLDAHWGIEHTYDYFKSVHNRSSFDGEDAKIVNNVHYT KVLNFNNAHWNPITEELEYTYCPHDSSLCHGINDEILLDPRFEDFTSLDIASHEFGHAINAYAAGFDYNAESAALDEGFG DIWNVGVNHYVNKILGMHKNVWRFGDETVLNGGMRSLQYPNSATPVTLGGADTYYGDLWDFTNKKTHENGLVLGHWFYIL SNGKSGINDHSCEYNTTGISIEKAEKIAYSTIHYLSPTSGYVATRSAAILAAKNLYGKFSSEVKSTIDAWDAVGVPAETT SRGGDGMRKVGNYITSVKLSGMENNSGNDCGYKDNTYLHPWVLKGGTYQLVLSSEGSQLPLKSHKWSVWIDLNRNGIFDS SEIILQTSNQLWGEGTLQRSIVIPTTALTGDTKMRVSMKAADSWEAYPRADEKFYDGEVEDYTISINSFRL
Sequences:
>Translated_791_residues MENFKWLGIDLRLKILICIFSILFSCKDNKQEFGESWISLFNNVKMDEKAISDRHYSSDGTLTFATFNSDLVPYNRKQAP EVLKTYLQLTLNSEPVFLRSNHIGDYDHDRFQQRYKGIKVENGTYTVVSKRNTIEFMMGEFYQVPENFNSSPKLSESEAF SKALKHFGAKKYIWESPEREEAFKKKQDDPSATNFPKGELLVYQHSLGKLNSQKEFRLVYKFGIVSIEPSFSRYVYVDSH SGEILANMDANRYEAGGGDTTPTTPQTPPDTHYGICFPDKTPCIKQGTAATRFSGIQSIITWTTEADYFELKDYSRGKGI VSYSWEFVRVAPSALETVKIPLIDTDNNWTKAEYHDDYNHDAVLDAHWGIEHTYDYFKSVHNRSSFDGEDAKIVNNVHYT KVLNFNNAHWNPITEELEYTYCPHDSSLCHGINDEILLDPRFEDFTSLDIASHEFGHAINAYAAGFDYNAESAALDEGFG DIWNVGVNHYVNKILGMHKNVWRFGDETVLNGGMRSLQYPNSATPVTLGGADTYYGDLWDFTNKKTHENGLVLGHWFYIL SNGKSGINDHSCEYNTTGISIEKAEKIAYSTIHYLSPTSGYVATRSAAILAAKNLYGKFSSEVKSTIDAWDAVGVPAETT SRGGDGMRKVGNYITSVKLSGMENNSGNDCGYKDNTYLHPWVLKGGTYQLVLSSEGSQLPLKSHKWSVWIDLNRNGIFDS SEIILQTSNQLWGEGTLQRSIVIPTTALTGDTKMRVSMKAADSWEAYPRADEKFYDGEVEDYTISINSFRL >Mature_791_residues MENFKWLGIDLRLKILICIFSILFSCKDNKQEFGESWISLFNNVKMDEKAISDRHYSSDGTLTFATFNSDLVPYNRKQAP EVLKTYLQLTLNSEPVFLRSNHIGDYDHDRFQQRYKGIKVENGTYTVVSKRNTIEFMMGEFYQVPENFNSSPKLSESEAF SKALKHFGAKKYIWESPEREEAFKKKQDDPSATNFPKGELLVYQHSLGKLNSQKEFRLVYKFGIVSIEPSFSRYVYVDSH SGEILANMDANRYEAGGGDTTPTTPQTPPDTHYGICFPDKTPCIKQGTAATRFSGIQSIITWTTEADYFELKDYSRGKGI VSYSWEFVRVAPSALETVKIPLIDTDNNWTKAEYHDDYNHDAVLDAHWGIEHTYDYFKSVHNRSSFDGEDAKIVNNVHYT KVLNFNNAHWNPITEELEYTYCPHDSSLCHGINDEILLDPRFEDFTSLDIASHEFGHAINAYAAGFDYNAESAALDEGFG DIWNVGVNHYVNKILGMHKNVWRFGDETVLNGGMRSLQYPNSATPVTLGGADTYYGDLWDFTNKKTHENGLVLGHWFYIL SNGKSGINDHSCEYNTTGISIEKAEKIAYSTIHYLSPTSGYVATRSAAILAAKNLYGKFSSEVKSTIDAWDAVGVPAETT SRGGDGMRKVGNYITSVKLSGMENNSGNDCGYKDNTYLHPWVLKGGTYQLVLSSEGSQLPLKSHKWSVWIDLNRNGIFDS SEIILQTSNQLWGEGTLQRSIVIPTTALTGDTKMRVSMKAADSWEAYPRADEKFYDGEVEDYTISINSFRL
Specific function: Extracellular zinc metalloprotease [H]
COG id: COG3227
COG function: function code E; Zinc metalloprotease (elastase)
Gene ontology:
Cell location: Secreted [H]
Metaboloic importance: NA
Operon status: Not Known
Operon components: None
Similarity: Belongs to the peptidase M4 family [H]
Homologues:
None
Paralogues:
None
Copy number: NA
Swissprot (AC and ID): NA
Other databases:
- InterPro: IPR005075 - InterPro: IPR013856 - InterPro: IPR001570 - InterPro: IPR011096 [H]
Pfam domain/function: PF07504 FTP; PF03413 PepSY; PF01447 Peptidase_M4; PF02868 Peptidase_M4_C [H]
EC number: =3.4.24.28 [H]
Molecular weight: Translated: 89490; Mature: 89490
Theoretical pI: Translated: 5.57; Mature: 5.57
Prosite motif: PS00013 PROKAR_LIPOPROTEIN ; PS00142 ZINC_PROTEASE
Important sites: NA
Signals:
None
Transmembrane regions:
None
Cys/Met content:
1.0 %Cys (Translated Protein) 1.4 %Met (Translated Protein) 2.4 %Cys+Met (Translated Protein) 1.0 %Cys (Mature Protein) 1.4 %Met (Mature Protein) 2.4 %Cys+Met (Mature Protein)
Secondary structure:
>Translated Secondary Structure MENFKWLGIDLRLKILICIFSILFSCKDNKQEFGESWISLFNNVKMDEKAISDRHYSSDG CCCCEEEEECHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHCCCCCHHHHCCCCCCCCC TLTFATFNSDLVPYNRKQAPEVLKTYLQLTLNSEPVFLRSNHIGDYDHDRFQQRYKGIKV CEEEEEECCCCCCCCCCCCHHHHHHHHHEEECCCCEEEECCCCCCCCHHHHHHHHCCEEE ENGTYTVVSKRNTIEFMMGEFYQVPENFNSSPKLSESEAFSKALKHFGAKKYIWESPERE CCCEEEEEECCCCHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHCCCCCCCCCCCCHH EAFKKKQDDPSATNFPKGELLVYQHSLGKLNSQKEFRLVYKFGIVSIEPSFSRYVYVDSH HHHHHCCCCCCCCCCCCCCEEEEEECCCCCCCCCCEEEEEEEEEEEECCCCCEEEEEECC SGEILANMDANRYEAGGGDTTPTTPQTPPDTHYGICFPDKTPCIKQGTAATRFSGIQSII CCCEEEECCCCCEECCCCCCCCCCCCCCCCCCEEEECCCCCCCCCCCCCHHHHHHHHHHE TWTTEADYFELKDYSRGKGIVSYSWEFVRVAPSALETVKIPLIDTDNNWTKAEYHDDYNH EECCCCCEEEECCCCCCCCEEEECEEEEEECCCCCCEEEEEEEECCCCEEEECCCCCCCC DAVLDAHWGIEHTYDYFKSVHNRSSFDGEDAKIVNNVHYTKVLNFNNAHWNPITEELEYT CEEEEECCCCHHHHHHHHHHHCCCCCCCCCHHEECCEEEEEEEECCCCCCCCCCCCCCEE YCPHDSSLCHGINDEILLDPRFEDFTSLDIASHEFGHAINAYAAGFDYNAESAALDEGFG ECCCCCHHHCCCCCCEEECCCCCCCCCCCCCCHHHCCHHHHEECCCCCCCCHHHHHCCCH DIWNVGVNHYVNKILGMHKNVWRFGDETVLNGGMRSLQYPNSATPVTLGGADTYYGDLWD HHHHHHHHHHHHHHHHCCHHHHHCCCHHHHCCCHHHCCCCCCCCCEEECCCCCCCCCHHH FTNKKTHENGLVLGHWFYILSNGKSGINDHSCEYNTTGISIEKAEKIAYSTIHYLSPTSG CCCCCCCCCCEEEEEEEEEEECCCCCCCCCCCCCCCCCEEHHHHHHHHHHHEEEECCCCC YVATRSAAILAAKNLYGKFSSEVKSTIDAWDAVGVPAETTSRGGDGMRKVGNYITSVKLS CEEECCCCEEEHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCHHHHHHHHHEEEEEE GMENNSGNDCGYKDNTYLHPWVLKGGTYQLVLSSEGSQLPLKSHKWSVWIDLNRNGIFDS CCCCCCCCCCCCCCCCEECEEEECCCEEEEEEECCCCCCCCCCCCEEEEEEECCCCCCCC SEIILQTSNQLWGEGTLQRSIVIPTTALTGDTKMRVSMKAADSWEAYPRADEKFYDGEVE CEEEEEECCCCCCCCCEEEEEEEEEEEECCCCEEEEEEECCCCCCCCCCCCCCCCCCCCC DYTISINSFRL EEEEEEEEECC >Mature Secondary Structure MENFKWLGIDLRLKILICIFSILFSCKDNKQEFGESWISLFNNVKMDEKAISDRHYSSDG CCCCEEEEECHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHCCCCCHHHHCCCCCCCCC TLTFATFNSDLVPYNRKQAPEVLKTYLQLTLNSEPVFLRSNHIGDYDHDRFQQRYKGIKV CEEEEEECCCCCCCCCCCCHHHHHHHHHEEECCCCEEEECCCCCCCCHHHHHHHHCCEEE ENGTYTVVSKRNTIEFMMGEFYQVPENFNSSPKLSESEAFSKALKHFGAKKYIWESPERE CCCEEEEEECCCCHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHCCCCCCCCCCCCHH EAFKKKQDDPSATNFPKGELLVYQHSLGKLNSQKEFRLVYKFGIVSIEPSFSRYVYVDSH HHHHHCCCCCCCCCCCCCCEEEEEECCCCCCCCCCEEEEEEEEEEEECCCCCEEEEEECC SGEILANMDANRYEAGGGDTTPTTPQTPPDTHYGICFPDKTPCIKQGTAATRFSGIQSII CCCEEEECCCCCEECCCCCCCCCCCCCCCCCCEEEECCCCCCCCCCCCCHHHHHHHHHHE TWTTEADYFELKDYSRGKGIVSYSWEFVRVAPSALETVKIPLIDTDNNWTKAEYHDDYNH EECCCCCEEEECCCCCCCCEEEECEEEEEECCCCCCEEEEEEEECCCCEEEECCCCCCCC DAVLDAHWGIEHTYDYFKSVHNRSSFDGEDAKIVNNVHYTKVLNFNNAHWNPITEELEYT CEEEEECCCCHHHHHHHHHHHCCCCCCCCCHHEECCEEEEEEEECCCCCCCCCCCCCCEE YCPHDSSLCHGINDEILLDPRFEDFTSLDIASHEFGHAINAYAAGFDYNAESAALDEGFG ECCCCCHHHCCCCCCEEECCCCCCCCCCCCCCHHHCCHHHHEECCCCCCCCHHHHHCCCH DIWNVGVNHYVNKILGMHKNVWRFGDETVLNGGMRSLQYPNSATPVTLGGADTYYGDLWD HHHHHHHHHHHHHHHHCCHHHHHCCCHHHHCCCHHHCCCCCCCCCEEECCCCCCCCCHHH FTNKKTHENGLVLGHWFYILSNGKSGINDHSCEYNTTGISIEKAEKIAYSTIHYLSPTSG CCCCCCCCCCEEEEEEEEEEECCCCCCCCCCCCCCCCCEEHHHHHHHHHHHEEEECCCCC YVATRSAAILAAKNLYGKFSSEVKSTIDAWDAVGVPAETTSRGGDGMRKVGNYITSVKLS CEEECCCCEEEHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCHHHHHHHHHEEEEEE GMENNSGNDCGYKDNTYLHPWVLKGGTYQLVLSSEGSQLPLKSHKWSVWIDLNRNGIFDS CCCCCCCCCCCCCCCCEECEEEECCCEEEEEEECCCCCCCCCCCCEEEEEEECCCCCCCC SEIILQTSNQLWGEGTLQRSIVIPTTALTGDTKMRVSMKAADSWEAYPRADEKFYDGEVE CEEEEEECCCCCCCCCEEEEEEEEEEEECCCCEEEEEEECCCCCCCCCCCCCCCCCCCCC DYTISINSFRL EEEEEEEEECC
PDB accession: NA
Resolution: NA
Structure class: Alpha Beta
Cofactors: NA
Metal ions: NA
Kcat value (1/min): NA
Specific activity: NA
Km value (mM): NA
Substrates: NA
Specific reaction: NA
General reaction: NA
Inhibitor: NA
Structure determination priority: 9.0
TargetDB status: NA
Availability: NA
References: 2203733; 3149972 [H]