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The map label for this gene is mmgC [H]

Identifier: 45659102

GI number: 45659102

Start: 4022356

End: 4023960

Strand: Reverse

Name: mmgC [H]

Synonym: LIC13281

Alternate gene names: 45659102

Gene position: 4023960-4022356 (Counterclockwise)

Preceding gene: 45659103

Following gene: 45659101

Centisome position: 94.08

GC content: 35.39

Gene sequence:

>1605_bases
ATGTTATTTTTAAATCCATACATAAAAGACGAGGATCTAGATTTTTACAATACGGTCAAAGAATTTGCAAAGGAAAAAAT
TCTTCCTTCTGTAGAACAAAGGGACGAAGATTGTACTTGGGATAACGAATTATGGAAAGAAATGGGTTCTATAGGATTAT
TGGGAATTCCTATTCCAGAAGAATATGGAGGTCAAGGAGGAAATTGTTTTCAATGTTGTCTTGCACAAGAAGCGTTTAAC
GCGGGTTCGTTGGACTCTGGGTTTGGACTTTCTTGGGGAGCACATATGATTATTGGAAGTCTACCGATTTTATTTCAAGG
AACTGAAATTCAAAAAAATAAATATTTACCTAAGTTAGTTAACGGAGAATGGATTGCTGGTTTAGGATTGACCGAACCCG
ATTCCGGATCGGATGCCGCCGGGATGAGAACTTACGCGGAAAAGACGAAAGACGGATTTGTTTTGAACGGAAGTAAAACT
TTCATAACTAACGGACCAATTGGCCAAGTGTTTATCATTATGGCAAGGACTACAAAATCTCGTGGACCGATGGGAATTTC
GGCGTTTATAGTAGAATCTAAAAACAAAGGGTTCAGTGTTTCTAAGGTTTTAAAAAAATTAGGGCATAATACTTCTACAA
CCGCAGAACTTACATTCGAAGATATGTATGTTCCAGATGAAAATTTGTTGGGTCCTTTACACTCTGGATTTTTAAGAATT
GGAAAAGCAACTTTAGAATGGGAGAGAACTGTACTTCTTGCTGCTTTGATGGGAGGGATGGAAAATATATTAGAAAATTG
TATTCGATATTCATGGCAGAGACAACAGTTCGGAAAATCGATTTTAAATTTTTTTGCAATTAAGGAAAAGATTGCGAGAA
TTTGGGTTTATCTATGTGCAGCAAGAAGGATGACTTACTTTGTAGCACGTAAAAAAGATTTTGAACCTAACGTAAGTTTG
CCGATGGAAAGTTCTATTTTAAAAGTATTTGCTTCTGAAGTAAGTGAAGAAGTTGCATCTGATGCGGTTCAGATTTACGG
AGGAATGGGCTATATGAGAGAGGTTTCGGTAAGTCGATTTTATAGAGATGTAAAATTGGGGACGATTGGAGGAGGAACTT
CGGAAATTCAAAGAAGTATTATATCCGCGAGTTATGGAGGATACGAACCTTATCGAAAAATAATTCAAAGTGAGCTCATA
GAAGACAAAATAAAAGAAACTCCAATCGGTGAATTGATGCGATCTTTGGGTGTTTTAATTCAAACCGTGGGAGAAAATCC
AGAAAGGAAAAAAAGACAAGTCTTTGAGTTTGGATTTGCGGATTTATTAACTTTAACGACAATTTTAAAATTAAGCCTAT
GGGACTTAACAAGAACCAACGGTCATTATGAAACTAATGATAAAGAAAGAGATTTTAATATACTCATATATTATCTTACA
GCCAGGTATATTCGAGGAATTGCATATTTAAAGGAATTAAATGAAGACGGAGTCAGCAAACTATTAAAAGCATTTGGAAA
ATTGAACGCGCCTGAAAAAGAAATAGAAGAGAGTATAGAATATTTAAAGTCGGGTATTTTGGATAATATAACATTCGGAA
AATAG

Upstream 100 bases:

>100_bases
AAGTTTCCGATTTAGACGAGTTGTAGGCTCTCTGTCGTGAAAAGTTTGGTAAAATGAAATACTTTAGAACTTTAAATTAT
ACTGGAGTTAATTAATTGAG

Downstream 100 bases:

>100_bases
GAGTAATTTAGGCGCGTCAGAGGACTGTGATGAATTTCACTTTATTCGTTATAAACTGAGGAATATTCTCTACACTACTG
TTTTTTACAATGGTTAGTGG

Product: acyl-CoA dehydrogenase

Products: 2,3-dehydroacyl-CoA; reduced acceptor

Alternate protein names: NA

Number of amino acids: Translated: 534; Mature: 534

Protein sequence:

>534_residues
MLFLNPYIKDEDLDFYNTVKEFAKEKILPSVEQRDEDCTWDNELWKEMGSIGLLGIPIPEEYGGQGGNCFQCCLAQEAFN
AGSLDSGFGLSWGAHMIIGSLPILFQGTEIQKNKYLPKLVNGEWIAGLGLTEPDSGSDAAGMRTYAEKTKDGFVLNGSKT
FITNGPIGQVFIIMARTTKSRGPMGISAFIVESKNKGFSVSKVLKKLGHNTSTTAELTFEDMYVPDENLLGPLHSGFLRI
GKATLEWERTVLLAALMGGMENILENCIRYSWQRQQFGKSILNFFAIKEKIARIWVYLCAARRMTYFVARKKDFEPNVSL
PMESSILKVFASEVSEEVASDAVQIYGGMGYMREVSVSRFYRDVKLGTIGGGTSEIQRSIISASYGGYEPYRKIIQSELI
EDKIKETPIGELMRSLGVLIQTVGENPERKKRQVFEFGFADLLTLTTILKLSLWDLTRTNGHYETNDKERDFNILIYYLT
ARYIRGIAYLKELNEDGVSKLLKAFGKLNAPEKEIEESIEYLKSGILDNITFGK

Sequences:

>Translated_534_residues
MLFLNPYIKDEDLDFYNTVKEFAKEKILPSVEQRDEDCTWDNELWKEMGSIGLLGIPIPEEYGGQGGNCFQCCLAQEAFN
AGSLDSGFGLSWGAHMIIGSLPILFQGTEIQKNKYLPKLVNGEWIAGLGLTEPDSGSDAAGMRTYAEKTKDGFVLNGSKT
FITNGPIGQVFIIMARTTKSRGPMGISAFIVESKNKGFSVSKVLKKLGHNTSTTAELTFEDMYVPDENLLGPLHSGFLRI
GKATLEWERTVLLAALMGGMENILENCIRYSWQRQQFGKSILNFFAIKEKIARIWVYLCAARRMTYFVARKKDFEPNVSL
PMESSILKVFASEVSEEVASDAVQIYGGMGYMREVSVSRFYRDVKLGTIGGGTSEIQRSIISASYGGYEPYRKIIQSELI
EDKIKETPIGELMRSLGVLIQTVGENPERKKRQVFEFGFADLLTLTTILKLSLWDLTRTNGHYETNDKERDFNILIYYLT
ARYIRGIAYLKELNEDGVSKLLKAFGKLNAPEKEIEESIEYLKSGILDNITFGK
>Mature_534_residues
MLFLNPYIKDEDLDFYNTVKEFAKEKILPSVEQRDEDCTWDNELWKEMGSIGLLGIPIPEEYGGQGGNCFQCCLAQEAFN
AGSLDSGFGLSWGAHMIIGSLPILFQGTEIQKNKYLPKLVNGEWIAGLGLTEPDSGSDAAGMRTYAEKTKDGFVLNGSKT
FITNGPIGQVFIIMARTTKSRGPMGISAFIVESKNKGFSVSKVLKKLGHNTSTTAELTFEDMYVPDENLLGPLHSGFLRI
GKATLEWERTVLLAALMGGMENILENCIRYSWQRQQFGKSILNFFAIKEKIARIWVYLCAARRMTYFVARKKDFEPNVSL
PMESSILKVFASEVSEEVASDAVQIYGGMGYMREVSVSRFYRDVKLGTIGGGTSEIQRSIISASYGGYEPYRKIIQSELI
EDKIKETPIGELMRSLGVLIQTVGENPERKKRQVFEFGFADLLTLTTILKLSLWDLTRTNGHYETNDKERDFNILIYYLT
ARYIRGIAYLKELNEDGVSKLLKAFGKLNAPEKEIEESIEYLKSGILDNITFGK

Specific function: Catalyzes the reduction of crotonobetainyl-CoA to gamma-butyrobetainyl-CoA. [C]

COG id: COG1960

COG function: function code I; Acyl-CoA dehydrogenases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the acyl-CoA dehydrogenase family [H]

Homologues:

Organism=Homo sapiens, GI226958412, Length=382, Percent_Identity=37.434554973822, Blast_Score=248, Evalue=8e-66,
Organism=Homo sapiens, GI226958414, Length=345, Percent_Identity=39.4202898550725, Blast_Score=238, Evalue=1e-62,
Organism=Homo sapiens, GI76496475, Length=378, Percent_Identity=37.8306878306878, Blast_Score=213, Evalue=3e-55,
Organism=Homo sapiens, GI4557235, Length=378, Percent_Identity=37.8306878306878, Blast_Score=213, Evalue=3e-55,
Organism=Homo sapiens, GI21361497, Length=426, Percent_Identity=33.5680751173709, Blast_Score=210, Evalue=3e-54,
Organism=Homo sapiens, GI4501859, Length=373, Percent_Identity=32.4396782841823, Blast_Score=200, Evalue=3e-51,
Organism=Homo sapiens, GI4557233, Length=369, Percent_Identity=33.3333333333333, Blast_Score=199, Evalue=5e-51,
Organism=Homo sapiens, GI4501857, Length=372, Percent_Identity=33.6021505376344, Blast_Score=197, Evalue=2e-50,
Organism=Homo sapiens, GI4557231, Length=379, Percent_Identity=30.8707124010554, Blast_Score=186, Evalue=5e-47,
Organism=Homo sapiens, GI187960098, Length=379, Percent_Identity=30.8707124010554, Blast_Score=186, Evalue=7e-47,
Organism=Homo sapiens, GI7656849, Length=379, Percent_Identity=29.8153034300792, Blast_Score=155, Evalue=7e-38,
Organism=Homo sapiens, GI4503943, Length=399, Percent_Identity=26.3157894736842, Blast_Score=137, Evalue=2e-32,
Organism=Homo sapiens, GI7669494, Length=373, Percent_Identity=26.8096514745308, Blast_Score=133, Evalue=4e-31,
Organism=Homo sapiens, GI38505218, Length=397, Percent_Identity=23.6775818639798, Blast_Score=81, Evalue=3e-15,
Organism=Homo sapiens, GI48976061, Length=284, Percent_Identity=25.3521126760563, Blast_Score=76, Evalue=7e-14,
Organism=Homo sapiens, GI211971008, Length=284, Percent_Identity=25.3521126760563, Blast_Score=76, Evalue=8e-14,
Organism=Escherichia coli, GI1786223, Length=386, Percent_Identity=27.979274611399, Blast_Score=139, Evalue=4e-34,
Organism=Escherichia coli, GI87081958, Length=344, Percent_Identity=30.2325581395349, Blast_Score=136, Evalue=3e-33,
Organism=Escherichia coli, GI87082384, Length=292, Percent_Identity=21.9178082191781, Blast_Score=70, Evalue=3e-13,
Organism=Escherichia coli, GI87081702, Length=379, Percent_Identity=24.802110817942, Blast_Score=67, Evalue=4e-12,
Organism=Caenorhabditis elegans, GI17538396, Length=376, Percent_Identity=36.968085106383, Blast_Score=244, Evalue=7e-65,
Organism=Caenorhabditis elegans, GI71985184, Length=371, Percent_Identity=35.8490566037736, Blast_Score=201, Evalue=1e-51,
Organism=Caenorhabditis elegans, GI17508101, Length=375, Percent_Identity=33.6, Blast_Score=200, Evalue=1e-51,
Organism=Caenorhabditis elegans, GI17569725, Length=365, Percent_Identity=34.7945205479452, Blast_Score=198, Evalue=6e-51,
Organism=Caenorhabditis elegans, GI17506239, Length=375, Percent_Identity=31.4666666666667, Blast_Score=195, Evalue=6e-50,
Organism=Caenorhabditis elegans, GI17534899, Length=378, Percent_Identity=33.0687830687831, Blast_Score=186, Evalue=2e-47,
Organism=Caenorhabditis elegans, GI17570075, Length=390, Percent_Identity=31.025641025641, Blast_Score=181, Evalue=1e-45,
Organism=Caenorhabditis elegans, GI71985192, Length=302, Percent_Identity=35.7615894039735, Blast_Score=162, Evalue=6e-40,
Organism=Caenorhabditis elegans, GI71990804, Length=282, Percent_Identity=34.3971631205674, Blast_Score=155, Evalue=4e-38,
Organism=Caenorhabditis elegans, GI17533517, Length=370, Percent_Identity=28.9189189189189, Blast_Score=152, Evalue=5e-37,
Organism=Caenorhabditis elegans, GI17534353, Length=395, Percent_Identity=30.126582278481, Blast_Score=149, Evalue=2e-36,
Organism=Caenorhabditis elegans, GI17551932, Length=382, Percent_Identity=27.2251308900524, Blast_Score=138, Evalue=6e-33,
Organism=Caenorhabditis elegans, GI17505929, Length=364, Percent_Identity=28.021978021978, Blast_Score=134, Evalue=1e-31,
Organism=Caenorhabditis elegans, GI71982178, Length=278, Percent_Identity=29.4964028776978, Blast_Score=131, Evalue=1e-30,
Organism=Caenorhabditis elegans, GI32563615, Length=247, Percent_Identity=31.5789473684211, Blast_Score=125, Evalue=4e-29,
Organism=Caenorhabditis elegans, GI17531909, Length=243, Percent_Identity=28.8065843621399, Blast_Score=102, Evalue=4e-22,
Organism=Caenorhabditis elegans, GI17562446, Length=320, Percent_Identity=22.8125, Blast_Score=72, Evalue=1e-12,
Organism=Drosophila melanogaster, GI21355753, Length=340, Percent_Identity=40.8823529411765, Blast_Score=231, Evalue=1e-60,
Organism=Drosophila melanogaster, GI21356377, Length=367, Percent_Identity=35.149863760218, Blast_Score=211, Evalue=7e-55,
Organism=Drosophila melanogaster, GI24666513, Length=377, Percent_Identity=35.2785145888594, Blast_Score=210, Evalue=2e-54,
Organism=Drosophila melanogaster, GI281363737, Length=379, Percent_Identity=35.0923482849604, Blast_Score=200, Evalue=3e-51,
Organism=Drosophila melanogaster, GI24660351, Length=378, Percent_Identity=31.4814814814815, Blast_Score=182, Evalue=6e-46,
Organism=Drosophila melanogaster, GI24646207, Length=369, Percent_Identity=30.8943089430894, Blast_Score=177, Evalue=1e-44,
Organism=Drosophila melanogaster, GI19920834, Length=401, Percent_Identity=26.6832917705736, Blast_Score=124, Evalue=1e-28,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006089
- InterPro:   IPR006092
- InterPro:   IPR006090
- InterPro:   IPR006091
- InterPro:   IPR009075
- InterPro:   IPR013786
- InterPro:   IPR009100 [H]

Pfam domain/function: PF00441 Acyl-CoA_dh_1; PF02770 Acyl-CoA_dh_M; PF02771 Acyl-CoA_dh_N [H]

EC number: 1.3.99.3

Molecular weight: Translated: 59965; Mature: 59965

Theoretical pI: Translated: 5.50; Mature: 5.50

Prosite motif: PS00318 HMG_COA_REDUCTASE_2 ; PS00072 ACYL_COA_DH_1 ; PS00073 ACYL_COA_DH_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
2.6 %Met     (Translated Protein)
3.7 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
2.6 %Met     (Mature Protein)
3.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLFLNPYIKDEDLDFYNTVKEFAKEKILPSVEQRDEDCTWDNELWKEMGSIGLLGIPIPE
CEEECCCCCCCCCCHHHHHHHHHHHHCCCCHHHCCCCCCCCHHHHHHHCCCCEEECCCCH
EYGGQGGNCFQCCLAQEAFNAGSLDSGFGLSWGAHMIIGSLPILFQGTEIQKNKYLPKLV
HHCCCCCCHHHHHHHHHHCCCCCCCCCCCCCCHHHHHHCCCCEEEECCCCCCCCCCCHHC
NGEWIAGLGLTEPDSGSDAAGMRTYAEKTKDGFVLNGSKTFITNGPIGQVFIIMARTTKS
CCCEEEECCCCCCCCCCCCHHHHHHHHHCCCCEEECCCEEEEECCCCCEEEEEEEECCCC
RGPMGISAFIVESKNKGFSVSKVLKKLGHNTSTTAELTFEDMYVPDENLLGPLHSGFLRI
CCCCCEEEEEEECCCCCCCHHHHHHHHCCCCCCEEEEEEEEEECCCHHHCCHHHHHHHHH
GKATLEWERTVLLAALMGGMENILENCIRYSWQRQQFGKSILNFFAIKEKIARIWVYLCA
CCHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
ARRMTYFVARKKDFEPNVSLPMESSILKVFASEVSEEVASDAVQIYGGMGYMREVSVSRF
HHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHH
YRDVKLGTIGGGTSEIQRSIISASYGGYEPYRKIIQSELIEDKIKETPIGELMRSLGVLI
HHHHEEEECCCCHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHH
QTVGENPERKKRQVFEFGFADLLTLTTILKLSLWDLTRTNGHYETNDKERDFNILIYYLT
HHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCEEHHHHH
ARYIRGIAYLKELNEDGVSKLLKAFGKLNAPEKEIEESIEYLKSGILDNITFGK
HHHHHHHHHHHHHCHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHCCCCCCCCCC
>Mature Secondary Structure
MLFLNPYIKDEDLDFYNTVKEFAKEKILPSVEQRDEDCTWDNELWKEMGSIGLLGIPIPE
CEEECCCCCCCCCCHHHHHHHHHHHHCCCCHHHCCCCCCCCHHHHHHHCCCCEEECCCCH
EYGGQGGNCFQCCLAQEAFNAGSLDSGFGLSWGAHMIIGSLPILFQGTEIQKNKYLPKLV
HHCCCCCCHHHHHHHHHHCCCCCCCCCCCCCCHHHHHHCCCCEEEECCCCCCCCCCCHHC
NGEWIAGLGLTEPDSGSDAAGMRTYAEKTKDGFVLNGSKTFITNGPIGQVFIIMARTTKS
CCCEEEECCCCCCCCCCCCHHHHHHHHHCCCCEEECCCEEEEECCCCCEEEEEEEECCCC
RGPMGISAFIVESKNKGFSVSKVLKKLGHNTSTTAELTFEDMYVPDENLLGPLHSGFLRI
CCCCCEEEEEEECCCCCCCHHHHHHHHCCCCCCEEEEEEEEEECCCHHHCCHHHHHHHHH
GKATLEWERTVLLAALMGGMENILENCIRYSWQRQQFGKSILNFFAIKEKIARIWVYLCA
CCHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
ARRMTYFVARKKDFEPNVSLPMESSILKVFASEVSEEVASDAVQIYGGMGYMREVSVSRF
HHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHH
YRDVKLGTIGGGTSEIQRSIISASYGGYEPYRKIIQSELIEDKIKETPIGELMRSLGVLI
HHHHEEEECCCCHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHH
QTVGENPERKKRQVFEFGFADLLTLTTILKLSLWDLTRTNGHYETNDKERDFNILIYYLT
HHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCEEHHHHH
ARYIRGIAYLKELNEDGVSKLLKAFGKLNAPEKEIEESIEYLKSGILDNITFGK
HHHHHHHHHHHHHCHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: acyl-CoA; acceptor

Specific reaction: acyl-CoA + acceptor = 2,3-dehydroacyl-CoA + reduced acceptor

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8759838; 8969508; 9384377 [H]