Click here to switch to the map view.

The map label for this gene is gluP [H]

Identifier: 45658531

GI number: 45658531

Start: 3282304

End: 3283023

Strand: Reverse

Name: gluP [H]

Synonym: LIC12696

Alternate gene names: 45658531

Gene position: 3283023-3282304 (Counterclockwise)

Preceding gene: 45658532

Following gene: 45658530

Centisome position: 76.76

GC content: 34.44

Gene sequence:

>720_bases
TTGGCTTTCGGGATTGGGGTTGGAATTTTGTTGGTTTTAATGATATTTCCGAGTTATAAAGTAAATGATTCTGAAATATT
ATCACAAGAAGATGAAACGGAAAAAGATTCTTTGAGAGATATGTTGGAGTATTTGCTTCCTCGAGGCAATCACATGATTA
CTTCAATTTTATTAAATTTAAATATTTTAATTTTCTTAATAATGATTTTTTCAGGAGTTCATTTTTTTTATCCGGATGGA
CCTAGTTTGTTGGAATGGGGGGCAAATCGAAGAATTGAAACGTTAGCCGGCCAATGGTGGAGGCTTTTAACCAATGTATT
TGTTCATGCTGGTTTCCCACATTTATTTTTTAATGGATTTGGTCTTATCATTTCAGCAATTTTCGTAGAGCCTATTCTTG
GACGAATTCGATTTTTAATTCTTTATATTTTCTCTGGACTTTGTGGAAGTCTTGCTAGTATTGTATGGTATCCGAATACA
ATTAGTGTAGGGGCTTCCGGTGCAATTTTTGGACTTTACGGTGCGATCTTAGGACTTGTGCTAATGGATGCATTTCCCAG
AGATGATAAAAAAAATGTTTTGATCATGATAGTAACGTTTATACTAACTGGTTTGCTTTGGGGATTGTTTGGTGGAATTG
ATAACGCTGCTCATATAGGAGGGCTTGTAAGTGGAACTCTTTCTGGAATCATTTTATTTCAATTTGGCAAAAAGGATTAA

Upstream 100 bases:

>100_bases
AATCATCGATAAAACAAAACCAGACGAAAGTTACATTGTTTTAGAGCCGGTACAGGAAAAATTTGAAAACAAGAATGAAA
ATAAAATCGCTTGGTTTTTT

Downstream 100 bases:

>100_bases
AGAAATGTGGATGATGGTTTTGTTAAATTTATGTTGTTTACGGATCCATCGTTTTTTTTTTGAATAAATTGAATGTCCTT
TAAGTGATTTTACGTAAAGA

Product: hypothetical protein

Products: NA

Alternate protein names: Intramembrane serine protease [H]

Number of amino acids: Translated: 239; Mature: 238

Protein sequence:

>239_residues
MAFGIGVGILLVLMIFPSYKVNDSEILSQEDETEKDSLRDMLEYLLPRGNHMITSILLNLNILIFLIMIFSGVHFFYPDG
PSLLEWGANRRIETLAGQWWRLLTNVFVHAGFPHLFFNGFGLIISAIFVEPILGRIRFLILYIFSGLCGSLASIVWYPNT
ISVGASGAIFGLYGAILGLVLMDAFPRDDKKNVLIMIVTFILTGLLWGLFGGIDNAAHIGGLVSGTLSGIILFQFGKKD

Sequences:

>Translated_239_residues
MAFGIGVGILLVLMIFPSYKVNDSEILSQEDETEKDSLRDMLEYLLPRGNHMITSILLNLNILIFLIMIFSGVHFFYPDG
PSLLEWGANRRIETLAGQWWRLLTNVFVHAGFPHLFFNGFGLIISAIFVEPILGRIRFLILYIFSGLCGSLASIVWYPNT
ISVGASGAIFGLYGAILGLVLMDAFPRDDKKNVLIMIVTFILTGLLWGLFGGIDNAAHIGGLVSGTLSGIILFQFGKKD
>Mature_238_residues
AFGIGVGILLVLMIFPSYKVNDSEILSQEDETEKDSLRDMLEYLLPRGNHMITSILLNLNILIFLIMIFSGVHFFYPDGP
SLLEWGANRRIETLAGQWWRLLTNVFVHAGFPHLFFNGFGLIISAIFVEPILGRIRFLILYIFSGLCGSLASIVWYPNTI
SVGASGAIFGLYGAILGLVLMDAFPRDDKKNVLIMIVTFILTGLLWGLFGGIDNAAHIGGLVSGTLSGIILFQFGKKD

Specific function: Rhomboid-type serine protease that catalyzes intramembrane proteolysis. Important for normal cell division and sporulation. May act as a glucose exporter [H]

COG id: COG0705

COG function: function code R; Uncharacterized membrane protein (homolog of Drosophila rhomboid)

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein [H]

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Contains 2 TPR repeats [H]

Homologues:

Organism=Homo sapiens, GI93352558, Length=153, Percent_Identity=31.3725490196078, Blast_Score=66, Evalue=2e-11,
Organism=Homo sapiens, GI301069362, Length=153, Percent_Identity=31.3725490196078, Blast_Score=66, Evalue=2e-11,
Organism=Caenorhabditis elegans, GI115534507, Length=151, Percent_Identity=33.7748344370861, Blast_Score=71, Evalue=5e-13,
Organism=Caenorhabditis elegans, GI115532986, Length=170, Percent_Identity=30.5882352941176, Blast_Score=68, Evalue=5e-12,
Organism=Caenorhabditis elegans, GI133901888, Length=170, Percent_Identity=30.5882352941176, Blast_Score=68, Evalue=5e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002610
- InterPro:   IPR022764
- InterPro:   IPR001440
- InterPro:   IPR013026
- InterPro:   IPR011990
- InterPro:   IPR019734 [H]

Pfam domain/function: PF01694 Rhomboid; PF00515 TPR_1 [H]

EC number: =3.4.21.105 [H]

Molecular weight: Translated: 26407; Mature: 26275

Theoretical pI: Translated: 5.99; Mature: 5.99

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
2.9 %Met     (Translated Protein)
3.3 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
2.5 %Met     (Mature Protein)
2.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAFGIGVGILLVLMIFPSYKVNDSEILSQEDETEKDSLRDMLEYLLPRGNHMITSILLNL
CCCHHHHHHHHHHHHCCCCCCCHHHHHCCCCCCHHHHHHHHHHHHCCCCCHHHHHHHHHH
NILIFLIMIFSGVHFFYPDGPSLLEWGANRRIETLAGQWWRLLTNVFVHAGFPHLFFNGF
HHHHHHHHHHHCCEEECCCCHHHHHHCCCCHHHHHHHHHHHHHHHHHHHCCCHHHHHHHH
GLIISAIFVEPILGRIRFLILYIFSGLCGSLASIVWYPNTISVGASGAIFGLYGAILGLV
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEECCCCCHHHHHHHHHHHHHH
LMDAFPRDDKKNVLIMIVTFILTGLLWGLFGGIDNAAHIGGLVSGTLSGIILFQFGKKD
HHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHEEEEECCCCC
>Mature Secondary Structure 
AFGIGVGILLVLMIFPSYKVNDSEILSQEDETEKDSLRDMLEYLLPRGNHMITSILLNL
CCHHHHHHHHHHHHCCCCCCCHHHHHCCCCCCHHHHHHHHHHHHCCCCCHHHHHHHHHH
NILIFLIMIFSGVHFFYPDGPSLLEWGANRRIETLAGQWWRLLTNVFVHAGFPHLFFNGF
HHHHHHHHHHHCCEEECCCCHHHHHHCCCCHHHHHHHHHHHHHHHHHHHCCCHHHHHHHH
GLIISAIFVEPILGRIRFLILYIFSGLCGSLASIVWYPNTISVGASGAIFGLYGAILGLV
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEECCCCCHHHHHHHHHHHHHH
LMDAFPRDDKKNVLIMIVTFILTGLLWGLFGGIDNAAHIGGLVSGTLSGIILFQFGKKD
HHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHEEEEECCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: 8969508; 9384377 [H]