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The map label for this gene is mpg1 [H]

Identifier: 45658020

GI number: 45658020

Start: 2624077

End: 2625132

Strand: Reverse

Name: mpg1 [H]

Synonym: LIC12171

Alternate gene names: 45658020

Gene position: 2625132-2624077 (Counterclockwise)

Preceding gene: 45658021

Following gene: 45658019

Centisome position: 61.38

GC content: 36.27

Gene sequence:

>1056_bases
ATGAAAAATTGGAAAAATGTCCTTATTAACTCTGATTTAAGCCTACAGGATGCTATTAAAATCTTAGACAAAGAAGCGCT
TCGTATTGTCTTAATCGTTGATGAAAATAAAAAACTTTTAGGTACATTAACCGACGGTGATGTTCGTCGTGCATTGATGC
AAAATAAAGGACTTGCAATTTCAGTGAATGAGGTGATGTCATCCAAGCCTAAAGTGGCTCATGCTAATTGGACTAAGGAG
CGTATGCTTCTCGAAATGGAAAAGTATGAACTTTTACATTTACCGATTGTAGACGAACAAGGAATTTTGGTAGGATTGGA
AACGGTTCACGGTCTTTTAGAAAAACCTAAATTTGATAATCCTGTTTTTCTAATGGCTGGAGGGTTTGGAACTCGATTGT
ATCCTTTGACGAATCATTGCCCCAAGCCTATGTTGAAAGTGGGGAATAAGCCAATATTAGAATTAATTTTAGAAGGGTTT
GTAACCGCCGGTTTTCATCGTTTTTTTATTTCTACTCATTTTATGTCGGATGTAATCAAGAATTACTTTGAAAATGGAAA
ACGATGGAATGTAAGTATTGAATACGTTCATGAAGAGAATCCTTTGGGAACAGGTGGTGCTCTTGGATTACTACCACACG
ATCAAATTGATCAACCTATGTTCATGATGAATGGGGATTTATTGACTAATCTCAATTATCTTTCTTTATTAGAATTTCAT
GAAAAAGAAGGTGGGGTTGCTACGGTTTGTGTTAGAGAGTTCGACTATCAAGTTCCCTACGGCGTTATACAATCTAACGG
TCATCGTGTGGTCGAAATTGTTGAAAAGCCTGTACAACGTTTTAACGTGAATGCAGGTATCTATCTATTAAATCCTGATT
TCGTAAAATCGGTCAAAAAAGGACAAACGATCGATATGCCTAGTCTCATAGAAAAAGAATTGAAGTCTTCTAAACAAATA
AACATTTTTCCAATTCACGAATATTGGTTGGATATCGGAAGAATGGAGGAATTCGAACGCGCTCAAGGAGACTGGGTACA
ATTATTCAACGAATGA

Upstream 100 bases:

>100_bases
CTATTGAAGACAATCAAATCTAAAGCCTTTCGGAAAAGACTGTTTTTAGATCGATGGCTATTGTTGTGTGACTTTTAAAT
CATTTTTTAATTAAATTGAT

Downstream 100 bases:

>100_bases
TTTGAAGGATAGCGATACCGCAAGAGATTATCAAAACTTCCTCTAATAAGAAAATGTTTTATCATCGAATTAATAGAATT
ATTTATAGTTTGTCCTAAAA

Product: nucleoside-diphosphate-sugar pyrophosphorylase

Products: NA

Alternate protein names: ATP-mannose-1-phosphate guanylyltransferase; GDP-mannose pyrophosphorylase; NDP-hexose pyrophosphorylase [H]

Number of amino acids: Translated: 351; Mature: 351

Protein sequence:

>351_residues
MKNWKNVLINSDLSLQDAIKILDKEALRIVLIVDENKKLLGTLTDGDVRRALMQNKGLAISVNEVMSSKPKVAHANWTKE
RMLLEMEKYELLHLPIVDEQGILVGLETVHGLLEKPKFDNPVFLMAGGFGTRLYPLTNHCPKPMLKVGNKPILELILEGF
VTAGFHRFFISTHFMSDVIKNYFENGKRWNVSIEYVHEENPLGTGGALGLLPHDQIDQPMFMMNGDLLTNLNYLSLLEFH
EKEGGVATVCVREFDYQVPYGVIQSNGHRVVEIVEKPVQRFNVNAGIYLLNPDFVKSVKKGQTIDMPSLIEKELKSSKQI
NIFPIHEYWLDIGRMEEFERAQGDWVQLFNE

Sequences:

>Translated_351_residues
MKNWKNVLINSDLSLQDAIKILDKEALRIVLIVDENKKLLGTLTDGDVRRALMQNKGLAISVNEVMSSKPKVAHANWTKE
RMLLEMEKYELLHLPIVDEQGILVGLETVHGLLEKPKFDNPVFLMAGGFGTRLYPLTNHCPKPMLKVGNKPILELILEGF
VTAGFHRFFISTHFMSDVIKNYFENGKRWNVSIEYVHEENPLGTGGALGLLPHDQIDQPMFMMNGDLLTNLNYLSLLEFH
EKEGGVATVCVREFDYQVPYGVIQSNGHRVVEIVEKPVQRFNVNAGIYLLNPDFVKSVKKGQTIDMPSLIEKELKSSKQI
NIFPIHEYWLDIGRMEEFERAQGDWVQLFNE
>Mature_351_residues
MKNWKNVLINSDLSLQDAIKILDKEALRIVLIVDENKKLLGTLTDGDVRRALMQNKGLAISVNEVMSSKPKVAHANWTKE
RMLLEMEKYELLHLPIVDEQGILVGLETVHGLLEKPKFDNPVFLMAGGFGTRLYPLTNHCPKPMLKVGNKPILELILEGF
VTAGFHRFFISTHFMSDVIKNYFENGKRWNVSIEYVHEENPLGTGGALGLLPHDQIDQPMFMMNGDLLTNLNYLSLLEFH
EKEGGVATVCVREFDYQVPYGVIQSNGHRVVEIVEKPVQRFNVNAGIYLLNPDFVKSVKKGQTIDMPSLIEKELKSSKQI
NIFPIHEYWLDIGRMEEFERAQGDWVQLFNE

Specific function: Lipopolysaccharide biosynthesis. [C]

COG id: COG1208

COG function: function code MJ; Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis/translation initiation factor 2B, gamma/epsilon subunits (eIF-2Bgamma/eIF-2Bepsilon)

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the transferase hexapeptide repeat family [H]

Homologues:

Organism=Homo sapiens, GI11761621, Length=228, Percent_Identity=31.140350877193, Blast_Score=120, Evalue=2e-27,
Organism=Homo sapiens, GI11761619, Length=229, Percent_Identity=31.0043668122271, Blast_Score=120, Evalue=2e-27,
Organism=Caenorhabditis elegans, GI133931050, Length=228, Percent_Identity=28.0701754385965, Blast_Score=103, Evalue=2e-22,
Organism=Saccharomyces cerevisiae, GI6320148, Length=229, Percent_Identity=31.0043668122271, Blast_Score=114, Evalue=2e-26,
Organism=Drosophila melanogaster, GI21355443, Length=227, Percent_Identity=29.9559471365639, Blast_Score=113, Evalue=2e-25,
Organism=Drosophila melanogaster, GI24644084, Length=227, Percent_Identity=29.9559471365639, Blast_Score=113, Evalue=2e-25,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005835 [H]

Pfam domain/function: PF00483 NTP_transferase [H]

EC number: =2.7.7.13 [H]

Molecular weight: Translated: 40076; Mature: 40076

Theoretical pI: Translated: 6.14; Mature: 6.14

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
3.7 %Met     (Translated Protein)
4.3 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
3.7 %Met     (Mature Protein)
4.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKNWKNVLINSDLSLQDAIKILDKEALRIVLIVDENKKLLGTLTDGDVRRALMQNKGLAI
CCCCCCEEEECCCCHHHHHHHHCCCCEEEEEEEECCCEEEEEECCHHHHHHHHHCCCCEE
SVNEVMSSKPKVAHANWTKERMLLEMEKYELLHLPIVDEQGILVGLETVHGLLEKPKFDN
EHHHHHCCCCCEEECCCCHHHHHHHHHCCEEEEEEEECCCCCEEEHHHHHHHHHCCCCCC
PVFLMAGGFGTRLYPLTNHCPKPMLKVGNKPILELILEGFVTAGFHRFFISTHFMSDVIK
CEEEEECCCCCEEEECCCCCCCHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
NYFENGKRWNVSIEYVHEENPLGTGGALGLLPHDQIDQPMFMMNGDLLTNLNYLSLLEFH
HHHCCCCEEEEEEEEEECCCCCCCCCEEECCCCCCCCCCEEEECCCHHHCCHHHHHHHHH
EKEGGVATVCVREFDYQVPYGVIQSNGHRVVEIVEKPVQRFNVNAGIYLLNPDFVKSVKK
HCCCCEEEEEEECCCCCCCCCEEECCCCHHHHHHHHHHHHHCCCCCEEEECHHHHHHHHC
GQTIDMPSLIEKELKSSKQINIFPIHEYWLDIGRMEEFERAQGDWVQLFNE
CCCCCCHHHHHHHHHCCCCEEEEEHHHHHHHHHHHHHHHHCCCCHHHHCCC
>Mature Secondary Structure
MKNWKNVLINSDLSLQDAIKILDKEALRIVLIVDENKKLLGTLTDGDVRRALMQNKGLAI
CCCCCCEEEECCCCHHHHHHHHCCCCEEEEEEEECCCEEEEEECCHHHHHHHHHCCCCEE
SVNEVMSSKPKVAHANWTKERMLLEMEKYELLHLPIVDEQGILVGLETVHGLLEKPKFDN
EHHHHHCCCCCEEECCCCHHHHHHHHHCCEEEEEEEECCCCCEEEHHHHHHHHHCCCCCC
PVFLMAGGFGTRLYPLTNHCPKPMLKVGNKPILELILEGFVTAGFHRFFISTHFMSDVIK
CEEEEECCCCCEEEECCCCCCCHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
NYFENGKRWNVSIEYVHEENPLGTGGALGLLPHDQIDQPMFMMNGDLLTNLNYLSLLEFH
HHHCCCCEEEEEEEEEECCCCCCCCCEEECCCCCCCCCCEEEECCCHHHCCHHHHHHHHH
EKEGGVATVCVREFDYQVPYGVIQSNGHRVVEIVEKPVQRFNVNAGIYLLNPDFVKSVKK
HCCCCEEEEEEECCCCCCCCCEEECCCCHHHHHHHHHHHHHCCCCCEEEECHHHHHHHHC
GQTIDMPSLIEKELKSSKQINIFPIHEYWLDIGRMEEFERAQGDWVQLFNE
CCCCCCHHHHHHHHHCCCCEEEEEHHHHHHHHHHHHHHHHCCCCHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8334170 [H]