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The map label for this gene is neuC [H]

Identifier: 45658021

GI number: 45658021

Start: 2625381

End: 2626544

Strand: Reverse

Name: neuC [H]

Synonym: LIC12172

Alternate gene names: 45658021

Gene position: 2626544-2625381 (Counterclockwise)

Preceding gene: 45658022

Following gene: 45658020

Centisome position: 61.41

GC content: 36.77

Gene sequence:

>1164_bases
ATGAAAAGGAAAATTTGTGTTATTACTGGCACTCGTGCTGACTACGGTCTGCTTCGTTGGTTGATTTTGGAAATTTCAAA
ATCTTCTAAACTTGACTTACAAATCATCGCTACGGGAATGCATCTGTCTCCTGAATTTGGTTTAACTTATAAGGAGATAG
AAAATGATGGTTTTCTCATTCATAAAAAGATAGAAATTCTTTTGAGTTCGGACAGTACAGTCGGGGTTTCTAAATCGATT
GGGTTAGGTTTAATTGGTTTTTCAGAGGCTTTTGCAGATTTAAATCCCGATATTATATTAGTCCTGGGGGATCGTTTCGA
AATTCTTGCAGCGACCGTGGCGGCTTTGATTTCGAGAATTCCAGTTGCGCATTTGCATGGAGGTGAAACTACCGAGGGGG
CTTTTGATGAAGGGATCAGACATTCCATTACAAAGATGTCGCACTTACATTTTGTGGCAGCTAATGAGTATCGTAATAGA
ATAATTCAGTTAGGCGAGGATCCTTCTAATGTTTTTTTGGTTGGGGGAATGGGGATAGACGGGATTAAAAAGTCGAATCT
TTTAAAAAAGGAAGAATTAGAATCGTCTCTCAATATTAAATTTAAAAAAAATAATTTATTAATTACGTTTCATCCGGTAA
CTTTAGAGGAATCTACTGCGAAGGTTCAAATGATCGAGTTGCTTTTAAGTTTGGAAACTCTAAGTCCGGAAATTGGTTTG
ATATTTACGATGCCAAATGCCGATACGGATGGTCGTATTATTTTCGAGCTTGTCAAAGAATTTACTAGTTCACACTCAAA
TGCATGGTATTTTACGTCTCTCGGTCAGACTCGCTATTTGTCTTGTTTACAATTTGTGGATGCGGTTGTCGGGAACTCTT
CTAGTGGAATTATCGAAGCGCCGAGCTTTAAAATTGGTACAATCAATATAGGCGATCGCCAAAAGGGTAGGTTGAGAGCG
AAAAGCATCATCGATTGTGAGCCGAAGAAGATAGAAATCATAGATGCTTTTAAAAGACTTTATTCTTCTGATTTTCAAAA
AAATCTTTCTACGACTGTCAATCCTTATGGTGAAGGCGGAGCGAGTGAGAAAATTGTAAGGATATTAGAAAAGATTGATA
TACAAGGAATTCTTAAAAAGAAATTTTTTAATCTTCAATTCTAA

Upstream 100 bases:

>100_bases
CAACAAAAAGACCAGGAGATGGACTGTCTCCTATGAATTGGGATATGGTAATCGGAAAGCAAGCTAGAAGAGATTTCCAG
ATCGATGAATTGATCGAGTT

Downstream 100 bases:

>100_bases
GAGTTTATCTTAAAACATATAAGGACCTTCCCAAAACAACGGGACGGGTCCTTGCAGTTTAATCTTTCTGATAACGTAAA
CTGGAATTTTGGGACACGCT

Product: putative UDP-N-acetylglucosamine-2-epimerase

Products: UDP-N-acetyl-D-mannosamine [C]

Alternate protein names: NA

Number of amino acids: Translated: 387; Mature: 387

Protein sequence:

>387_residues
MKRKICVITGTRADYGLLRWLILEISKSSKLDLQIIATGMHLSPEFGLTYKEIENDGFLIHKKIEILLSSDSTVGVSKSI
GLGLIGFSEAFADLNPDIILVLGDRFEILAATVAALISRIPVAHLHGGETTEGAFDEGIRHSITKMSHLHFVAANEYRNR
IIQLGEDPSNVFLVGGMGIDGIKKSNLLKKEELESSLNIKFKKNNLLITFHPVTLEESTAKVQMIELLLSLETLSPEIGL
IFTMPNADTDGRIIFELVKEFTSSHSNAWYFTSLGQTRYLSCLQFVDAVVGNSSSGIIEAPSFKIGTINIGDRQKGRLRA
KSIIDCEPKKIEIIDAFKRLYSSDFQKNLSTTVNPYGEGGASEKIVRILEKIDIQGILKKKFFNLQF

Sequences:

>Translated_387_residues
MKRKICVITGTRADYGLLRWLILEISKSSKLDLQIIATGMHLSPEFGLTYKEIENDGFLIHKKIEILLSSDSTVGVSKSI
GLGLIGFSEAFADLNPDIILVLGDRFEILAATVAALISRIPVAHLHGGETTEGAFDEGIRHSITKMSHLHFVAANEYRNR
IIQLGEDPSNVFLVGGMGIDGIKKSNLLKKEELESSLNIKFKKNNLLITFHPVTLEESTAKVQMIELLLSLETLSPEIGL
IFTMPNADTDGRIIFELVKEFTSSHSNAWYFTSLGQTRYLSCLQFVDAVVGNSSSGIIEAPSFKIGTINIGDRQKGRLRA
KSIIDCEPKKIEIIDAFKRLYSSDFQKNLSTTVNPYGEGGASEKIVRILEKIDIQGILKKKFFNLQF
>Mature_387_residues
MKRKICVITGTRADYGLLRWLILEISKSSKLDLQIIATGMHLSPEFGLTYKEIENDGFLIHKKIEILLSSDSTVGVSKSI
GLGLIGFSEAFADLNPDIILVLGDRFEILAATVAALISRIPVAHLHGGETTEGAFDEGIRHSITKMSHLHFVAANEYRNR
IIQLGEDPSNVFLVGGMGIDGIKKSNLLKKEELESSLNIKFKKNNLLITFHPVTLEESTAKVQMIELLLSLETLSPEIGL
IFTMPNADTDGRIIFELVKEFTSSHSNAWYFTSLGQTRYLSCLQFVDAVVGNSSSGIIEAPSFKIGTINIGDRQKGRLRA
KSIIDCEPKKIEIIDAFKRLYSSDFQKNLSTTVNPYGEGGASEKIVRILEKIDIQGILKKKFFNLQF

Specific function: May be involved in the synthesis of polysialic acid (PSA) [H]

COG id: COG0381

COG function: function code M; UDP-N-acetylglucosamine 2-epimerase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: NA

Homologues:

Organism=Homo sapiens, GI298566312, Length=387, Percent_Identity=27.906976744186, Blast_Score=153, Evalue=2e-37,
Organism=Homo sapiens, GI190014632, Length=387, Percent_Identity=27.906976744186, Blast_Score=153, Evalue=3e-37,
Organism=Homo sapiens, GI4885285, Length=387, Percent_Identity=27.906976744186, Blast_Score=153, Evalue=3e-37,
Organism=Homo sapiens, GI298566325, Length=362, Percent_Identity=26.7955801104972, Blast_Score=132, Evalue=5e-31,
Organism=Homo sapiens, GI298566315, Length=128, Percent_Identity=32.8125, Blast_Score=80, Evalue=4e-15,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR020004
- InterPro:   IPR003331 [H]

Pfam domain/function: PF02350 Epimerase_2 [H]

EC number: 5.1.3.14 [C]

Molecular weight: Translated: 42923; Mature: 42923

Theoretical pI: Translated: 7.30; Mature: 7.30

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
1.6 %Met     (Translated Protein)
2.3 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
1.6 %Met     (Mature Protein)
2.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKRKICVITGTRADYGLLRWLILEISKSSKLDLQIIATGMHLSPEFGLTYKEIENDGFLI
CCCEEEEEECCCCHHHHHHHHHHHHCCCCCCEEEEEEECCEECCCCCCCCEEECCCCEEE
HKKIEILLSSDSTVGVSKSIGLGLIGFSEAFADLNPDIILVLGDRFEILAATVAALISRI
EEEEEEEEECCCCCCCCCCCCEEEEEHHHHHHCCCCCEEEEECCCHHHHHHHHHHHHHHC
PVAHLHGGETTEGAFDEGIRHSITKMSHLHFVAANEYRNRIIQLGEDPSNVFLVGGMGID
CEEEECCCCCCCCHHHHHHHHHHHHHHHEEEEEECHHHHHHEECCCCCCCEEEEECCCCC
GIKKSNLLKKEELESSLNIKFKKNNLLITFHPVTLEESTAKVQMIELLLSLETLSPEIGL
CCCCCCCCCHHHHCCCCEEEEECCCEEEEEECEEECCCHHHHHHHHHHHHHHHCCCCEEE
IFTMPNADTDGRIIFELVKEFTSSHSNAWYFTSLGQTRYLSCLQFVDAVVGNSSSGIIEA
EEECCCCCCCCHHHHHHHHHHHCCCCCEEEEEECCHHHHHHHHHHHHHHHCCCCCCEEEC
PSFKIGTINIGDRQKGRLRAKSIIDCEPKKIEIIDAFKRLYSSDFQKNLSTTVNPYGEGG
CCEEEEEEECCCCCCCCCHHHHEECCCCCEEHHHHHHHHHHHHHHHHHHCCCCCCCCCCC
ASEKIVRILEKIDIQGILKKKFFNLQF
CHHHHHHHHHHHCHHHHHHHHHCCCCC
>Mature Secondary Structure
MKRKICVITGTRADYGLLRWLILEISKSSKLDLQIIATGMHLSPEFGLTYKEIENDGFLI
CCCEEEEEECCCCHHHHHHHHHHHHCCCCCCEEEEEEECCEECCCCCCCCEEECCCCEEE
HKKIEILLSSDSTVGVSKSIGLGLIGFSEAFADLNPDIILVLGDRFEILAATVAALISRI
EEEEEEEEECCCCCCCCCCCCEEEEEHHHHHHCCCCCEEEEECCCHHHHHHHHHHHHHHC
PVAHLHGGETTEGAFDEGIRHSITKMSHLHFVAANEYRNRIIQLGEDPSNVFLVGGMGID
CEEEECCCCCCCCHHHHHHHHHHHHHHHEEEEEECHHHHHHEECCCCCCCEEEEECCCCC
GIKKSNLLKKEELESSLNIKFKKNNLLITFHPVTLEESTAKVQMIELLLSLETLSPEIGL
CCCCCCCCCHHHHCCCCEEEEECCCEEEEEECEEECCCHHHHHHHHHHHHHHHCCCCEEE
IFTMPNADTDGRIIFELVKEFTSSHSNAWYFTSLGQTRYLSCLQFVDAVVGNSSSGIIEA
EEECCCCCCCCHHHHHHHHHHHCCCCCEEEEEECCHHHHHHHHHHHHHHHCCCCCCEEEC
PSFKIGTINIGDRQKGRLRAKSIIDCEPKKIEIIDAFKRLYSSDFQKNLSTTVNPYGEGG
CCEEEEEEECCCCCCCCCHHHHEECCCCCEEHHHHHHHHHHHHHHHHHHCCCCCCCCCCC
ASEKIVRILEKIDIQGILKKKFFNLQF
CHHHHHHHHHHHCHHHHHHHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: UDP-N-acetylglucosamine [C]

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): 0.63 {UDP-N-acetylglucosamine}} 1 {UDP-N-acetylmannosamine}} 0.5 {UDP-N-acetylmannosamine}} [C]

Substrates: UDP-N-acetyl-D-glucosamine [C]

Specific reaction: UDP-N-acetyl-D-glucosamine --> UDP-N-acetyl-D-mannosamine [C]

General reaction: Epimerization [C]

Inhibitor: PCMB [C]

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 1729218 [H]