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The map label for this gene is clpB

Identifier: 45657869

GI number: 45657869

Start: 2428166

End: 2430748

Strand: Reverse

Name: clpB

Synonym: LIC12017

Alternate gene names: 45657869

Gene position: 2430748-2428166 (Counterclockwise)

Preceding gene: 45657874

Following gene: 45657865

Centisome position: 56.83

GC content: 38.4

Gene sequence:

>2583_bases
ATGAAATTAGATAAACTTACATCCAAATTAAACGAAGCGATTTATAACGCACAAGCGTCTGCCGAAAAATTGGGAAATCC
GGAAATTAGTGAAGAACATATTTTAAAGGAAGTTCTATCACAGCCGGACGGACTTGTACCTCTTTTAATTTCTAAACTCA
ATCTGAGTCCAAAATCATTTTTGGAAAGTACAGAAAATGCTTTGGGAAAACAACCGAAAGTAGGAGGAAATACGTCTGCA
GATGTAGGCTTTTCGCGTTCGGCGGTTTCACTTTTAAAAGCCGCCGATGAAGTAAGAAAAGAATTAAAAGACGAGTATCT
TTCTACGGACCATATCTTACTCGGGCTCATGAAAAACGGTACTGGGTCGTTAAAAACTGAGTTTTTAAAATTAGGATTAG
AATATCATAAATTACTTAAAATCACTTTGGAAAATAGAAAGGGAAAAACAATCATGGACGACTCGCCAGAAGGAAAAACG
GATGCACTTGCAAAGTATGCAAAAAACCTAAATGAACTTGCCAAACAAGGAAAATTAGATCCTGTCATAGGAAGAGACGA
GGAAATTAGAAGGACAATACAAGTTTTATCTAGAAGAACAAAAAACAATCCTGTGCTTATTGGAGAACCAGGAGTTGGAA
AAACTGCAATCGTGGAAGGGCTAGCTAACAAAATCGTTCAAGGAGAAGTGCCTGAAGGAATCAAAAATAAAACACTTTAT
ACCTTGGACTTAGGTTCCATGATCGCCGGGGCTAAATATAGAGGGGAATTTGAAGACAGACTCAAAGCGTTGTTAGACGA
GGTCAAATCTTCAGACGGAGAAGTGATTTTATTCATAGACGAAATTCATACTCTTGTAGGCGCTGGAGCCACAGAAGGAG
CATTAGATGCTTCTAATATGTTAAAACCCATGCTTGCTAGAGGAGAACTACGTTGTATAGGTGCAACTACTCTAAAAGAA
TATCAGAAATATATAGAGAAAGACGCGGCTTTAGAAAGAAGGTTTCAACCTGTTTATGTCAAGGAACCTTCCGTAGAGGA
AACCGTAACGATTTTAAGAGGGCTTAAGGGGCGTTACGAATTACATCATGGAATTAGAATATTAGATTCTGCTTTGATTG
CTGCCGCTACACTTTCTAATCGTTATATATCCGATCGATTTCTTCCAGATAAGGCGGTGGACTTGATCGATGAGGCCTCT
TCTAAAATGAGGATTGAGATAGATTCTATGCCCGAGGAACTCGATCGTGCAAACAAAAGGATTCAATCTCTAAAGATAGA
AAGAGAAGCTCTAAAAAAAGAACAGGATACGGCTTCGAAAGAAAGATTAAAAACTCTCGAAAGGGATTTATCCGAACAAG
AGCAAAATTTTCAAACTTTAAAGGCGAGATGGGATTTAGAAAAATCTAAAATTGGTCGTTTGAAACAAATTAAAGAAGAA
ATAGAAAAGTATAAAAATTTAGAAGCGGAAGCAGAAAGAAGAGGAGAGATTAATCGAGTGGCTGAGATTCGCTACGGAAA
GTTAGTAGATCTTCAAAAAGAACTCGAATCCGCAAACGAAGAATTAAAAAAACAAGAAAGTGCTTCCAGACTTTTAAAAG
AAGAAGTCTCCGAAGAGGATATAGCGAATATAGTCTCTCGTTGGACTGGAATTCCAGTTTCTAAAATGCTTCAAGGCGAA
AGGGCAAAACTTCTTTTGATGGAGGATGTATTAAAAACCAAAGTGATCGGACAGGATCATGCTCTTAGACTCGTTTCGGA
AGCGGTACAGAGATCTAGGGCCGGAATTGCAGATCCAAATCGTCCCATAGGAACGTTTTTATTTCTTGGACCTACTGGAG
TAGGAAAGACCGAAACTGCAAAAGCACTCGCCGAATTCTTGTTTGACGATGTAAACGCGATGACCCGGATCGATATGAGT
GAATACATGGAGGCTCATTCCGTAGCCAGGCTGATCGGTGCACCTCCGGGTTATGTAGGATACGATGAAGGAGGACAGCT
TACGGAAGCGGTTCGAAGAAGACCATATTCTTTGATACTTTTTGACGAGATTGAAAAAGCAAATCCGGAAGTATTCAACA
TTTTCCTTCAGATTTTAGATGAAGGAAGATTGACCGATGGAAAGGGACGTAACGTTGATTTTAAGAATACGGTGATCATT
CTTACTTCGAATATAGGCTCCGAAATTTTAGGATCTTCTGAATACACTTCGGAAGAAAAAGAAAGATTGGTGGAACAAAG
ATTAAAAAAGCATTTTAAACCAGAATTTTTAAATCGAATTGACGAAGTAATTTTGTTTCATTCGATTACGGATTCCGTGA
TTCATAAAATTGCGGATATTCAATTAGAAGGTTTGAGACAAAAGGCGAAAGAAAACGGGCTGGACGTAAGTTTTACAAAC
GAGTTAAAAGATTATGTTTCTAAAGCCGGTTTTGACGCAGAATATGGAGCCAGACCTCTCAAACGTTTGATCCAAAGAGA
AGTAGGAAATGCACTGAGTCGATATATATTAGACGGTAAGTTTACAAACGGGCAAAACGTAACCGTGGATTATAGACAGG
GAAAGGTAGTTGTTGTAGTTTAA

Upstream 100 bases:

>100_bases
AATAAAATGCCAATATGGCAGAAAAAACGAGAAATTTTAAAGATCAAAAAGTCTAAATTCTAAACTAAAAAATCAGAACT
TTATTAGAAAGAGTCGGAAA

Downstream 100 bases:

>100_bases
TGGTATTTAATGACCACAAACTATCTTAAAATGATTTTGCCGTTGATAGTTTGGGCTATAAGCCAAACCAAATAGAAATA
GAAACCTTTCATCTACATAA

Product: ATP-dependent protease

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 860; Mature: 860

Protein sequence:

>860_residues
MKLDKLTSKLNEAIYNAQASAEKLGNPEISEEHILKEVLSQPDGLVPLLISKLNLSPKSFLESTENALGKQPKVGGNTSA
DVGFSRSAVSLLKAADEVRKELKDEYLSTDHILLGLMKNGTGSLKTEFLKLGLEYHKLLKITLENRKGKTIMDDSPEGKT
DALAKYAKNLNELAKQGKLDPVIGRDEEIRRTIQVLSRRTKNNPVLIGEPGVGKTAIVEGLANKIVQGEVPEGIKNKTLY
TLDLGSMIAGAKYRGEFEDRLKALLDEVKSSDGEVILFIDEIHTLVGAGATEGALDASNMLKPMLARGELRCIGATTLKE
YQKYIEKDAALERRFQPVYVKEPSVEETVTILRGLKGRYELHHGIRILDSALIAAATLSNRYISDRFLPDKAVDLIDEAS
SKMRIEIDSMPEELDRANKRIQSLKIEREALKKEQDTASKERLKTLERDLSEQEQNFQTLKARWDLEKSKIGRLKQIKEE
IEKYKNLEAEAERRGEINRVAEIRYGKLVDLQKELESANEELKKQESASRLLKEEVSEEDIANIVSRWTGIPVSKMLQGE
RAKLLLMEDVLKTKVIGQDHALRLVSEAVQRSRAGIADPNRPIGTFLFLGPTGVGKTETAKALAEFLFDDVNAMTRIDMS
EYMEAHSVARLIGAPPGYVGYDEGGQLTEAVRRRPYSLILFDEIEKANPEVFNIFLQILDEGRLTDGKGRNVDFKNTVII
LTSNIGSEILGSSEYTSEEKERLVEQRLKKHFKPEFLNRIDEVILFHSITDSVIHKIADIQLEGLRQKAKENGLDVSFTN
ELKDYVSKAGFDAEYGARPLKRLIQREVGNALSRYILDGKFTNGQNVTVDYRQGKVVVVV

Sequences:

>Translated_860_residues
MKLDKLTSKLNEAIYNAQASAEKLGNPEISEEHILKEVLSQPDGLVPLLISKLNLSPKSFLESTENALGKQPKVGGNTSA
DVGFSRSAVSLLKAADEVRKELKDEYLSTDHILLGLMKNGTGSLKTEFLKLGLEYHKLLKITLENRKGKTIMDDSPEGKT
DALAKYAKNLNELAKQGKLDPVIGRDEEIRRTIQVLSRRTKNNPVLIGEPGVGKTAIVEGLANKIVQGEVPEGIKNKTLY
TLDLGSMIAGAKYRGEFEDRLKALLDEVKSSDGEVILFIDEIHTLVGAGATEGALDASNMLKPMLARGELRCIGATTLKE
YQKYIEKDAALERRFQPVYVKEPSVEETVTILRGLKGRYELHHGIRILDSALIAAATLSNRYISDRFLPDKAVDLIDEAS
SKMRIEIDSMPEELDRANKRIQSLKIEREALKKEQDTASKERLKTLERDLSEQEQNFQTLKARWDLEKSKIGRLKQIKEE
IEKYKNLEAEAERRGEINRVAEIRYGKLVDLQKELESANEELKKQESASRLLKEEVSEEDIANIVSRWTGIPVSKMLQGE
RAKLLLMEDVLKTKVIGQDHALRLVSEAVQRSRAGIADPNRPIGTFLFLGPTGVGKTETAKALAEFLFDDVNAMTRIDMS
EYMEAHSVARLIGAPPGYVGYDEGGQLTEAVRRRPYSLILFDEIEKANPEVFNIFLQILDEGRLTDGKGRNVDFKNTVII
LTSNIGSEILGSSEYTSEEKERLVEQRLKKHFKPEFLNRIDEVILFHSITDSVIHKIADIQLEGLRQKAKENGLDVSFTN
ELKDYVSKAGFDAEYGARPLKRLIQREVGNALSRYILDGKFTNGQNVTVDYRQGKVVVVV
>Mature_860_residues
MKLDKLTSKLNEAIYNAQASAEKLGNPEISEEHILKEVLSQPDGLVPLLISKLNLSPKSFLESTENALGKQPKVGGNTSA
DVGFSRSAVSLLKAADEVRKELKDEYLSTDHILLGLMKNGTGSLKTEFLKLGLEYHKLLKITLENRKGKTIMDDSPEGKT
DALAKYAKNLNELAKQGKLDPVIGRDEEIRRTIQVLSRRTKNNPVLIGEPGVGKTAIVEGLANKIVQGEVPEGIKNKTLY
TLDLGSMIAGAKYRGEFEDRLKALLDEVKSSDGEVILFIDEIHTLVGAGATEGALDASNMLKPMLARGELRCIGATTLKE
YQKYIEKDAALERRFQPVYVKEPSVEETVTILRGLKGRYELHHGIRILDSALIAAATLSNRYISDRFLPDKAVDLIDEAS
SKMRIEIDSMPEELDRANKRIQSLKIEREALKKEQDTASKERLKTLERDLSEQEQNFQTLKARWDLEKSKIGRLKQIKEE
IEKYKNLEAEAERRGEINRVAEIRYGKLVDLQKELESANEELKKQESASRLLKEEVSEEDIANIVSRWTGIPVSKMLQGE
RAKLLLMEDVLKTKVIGQDHALRLVSEAVQRSRAGIADPNRPIGTFLFLGPTGVGKTETAKALAEFLFDDVNAMTRIDMS
EYMEAHSVARLIGAPPGYVGYDEGGQLTEAVRRRPYSLILFDEIEKANPEVFNIFLQILDEGRLTDGKGRNVDFKNTVII
LTSNIGSEILGSSEYTSEEKERLVEQRLKKHFKPEFLNRIDEVILFHSITDSVIHKIADIQLEGLRQKAKENGLDVSFTN
ELKDYVSKAGFDAEYGARPLKRLIQREVGNALSRYILDGKFTNGQNVTVDYRQGKVVVVV

Specific function: Part of a stress-induced multi-chaperone system, it is involved in the recovery of the cell from heat-induced damage, in cooperation with DnaK, DnaJ and GrpE. Acts before DnaK, in the processing of protein aggregates. Protein binding stimulates the ATPase

COG id: COG0542

COG function: function code O; ATPases with chaperone activity, ATP-binding subunit

Gene ontology:

Cell location: Cytoplasm (Probable)

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the clpA/clpB family

Homologues:

Organism=Homo sapiens, GI13540606, Length=299, Percent_Identity=37.123745819398, Blast_Score=201, Evalue=4e-51,
Organism=Escherichia coli, GI1788943, Length=863, Percent_Identity=52.2595596755504, Blast_Score=897, Evalue=0.0,
Organism=Escherichia coli, GI1787109, Length=249, Percent_Identity=54.6184738955823, Blast_Score=288, Evalue=1e-78,
Organism=Saccharomyces cerevisiae, GI6320464, Length=715, Percent_Identity=50.0699300699301, Blast_Score=745, Evalue=0.0,
Organism=Saccharomyces cerevisiae, GI6323002, Length=854, Percent_Identity=40.9836065573771, Blast_Score=653, Evalue=0.0,

Paralogues:

None

Copy number: 560 Molecules/Cell In: Glucose minimal media [C]

Swissprot (AC and ID): CLPB_LEPIC (Q72QU2)

Other databases:

- EMBL:   AE016823
- RefSeq:   YP_001955.1
- ProteinModelPortal:   Q72QU2
- GeneID:   2772251
- GenomeReviews:   AE016823_GR
- KEGG:   lic:LIC12017
- NMPDR:   fig|267671.1.peg.1955
- HOGENOM:   HBG413133
- OMA:   DLNELWK
- ProtClustDB:   CLSK574073
- BioCyc:   LINT267671:LIC_12017-MONOMER
- GO:   GO:0005737
- InterPro:   IPR003593
- InterPro:   IPR013093
- InterPro:   IPR003959
- InterPro:   IPR018368
- InterPro:   IPR017730
- InterPro:   IPR001270
- InterPro:   IPR019489
- InterPro:   IPR004176
- InterPro:   IPR023150
- Gene3D:   G3DSA:1.10.1780.10
- PRINTS:   PR00300
- SMART:   SM00382
- TIGRFAMs:   TIGR03346

Pfam domain/function: PF00004 AAA; PF07724 AAA_2; PF02861 Clp_N; PF10431 ClpB_D2-small

EC number: NA

Molecular weight: Translated: 96327; Mature: 96327

Theoretical pI: Translated: 6.36; Mature: 6.36

Prosite motif: PS00870 CLPAB_1; PS00871 CLPAB_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.1 %Cys     (Translated Protein)
1.5 %Met     (Translated Protein)
1.6 %Cys+Met (Translated Protein)
0.1 %Cys     (Mature Protein)
1.5 %Met     (Mature Protein)
1.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKLDKLTSKLNEAIYNAQASAEKLGNPEISEEHILKEVLSQPDGLVPLLISKLNLSPKSF
CCHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHCCCCCCHHHHHHHHCCCHHHH
LESTENALGKQPKVGGNTSADVGFSRSAVSLLKAADEVRKELKDEYLSTDHILLGLMKNG
HHHHHHHCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHCC
TGSLKTEFLKLGLEYHKLLKITLENRKGKTIMDDSPEGKTDALAKYAKNLNELAKQGKLD
CCHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHCCCCC
PVIGRDEEIRRTIQVLSRRTKNNPVLIGEPGVGKTAIVEGLANKIVQGEVPEGIKNKTLY
CCCCCCHHHHHHHHHHHHHCCCCCEEEECCCCCHHHHHHHHHHHHHCCCCCCCCCCCEEE
TLDLGSMIAGAKYRGEFEDRLKALLDEVKSSDGEVILFIDEIHTLVGAGATEGALDASNM
EEEHHHHHHCCCCCCCHHHHHHHHHHHHHCCCCCEEEEHHHHHHHHCCCCCCCCCCHHHH
LKPMLARGELRCIGATTLKEYQKYIEKDAALERRFQPVYVKEPSVEETVTILRGLKGRYE
HHHHHHCCCEEEECHHHHHHHHHHHHHHHHHHHCCCCEEECCCCHHHHHHHHHHCCCHHH
LHHGIRILDSALIAAATLSNRYISDRFLPDKAVDLIDEASSKMRIEIDSMPEELDRANKR
HHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHCCCCEEEEECCCHHHHHHHHHH
IQSLKIEREALKKEQDTASKERLKTLERDLSEQEQNFQTLKARWDLEKSKIGRLKQIKEE
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHH
IEKYKNLEAEAERRGEINRVAEIRYGKLVDLQKELESANEELKKQESASRLLKEEVSEED
HHHHHCCCHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCHHH
IANIVSRWTGIPVSKMLQGERAKLLLMEDVLKTKVIGQDHALRLVSEAVQRSRAGIADPN
HHHHHHHHCCCCHHHHHCCCHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHCCCCCCC
RPIGTFLFLGPTGVGKTETAKALAEFLFDDVNAMTRIDMSEYMEAHSVARLIGAPPGYVG
CCCEEEEEECCCCCCCHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHCCCCCCCC
YDEGGQLTEAVRRRPYSLILFDEIEKANPEVFNIFLQILDEGRLTDGKGRNVDFKNTVII
CCCCCHHHHHHHHCCCEEEEEHHHHHCCHHHHHHHHHHHHCCCCCCCCCCCCCCCCEEEE
LTSNIGSEILGSSEYTSEEKERLVEQRLKKHFKPEFLNRIDEVILFHSITDSVIHKIADI
EECCCCHHHCCCCCCCCHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHH
QLEGLRQKAKENGLDVSFTNELKDYVSKAGFDAEYGARPLKRLIQREVGNALSRYILDGK
HHHHHHHHHHHCCCCEEEHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHCCC
FTNGQNVTVDYRQGKVVVVV
CCCCCEEEEEECCCEEEEEC
>Mature Secondary Structure
MKLDKLTSKLNEAIYNAQASAEKLGNPEISEEHILKEVLSQPDGLVPLLISKLNLSPKSF
CCHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHCCCCCCHHHHHHHHCCCHHHH
LESTENALGKQPKVGGNTSADVGFSRSAVSLLKAADEVRKELKDEYLSTDHILLGLMKNG
HHHHHHHCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHCC
TGSLKTEFLKLGLEYHKLLKITLENRKGKTIMDDSPEGKTDALAKYAKNLNELAKQGKLD
CCHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHCCCCC
PVIGRDEEIRRTIQVLSRRTKNNPVLIGEPGVGKTAIVEGLANKIVQGEVPEGIKNKTLY
CCCCCCHHHHHHHHHHHHHCCCCCEEEECCCCCHHHHHHHHHHHHHCCCCCCCCCCCEEE
TLDLGSMIAGAKYRGEFEDRLKALLDEVKSSDGEVILFIDEIHTLVGAGATEGALDASNM
EEEHHHHHHCCCCCCCHHHHHHHHHHHHHCCCCCEEEEHHHHHHHHCCCCCCCCCCHHHH
LKPMLARGELRCIGATTLKEYQKYIEKDAALERRFQPVYVKEPSVEETVTILRGLKGRYE
HHHHHHCCCEEEECHHHHHHHHHHHHHHHHHHHCCCCEEECCCCHHHHHHHHHHCCCHHH
LHHGIRILDSALIAAATLSNRYISDRFLPDKAVDLIDEASSKMRIEIDSMPEELDRANKR
HHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHCCCCEEEEECCCHHHHHHHHHH
IQSLKIEREALKKEQDTASKERLKTLERDLSEQEQNFQTLKARWDLEKSKIGRLKQIKEE
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHH
IEKYKNLEAEAERRGEINRVAEIRYGKLVDLQKELESANEELKKQESASRLLKEEVSEED
HHHHHCCCHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCHHH
IANIVSRWTGIPVSKMLQGERAKLLLMEDVLKTKVIGQDHALRLVSEAVQRSRAGIADPN
HHHHHHHHCCCCHHHHHCCCHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHCCCCCCC
RPIGTFLFLGPTGVGKTETAKALAEFLFDDVNAMTRIDMSEYMEAHSVARLIGAPPGYVG
CCCEEEEEECCCCCCCHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHCCCCCCCC
YDEGGQLTEAVRRRPYSLILFDEIEKANPEVFNIFLQILDEGRLTDGKGRNVDFKNTVII
CCCCCHHHHHHHHCCCEEEEEHHHHHCCHHHHHHHHHHHHCCCCCCCCCCCCCCCCEEEE
LTSNIGSEILGSSEYTSEEKERLVEQRLKKHFKPEFLNRIDEVILFHSITDSVIHKIADI
EECCCCHHHCCCCCCCCHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHH
QLEGLRQKAKENGLDVSFTNELKDYVSKAGFDAEYGARPLKRLIQREVGNALSRYILDGK
HHHHHHHHHHHCCCCEEEHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHCCC
FTNGQNVTVDYRQGKVVVVV
CCCCCEEEEEECCCEEEEEC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: Hydrolase; Acting on peptide bonds (Peptidases); Serine endopeptidases [C]

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA