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The map label for this gene is mmgC [H]

Identifier: 45657829

GI number: 45657829

Start: 2381074

End: 2382204

Strand: Reverse

Name: mmgC [H]

Synonym: LIC11976

Alternate gene names: 45657829

Gene position: 2382204-2381074 (Counterclockwise)

Preceding gene: 45657830

Following gene: 45657828

Centisome position: 55.7

GC content: 40.05

Gene sequence:

>1131_bases
ATGGATAGAATTCTTCAATTTACGGAAGAACATGAATCCTTCCGTACGATGGCTAGAAAATTTTTCGAAACGGAAGTTGC
ACCGAATCACGAATCTTGGGAAAAAGTAGGGGTTGTTCCGAAAGAAATTTGGAAAAAAGCAGGAGCAAACGGACTTTTAT
GTCCAGATGTTCCTGCGGAATATGGCGGAGCCGGTGCAGATTTTTTATATAACGTAATTGTAATCGAGGAATCTTCAAGA
GTAGGAAATAGTGGTTTTTTTATATCTCTACATAACGATGTAATTGCACCTTATATTACGGCTTACGCAAACGAAGAACA
AAAAAAACGTTGGTTGCCTGGTTGTACAACCGGAGATAGTATTCTTGCCGTTGCTATGACCGAACCCGGAGCTGGTTCTG
ATTTAAAAAATATTAGAACTTCCGCTATTGAAAAAAGTGATCACTACGTAGTAAATGGACAAAAAACCTTTATTTCTAAC
GGACAGTTGGCAAATTTAATCATTACGGCTGTTAAACATGATAACGGCACGATGTCCCTTCTGATGGTAGAAGAAGGAAT
GAAAGGTTTTGAAAGAGGAAGAAGATTAGAAAAAATTGGTCTGAAAGCTCAGGATACTTCGGAACTGTATTACAACGACG
TGATTGTTCCTAAGGAAAACTTGATCGGAAAACAAGGACAAGGTTTTCGTTATCTCATGCAAAAGTTGGCTACGGAACGA
TTGGTTCTTTCCATCGCAGCCGTAGAAGCGACCGCACTCGTACAAAGAATTACCCTTCAATACATTAAAGAAAGACAGGC
CTTCGGAAAGAAAATCGGAACCTTTCAGAACATTAAATTTAAAATGGCTGAAATGGCTACGGAACTGGAGATGTGCCGTA
CTTTTGTAGATAAGATTACTCTGGAAACTATAGCCGGAAGATCAAATACCGCAGAAGCCTCTATGGCAAAATGGTATTCA
ACCGAAATGCAAAAACGTCATACAGATGAATGTTTGCAGTTTTTCGGTGGTTACGGTTATATGATGGAGTATCCAATCGC
GAGAGCGTACCTGGATGCGAGAATCCAGACAATCTATGCGGGAACTACGGAAATTATGAAAGAGATCATAGGCAGAAGCC
TGGGACTCTGA

Upstream 100 bases:

>100_bases
ATTCCATTCGGCAAAATGATTTGGTCGATTATGTGAAGAAGAATCCAGGCGTTTACATGAGAATGAATACAGTCTACGCG
TAGACGTTTGGGAGAAATGA

Downstream 100 bases:

>100_bases
AATAAATTTCTAATGGTTCCCGTCGAATGAAACGGGGTAATGATGAATACCTTCCGCAGTTTAGTGGTAGGAAAGTTTTT
TCCTATTTTAGTTTTTTCTT

Product: acyl-CoA dehydrogenase

Products: 2,3-dehydroacyl-CoA; reduced acceptor

Alternate protein names: NA

Number of amino acids: Translated: 376; Mature: 376

Protein sequence:

>376_residues
MDRILQFTEEHESFRTMARKFFETEVAPNHESWEKVGVVPKEIWKKAGANGLLCPDVPAEYGGAGADFLYNVIVIEESSR
VGNSGFFISLHNDVIAPYITAYANEEQKKRWLPGCTTGDSILAVAMTEPGAGSDLKNIRTSAIEKSDHYVVNGQKTFISN
GQLANLIITAVKHDNGTMSLLMVEEGMKGFERGRRLEKIGLKAQDTSELYYNDVIVPKENLIGKQGQGFRYLMQKLATER
LVLSIAAVEATALVQRITLQYIKERQAFGKKIGTFQNIKFKMAEMATELEMCRTFVDKITLETIAGRSNTAEASMAKWYS
TEMQKRHTDECLQFFGGYGYMMEYPIARAYLDARIQTIYAGTTEIMKEIIGRSLGL

Sequences:

>Translated_376_residues
MDRILQFTEEHESFRTMARKFFETEVAPNHESWEKVGVVPKEIWKKAGANGLLCPDVPAEYGGAGADFLYNVIVIEESSR
VGNSGFFISLHNDVIAPYITAYANEEQKKRWLPGCTTGDSILAVAMTEPGAGSDLKNIRTSAIEKSDHYVVNGQKTFISN
GQLANLIITAVKHDNGTMSLLMVEEGMKGFERGRRLEKIGLKAQDTSELYYNDVIVPKENLIGKQGQGFRYLMQKLATER
LVLSIAAVEATALVQRITLQYIKERQAFGKKIGTFQNIKFKMAEMATELEMCRTFVDKITLETIAGRSNTAEASMAKWYS
TEMQKRHTDECLQFFGGYGYMMEYPIARAYLDARIQTIYAGTTEIMKEIIGRSLGL
>Mature_376_residues
MDRILQFTEEHESFRTMARKFFETEVAPNHESWEKVGVVPKEIWKKAGANGLLCPDVPAEYGGAGADFLYNVIVIEESSR
VGNSGFFISLHNDVIAPYITAYANEEQKKRWLPGCTTGDSILAVAMTEPGAGSDLKNIRTSAIEKSDHYVVNGQKTFISN
GQLANLIITAVKHDNGTMSLLMVEEGMKGFERGRRLEKIGLKAQDTSELYYNDVIVPKENLIGKQGQGFRYLMQKLATER
LVLSIAAVEATALVQRITLQYIKERQAFGKKIGTFQNIKFKMAEMATELEMCRTFVDKITLETIAGRSNTAEASMAKWYS
TEMQKRHTDECLQFFGGYGYMMEYPIARAYLDARIQTIYAGTTEIMKEIIGRSLGL

Specific function: Unknown

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the acyl-CoA dehydrogenase family [H]

Homologues:

Organism=Homo sapiens, GI4501857, Length=374, Percent_Identity=44.3850267379679, Blast_Score=345, Evalue=4e-95,
Organism=Homo sapiens, GI226958412, Length=382, Percent_Identity=33.7696335078534, Blast_Score=235, Evalue=6e-62,
Organism=Homo sapiens, GI226958414, Length=341, Percent_Identity=35.1906158357771, Blast_Score=225, Evalue=6e-59,
Organism=Homo sapiens, GI4557233, Length=375, Percent_Identity=32.8, Blast_Score=210, Evalue=2e-54,
Organism=Homo sapiens, GI4501859, Length=374, Percent_Identity=32.8877005347594, Blast_Score=208, Evalue=7e-54,
Organism=Homo sapiens, GI4557231, Length=380, Percent_Identity=33.1578947368421, Blast_Score=203, Evalue=2e-52,
Organism=Homo sapiens, GI187960098, Length=380, Percent_Identity=33.1578947368421, Blast_Score=203, Evalue=2e-52,
Organism=Homo sapiens, GI7656849, Length=379, Percent_Identity=29.5514511873351, Blast_Score=194, Evalue=1e-49,
Organism=Homo sapiens, GI21361497, Length=376, Percent_Identity=31.9148936170213, Blast_Score=167, Evalue=1e-41,
Organism=Homo sapiens, GI4557235, Length=368, Percent_Identity=30.1630434782609, Blast_Score=155, Evalue=7e-38,
Organism=Homo sapiens, GI76496475, Length=368, Percent_Identity=30.1630434782609, Blast_Score=155, Evalue=7e-38,
Organism=Homo sapiens, GI4503943, Length=385, Percent_Identity=26.7532467532467, Blast_Score=119, Evalue=5e-27,
Organism=Homo sapiens, GI7669494, Length=291, Percent_Identity=27.8350515463918, Blast_Score=110, Evalue=3e-24,
Organism=Homo sapiens, GI211971008, Length=286, Percent_Identity=27.972027972028, Blast_Score=94, Evalue=2e-19,
Organism=Homo sapiens, GI48976061, Length=286, Percent_Identity=27.972027972028, Blast_Score=94, Evalue=2e-19,
Organism=Homo sapiens, GI38505218, Length=355, Percent_Identity=26.1971830985915, Blast_Score=92, Evalue=8e-19,
Organism=Escherichia coli, GI87081958, Length=377, Percent_Identity=29.4429708222812, Blast_Score=156, Evalue=2e-39,
Organism=Escherichia coli, GI1786223, Length=378, Percent_Identity=23.5449735449735, Blast_Score=123, Evalue=2e-29,
Organism=Caenorhabditis elegans, GI17570075, Length=378, Percent_Identity=33.8624338624339, Blast_Score=218, Evalue=4e-57,
Organism=Caenorhabditis elegans, GI17538396, Length=385, Percent_Identity=32.2077922077922, Blast_Score=216, Evalue=2e-56,
Organism=Caenorhabditis elegans, GI17533517, Length=365, Percent_Identity=32.6027397260274, Blast_Score=199, Evalue=1e-51,
Organism=Caenorhabditis elegans, GI17534899, Length=378, Percent_Identity=30.6878306878307, Blast_Score=199, Evalue=2e-51,
Organism=Caenorhabditis elegans, GI17551932, Length=377, Percent_Identity=31.8302387267904, Blast_Score=196, Evalue=2e-50,
Organism=Caenorhabditis elegans, GI17569725, Length=380, Percent_Identity=30.2631578947368, Blast_Score=190, Evalue=9e-49,
Organism=Caenorhabditis elegans, GI17508101, Length=372, Percent_Identity=27.4193548387097, Blast_Score=187, Evalue=6e-48,
Organism=Caenorhabditis elegans, GI17505929, Length=377, Percent_Identity=31.0344827586207, Blast_Score=180, Evalue=1e-45,
Organism=Caenorhabditis elegans, GI17506239, Length=371, Percent_Identity=28.3018867924528, Blast_Score=179, Evalue=2e-45,
Organism=Caenorhabditis elegans, GI71990804, Length=277, Percent_Identity=32.129963898917, Blast_Score=158, Evalue=4e-39,
Organism=Caenorhabditis elegans, GI71985184, Length=361, Percent_Identity=30.1939058171745, Blast_Score=153, Evalue=1e-37,
Organism=Caenorhabditis elegans, GI17534353, Length=377, Percent_Identity=26.525198938992, Blast_Score=131, Evalue=4e-31,
Organism=Caenorhabditis elegans, GI71985192, Length=286, Percent_Identity=31.4685314685315, Blast_Score=129, Evalue=3e-30,
Organism=Caenorhabditis elegans, GI71982178, Length=275, Percent_Identity=26.5454545454545, Blast_Score=121, Evalue=6e-28,
Organism=Caenorhabditis elegans, GI32563615, Length=227, Percent_Identity=29.0748898678414, Blast_Score=120, Evalue=9e-28,
Organism=Caenorhabditis elegans, GI17531909, Length=239, Percent_Identity=25.1046025104602, Blast_Score=99, Evalue=4e-21,
Organism=Caenorhabditis elegans, GI17562446, Length=289, Percent_Identity=26.2975778546713, Blast_Score=90, Evalue=2e-18,
Organism=Caenorhabditis elegans, GI17531913, Length=176, Percent_Identity=25.5681818181818, Blast_Score=76, Evalue=3e-14,
Organism=Drosophila melanogaster, GI21355753, Length=382, Percent_Identity=32.1989528795811, Blast_Score=219, Evalue=3e-57,
Organism=Drosophila melanogaster, GI21356377, Length=375, Percent_Identity=31.7333333333333, Blast_Score=214, Evalue=1e-55,
Organism=Drosophila melanogaster, GI24660351, Length=380, Percent_Identity=33.6842105263158, Blast_Score=196, Evalue=3e-50,
Organism=Drosophila melanogaster, GI24666513, Length=330, Percent_Identity=31.5151515151515, Blast_Score=186, Evalue=2e-47,
Organism=Drosophila melanogaster, GI24646207, Length=378, Percent_Identity=30.4232804232804, Blast_Score=182, Evalue=3e-46,
Organism=Drosophila melanogaster, GI281363737, Length=372, Percent_Identity=30.3763440860215, Blast_Score=148, Evalue=7e-36,
Organism=Drosophila melanogaster, GI19920834, Length=386, Percent_Identity=27.2020725388601, Blast_Score=118, Evalue=8e-27,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006089
- InterPro:   IPR006092
- InterPro:   IPR006090
- InterPro:   IPR006091
- InterPro:   IPR009075
- InterPro:   IPR013786
- InterPro:   IPR009100 [H]

Pfam domain/function: PF00441 Acyl-CoA_dh_1; PF02770 Acyl-CoA_dh_M; PF02771 Acyl-CoA_dh_N [H]

EC number: 1.3.99.3

Molecular weight: Translated: 42206; Mature: 42206

Theoretical pI: Translated: 6.80; Mature: 6.80

Prosite motif: PS00073 ACYL_COA_DH_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
4.0 %Met     (Translated Protein)
5.1 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
4.0 %Met     (Mature Protein)
5.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MDRILQFTEEHESFRTMARKFFETEVAPNHESWEKVGVVPKEIWKKAGANGLLCPDVPAE
CCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHCCCHHHHHHHCCCCCCCCCCCCHH
YGGAGADFLYNVIVIEESSRVGNSGFFISLHNDVIAPYITAYANEEQKKRWLPGCTTGDS
HCCCCHHHEEEEEEEECCCCCCCCCEEEEECCCHHHHHHHHHCCCHHHHHCCCCCCCCCC
ILAVAMTEPGAGSDLKNIRTSAIEKSDHYVVNGQKTFISNGQLANLIITAVKHDNGTMSL
EEEEEEECCCCCCHHHHHHHHHHCCCCCEEECCCEEEECCCCEEEEEEEEEECCCCCEEE
LMVEEGMKGFERGRRLEKIGLKAQDTSELYYNDVIVPKENLIGKQGQGFRYLMQKLATER
EEEHHHHHHHHHCCHHHHHCCCCCCCCHHHHCCEECCCHHHCCCCCCCHHHHHHHHHHHH
LVLSIAAVEATALVQRITLQYIKERQAFGKKIGTFQNIKFKMAEMATELEMCRTFVDKIT
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHH
LETIAGRSNTAEASMAKWYSTEMQKRHTDECLQFFGGYGYMMEYPIARAYLDARIQTIYA
HHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHCC
GTTEIMKEIIGRSLGL
CHHHHHHHHHHHHCCC
>Mature Secondary Structure
MDRILQFTEEHESFRTMARKFFETEVAPNHESWEKVGVVPKEIWKKAGANGLLCPDVPAE
CCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHCCCHHHHHHHCCCCCCCCCCCCHH
YGGAGADFLYNVIVIEESSRVGNSGFFISLHNDVIAPYITAYANEEQKKRWLPGCTTGDS
HCCCCHHHEEEEEEEECCCCCCCCCEEEEECCCHHHHHHHHHCCCHHHHHCCCCCCCCCC
ILAVAMTEPGAGSDLKNIRTSAIEKSDHYVVNGQKTFISNGQLANLIITAVKHDNGTMSL
EEEEEEECCCCCCHHHHHHHHHHCCCCCEEECCCEEEECCCCEEEEEEEEEECCCCCEEE
LMVEEGMKGFERGRRLEKIGLKAQDTSELYYNDVIVPKENLIGKQGQGFRYLMQKLATER
EEEHHHHHHHHHCCHHHHHCCCCCCCCHHHHCCEECCCHHHCCCCCCCHHHHHHHHHHHH
LVLSIAAVEATALVQRITLQYIKERQAFGKKIGTFQNIKFKMAEMATELEMCRTFVDKIT
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHH
LETIAGRSNTAEASMAKWYSTEMQKRHTDECLQFFGGYGYMMEYPIARAYLDARIQTIYA
HHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHCC
GTTEIMKEIIGRSLGL
CHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: acyl-CoA; acceptor

Specific reaction: acyl-CoA + acceptor = 2,3-dehydroacyl-CoA + reduced acceptor

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8759838; 8969508; 9384377 [H]