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The map label for this gene is guaB

Identifier: 45657779

GI number: 45657779

Start: 2316145

End: 2317671

Strand: Reverse

Name: guaB

Synonym: LIC11919

Alternate gene names: 45657779

Gene position: 2317671-2316145 (Counterclockwise)

Preceding gene: 45657781

Following gene: 45657778

Centisome position: 54.19

GC content: 40.21

Gene sequence:

>1527_bases
ATGTCAAACCAAACTTACCGCGACTCCGAATATTTAGACGGACTATCTGGAGAGGAATTATTCAATCTTCAGATTGGTCT
AACTTACAGAGATTTTCTCGTTCTACCTGGATTTATCGACTTCCATCCTTCTGAAGTTGAGCTTGAAACCAGACTGACCA
GAAATATAAAATTGAAAAGACCTTTTATCAGTTCTCCTATGGACACAGTTACCGAATCCCAGATGGCGATTGCCCAAGCA
CTTATGGGAGGGATCGGGATCATTCATTATAACAATACGATCGAAGAACAGGTTGCACTTGTAGAAAAGGTAAAACGTTT
TGAAAACGGATTTATCACAGATCCGGTGATTTTAGGGCCAAAAAACGTCATTCGTGATTTAGATGCAATTAAAGAACGTA
AAGGATTTACAGGAATTCCGGTAACTGAGGATGGAACAAGAAATTCTAAACTTATCGGAATCGTAACAAACAGAGATATA
GATTTCGAAAAAAATAGAGAAATCACCTTGGACAAAGTGATGACTACCAATCTAATTACTGGAAAAGAGGGGATCACTTT
ACAAGACGCAAACGAAATCATCAAAAAATCTAAGATCGGAAAACTTCCGATTGTAGATTCTCAAGGAAAATTAGTATCTC
TTGTAAGTCGTTCCGATTTAAAGAAAAATAAAGAATTCCCAGATGCCTCCAAAGACGAAAGAAAAAGGCTTCGTTGTGGA
GCTGCAGTTTCTACTTTGCTGGAATCTAGAGATAGAGTGGCTGCGTTGTATGAAGCGGGAGTAGACGTGATCATCATCGA
TTCTGCCCAAGGAAATTCTAATTACCAAATCGAAATGATTCAATTCATTAAAAAGGAATTTAAAAATCTAGACATAGTTG
CAGGAAACGTAGTGACACGTGCTCAAGCAGAAAATCTAATTCGTGCGGGTGCGGATGGGCTTCGAATTGGAATGGGCCCC
GGTTCTATTTGTATTACTCAAGATACAATGGCAGTGGGACGTGCTCAAGCGACTGCAATCTATCAAACTGCAAAACATTC
CGCAAAGTATGACGTTCCTGTAATTGCAGATGGTGGAATTTCTAACATAGGAGATATTGCAAACTCACTCGCGATTGGTG
CGTCTACGTGTATGATGGGGTTTATGTTTGCCGGAACCACAGAAGCTCCCGGAGAATATTTTTATGAGAACGGGATTCGC
CTTAAAAAATACAGAGGAATGGCGTCCATCGAAGCTATGAAAGCAGGTGGAGATAAACGTTATTTTAACGAAGGTCAAAA
AGTAAAGGTGGCTCAAGGAGTCAGTGGGTCCGTAGTAGACAGAGGATCGATTTTGAATTTTATTCCTTACCTATCTCAAG
GTCTCAGATTATCCTTTCAAGATATGGGTTATAAATCCATACCCGAAATTCATAAAGCTCTTAGGGATGGGAAACTGCGT
TTTGAAAGAAGGTCCGAATCCGCACAGGCTCAGGGTTCAGTACATGGACTCTATTCTTTTAGTGCTCCTACTATGAGGGC
GGAGTAA

Upstream 100 bases:

>100_bases
CTCTCTTTTTTTTCTCTGAATTGTTTCCATAGTTTTTCAAAGCGAACGAGGGGAAATTCTCTTGATCTTAGTTCTCAGTT
TACCTTTTATGTACTAGGTA

Downstream 100 bases:

>100_bases
TTGGATCGGATTCTTGCGTTTACGTTTGGTTTTTTTGCTCTTGTAGTATTGAGCAAAGAAATAAACTCGCAAGGATCTGC
TATAAGAGTCGCTCAGGAAT

Product: IMP dehydrogenase

Products: NA

Alternate protein names: IMP dehydrogenase; IMPD; IMPDH [H]

Number of amino acids: Translated: 508; Mature: 507

Protein sequence:

>508_residues
MSNQTYRDSEYLDGLSGEELFNLQIGLTYRDFLVLPGFIDFHPSEVELETRLTRNIKLKRPFISSPMDTVTESQMAIAQA
LMGGIGIIHYNNTIEEQVALVEKVKRFENGFITDPVILGPKNVIRDLDAIKERKGFTGIPVTEDGTRNSKLIGIVTNRDI
DFEKNREITLDKVMTTNLITGKEGITLQDANEIIKKSKIGKLPIVDSQGKLVSLVSRSDLKKNKEFPDASKDERKRLRCG
AAVSTLLESRDRVAALYEAGVDVIIIDSAQGNSNYQIEMIQFIKKEFKNLDIVAGNVVTRAQAENLIRAGADGLRIGMGP
GSICITQDTMAVGRAQATAIYQTAKHSAKYDVPVIADGGISNIGDIANSLAIGASTCMMGFMFAGTTEAPGEYFYENGIR
LKKYRGMASIEAMKAGGDKRYFNEGQKVKVAQGVSGSVVDRGSILNFIPYLSQGLRLSFQDMGYKSIPEIHKALRDGKLR
FERRSESAQAQGSVHGLYSFSAPTMRAE

Sequences:

>Translated_508_residues
MSNQTYRDSEYLDGLSGEELFNLQIGLTYRDFLVLPGFIDFHPSEVELETRLTRNIKLKRPFISSPMDTVTESQMAIAQA
LMGGIGIIHYNNTIEEQVALVEKVKRFENGFITDPVILGPKNVIRDLDAIKERKGFTGIPVTEDGTRNSKLIGIVTNRDI
DFEKNREITLDKVMTTNLITGKEGITLQDANEIIKKSKIGKLPIVDSQGKLVSLVSRSDLKKNKEFPDASKDERKRLRCG
AAVSTLLESRDRVAALYEAGVDVIIIDSAQGNSNYQIEMIQFIKKEFKNLDIVAGNVVTRAQAENLIRAGADGLRIGMGP
GSICITQDTMAVGRAQATAIYQTAKHSAKYDVPVIADGGISNIGDIANSLAIGASTCMMGFMFAGTTEAPGEYFYENGIR
LKKYRGMASIEAMKAGGDKRYFNEGQKVKVAQGVSGSVVDRGSILNFIPYLSQGLRLSFQDMGYKSIPEIHKALRDGKLR
FERRSESAQAQGSVHGLYSFSAPTMRAE
>Mature_507_residues
SNQTYRDSEYLDGLSGEELFNLQIGLTYRDFLVLPGFIDFHPSEVELETRLTRNIKLKRPFISSPMDTVTESQMAIAQAL
MGGIGIIHYNNTIEEQVALVEKVKRFENGFITDPVILGPKNVIRDLDAIKERKGFTGIPVTEDGTRNSKLIGIVTNRDID
FEKNREITLDKVMTTNLITGKEGITLQDANEIIKKSKIGKLPIVDSQGKLVSLVSRSDLKKNKEFPDASKDERKRLRCGA
AVSTLLESRDRVAALYEAGVDVIIIDSAQGNSNYQIEMIQFIKKEFKNLDIVAGNVVTRAQAENLIRAGADGLRIGMGPG
SICITQDTMAVGRAQATAIYQTAKHSAKYDVPVIADGGISNIGDIANSLAIGASTCMMGFMFAGTTEAPGEYFYENGIRL
KKYRGMASIEAMKAGGDKRYFNEGQKVKVAQGVSGSVVDRGSILNFIPYLSQGLRLSFQDMGYKSIPEIHKALRDGKLRF
ERRSESAQAQGSVHGLYSFSAPTMRAE

Specific function: GMP biosynthesis from IMP; first step. [C]

COG id: COG0516

COG function: function code F; IMP dehydrogenase/GMP reductase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 2 CBS domains [H]

Homologues:

Organism=Homo sapiens, GI217035146, Length=494, Percent_Identity=56.2753036437247, Blast_Score=577, Evalue=1e-165,
Organism=Homo sapiens, GI34328928, Length=494, Percent_Identity=56.2753036437247, Blast_Score=577, Evalue=1e-165,
Organism=Homo sapiens, GI34328930, Length=494, Percent_Identity=56.2753036437247, Blast_Score=577, Evalue=1e-165,
Organism=Homo sapiens, GI156616279, Length=494, Percent_Identity=56.2753036437247, Blast_Score=577, Evalue=1e-164,
Organism=Homo sapiens, GI66933016, Length=494, Percent_Identity=54.6558704453441, Blast_Score=568, Evalue=1e-162,
Organism=Homo sapiens, GI217035148, Length=494, Percent_Identity=55.4655870445344, Blast_Score=566, Evalue=1e-161,
Organism=Homo sapiens, GI217035152, Length=476, Percent_Identity=56.5126050420168, Blast_Score=560, Evalue=1e-159,
Organism=Homo sapiens, GI217035150, Length=494, Percent_Identity=53.0364372469636, Blast_Score=536, Evalue=1e-152,
Organism=Homo sapiens, GI156104880, Length=215, Percent_Identity=35.8139534883721, Blast_Score=128, Evalue=1e-29,
Organism=Homo sapiens, GI50541956, Length=173, Percent_Identity=39.3063583815029, Blast_Score=118, Evalue=1e-26,
Organism=Homo sapiens, GI50541954, Length=173, Percent_Identity=39.3063583815029, Blast_Score=118, Evalue=1e-26,
Organism=Homo sapiens, GI50541952, Length=173, Percent_Identity=39.3063583815029, Blast_Score=118, Evalue=1e-26,
Organism=Homo sapiens, GI50541948, Length=173, Percent_Identity=39.3063583815029, Blast_Score=118, Evalue=1e-26,
Organism=Escherichia coli, GI1788855, Length=478, Percent_Identity=38.0753138075314, Blast_Score=276, Evalue=3e-75,
Organism=Escherichia coli, GI1786293, Length=212, Percent_Identity=31.1320754716981, Blast_Score=108, Evalue=1e-24,
Organism=Caenorhabditis elegans, GI71994385, Length=527, Percent_Identity=48.7666034155598, Blast_Score=478, Evalue=1e-135,
Organism=Caenorhabditis elegans, GI71994389, Length=449, Percent_Identity=49.2204899777283, Blast_Score=408, Evalue=1e-114,
Organism=Caenorhabditis elegans, GI17560440, Length=209, Percent_Identity=32.0574162679426, Blast_Score=116, Evalue=3e-26,
Organism=Saccharomyces cerevisiae, GI6323464, Length=498, Percent_Identity=56.8273092369478, Blast_Score=561, Evalue=1e-160,
Organism=Saccharomyces cerevisiae, GI6322012, Length=497, Percent_Identity=53.9235412474849, Blast_Score=559, Evalue=1e-160,
Organism=Saccharomyces cerevisiae, GI6323585, Length=497, Percent_Identity=54.5271629778672, Blast_Score=557, Evalue=1e-159,
Organism=Saccharomyces cerevisiae, GI6319352, Length=351, Percent_Identity=52.991452991453, Blast_Score=389, Evalue=1e-109,
Organism=Saccharomyces cerevisiae, GI6319353, Length=146, Percent_Identity=54.7945205479452, Blast_Score=154, Evalue=4e-38,
Organism=Drosophila melanogaster, GI24641071, Length=500, Percent_Identity=55.4, Blast_Score=572, Evalue=1e-163,
Organism=Drosophila melanogaster, GI24641073, Length=500, Percent_Identity=55.4, Blast_Score=572, Evalue=1e-163,
Organism=Drosophila melanogaster, GI28571163, Length=441, Percent_Identity=55.5555555555556, Blast_Score=503, Evalue=1e-142,

Paralogues:

None

Copy number: 600 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013785
- InterPro:   IPR000644
- InterPro:   IPR005990
- InterPro:   IPR018529
- InterPro:   IPR015875
- InterPro:   IPR001093 [H]

Pfam domain/function: PF00571 CBS; PF00478 IMPDH [H]

EC number: =1.1.1.205 [H]

Molecular weight: Translated: 55882; Mature: 55751

Theoretical pI: Translated: 8.65; Mature: 8.65

Prosite motif: PS00487 IMP_DH_GMP_RED

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
3.0 %Met     (Translated Protein)
3.5 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
2.8 %Met     (Mature Protein)
3.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSNQTYRDSEYLDGLSGEELFNLQIGLTYRDFLVLPGFIDFHPSEVELETRLTRNIKLKR
CCCCCCCCHHHHCCCCCCEEEEEEEECEEEHHEEECCEECCCCCCEEEHHHHCCCEEEEC
PFISSPMDTVTESQMAIAQALMGGIGIIHYNNTIEEQVALVEKVKRFENGFITDPVILGP
CCCCCCHHHHHHHHHHHHHHHHCCEEEEEECCCHHHHHHHHHHHHHHHCCCCCCCEEECC
KNVIRDLDAIKERKGFTGIPVTEDGTRNSKLIGIVTNRDIDFEKNREITLDKVMTTNLIT
HHHHHHHHHHHHHCCCCCCCCCCCCCCCCEEEEEEECCCCCCCCCCCEEHHHHEEHHEEE
GKEGITLQDANEIIKKSKIGKLPIVDSQGKLVSLVSRSDLKKNKEFPDASKDERKRLRCG
CCCCCEECCHHHHHHHHCCCCCCEECCCCCEEEHHHHHHHHHCCCCCCCCHHHHHHHHHH
AAVSTLLESRDRVAALYEAGVDVIIIDSAQGNSNYQIEMIQFIKKEFKNLDIVAGNVVTR
HHHHHHHHHHHHHHHHHHCCCCEEEEECCCCCCCCCHHHHHHHHHHHCCCEEEECCCHHH
AQAENLIRAGADGLRIGMGPGSICITQDTMAVGRAQATAIYQTAKHSAKYDVPVIADGGI
HHHHHHHHCCCCCEEEECCCCCEEEECCHHHHHHHHHHHHHHHHHCCCCCCCCEEECCCC
SNIGDIANSLAIGASTCMMGFMFAGTTEAPGEYFYENGIRLKKYRGMASIEAMKAGGDKR
CHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHCCEEEEECCCCHHHHHHHCCCCHH
YFNEGQKVKVAQGVSGSVVDRGSILNFIPYLSQGLRLSFQDMGYKSIPEIHKALRDGKLR
HHCCCCEEEEECCCCCCEECCCHHHHHHHHHCCCCEEEHHHCCCCCHHHHHHHHHCCCEE
FERRSESAQAQGSVHGLYSFSAPTMRAE
EHHHCCCHHHCCCEEEEEEECCCCCCCC
>Mature Secondary Structure 
SNQTYRDSEYLDGLSGEELFNLQIGLTYRDFLVLPGFIDFHPSEVELETRLTRNIKLKR
CCCCCCCHHHHCCCCCCEEEEEEEECEEEHHEEECCEECCCCCCEEEHHHHCCCEEEEC
PFISSPMDTVTESQMAIAQALMGGIGIIHYNNTIEEQVALVEKVKRFENGFITDPVILGP
CCCCCCHHHHHHHHHHHHHHHHCCEEEEEECCCHHHHHHHHHHHHHHHCCCCCCCEEECC
KNVIRDLDAIKERKGFTGIPVTEDGTRNSKLIGIVTNRDIDFEKNREITLDKVMTTNLIT
HHHHHHHHHHHHHCCCCCCCCCCCCCCCCEEEEEEECCCCCCCCCCCEEHHHHEEHHEEE
GKEGITLQDANEIIKKSKIGKLPIVDSQGKLVSLVSRSDLKKNKEFPDASKDERKRLRCG
CCCCCEECCHHHHHHHHCCCCCCEECCCCCEEEHHHHHHHHHCCCCCCCCHHHHHHHHHH
AAVSTLLESRDRVAALYEAGVDVIIIDSAQGNSNYQIEMIQFIKKEFKNLDIVAGNVVTR
HHHHHHHHHHHHHHHHHHCCCCEEEEECCCCCCCCCHHHHHHHHHHHCCCEEEECCCHHH
AQAENLIRAGADGLRIGMGPGSICITQDTMAVGRAQATAIYQTAKHSAKYDVPVIADGGI
HHHHHHHHCCCCCEEEECCCCCEEEECCHHHHHHHHHHHHHHHHHCCCCCCCCEEECCCC
SNIGDIANSLAIGASTCMMGFMFAGTTEAPGEYFYENGIRLKKYRGMASIEAMKAGGDKR
CHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHCCEEEEECCCCHHHHHHHCCCCHH
YFNEGQKVKVAQGVSGSVVDRGSILNFIPYLSQGLRLSFQDMGYKSIPEIHKALRDGKLR
HHCCCCEEEEECCCCCCEECCCHHHHHHHHHCCCCEEEHHHCCCCCHHHHHHHHHCCCEE
FERRSESAQAQGSVHGLYSFSAPTMRAE
EHHHCCCHHHCCCEEEEEEECCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9537320 [H]