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The map label for this gene is kdsA

Identifier: 45657414

GI number: 45657414

Start: 1903682

End: 1904551

Strand: Direct

Name: kdsA

Synonym: LIC11541

Alternate gene names: 45657414

Gene position: 1903682-1904551 (Clockwise)

Preceding gene: 45657413

Following gene: 45657415

Centisome position: 44.51

GC content: 37.7

Gene sequence:

>870_bases
ATGAACATGAAAGACAATACTTGTACAAAAAGAGATTTTTTAAACGGAACTAAAATAGGAGGAGACGAACCTTTTTTTCT
AATTTCCGGTCCTTGTGTTATGGAAAATAGGGATCTATTGGATCGGGTCTGCGCCGAGATGATAGAAGTTTGTGGAGAAT
TAAAAATTCCTTATATTTTTAAAAGTAGTTTTGATAAGGCCAATCGTTCTTCCGTAAATTCCTATCGTGGACCAGGGCTT
GCAGAAGGTATTAAAAATTTAGAATATATTAAAAATAAGTACAACGTTCCTGTTTTGACGGATATTCACGAAACCTCTCA
GATTTCTCCTTTGAAAGACGTGATAGACGTATATCAGATCCCTGCGTTCTTGTGTAGACAAACAGATCTAATTTCACAAT
CCGCTCAAACAGGTAAATGGGTAAACGTAAAAAAAGGCCAATTTCTTGCACCTGCGGATACGCGTCATATCGCGGTTAAG
ATGAACGAATCCGGAAATAATAAGCTACTCGTAACCGAAAGAGGAACTTCGTTTGGTTACGGAAATTTAATATTCGATGG
AAGAGCAATTCCGATCATTCACGGATTTGATATTCCTCTTGTATTTGATGCGACACATTCTGCACAACTTCCCGGAGCTG
CTGGAAACAGTACTGGTGGACAAAGAGAATTTATTCCGAGTATTCTTCGTTCTGCCGTTTCTTTTGGTATTGAAGGTATT
TTTATGGAAGTACATCCAGATCCACCAAACGCACTTTCGGATGCCACGACTCAGTATCCACTTTCTCAGATTAAGAGCCT
TTTGAAAGAGATGATCGGTCTAGATCGTTATATTAAAAAAGAAATTCTAATTTCTAGAAGCAGCTTATAA

Upstream 100 bases:

>100_bases
TAGGAGTTCAGTTTCATCCTGAATTTCAGTCTAAACCTACTTTACCTCATCCCTTATTCGCTGGATTTATCCGCGCCTCT
GTGAAATACTCTAAAAAAGG

Downstream 100 bases:

>100_bases
TCGGTTTTTTTATGAAAAATAAAAACAACAATCGGATTTTAGTTTTTTTGATTTCGGTTGTTTGCGGATTTTTTCTAATC
ATATTCGAAAATTGTAAAAA

Product: 2-dehydro-3-deoxyphosphooctonate aldolase

Products: NA

Alternate protein names: 3-deoxy-D-manno-octulosonic acid 8-phosphate synthase; KDO-8-phosphate synthase; KDO 8-P synthase; KDOPS; Phospho-2-dehydro-3-deoxyoctonate aldolase [H]

Number of amino acids: Translated: 289; Mature: 289

Protein sequence:

>289_residues
MNMKDNTCTKRDFLNGTKIGGDEPFFLISGPCVMENRDLLDRVCAEMIEVCGELKIPYIFKSSFDKANRSSVNSYRGPGL
AEGIKNLEYIKNKYNVPVLTDIHETSQISPLKDVIDVYQIPAFLCRQTDLISQSAQTGKWVNVKKGQFLAPADTRHIAVK
MNESGNNKLLVTERGTSFGYGNLIFDGRAIPIIHGFDIPLVFDATHSAQLPGAAGNSTGGQREFIPSILRSAVSFGIEGI
FMEVHPDPPNALSDATTQYPLSQIKSLLKEMIGLDRYIKKEILISRSSL

Sequences:

>Translated_289_residues
MNMKDNTCTKRDFLNGTKIGGDEPFFLISGPCVMENRDLLDRVCAEMIEVCGELKIPYIFKSSFDKANRSSVNSYRGPGL
AEGIKNLEYIKNKYNVPVLTDIHETSQISPLKDVIDVYQIPAFLCRQTDLISQSAQTGKWVNVKKGQFLAPADTRHIAVK
MNESGNNKLLVTERGTSFGYGNLIFDGRAIPIIHGFDIPLVFDATHSAQLPGAAGNSTGGQREFIPSILRSAVSFGIEGI
FMEVHPDPPNALSDATTQYPLSQIKSLLKEMIGLDRYIKKEILISRSSL
>Mature_289_residues
MNMKDNTCTKRDFLNGTKIGGDEPFFLISGPCVMENRDLLDRVCAEMIEVCGELKIPYIFKSSFDKANRSSVNSYRGPGL
AEGIKNLEYIKNKYNVPVLTDIHETSQISPLKDVIDVYQIPAFLCRQTDLISQSAQTGKWVNVKKGQFLAPADTRHIAVK
MNESGNNKLLVTERGTSFGYGNLIFDGRAIPIIHGFDIPLVFDATHSAQLPGAAGNSTGGQREFIPSILRSAVSFGIEGI
FMEVHPDPPNALSDATTQYPLSQIKSLLKEMIGLDRYIKKEILISRSSL

Specific function: Synthesis Of Kdo 8-P Which Is Required For Lipid A Maturation And Cellular Growth. [C]

COG id: COG2877

COG function: function code M; 3-deoxy-D-manno-octulosonic acid (KDO) 8-phosphate synthase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the kdsA family [H]

Homologues:

Organism=Escherichia coli, GI1787466, Length=263, Percent_Identity=43.3460076045627, Blast_Score=246, Evalue=2e-66,

Paralogues:

None

Copy number: 200 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013785
- InterPro:   IPR006218
- InterPro:   IPR006269 [H]

Pfam domain/function: PF00793 DAHP_synth_1 [H]

EC number: =2.5.1.55 [H]

Molecular weight: Translated: 31949; Mature: 31949

Theoretical pI: Translated: 7.45; Mature: 7.45

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.7 %Cys     (Translated Protein)
2.4 %Met     (Translated Protein)
4.2 %Cys+Met (Translated Protein)
1.7 %Cys     (Mature Protein)
2.4 %Met     (Mature Protein)
4.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNMKDNTCTKRDFLNGTKIGGDEPFFLISGPCVMENRDLLDRVCAEMIEVCGELKIPYIF
CCCCCCCCHHHHCCCCCCCCCCCCEEEEECCEEECCHHHHHHHHHHHHHHHCCCCCCEEE
KSSFDKANRSSVNSYRGPGLAEGIKNLEYIKNKYNVPVLTDIHETSQISPLKDVIDVYQI
CCCCCCCCHHHCHHCCCCCHHHHHHHHHHHHHCCCCCEEECCCCCCCCCHHHHHHHHHHH
PAFLCRQTDLISQSAQTGKWVNVKKGQFLAPADTRHIAVKMNESGNNKLLVTERGTSFGY
HHHHHHHHHHHHHHCCCCCEEEECCCCEECCCCCCEEEEEECCCCCCEEEEEECCCCCCC
GNLIFDGRAIPIIHGFDIPLVFDATHSAQLPGAAGNSTGGQREFIPSILRSAVSFGIEGI
CCEEECCEEEEEEECCCCCEEEECCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHCCCEE
FMEVHPDPPNALSDATTQYPLSQIKSLLKEMIGLDRYIKKEILISRSSL
EEEECCCCCCHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCC
>Mature Secondary Structure
MNMKDNTCTKRDFLNGTKIGGDEPFFLISGPCVMENRDLLDRVCAEMIEVCGELKIPYIF
CCCCCCCCHHHHCCCCCCCCCCCCEEEEECCEEECCHHHHHHHHHHHHHHHCCCCCCEEE
KSSFDKANRSSVNSYRGPGLAEGIKNLEYIKNKYNVPVLTDIHETSQISPLKDVIDVYQI
CCCCCCCCHHHCHHCCCCCHHHHHHHHHHHHHCCCCCEEECCCCCCCCCHHHHHHHHHHH
PAFLCRQTDLISQSAQTGKWVNVKKGQFLAPADTRHIAVKMNESGNNKLLVTERGTSFGY
HHHHHHHHHHHHHHCCCCCEEEECCCCEECCCCCCEEEEEECCCCCCEEEEEECCCCCCC
GNLIFDGRAIPIIHGFDIPLVFDATHSAQLPGAAGNSTGGQREFIPSILRSAVSFGIEGI
CCEEECCEEEEEEECCCCCEEEECCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHCCCEE
FMEVHPDPPNALSDATTQYPLSQIKSLLKEMIGLDRYIKKEILISRSSL
EEEECCCCCCHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA