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The map label for this gene is pyrG

Identifier: 45657413

GI number: 45657413

Start: 1902057

End: 1903685

Strand: Direct

Name: pyrG

Synonym: LIC11540

Alternate gene names: 45657413

Gene position: 1902057-1903685 (Clockwise)

Preceding gene: 45657412

Following gene: 45657414

Centisome position: 44.47

GC content: 38.24

Gene sequence:

>1629_bases
GTGGAATATACGTTGTCGAGAACTAAGTTTATCTTTGTAACCGGAGGGGTGAGTTCCTCGCTTGGAAAAGGAGTCACCGT
CGCGGCTCTAGGTTGTTTGTTGGAAAGTAGGGGATATACTGTCTCTCTCCAAAAAATGGATCCTTACATCAATATAGATC
CTGGAACCATGAGCCCTTATCAGCATGGAGAAGTTTATGTAACCGCAGACGGAGCCGAAACCGACCTCGATTTAGGTTAT
TACGAACGTTTTACTCATTCTAAATTGACTCGAAAAAATTCAGTATCTACCGGTCAGATTTATAATACTGTCATTCAAAG
AGAAAGAAAGGGAGATTACCTAGGTCGTACAGTCCAAGTTGTCCCTCATATCACAAACGAAATCCGAAATCGGATGTATA
TTGTCGCCAGAGAAGAAAATCCAGATTTTATCATCGTTGAAATTGGAGGAACGGTAGGCGACATTGAATCGATTCCGTTT
TTAGAGGCGATTCGTCAAATGCGTTATGAACATGGAAGTTCTAACGTATTGTTTGTTCACCTAACACTGGTTCCAACGAT
TACCGCTGCAGGAGAAGCAAAGACAAAACCAACCCAACATTCCGTCAAAGAATTACTCGGACTTGGAATTCAACCGGATA
TACTCGTTTGTAGAGTTTCTCAACCGATGACAAAAGAGATGAAAAACAAACTTTCTCTTTTTTGTAATGTGAAAGAAGAG
AACGTAATCTCAGCAAGTGATATTTCCACTTCTATATACGAAATTCCTAAAATGTATAAAGAAGAAAAATTAGACGAAGT
AGTTTTGAAAACCATGGGAATGGAACTTAGAGAATCTAATTTTTCCGAATGGGATAAAATGGTGAAAGGTTTGTTGACCA
CTAAACAAACCGTTCAAATCGCCGTTGTTGGAAAGTATATTTCTCTACAAGATGCATATCGTTCCATTTATGAAAGTCTT
TCTCACGGTGGTATTGCACATGATACAAAAGTAGAGTTTATCAAAGTGGACCCGGAGAATTTAAACAAAGATTCTTATGT
AGAGATTCTAAAAAAAGTACACGGTATTTTAGTTCCAGGCGGTTTTGGTGATAGAGGAATCGAAGGAAAGATTCTTGCGA
TCCAATATGCAAGAACGAATGGAATTCCTTTTTTAGGAATTTGTCTAGGGATGCAATGTGCGGTTGTGGAATACGGAAGA
AACGTTTTGGGACTTAAAGATGCAAATTCTACGGAAATTAGACCTGACACAGAACATCCGGTGATTTCTCTTTTAGAAGA
ACAAAACGACATCGAACAAATGGGTGGGACGATGAGGTTAGGTTCTTATCCTTGTAAGGTTAAAGAAAATACTCTCTCTT
ATTCCGAATATAAGTCTATTCTCATACACGAACGTCATAGACATAGATTTGAATTTACAAATCGTTATAGAAAACAATAT
GAAGAAAATGGAATGATCATTGCGGGCACTTCTCCTGACGATAACCTCGTCGAAATTGTGGAAATTCCAAAACACAATTG
GTTTATAGGAGTTCAGTTTCATCCTGAATTTCAGTCTAAACCTACTTTACCTCATCCCTTATTCGCTGGATTTATCCGCG
CCTCTGTGAAATACTCTAAAAAAGGATGA

Upstream 100 bases:

>100_bases
ATTTACAAATAGAAACCAATATTCTACTTTTTAGAAACAGAATTCCTGGAAATTCCGGTTTGAATTTCTAAGAAACACCC
GAAACTCTGTTCTTTAGAAG

Downstream 100 bases:

>100_bases
ACATGAAAGACAATACTTGTACAAAAAGAGATTTTTTAAACGGAACTAAAATAGGAGGAGACGAACCTTTTTTTCTAATT
TCCGGTCCTTGTGTTATGGA

Product: CTP synthetase

Products: NA

Alternate protein names: CTP synthetase; UTP--ammonia ligase [H]

Number of amino acids: Translated: 542; Mature: 542

Protein sequence:

>542_residues
MEYTLSRTKFIFVTGGVSSSLGKGVTVAALGCLLESRGYTVSLQKMDPYINIDPGTMSPYQHGEVYVTADGAETDLDLGY
YERFTHSKLTRKNSVSTGQIYNTVIQRERKGDYLGRTVQVVPHITNEIRNRMYIVAREENPDFIIVEIGGTVGDIESIPF
LEAIRQMRYEHGSSNVLFVHLTLVPTITAAGEAKTKPTQHSVKELLGLGIQPDILVCRVSQPMTKEMKNKLSLFCNVKEE
NVISASDISTSIYEIPKMYKEEKLDEVVLKTMGMELRESNFSEWDKMVKGLLTTKQTVQIAVVGKYISLQDAYRSIYESL
SHGGIAHDTKVEFIKVDPENLNKDSYVEILKKVHGILVPGGFGDRGIEGKILAIQYARTNGIPFLGICLGMQCAVVEYGR
NVLGLKDANSTEIRPDTEHPVISLLEEQNDIEQMGGTMRLGSYPCKVKENTLSYSEYKSILIHERHRHRFEFTNRYRKQY
EENGMIIAGTSPDDNLVEIVEIPKHNWFIGVQFHPEFQSKPTLPHPLFAGFIRASVKYSKKG

Sequences:

>Translated_542_residues
MEYTLSRTKFIFVTGGVSSSLGKGVTVAALGCLLESRGYTVSLQKMDPYINIDPGTMSPYQHGEVYVTADGAETDLDLGY
YERFTHSKLTRKNSVSTGQIYNTVIQRERKGDYLGRTVQVVPHITNEIRNRMYIVAREENPDFIIVEIGGTVGDIESIPF
LEAIRQMRYEHGSSNVLFVHLTLVPTITAAGEAKTKPTQHSVKELLGLGIQPDILVCRVSQPMTKEMKNKLSLFCNVKEE
NVISASDISTSIYEIPKMYKEEKLDEVVLKTMGMELRESNFSEWDKMVKGLLTTKQTVQIAVVGKYISLQDAYRSIYESL
SHGGIAHDTKVEFIKVDPENLNKDSYVEILKKVHGILVPGGFGDRGIEGKILAIQYARTNGIPFLGICLGMQCAVVEYGR
NVLGLKDANSTEIRPDTEHPVISLLEEQNDIEQMGGTMRLGSYPCKVKENTLSYSEYKSILIHERHRHRFEFTNRYRKQY
EENGMIIAGTSPDDNLVEIVEIPKHNWFIGVQFHPEFQSKPTLPHPLFAGFIRASVKYSKKG
>Mature_542_residues
MEYTLSRTKFIFVTGGVSSSLGKGVTVAALGCLLESRGYTVSLQKMDPYINIDPGTMSPYQHGEVYVTADGAETDLDLGY
YERFTHSKLTRKNSVSTGQIYNTVIQRERKGDYLGRTVQVVPHITNEIRNRMYIVAREENPDFIIVEIGGTVGDIESIPF
LEAIRQMRYEHGSSNVLFVHLTLVPTITAAGEAKTKPTQHSVKELLGLGIQPDILVCRVSQPMTKEMKNKLSLFCNVKEE
NVISASDISTSIYEIPKMYKEEKLDEVVLKTMGMELRESNFSEWDKMVKGLLTTKQTVQIAVVGKYISLQDAYRSIYESL
SHGGIAHDTKVEFIKVDPENLNKDSYVEILKKVHGILVPGGFGDRGIEGKILAIQYARTNGIPFLGICLGMQCAVVEYGR
NVLGLKDANSTEIRPDTEHPVISLLEEQNDIEQMGGTMRLGSYPCKVKENTLSYSEYKSILIHERHRHRFEFTNRYRKQY
EENGMIIAGTSPDDNLVEIVEIPKHNWFIGVQFHPEFQSKPTLPHPLFAGFIRASVKYSKKG

Specific function: Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen [H]

COG id: COG0504

COG function: function code F; CTP synthase (UTP-ammonia lyase)

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 glutamine amidotransferase type-1 domain [H]

Homologues:

Organism=Homo sapiens, GI148491070, Length=559, Percent_Identity=45.6171735241503, Blast_Score=483, Evalue=1e-136,
Organism=Homo sapiens, GI28559085, Length=548, Percent_Identity=44.1605839416058, Blast_Score=476, Evalue=1e-134,
Organism=Homo sapiens, GI28559083, Length=548, Percent_Identity=44.1605839416058, Blast_Score=476, Evalue=1e-134,
Organism=Homo sapiens, GI221316689, Length=548, Percent_Identity=44.1605839416058, Blast_Score=476, Evalue=1e-134,
Organism=Escherichia coli, GI1789142, Length=544, Percent_Identity=52.2058823529412, Blast_Score=578, Evalue=1e-166,
Organism=Caenorhabditis elegans, GI25148299, Length=605, Percent_Identity=36.198347107438, Blast_Score=397, Evalue=1e-111,
Organism=Saccharomyces cerevisiae, GI6322563, Length=563, Percent_Identity=42.0959147424512, Blast_Score=438, Evalue=1e-124,
Organism=Saccharomyces cerevisiae, GI6319432, Length=566, Percent_Identity=42.0494699646643, Blast_Score=437, Evalue=1e-123,
Organism=Drosophila melanogaster, GI24664469, Length=554, Percent_Identity=45.4873646209386, Blast_Score=472, Evalue=1e-133,
Organism=Drosophila melanogaster, GI21357815, Length=499, Percent_Identity=43.8877755511022, Blast_Score=405, Evalue=1e-113,

Paralogues:

None

Copy number: 480 Molecules/Cell In: Growth-Phase, Minimal-Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004468
- InterPro:   IPR017456
- InterPro:   IPR017926
- InterPro:   IPR000991 [H]

Pfam domain/function: PF06418 CTP_synth_N; PF00117 GATase [H]

EC number: =6.3.4.2 [H]

Molecular weight: Translated: 61025; Mature: 61025

Theoretical pI: Translated: 6.96; Mature: 6.96

Prosite motif: PS00442 GATASE_TYPE_I

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
2.8 %Met     (Translated Protein)
3.9 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
2.8 %Met     (Mature Protein)
3.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MEYTLSRTKFIFVTGGVSSSLGKGVTVAALGCLLESRGYTVSLQKMDPYINIDPGTMSPY
CCCCCCCEEEEEEECCCCCHHCCCHHHHHHHHHHHCCCCEEEEEECCCEEEECCCCCCCC
QHGEVYVTADGAETDLDLGYYERFTHSKLTRKNSVSTGQIYNTVIQRERKGDYLGRTVQV
CCCEEEEEECCCCCCCCCHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHCCCCCCCEEEE
VPHITNEIRNRMYIVAREENPDFIIVEIGGTVGDIESIPFLEAIRQMRYEHGSSNVLFVH
HHHHHHHHCCEEEEEEECCCCCEEEEEECCCCCCCCCCCHHHHHHHHHHHCCCCCEEEEE
LTLVPTITAAGEAKTKPTQHSVKELLGLGIQPDILVCRVSQPMTKEMKNKLSLFCNVKEE
EEEEEEEECCCCCCCCCHHHHHHHHHCCCCCCCEEEEECCCCHHHHHHHHEEEEEECCCC
NVISASDISTSIYEIPKMYKEEKLDEVVLKTMGMELRESNFSEWDKMVKGLLTTKQTVQI
CEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHCCHHHHHHHHHHHHCCCCEEEE
AVVGKYISLQDAYRSIYESLSHGGIAHDTKVEFIKVDPENLNKDSYVEILKKVHGILVPG
EEEECHHHHHHHHHHHHHHHHCCCCCCCCEEEEEEECCCCCCCHHHHHHHHHHCCEEECC
GFGDRGIEGKILAIQYARTNGIPFLGICLGMQCAVVEYGRNVLGLKDANSTEIRPDTEHP
CCCCCCCCCEEEEEEEECCCCCCEEHHHHCCHHHHHHHCCCEEEECCCCCCCCCCCCCCH
VISLLEEQNDIEQMGGTMRLGSYPCKVKENTLSYSEYKSILIHERHRHRFEFTNRYRKQY
HHHHHHHHHHHHHCCCEEEECCCCCEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHH
EENGMIIAGTSPDDNLVEIVEIPKHNWFIGVQFHPEFQSKPTLPHPLFAGFIRASVKYSK
HHCCEEEEECCCCCCEEEEEEECCCCEEEEEEECCCCCCCCCCCCHHHHHHHHHHCCCCC
KG
CC
>Mature Secondary Structure
MEYTLSRTKFIFVTGGVSSSLGKGVTVAALGCLLESRGYTVSLQKMDPYINIDPGTMSPY
CCCCCCCEEEEEEECCCCCHHCCCHHHHHHHHHHHCCCCEEEEEECCCEEEECCCCCCCC
QHGEVYVTADGAETDLDLGYYERFTHSKLTRKNSVSTGQIYNTVIQRERKGDYLGRTVQV
CCCEEEEEECCCCCCCCCHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHCCCCCCCEEEE
VPHITNEIRNRMYIVAREENPDFIIVEIGGTVGDIESIPFLEAIRQMRYEHGSSNVLFVH
HHHHHHHHCCEEEEEEECCCCCEEEEEECCCCCCCCCCCHHHHHHHHHHHCCCCCEEEEE
LTLVPTITAAGEAKTKPTQHSVKELLGLGIQPDILVCRVSQPMTKEMKNKLSLFCNVKEE
EEEEEEEECCCCCCCCCHHHHHHHHHCCCCCCCEEEEECCCCHHHHHHHHEEEEEECCCC
NVISASDISTSIYEIPKMYKEEKLDEVVLKTMGMELRESNFSEWDKMVKGLLTTKQTVQI
CEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHCCHHHHHHHHHHHHCCCCEEEE
AVVGKYISLQDAYRSIYESLSHGGIAHDTKVEFIKVDPENLNKDSYVEILKKVHGILVPG
EEEECHHHHHHHHHHHHHHHHCCCCCCCCEEEEEEECCCCCCCHHHHHHHHHHCCEEECC
GFGDRGIEGKILAIQYARTNGIPFLGICLGMQCAVVEYGRNVLGLKDANSTEIRPDTEHP
CCCCCCCCCEEEEEEEECCCCCCEEHHHHCCHHHHHHHCCCEEEECCCCCCCCCCCCCCH
VISLLEEQNDIEQMGGTMRLGSYPCKVKENTLSYSEYKSILIHERHRHRFEFTNRYRKQY
HHHHHHHHHHHHHCCCEEEECCCCCEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHH
EENGMIIAGTSPDDNLVEIVEIPKHNWFIGVQFHPEFQSKPTLPHPLFAGFIRASVKYSK
HHCCEEEEECCCCCCEEEEEEECCCCEEEEEEECCCCCCCCCCCCHHHHHHHHHHCCCCC
KG
CC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA