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The map label for this gene is panC

Identifier: 45657329

GI number: 45657329

Start: 1791554

End: 1792411

Strand: Direct

Name: panC

Synonym: LIC11454

Alternate gene names: 45657329

Gene position: 1791554-1792411 (Clockwise)

Preceding gene: 45657328

Following gene: 45657330

Centisome position: 41.89

GC content: 36.48

Gene sequence:

>858_bases
ATGATTGTATGTAAAATCCCTGAAGAAGTTTTGGACCAAGTTCGTCTATGGAAAGCCCAAGGAAAAAGGATCGGTTTTGT
TCCTACCATGGGTTTTTTGCACGAGGGTCACGCCTACTTATTTGAAGAATGTATATCCAAAGCGGATAAAACCGTGGTTT
CTATTTTTGTAAACCCCGCTCAGTTTAATGATCCGGAGGATTACGCCAAATATCCGGTCAATACGGAAGGGGATTTGAAA
CTTTGTGAATCTAAAAAGGTAGATCTTGTTTTTTTACCGGACAAAGAAACTATATATCCCGATGGAATTCCAGATATTGT
ATTAAAAATTCCTAATTTAATGAAAAGCTTATGTGCGGTTTCTAGGCCAGGGCATTTTGAAGGTGTACTTCTGGTAATTT
CTAGACTCTTTCATTTTGTACAGCCGGATTTTGCTTTTTTTGGCAAAAAAGATTATCAGCAATATCTACTCATCCGGGAG
TTTTGTAATACTTTGGCCTTTCCGATAGAAGTCATCGGTTGTGAAACGGTACGTTCTTCCCAAGGTTTAGCTCTTAGTTC
TAGAAATTCTCGTCTAAGTGAAACAGAAAAAGAAGAATCACTTTTGATTTATAGATCTCTCAAACTAGGAGAAAATCAAA
TTTTTTCCGGAATAAAAAATCCGCTTTTGGTTAAAGAGATCATGAAGGACGTTTTAGATTCTTCTTCTAAAATTCGTCTG
GATTATTTAGAAATTTTGAATGCAGATACTCTTGACCCTTTGGAAGTTTTAGAAGGAGAAATTTTACTTGCGATTGCCGC
TTTTATAGGCCCAGTGCGTTTGATAGATAACCTTACTTTGAGTGTTCCTATTTCATGA

Upstream 100 bases:

>100_bases
CGTTAAAGTTCTTTCCGAATTCGAGGGTCTTGACGAGGAACACGGAAATTCGGTTAGAATCAGACGGTAAAAGATTAGAA
CTTAAGTATATTTAAATATT

Downstream 100 bases:

>100_bases
AAGATCTTTTGAACATGATAGGCGATGGGGTTTTTTCAAGATTTGAATCTTCTCTTAAAAAAAAGAATTCTACTTCAAAA
ATAAAATCTTCATTTGCGGA

Product: pantoate--beta-alanine ligase

Products: NA

Alternate protein names: PS; Pantoate--beta-alanine ligase; Pantoate-activating enzyme

Number of amino acids: Translated: 285; Mature: 285

Protein sequence:

>285_residues
MIVCKIPEEVLDQVRLWKAQGKRIGFVPTMGFLHEGHAYLFEECISKADKTVVSIFVNPAQFNDPEDYAKYPVNTEGDLK
LCESKKVDLVFLPDKETIYPDGIPDIVLKIPNLMKSLCAVSRPGHFEGVLLVISRLFHFVQPDFAFFGKKDYQQYLLIRE
FCNTLAFPIEVIGCETVRSSQGLALSSRNSRLSETEKEESLLIYRSLKLGENQIFSGIKNPLLVKEIMKDVLDSSSKIRL
DYLEILNADTLDPLEVLEGEILLAIAAFIGPVRLIDNLTLSVPIS

Sequences:

>Translated_285_residues
MIVCKIPEEVLDQVRLWKAQGKRIGFVPTMGFLHEGHAYLFEECISKADKTVVSIFVNPAQFNDPEDYAKYPVNTEGDLK
LCESKKVDLVFLPDKETIYPDGIPDIVLKIPNLMKSLCAVSRPGHFEGVLLVISRLFHFVQPDFAFFGKKDYQQYLLIRE
FCNTLAFPIEVIGCETVRSSQGLALSSRNSRLSETEKEESLLIYRSLKLGENQIFSGIKNPLLVKEIMKDVLDSSSKIRL
DYLEILNADTLDPLEVLEGEILLAIAAFIGPVRLIDNLTLSVPIS
>Mature_285_residues
MIVCKIPEEVLDQVRLWKAQGKRIGFVPTMGFLHEGHAYLFEECISKADKTVVSIFVNPAQFNDPEDYAKYPVNTEGDLK
LCESKKVDLVFLPDKETIYPDGIPDIVLKIPNLMKSLCAVSRPGHFEGVLLVISRLFHFVQPDFAFFGKKDYQQYLLIRE
FCNTLAFPIEVIGCETVRSSQGLALSSRNSRLSETEKEESLLIYRSLKLGENQIFSGIKNPLLVKEIMKDVLDSSSKIRL
DYLEILNADTLDPLEVLEGEILLAIAAFIGPVRLIDNLTLSVPIS

Specific function: Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate

COG id: COG0414

COG function: function code H; Panthothenate synthetase

Gene ontology:

Cell location: Cytoplasm (Potential)

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the pantothenate synthetase family

Homologues:

Organism=Escherichia coli, GI1786325, Length=266, Percent_Identity=40.6015037593985, Blast_Score=207, Evalue=9e-55,
Organism=Saccharomyces cerevisiae, GI6322046, Length=305, Percent_Identity=35.0819672131148, Blast_Score=162, Evalue=5e-41,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): PANC_LEPIC (Q72SD0)

Other databases:

- EMBL:   AE016823
- RefSeq:   YP_001415.1
- HSSP:   P0A5R0
- ProteinModelPortal:   Q72SD0
- SMR:   Q72SD0
- GeneID:   2769926
- GenomeReviews:   AE016823_GR
- KEGG:   lic:LIC11454
- NMPDR:   fig|267671.1.peg.1415
- HOGENOM:   HBG428839
- OMA:   RLIDNFT
- ProtClustDB:   PRK00380
- BioCyc:   LINT267671:LIC_11454-MONOMER
- GO:   GO:0005737
- HAMAP:   MF_00158
- InterPro:   IPR004821
- InterPro:   IPR003721
- InterPro:   IPR014729
- Gene3D:   G3DSA:3.40.50.620
- PANTHER:   PTHR21299:SF1
- TIGRFAMs:   TIGR00125
- TIGRFAMs:   TIGR00018

Pfam domain/function: PF02569 Pantoate_ligase

EC number: =6.3.2.1

Molecular weight: Translated: 32113; Mature: 32113

Theoretical pI: Translated: 4.86; Mature: 4.86

Prosite motif: NA

Important sites: ACT_SITE 37-37 BINDING 61-61 BINDING 61-61 BINDING 154-154 BINDING 177-177

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.1 %Cys     (Translated Protein)
1.4 %Met     (Translated Protein)
3.5 %Cys+Met (Translated Protein)
2.1 %Cys     (Mature Protein)
1.4 %Met     (Mature Protein)
3.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MIVCKIPEEVLDQVRLWKAQGKRIGFVPTMGFLHEGHAYLFEECISKADKTVVSIFVNPA
CEEEECCHHHHHHHHHHHHCCCEEECCCCHHHHHCCHHHHHHHHHHHHCCEEEEEEECCC
QFNDPEDYAKYPVNTEGDLKLCESKKVDLVFLPDKETIYPDGIPDIVLKIPNLMKSLCAV
CCCCCHHHHCCCCCCCCCCEECCCCCEEEEEECCCCCCCCCCCHHHHHHHHHHHHHHHHC
SRPGHFEGVLLVISRLFHFVQPDFAFFGKKDYQQYLLIREFCNTLAFPIEVIGCETVRSS
CCCCCHHHHHHHHHHHHHHHCCCHHHHCCHHHHHHHHHHHHHHHHCCCHHEEEHHHHCCC
QGLALSSRNSRLSETEKEESLLIYRSLKLGENQIFSGIKNPLLVKEIMKDVLDSSSKIRL
CCCEECCCCCCCHHHHHHHHEEEEEHHHCCHHHHHHHCCCHHHHHHHHHHHHCCCCCEEH
DYLEILNADTLDPLEVLEGEILLAIAAFIGPVRLIDNLTLSVPIS
HHHHHHCCCCCCHHHHHCCHHHHHHHHHHHHHHHHHCCEEEEECC
>Mature Secondary Structure
MIVCKIPEEVLDQVRLWKAQGKRIGFVPTMGFLHEGHAYLFEECISKADKTVVSIFVNPA
CEEEECCHHHHHHHHHHHHCCCEEECCCCHHHHHCCHHHHHHHHHHHHCCEEEEEEECCC
QFNDPEDYAKYPVNTEGDLKLCESKKVDLVFLPDKETIYPDGIPDIVLKIPNLMKSLCAV
CCCCCHHHHCCCCCCCCCCEECCCCCEEEEEECCCCCCCCCCCHHHHHHHHHHHHHHHHC
SRPGHFEGVLLVISRLFHFVQPDFAFFGKKDYQQYLLIREFCNTLAFPIEVIGCETVRSS
CCCCCHHHHHHHHHHHHHHHCCCHHHHCCHHHHHHHHHHHHHHHHCCCHHEEEHHHHCCC
QGLALSSRNSRLSETEKEESLLIYRSLKLGENQIFSGIKNPLLVKEIMKDVLDSSSKIRL
CCCEECCCCCCCHHHHHHHHEEEEEHHHCCHHHHHHHCCCHHHHHHHHHHHHCCCCCEEH
DYLEILNADTLDPLEVLEGEILLAIAAFIGPVRLIDNLTLSVPIS
HHHHHHCCCCCCHHHHHCCHHHHHHHHHHHHHHHHHCCEEEEECC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA