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The map label for this gene is hisD

Identifier: 45657328

GI number: 45657328

Start: 1790240

End: 1791523

Strand: Direct

Name: hisD

Synonym: LIC11453

Alternate gene names: 45657328

Gene position: 1790240-1791523 (Clockwise)

Preceding gene: 45657323

Following gene: 45657329

Centisome position: 41.86

GC content: 39.8

Gene sequence:

>1284_bases
ATGGCGATACAAATTTTTAAAGTTGGTTTAAAGGATCATTCTGTTTTAGATCCCGTTTTAAAACGCGCTAGAGAAGACTT
AAGTTCCACGCTGGCTCTCGTAAAGCCGATCGTAGAAGACGTAAAAAATAGAGGAGACTCTGCACTTCGAGAATACACTC
AAAAATTTGACGAGGTTATCCCTCCTAAATCCTTTGTTTTGGAAATTTCTAAACTGAATCCTAAAATCGATCCTAAACTC
AAAACGGCTCTGGTAAAAGCCGCAAAAAATATACGTAACTTTCATAAAATTCAAATTCCAGAAAATAAAGAAATTATAAT
ACATGGAAATAAACTTGGGATCCTCCATACTCCGATTGAATCTGTTTCCGTTTATGCTCCTGGTGGAAAAGCATTGTACC
CATCTACAATTTTAATGGGAGTGATTCCAGCAAAACTCGCCGGAGTAAAAAATATACAAATTGTAACTCCCCCAAGAAAA
GGAACTCTGCCAGATGGTCTGATTGCAGCCGCCAAAATTGCCGGAGCTGATAGAATCGTTATGGCGGGAGGCGCACAGGG
AATTGCAGCGGTTTCTTATGGAACGGAAAGTATTCCTTCTTCCGAATTTGTGGTTGGTCCCGGAAATAAGTTTGTGACCG
CCGCAAAAGTATATTTAAGCGGTCAAGGTGTAATCGGAATCGATAGCCCAGCAGGTCCGAGCGAGGTTTTGATCATAGCC
GACGATTCTGCAGATCCTATGTGGGTTGCGGCAGATCTTTTGTCTCAAGCAGAACACGGAGAAGATTCCGTTGCAATTCT
TTGTACGAATTCTTTATCTCTTGCCCAAAAAGTAAAGGAAGAAGTGGAAAAGGCTCTTATAGAAAGACCTAAAAGGGGAG
AGATGAAACGTAAATCCATCGAAGATCATGGAAAAATATTCGTTTTTTCTAATTTAGAAGAATGTTTTGTATTTTCAAAT
CTGTTTGCTCCCGAACATCTAGAGATCCAAACCAAAAATTTTAAAAAGGATCTAAAAAAAGTAAAACACGCAGGTTCCGT
CTTTTTAGGGAATTATTCTCCGGTTGCCATGGGAGATTATATTAGTGGAACTAATCATATACTTCCAACCGCAGGAGCTG
CTAGGATTTACTCTTCCTTAGGAGTTTCTACGTTCTTAAAACGGGTTACTTGGCAAGAGGTTTCTAAGAAGTCCATCCAA
AATTTGTATCCACACGTTAAAGTTCTTTCCGAATTCGAGGGTCTTGACGAGGAACACGGAAATTCGGTTAGAATCAGACG
GTAA

Upstream 100 bases:

>100_bases
TAAGCAGAGTGTAAATTGGAGGAATTCCTTTTATAAGCAATTGTTTTTTGAATAAATTTCAGATGCAAGATTCGTTCTTT
TGGAAAATCTGGTTTCTTAG

Downstream 100 bases:

>100_bases
AAGATTAGAACTTAAGTATATTTAAATATTATGATTGTATGTAAAATCCCTGAAGAAGTTTTGGACCAAGTTCGTCTATG
GAAAGCCCAAGGAAAAAGGA

Product: histidinol dehydrogenase

Products: NA

Alternate protein names: HDH

Number of amino acids: Translated: 427; Mature: 426

Protein sequence:

>427_residues
MAIQIFKVGLKDHSVLDPVLKRAREDLSSTLALVKPIVEDVKNRGDSALREYTQKFDEVIPPKSFVLEISKLNPKIDPKL
KTALVKAAKNIRNFHKIQIPENKEIIIHGNKLGILHTPIESVSVYAPGGKALYPSTILMGVIPAKLAGVKNIQIVTPPRK
GTLPDGLIAAAKIAGADRIVMAGGAQGIAAVSYGTESIPSSEFVVGPGNKFVTAAKVYLSGQGVIGIDSPAGPSEVLIIA
DDSADPMWVAADLLSQAEHGEDSVAILCTNSLSLAQKVKEEVEKALIERPKRGEMKRKSIEDHGKIFVFSNLEECFVFSN
LFAPEHLEIQTKNFKKDLKKVKHAGSVFLGNYSPVAMGDYISGTNHILPTAGAARIYSSLGVSTFLKRVTWQEVSKKSIQ
NLYPHVKVLSEFEGLDEEHGNSVRIRR

Sequences:

>Translated_427_residues
MAIQIFKVGLKDHSVLDPVLKRAREDLSSTLALVKPIVEDVKNRGDSALREYTQKFDEVIPPKSFVLEISKLNPKIDPKL
KTALVKAAKNIRNFHKIQIPENKEIIIHGNKLGILHTPIESVSVYAPGGKALYPSTILMGVIPAKLAGVKNIQIVTPPRK
GTLPDGLIAAAKIAGADRIVMAGGAQGIAAVSYGTESIPSSEFVVGPGNKFVTAAKVYLSGQGVIGIDSPAGPSEVLIIA
DDSADPMWVAADLLSQAEHGEDSVAILCTNSLSLAQKVKEEVEKALIERPKRGEMKRKSIEDHGKIFVFSNLEECFVFSN
LFAPEHLEIQTKNFKKDLKKVKHAGSVFLGNYSPVAMGDYISGTNHILPTAGAARIYSSLGVSTFLKRVTWQEVSKKSIQ
NLYPHVKVLSEFEGLDEEHGNSVRIRR
>Mature_426_residues
AIQIFKVGLKDHSVLDPVLKRAREDLSSTLALVKPIVEDVKNRGDSALREYTQKFDEVIPPKSFVLEISKLNPKIDPKLK
TALVKAAKNIRNFHKIQIPENKEIIIHGNKLGILHTPIESVSVYAPGGKALYPSTILMGVIPAKLAGVKNIQIVTPPRKG
TLPDGLIAAAKIAGADRIVMAGGAQGIAAVSYGTESIPSSEFVVGPGNKFVTAAKVYLSGQGVIGIDSPAGPSEVLIIAD
DSADPMWVAADLLSQAEHGEDSVAILCTNSLSLAQKVKEEVEKALIERPKRGEMKRKSIEDHGKIFVFSNLEECFVFSNL
FAPEHLEIQTKNFKKDLKKVKHAGSVFLGNYSPVAMGDYISGTNHILPTAGAARIYSSLGVSTFLKRVTWQEVSKKSIQN
LYPHVKVLSEFEGLDEEHGNSVRIRR

Specific function: Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine

COG id: COG0141

COG function: function code E; Histidinol dehydrogenase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the histidinol dehydrogenase family

Homologues:

Organism=Escherichia coli, GI1788331, Length=409, Percent_Identity=43.2762836185819, Blast_Score=301, Evalue=5e-83,
Organism=Saccharomyces cerevisiae, GI6319819, Length=427, Percent_Identity=42.6229508196721, Blast_Score=304, Evalue=2e-83,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): HISX_LEPIC (P62458)

Other databases:

- EMBL:   AE016823
- RefSeq:   YP_001414.1
- ProteinModelPortal:   P62458
- SMR:   P62458
- GeneID:   2772163
- GenomeReviews:   AE016823_GR
- KEGG:   lic:LIC11453
- NMPDR:   fig|267671.1.peg.1414
- HOGENOM:   HBG329596
- OMA:   LDAHKNA
- ProtClustDB:   PRK00877
- BioCyc:   LINT-130-01:LINT-130-01-001414-MONOMER
- BioCyc:   LINT267671:LIC_11453-MONOMER
- HAMAP:   MF_01024
- InterPro:   IPR016161
- InterPro:   IPR022695
- InterPro:   IPR001692
- InterPro:   IPR012131
- PANTHER:   PTHR21256:SF2
- PIRSF:   PIRSF000099
- PRINTS:   PR00083
- TIGRFAMs:   TIGR00069

Pfam domain/function: PF00815 Histidinol_dh; SSF53720 Aldehyde_DH/Histidinol_DH

EC number: =1.1.1.23

Molecular weight: Translated: 46381; Mature: 46250

Theoretical pI: Translated: 9.67; Mature: 9.67

Prosite motif: PS00611 HISOL_DEHYDROGENASE

Important sites: ACT_SITE 325-325 ACT_SITE 326-326 BINDING 125-125 BINDING 186-186 BINDING 209-209 BINDING 234-234 BINDING 256-256 BINDING 259-259 BINDING 326-326 BINDING 359-359 BINDING 413-413 BINDING 419-419

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
1.4 %Met     (Translated Protein)
1.9 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
1.2 %Met     (Mature Protein)
1.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAIQIFKVGLKDHSVLDPVLKRAREDLSSTLALVKPIVEDVKNRGDSALREYTQKFDEVI
CEEEEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHC
PPKSFVLEISKLNPKIDPKLKTALVKAAKNIRNFHKIQIPENKEIIIHGNKLGILHTPIE
CCHHHEEEEECCCCCCCHHHHHHHHHHHHHHCCCEEEECCCCCEEEEECCEEEEEECCCC
SVSVYAPGGKALYPSTILMGVIPAKLAGVKNIQIVTPPRKGTLPDGLIAAAKIAGADRIV
CEEEECCCCCCCCHHHHHHHHHHHHHCCCCEEEEECCCCCCCCCCHHHHHHHHCCCCEEE
MAGGAQGIAAVSYGTESIPSSEFVVGPGNKFVTAAKVYLSGQGVIGIDSPAGPSEVLIIA
EECCCCCEEEEECCCCCCCCCCEEECCCCCEEEEEEEEEECCCEEEECCCCCCCEEEEEE
DDSADPMWVAADLLSQAEHGEDSVAILCTNSLSLAQKVKEEVEKALIERPKRGEMKRKSI
CCCCCCHHHHHHHHHHHCCCCCCEEEEEECCHHHHHHHHHHHHHHHHCCCCCCCHHHHHH
EDHGKIFVFSNLEECFVFSNLFAPEHLEIQTKNFKKDLKKVKHAGSVFLGNYSPVAMGDY
HCCCCEEEECCHHHHHHHHHCCCCCCEEEEHHHHHHHHHHHHHCCCEEECCCCCEECCCC
ISGTNHILPTAGAARIYSSLGVSTFLKRVTWQEVSKKSIQNLYPHVKVLSEFEGLDEEHG
CCCCCCCCCCCHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCC
NSVRIRR
CEEEEEC
>Mature Secondary Structure 
AIQIFKVGLKDHSVLDPVLKRAREDLSSTLALVKPIVEDVKNRGDSALREYTQKFDEVI
EEEEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHC
PPKSFVLEISKLNPKIDPKLKTALVKAAKNIRNFHKIQIPENKEIIIHGNKLGILHTPIE
CCHHHEEEEECCCCCCCHHHHHHHHHHHHHHCCCEEEECCCCCEEEEECCEEEEEECCCC
SVSVYAPGGKALYPSTILMGVIPAKLAGVKNIQIVTPPRKGTLPDGLIAAAKIAGADRIV
CEEEECCCCCCCCHHHHHHHHHHHHHCCCCEEEEECCCCCCCCCCHHHHHHHHCCCCEEE
MAGGAQGIAAVSYGTESIPSSEFVVGPGNKFVTAAKVYLSGQGVIGIDSPAGPSEVLIIA
EECCCCCEEEEECCCCCCCCCCEEECCCCCEEEEEEEEEECCCEEEECCCCCCCEEEEEE
DDSADPMWVAADLLSQAEHGEDSVAILCTNSLSLAQKVKEEVEKALIERPKRGEMKRKSI
CCCCCCHHHHHHHHHHHCCCCCCEEEEEECCHHHHHHHHHHHHHHHHCCCCCCCHHHHHH
EDHGKIFVFSNLEECFVFSNLFAPEHLEIQTKNFKKDLKKVKHAGSVFLGNYSPVAMGDY
HCCCCEEEECCHHHHHHHHHCCCCCCEEEEHHHHHHHHHHHHHCCCEEECCCCCEECCCC
ISGTNHILPTAGAARIYSSLGVSTFLKRVTWQEVSKKSIQNLYPHVKVLSEFEGLDEEHG
CCCCCCCCCCCHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCC
NSVRIRR
CEEEEEC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA