Click here to switch to the map view.

The map label for this gene is pepP

Identifier: 45657193

GI number: 45657193

Start: 1620508

End: 1621797

Strand: Direct

Name: pepP

Synonym: LIC11313

Alternate gene names: 45657193

Gene position: 1620508-1621797 (Clockwise)

Preceding gene: 45657192

Following gene: 45657194

Centisome position: 37.89

GC content: 37.13

Gene sequence:

>1290_bases
ATGACTTCATATATTTATTCGGAACGAATCGAAAAAGTTCAAAAAAGATTAAAAGATGGTGAGGTTTTGATCGTCTTTGC
GGCTTCTCATTTAATCCGAAATCGGGACGTAGAATATAAATTTCGCCAGGACTCCGATTATTATTATCTAACTGGTATTG
AGGAATCGGATGGAATTCTAATATTAAAAAATTCTTATAAATCGATTTTTGTACTTCCAAAAGATAAAGATAAAGAAATC
TGGACCGGAATTAGAATCGGGAAAGAAAAAGCGAAAGAACTGTTAGGTTTGGACGAGTCTTTTGATACGAACGAATGGGA
ATCAAAGCTGGATGAAATTTTACTCAACCAACATACTTTGTTTCATTTTTTTGGAAAAAATTTGGTTCGTGATTCTAAAC
TTATCGAATGGATTTATTCTCTCAATCAAAGATCCAGAGAAGGCAAGTTCGGTCCTAAAAGGATTGAAACTCCGGATTTT
TTACATTGGATGAGAATGTTTAAGTCTGCCGTGGAAATAGAAGCTCTTCGAGAATCTGCAAGAATCACTGCTTTAGGTCA
TGTAAGATTGATGAGAGAATCTAAACCTGGAATGTTTGAATATGAACTCGAAGCGATTTTAGAATCTGAATATTTAAAAC
ACGGGGCTTGGGGGGGCGGTTACGGACATATCGTCGCAAGTGGAAAAAACGCAACCATTCTTCATTATACGTCTAACAAC
TGTCAGTTGAAACCAGGAGATCTTGTGTTGGTGGACAGCGGGGCTGAAAAAGGATATTATACTGCAGACGTGACTCGTAA
CTTTCCCGTAGGAAAAAAATTTTCTCCTGAACAAAAGGCGGTCTACGAAGTGGTTTTGAGAGCACAGAAAGAAGCTGTTT
CCAATACGAAGGAAGGAGTGGAATTTGCTTCGATCCATAATCAAGCCGTTAAAACTCTTGTAGAAGGTTTGAAAGACTTA
GGCCTTTTGGAAGGTTCTATGGATTTCATTTTAGAGCAAAATACATTCAAAAAATATTATATGCATAGAACCAGTCATTA
TCTAGGTATGGATGTGCACGATGTAGGTTCCTATTATAAAGACGGAGCTTCTTGGTCTTTGCAGGACGGTCAGGTAATTA
CGATTGAACCGGGGCTTTATTTTGATCCTACTGATCTTACAATTCCAGAAAAATTTAGAGGGATAGGGATTCGGATAGAA
GACGATGTTTTGGTTCAAGGTCAAAACCCAGTAAATCTTACGTCTTTGATTCCCAAAGAAATTGATGAAATAGAATCTCT
CAAAAACTGA

Upstream 100 bases:

>100_bases
GTGGTAGAACTTGTCCTGAAGGACATTTTCGTTGTATGAAGGAACAAGATACCAATAAAATGTTTGAAGTAGCAGTCCAA
TTAGAACAAGGAAATGTAAA

Downstream 100 bases:

>100_bases
ACTTGAAATTTAAGAAAAACCTTTTCCTGATTATTTTTAAAGTTTATCTAAGAACTTGAGTATGTGGGAGTCTTACAATT
TTTAAGGACGGAAGTACGTT

Product: aminopeptidase P

Products: NA

Alternate protein names: Aminoacylproline aminopeptidase; Aminopeptidase P II; APP-II; X-Pro aminopeptidase [H]

Number of amino acids: Translated: 429; Mature: 428

Protein sequence:

>429_residues
MTSYIYSERIEKVQKRLKDGEVLIVFAASHLIRNRDVEYKFRQDSDYYYLTGIEESDGILILKNSYKSIFVLPKDKDKEI
WTGIRIGKEKAKELLGLDESFDTNEWESKLDEILLNQHTLFHFFGKNLVRDSKLIEWIYSLNQRSREGKFGPKRIETPDF
LHWMRMFKSAVEIEALRESARITALGHVRLMRESKPGMFEYELEAILESEYLKHGAWGGGYGHIVASGKNATILHYTSNN
CQLKPGDLVLVDSGAEKGYYTADVTRNFPVGKKFSPEQKAVYEVVLRAQKEAVSNTKEGVEFASIHNQAVKTLVEGLKDL
GLLEGSMDFILEQNTFKKYYMHRTSHYLGMDVHDVGSYYKDGASWSLQDGQVITIEPGLYFDPTDLTIPEKFRGIGIRIE
DDVLVQGQNPVNLTSLIPKEIDEIESLKN

Sequences:

>Translated_429_residues
MTSYIYSERIEKVQKRLKDGEVLIVFAASHLIRNRDVEYKFRQDSDYYYLTGIEESDGILILKNSYKSIFVLPKDKDKEI
WTGIRIGKEKAKELLGLDESFDTNEWESKLDEILLNQHTLFHFFGKNLVRDSKLIEWIYSLNQRSREGKFGPKRIETPDF
LHWMRMFKSAVEIEALRESARITALGHVRLMRESKPGMFEYELEAILESEYLKHGAWGGGYGHIVASGKNATILHYTSNN
CQLKPGDLVLVDSGAEKGYYTADVTRNFPVGKKFSPEQKAVYEVVLRAQKEAVSNTKEGVEFASIHNQAVKTLVEGLKDL
GLLEGSMDFILEQNTFKKYYMHRTSHYLGMDVHDVGSYYKDGASWSLQDGQVITIEPGLYFDPTDLTIPEKFRGIGIRIE
DDVLVQGQNPVNLTSLIPKEIDEIESLKN
>Mature_428_residues
TSYIYSERIEKVQKRLKDGEVLIVFAASHLIRNRDVEYKFRQDSDYYYLTGIEESDGILILKNSYKSIFVLPKDKDKEIW
TGIRIGKEKAKELLGLDESFDTNEWESKLDEILLNQHTLFHFFGKNLVRDSKLIEWIYSLNQRSREGKFGPKRIETPDFL
HWMRMFKSAVEIEALRESARITALGHVRLMRESKPGMFEYELEAILESEYLKHGAWGGGYGHIVASGKNATILHYTSNNC
QLKPGDLVLVDSGAEKGYYTADVTRNFPVGKKFSPEQKAVYEVVLRAQKEAVSNTKEGVEFASIHNQAVKTLVEGLKDLG
LLEGSMDFILEQNTFKKYYMHRTSHYLGMDVHDVGSYYKDGASWSLQDGQVITIEPGLYFDPTDLTIPEKFRGIGIRIED
DVLVQGQNPVNLTSLIPKEIDEIESLKN

Specific function: Unknown

COG id: COG0006

COG function: function code E; Xaa-Pro aminopeptidase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the peptidase M24B family [H]

Homologues:

Organism=Homo sapiens, GI11559925, Length=423, Percent_Identity=33.3333333333333, Blast_Score=236, Evalue=3e-62,
Organism=Homo sapiens, GI149589008, Length=463, Percent_Identity=28.9416846652268, Blast_Score=182, Evalue=7e-46,
Organism=Homo sapiens, GI260593665, Length=297, Percent_Identity=34.006734006734, Blast_Score=171, Evalue=1e-42,
Organism=Homo sapiens, GI260593663, Length=457, Percent_Identity=25.601750547046, Blast_Score=140, Evalue=3e-33,
Organism=Escherichia coli, GI1789275, Length=428, Percent_Identity=38.3177570093458, Blast_Score=320, Evalue=1e-88,
Organism=Escherichia coli, GI1788728, Length=269, Percent_Identity=29.368029739777, Blast_Score=96, Evalue=4e-21,
Organism=Escherichia coli, GI1790282, Length=290, Percent_Identity=27.9310344827586, Blast_Score=95, Evalue=1e-20,
Organism=Caenorhabditis elegans, GI17508215, Length=437, Percent_Identity=29.0617848970252, Blast_Score=167, Evalue=1e-41,
Organism=Caenorhabditis elegans, GI71989583, Length=271, Percent_Identity=32.4723247232472, Blast_Score=130, Evalue=1e-30,
Organism=Saccharomyces cerevisiae, GI6320922, Length=439, Percent_Identity=29.8405466970387, Blast_Score=172, Evalue=1e-43,
Organism=Saccharomyces cerevisiae, GI6321118, Length=428, Percent_Identity=28.7383177570093, Blast_Score=160, Evalue=3e-40,
Organism=Drosophila melanogaster, GI19920384, Length=394, Percent_Identity=32.741116751269, Blast_Score=202, Evalue=2e-52,
Organism=Drosophila melanogaster, GI21357079, Length=457, Percent_Identity=30.6345733041575, Blast_Score=186, Evalue=2e-47,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001714
- InterPro:   IPR000994
- InterPro:   IPR007865
- InterPro:   IPR001131 [H]

Pfam domain/function: PF05195 AMP_N; PF00557 Peptidase_M24 [H]

EC number: =3.4.11.9 [H]

Molecular weight: Translated: 49193; Mature: 49061

Theoretical pI: Translated: 5.97; Mature: 5.97

Prosite motif: PS00491 PROLINE_PEPTIDASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.2 %Cys     (Translated Protein)
1.9 %Met     (Translated Protein)
2.1 %Cys+Met (Translated Protein)
0.2 %Cys     (Mature Protein)
1.6 %Met     (Mature Protein)
1.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTSYIYSERIEKVQKRLKDGEVLIVFAASHLIRNRDVEYKFRQDSDYYYLTGIEESDGIL
CCCHHHHHHHHHHHHHCCCCCEEEEEEHHHHHHCCCCCEEEECCCCEEEEEECCCCCCEE
ILKNSYKSIFVLPKDKDKEIWTGIRIGKEKAKELLGLDESFDTNEWESKLDEILLNQHTL
EEECCCCEEEEEECCCCCHHHHHHEECHHHHHHHHCCCCCCCCCHHHHHHHHHHHCCHHH
FHFFGKNLVRDSKLIEWIYSLNQRSREGKFGPKRIETPDFLHWMRMFKSAVEIEALRESA
HHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHCC
RITALGHVRLMRESKPGMFEYELEAILESEYLKHGAWGGGYGHIVASGKNATILHYTSNN
CEEEEHHEEEEECCCCCEEHHHHHHHHHHHHHHCCCCCCCCEEEEECCCCEEEEEEECCC
CQLKPGDLVLVDSGAEKGYYTADVTRNFPVGKKFSPEQKAVYEVVLRAQKEAVSNTKEGV
CEECCCCEEEEECCCCCCEEEEECCCCCCCCCCCCCHHHHHHHHHHHHHHHHHCCHHHCC
EFASIHNQAVKTLVEGLKDLGLLEGSMDFILEQNTFKKYYMHRTSHYLGMDVHDVGSYYK
HHHHHHHHHHHHHHHHHHHHHHHCCCHHHEEECCHHHHHHHHHHCCCCCCCHHHHHHHHC
DGASWSLQDGQVITIEPGLYFDPTDLTIPEKFRGIGIRIEDDVLVQGQNPVNLTSLIPKE
CCCCEEECCCEEEEECCCCEECCCCCCCCHHHCCCCEEEECCEEEECCCCCCHHHHHHHH
IDEIESLKN
HHHHHHHCC
>Mature Secondary Structure 
TSYIYSERIEKVQKRLKDGEVLIVFAASHLIRNRDVEYKFRQDSDYYYLTGIEESDGIL
CCHHHHHHHHHHHHHCCCCCEEEEEEHHHHHHCCCCCEEEECCCCEEEEEECCCCCCEE
ILKNSYKSIFVLPKDKDKEIWTGIRIGKEKAKELLGLDESFDTNEWESKLDEILLNQHTL
EEECCCCEEEEEECCCCCHHHHHHEECHHHHHHHHCCCCCCCCCHHHHHHHHHHHCCHHH
FHFFGKNLVRDSKLIEWIYSLNQRSREGKFGPKRIETPDFLHWMRMFKSAVEIEALRESA
HHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHCC
RITALGHVRLMRESKPGMFEYELEAILESEYLKHGAWGGGYGHIVASGKNATILHYTSNN
CEEEEHHEEEEECCCCCEEHHHHHHHHHHHHHHCCCCCCCCEEEEECCCCEEEEEEECCC
CQLKPGDLVLVDSGAEKGYYTADVTRNFPVGKKFSPEQKAVYEVVLRAQKEAVSNTKEGV
CEECCCCEEEEECCCCCCEEEEECCCCCCCCCCCCCHHHHHHHHHHHHHHHHHCCHHHCC
EFASIHNQAVKTLVEGLKDLGLLEGSMDFILEQNTFKKYYMHRTSHYLGMDVHDVGSYYK
HHHHHHHHHHHHHHHHHHHHHHHCCCHHHEEECCHHHHHHHHHHCCCCCCCHHHHHHHHC
DGASWSLQDGQVITIEPGLYFDPTDLTIPEKFRGIGIRIEDDVLVQGQNPVNLTSLIPKE
CCCCEEECCCEEEEECCCCEECCCCCCCCHHHCCCCEEEECCEEEECCCCCCHHHHHHHH
IDEIESLKN
HHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 2659585; 1339425; 9278503; 9520390 [H]