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The map label for this gene is cofH [H]

Identifier: 45657178

GI number: 45657178

Start: 1605283

End: 1606386

Strand: Direct

Name: cofH [H]

Synonym: LIC11298

Alternate gene names: 45657178

Gene position: 1605283-1606386 (Clockwise)

Preceding gene: 45657177

Following gene: 45657179

Centisome position: 37.53

GC content: 38.95

Gene sequence:

>1104_bases
GTGGCTTCTATTTTTTCATCTCAACCCACAGATCGTATTTTAGAAAAAGCATTGGATGGGAATCGGATTTCTCCCGAAGA
GGCTTTGGCTTTATACCGAGAAGGAGATCATCTTAAGATTATGGCGACTGCGCGCTCGCTTCGAGAAAAAATTCTACCTC
ATCACTATGCTAGTTATACGATGTTTCGGGTTGTGAATTATACAAATTACTGCAATGTAGAATGTAGTTTTTGCTCTTTT
ATGGATGAGATTGGAAACGGTAAGGGTTATGTATTATCCGTAGAAGAAATTTTGGAGAAGATGGACTATGCGGTTGGTGA
AGGTGCTGATCAAATGTTTTTACAAGGAGGGGTTTATCCAGATCTGTCTTTTGATTATTATCTGAATGTAATTTCTGCTG
TAAAAAAGAAATACCCACACATGCATATTCGTGCTTTTTCTCCGGTTGAAATTATTAACTTAGAAAAAATTACCGGACTT
CCACTCAAAGAAGTGCTTCAAATTTTAAAACAAACCGGATTAGATTCTGTTCCTGGAGCGGGGGCAGAAATTCTAACGGA
CAGAATGAGAAATATCATATCACCTAAAAAAGCAACCACAGAAGAATGGGTTCGTGCGATGGAAACCTGTCACGAAGTCG
GACTTCCAGGAAGTGCAAACATAGTATTCGGTTCGGAAGAAACTCAAGAAGAAGTGATCGAACATTTAAACGTTGTGCGA
AATCTACAAGATAGAACCGGAGGGTTTTTATCTTTTATTCCTTGGACCTTCCAACCACAAACGAAACGATTCAAAGTTCG
TGCGGTTCCAACTCAGGAATATCTAAAGGTTCTCGGAATTTGTAGGATTTTTTTAGATAACATTCTACATATCGAAACTT
CGGTGATGGTTTTAGGCAAAGGAGTAGGGCAATTGGCTCTCACAAGCGGTGCGGACGATATATCCTCTGTGGTCATAGAA
GAAAACGTTTTGCGTTCTTACGGACTAAAGACCGAAAAGGAAGCGGTGAAGTTTTTAAAAGAAGGTGGATTTACTCCTAA
ACGAAGAGATCTTCTCTATAATTATGATCGATACGAAAACGAGTTGATCGTAGATTTTGTTTAG

Upstream 100 bases:

>100_bases
AAGTCTGCGCCTTTCAAAGTTTTAGAAAATGGCTTCGATTATTGAAATTACCGGAACTTTTTTATATATATTTAGATGGA
CTGGATCCTAAGGAGTAAAC

Downstream 100 bases:

>100_bases
AGAATTGATCGTGAATAGGGTTGCGCTTAAATAACGTGAGTTCGGAATAAGAAAAAATTTTCTAAAAGTACTAATTCCTA
CAATTTTAAAATTTGTTTCT

Product: hypothetical protein

Products: NA

Alternate protein names: 7,8-didemethyl-8-hydroxy-5-deazariboflavin synthase subunit 2 [H]

Number of amino acids: Translated: 367; Mature: 366

Protein sequence:

>367_residues
MASIFSSQPTDRILEKALDGNRISPEEALALYREGDHLKIMATARSLREKILPHHYASYTMFRVVNYTNYCNVECSFCSF
MDEIGNGKGYVLSVEEILEKMDYAVGEGADQMFLQGGVYPDLSFDYYLNVISAVKKKYPHMHIRAFSPVEIINLEKITGL
PLKEVLQILKQTGLDSVPGAGAEILTDRMRNIISPKKATTEEWVRAMETCHEVGLPGSANIVFGSEETQEEVIEHLNVVR
NLQDRTGGFLSFIPWTFQPQTKRFKVRAVPTQEYLKVLGICRIFLDNILHIETSVMVLGKGVGQLALTSGADDISSVVIE
ENVLRSYGLKTEKEAVKFLKEGGFTPKRRDLLYNYDRYENELIVDFV

Sequences:

>Translated_367_residues
MASIFSSQPTDRILEKALDGNRISPEEALALYREGDHLKIMATARSLREKILPHHYASYTMFRVVNYTNYCNVECSFCSF
MDEIGNGKGYVLSVEEILEKMDYAVGEGADQMFLQGGVYPDLSFDYYLNVISAVKKKYPHMHIRAFSPVEIINLEKITGL
PLKEVLQILKQTGLDSVPGAGAEILTDRMRNIISPKKATTEEWVRAMETCHEVGLPGSANIVFGSEETQEEVIEHLNVVR
NLQDRTGGFLSFIPWTFQPQTKRFKVRAVPTQEYLKVLGICRIFLDNILHIETSVMVLGKGVGQLALTSGADDISSVVIE
ENVLRSYGLKTEKEAVKFLKEGGFTPKRRDLLYNYDRYENELIVDFV
>Mature_366_residues
ASIFSSQPTDRILEKALDGNRISPEEALALYREGDHLKIMATARSLREKILPHHYASYTMFRVVNYTNYCNVECSFCSFM
DEIGNGKGYVLSVEEILEKMDYAVGEGADQMFLQGGVYPDLSFDYYLNVISAVKKKYPHMHIRAFSPVEIINLEKITGLP
LKEVLQILKQTGLDSVPGAGAEILTDRMRNIISPKKATTEEWVRAMETCHEVGLPGSANIVFGSEETQEEVIEHLNVVRN
LQDRTGGFLSFIPWTFQPQTKRFKVRAVPTQEYLKVLGICRIFLDNILHIETSVMVLGKGVGQLALTSGADDISSVVIEE
NVLRSYGLKTEKEAVKFLKEGGFTPKRRDLLYNYDRYENELIVDFV

Specific function: Catalyzes the radical-mediated transfer of the hydroxybenzyl group from 4-hydroxyphenylpyruvate (HPP) to 5-amino- 6-ribitylamino-2,4(1H,3H)-pyrimidinedione to form 7,8-didemethyl- 8-hydroxy-5-deazariboflavin (FO) [H]

COG id: COG1060

COG function: function code HR; Thiamine biosynthesis enzyme ThiH and related uncharacterized enzymes

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the radical SAM superfamily. CofH family [H]

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013785
- InterPro:   IPR019940
- InterPro:   IPR006638
- InterPro:   IPR020050
- InterPro:   IPR005244
- InterPro:   IPR007197 [H]

Pfam domain/function: PF04055 Radical_SAM [H]

EC number: NA

Molecular weight: Translated: 41498; Mature: 41367

Theoretical pI: Translated: 5.49; Mature: 5.49

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.4 %Cys     (Translated Protein)
2.7 %Met     (Translated Protein)
4.1 %Cys+Met (Translated Protein)
1.4 %Cys     (Mature Protein)
2.5 %Met     (Mature Protein)
3.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MASIFSSQPTDRILEKALDGNRISPEEALALYREGDHLKIMATARSLREKILPHHYASYT
CCCCCCCCCHHHHHHHHCCCCCCCHHHHHHHHCCCCCEEEHHHHHHHHHHHCCHHHHHHH
MFRVVNYTNYCNVECSFCSFMDEIGNGKGYVLSVEEILEKMDYAVGEGADQMFLQGGVYP
HHHHHCCCCCCCCEEHHHHHHHHHCCCCEEEEEHHHHHHHHHHHHCCCCHHHHHCCCCCC
DLSFDYYLNVISAVKKKYPHMHIRAFSPVEIINLEKITGLPLKEVLQILKQTGLDSVPGA
CCCHHHHHHHHHHHHHHCCCEEEEECCCEEEEEHHHHCCCCHHHHHHHHHHCCCCCCCCC
GAEILTDRMRNIISPKKATTEEWVRAMETCHEVGLPGSANIVFGSEETQEEVIEHLNVVR
CHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHCCCCCCCEEEECCCHHHHHHHHHHHHHH
NLQDRTGGFLSFIPWTFQPQTKRFKVRAVPTQEYLKVLGICRIFLDNILHIETSVMVLGK
HHHHHCCCEEEECCCCCCCCCCEEEEEECCHHHHHHHHHHHHHHHHHHHHHHHHHHEECC
GVGQLALTSGADDISSVVIEENVLRSYGLKTEKEAVKFLKEGGFTPKRRDLLYNYDRYEN
CCCCEEEECCCHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHCCCCCCHHHHHCCCCCCCC
ELIVDFV
CEEEEEC
>Mature Secondary Structure 
ASIFSSQPTDRILEKALDGNRISPEEALALYREGDHLKIMATARSLREKILPHHYASYT
CCCCCCCCHHHHHHHHCCCCCCCHHHHHHHHCCCCCEEEHHHHHHHHHHHCCHHHHHHH
MFRVVNYTNYCNVECSFCSFMDEIGNGKGYVLSVEEILEKMDYAVGEGADQMFLQGGVYP
HHHHHCCCCCCCCEEHHHHHHHHHCCCCEEEEEHHHHHHHHHHHHCCCCHHHHHCCCCCC
DLSFDYYLNVISAVKKKYPHMHIRAFSPVEIINLEKITGLPLKEVLQILKQTGLDSVPGA
CCCHHHHHHHHHHHHHHCCCEEEEECCCEEEEEHHHHCCCCHHHHHHHHHHCCCCCCCCC
GAEILTDRMRNIISPKKATTEEWVRAMETCHEVGLPGSANIVFGSEETQEEVIEHLNVVR
CHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHCCCCCCCEEEECCCHHHHHHHHHHHHHH
NLQDRTGGFLSFIPWTFQPQTKRFKVRAVPTQEYLKVLGICRIFLDNILHIETSVMVLGK
HHHHHCCCEEEECCCCCCCCCCEEEEEECCHHHHHHHHHHHHHHHHHHHHHHHHHHEECC
GVGQLALTSGADDISSVVIEENVLRSYGLKTEKEAVKFLKEGGFTPKRRDLLYNYDRYEN
CCCCEEEECCCHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHCCCCCCHHHHHCCCCCCCC
ELIVDFV
CEEEEEC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9371463 [H]