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The map label for this gene is ahpC

Identifier: 45657102

GI number: 45657102

Start: 1502226

End: 1502807

Strand: Direct

Name: ahpC

Synonym: LIC11219

Alternate gene names: 45657102

Gene position: 1502226-1502807 (Clockwise)

Preceding gene: 45657101

Following gene: 45657103

Centisome position: 35.12

GC content: 40.89

Gene sequence:

>582_bases
ATGCCTCAGGTCACATCTTTAGCGCCAGATTTTAAGGCAGAAGCCGTCCTTGGAAAAGAAATCAAGGAAATTAAACTTTC
AGACTACAAAGGAAAATGGGTAGTATTGTTCTTTTACCCACTTGATTTTACTTTCGTTTGCCCGACTGAGATCATCGAAT
ACGATAACAAACTTGCGGAATTCAAAAAACTGGGAACAGAAGTGTTGGGAGTTTCTGTGGACTCTGCATTTACTCACCTC
GCCTGGAAAAATACTCCTAAAAAAGAAGGAGGAATCGGCGAAATTAAATATCCTCTCATTGCGGATCTAACCAAATCTAT
TTCCAGAGATTATAACGTTTTGACGGAAGGAGGAGTGGCTCTAAGAGGGACTTTTATCATCGATCCCGCAGGTGTAATTC
GTCAAGCGACCATCAATGATCTTCCAGTAGGACGTAATATTGATGAAGCGATTCGTTTGATCAAAGCGTTTCAATTTGTT
GAAAAACACGGAGAAGTCTGCCCTGCCAATTGGGACGAAGGAAAGAAAACGATGAAAGCAGATCCAGAAAAATCTAAGGA
TTACTTTGCTGCCGTGAATTGA

Upstream 100 bases:

>100_bases
AAAATTAGAATGATTCTAAAAAATATTTGCTTCAAAGGGATTGAAGGATATTATGGAAGTGTCTAAGTTTCAAAATTAAA
TTTAAAAAAGGAGAATTAAA

Downstream 100 bases:

>100_bases
TTTTTTCCTATCCGCAGACGTAAGTCTGCGGATGATGACACTAACGATTTGAAAGAACCTAAAATCGGAAGGATTAAAAA
AGTAGTCTTGCCATTTGTGT

Product: peroxiredoxin

Products: NA

Alternate protein names: Thioredoxin reductase [H]

Number of amino acids: Translated: 193; Mature: 192

Protein sequence:

>193_residues
MPQVTSLAPDFKAEAVLGKEIKEIKLSDYKGKWVVLFFYPLDFTFVCPTEIIEYDNKLAEFKKLGTEVLGVSVDSAFTHL
AWKNTPKKEGGIGEIKYPLIADLTKSISRDYNVLTEGGVALRGTFIIDPAGVIRQATINDLPVGRNIDEAIRLIKAFQFV
EKHGEVCPANWDEGKKTMKADPEKSKDYFAAVN

Sequences:

>Translated_193_residues
MPQVTSLAPDFKAEAVLGKEIKEIKLSDYKGKWVVLFFYPLDFTFVCPTEIIEYDNKLAEFKKLGTEVLGVSVDSAFTHL
AWKNTPKKEGGIGEIKYPLIADLTKSISRDYNVLTEGGVALRGTFIIDPAGVIRQATINDLPVGRNIDEAIRLIKAFQFV
EKHGEVCPANWDEGKKTMKADPEKSKDYFAAVN
>Mature_192_residues
PQVTSLAPDFKAEAVLGKEIKEIKLSDYKGKWVVLFFYPLDFTFVCPTEIIEYDNKLAEFKKLGTEVLGVSVDSAFTHLA
WKNTPKKEGGIGEIKYPLIADLTKSISRDYNVLTEGGVALRGTFIIDPAGVIRQATINDLPVGRNIDEAIRLIKAFQFVE
KHGEVCPANWDEGKKTMKADPEKSKDYFAAVN

Specific function: Reduces peroxides. May play an important role in eliminating peroxides generated during metabolism [H]

COG id: COG0450

COG function: function code O; Peroxiredoxin

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 thioredoxin domain [H]

Homologues:

Organism=Homo sapiens, GI32189392, Length=187, Percent_Identity=64.1711229946524, Blast_Score=258, Evalue=2e-69,
Organism=Homo sapiens, GI5802974, Length=193, Percent_Identity=60.1036269430052, Blast_Score=253, Evalue=6e-68,
Organism=Homo sapiens, GI32483377, Length=190, Percent_Identity=60, Blast_Score=249, Evalue=2e-66,
Organism=Homo sapiens, GI4505591, Length=185, Percent_Identity=59.4594594594595, Blast_Score=240, Evalue=4e-64,
Organism=Homo sapiens, GI32455266, Length=185, Percent_Identity=59.4594594594595, Blast_Score=240, Evalue=4e-64,
Organism=Homo sapiens, GI32455264, Length=185, Percent_Identity=59.4594594594595, Blast_Score=240, Evalue=4e-64,
Organism=Homo sapiens, GI5453549, Length=192, Percent_Identity=55.2083333333333, Blast_Score=236, Evalue=7e-63,
Organism=Homo sapiens, GI33188454, Length=83, Percent_Identity=72.289156626506, Blast_Score=125, Evalue=3e-29,
Organism=Homo sapiens, GI4758638, Length=183, Percent_Identity=28.4153005464481, Blast_Score=80, Evalue=8e-16,
Organism=Escherichia coli, GI1786822, Length=170, Percent_Identity=42.9411764705882, Blast_Score=147, Evalue=5e-37,
Organism=Caenorhabditis elegans, GI193204376, Length=183, Percent_Identity=60.1092896174863, Blast_Score=239, Evalue=6e-64,
Organism=Caenorhabditis elegans, GI32565831, Length=183, Percent_Identity=60.1092896174863, Blast_Score=239, Evalue=7e-64,
Organism=Caenorhabditis elegans, GI17554494, Length=186, Percent_Identity=55.9139784946236, Blast_Score=231, Evalue=3e-61,
Organism=Caenorhabditis elegans, GI25153706, Length=191, Percent_Identity=29.8429319371728, Blast_Score=79, Evalue=2e-15,
Organism=Saccharomyces cerevisiae, GI6323613, Length=192, Percent_Identity=56.7708333333333, Blast_Score=218, Evalue=7e-58,
Organism=Saccharomyces cerevisiae, GI6320661, Length=192, Percent_Identity=52.0833333333333, Blast_Score=205, Evalue=4e-54,
Organism=Saccharomyces cerevisiae, GI6319407, Length=179, Percent_Identity=32.9608938547486, Blast_Score=100, Evalue=1e-22,
Organism=Drosophila melanogaster, GI17738015, Length=191, Percent_Identity=61.2565445026178, Blast_Score=256, Evalue=7e-69,
Organism=Drosophila melanogaster, GI24656348, Length=191, Percent_Identity=60.7329842931937, Blast_Score=249, Evalue=8e-67,
Organism=Drosophila melanogaster, GI17864676, Length=191, Percent_Identity=60.7329842931937, Blast_Score=249, Evalue=8e-67,
Organism=Drosophila melanogaster, GI17157991, Length=190, Percent_Identity=59.4736842105263, Blast_Score=246, Evalue=6e-66,
Organism=Drosophila melanogaster, GI24641739, Length=190, Percent_Identity=59.4736842105263, Blast_Score=246, Evalue=6e-66,
Organism=Drosophila melanogaster, GI21357347, Length=190, Percent_Identity=50.5263157894737, Blast_Score=214, Evalue=3e-56,
Organism=Drosophila melanogaster, GI17975518, Length=181, Percent_Identity=35.3591160220994, Blast_Score=100, Evalue=1e-21,
Organism=Drosophila melanogaster, GI24652434, Length=181, Percent_Identity=35.3591160220994, Blast_Score=99, Evalue=1e-21,
Organism=Drosophila melanogaster, GI24652436, Length=181, Percent_Identity=35.3591160220994, Blast_Score=99, Evalue=1e-21,
Organism=Drosophila melanogaster, GI24581278, Length=187, Percent_Identity=30.4812834224599, Blast_Score=98, Evalue=4e-21,

Paralogues:

None

Copy number: 300 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 2250 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 6040 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 1580 Molecules/Cell In: Stationary-Phase

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000866
- InterPro:   IPR019479
- InterPro:   IPR017936
- InterPro:   IPR012336
- InterPro:   IPR012335 [H]

Pfam domain/function: PF10417 1-cysPrx_C; PF00578 AhpC-TSA [H]

EC number: =1.11.1.15 [H]

Molecular weight: Translated: 21517; Mature: 21386

Theoretical pI: Translated: 5.88; Mature: 5.88

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
1.0 %Met     (Translated Protein)
2.1 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
0.5 %Met     (Mature Protein)
1.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPQVTSLAPDFKAEAVLGKEIKEIKLSDYKGKWVVLFFYPLDFTFVCPTEIIEYDNKLAE
CCCCCCCCCCCHHHHHHHHHHHHHCCCCCCCCEEEEEEECCCEEEECHHHHHHHHHHHHH
FKKLGTEVLGVSVDSAFTHLAWKNTPKKEGGIGEIKYPLIADLTKSISRDYNVLTEGGVA
HHHHCHHHEEEEHHHHHHHHHCCCCCCCCCCCCCCCCHHHHHHHHHHHCCCCEEECCCEE
LRGTFIIDPAGVIRQATINDLPVGRNIDEAIRLIKAFQFVEKHGEVCPANWDEGKKTMKA
EEEEEEECCHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHHHHCCCCCCCCCCCCCHHCCC
DPEKSKDYFAAVN
CCCCCCCEEEECC
>Mature Secondary Structure 
PQVTSLAPDFKAEAVLGKEIKEIKLSDYKGKWVVLFFYPLDFTFVCPTEIIEYDNKLAE
CCCCCCCCCCHHHHHHHHHHHHHCCCCCCCCEEEEEEECCCEEEECHHHHHHHHHHHHH
FKKLGTEVLGVSVDSAFTHLAWKNTPKKEGGIGEIKYPLIADLTKSISRDYNVLTEGGVA
HHHHCHHHEEEEHHHHHHHHHCCCCCCCCCCCCCCCCHHHHHHHHHHHCCCCEEECCCEE
LRGTFIIDPAGVIRQATINDLPVGRNIDEAIRLIKAFQFVEKHGEVCPANWDEGKKTMKA
EEEEEEECCHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHHHHCCCCCCCCCCCCCHHCCC
DPEKSKDYFAAVN
CCCCCCCEEEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8590279; 8905231 [H]