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The map label for this gene is pyrE

Identifier: 45656960

GI number: 45656960

Start: 1329282

End: 1329866

Strand: Direct

Name: pyrE

Synonym: LIC11076

Alternate gene names: 45656960

Gene position: 1329282-1329866 (Clockwise)

Preceding gene: 45656958

Following gene: 45656961

Centisome position: 31.08

GC content: 39.15

Gene sequence:

>585_bases
ATGCTTAAGAAAGAACTTTCTATGAAACAAGAACTTCTAGAACTCATTCGAACTCATGTGTATCGTTATTCGGAGCAGCC
TTTTACCTTGGCTTCCGGAAGAAAATCCAGACATTATTTTAACTGTAAGGAAATTACTCTTGTTCCGGATCGTTTGGAAC
TTCTATGTAAGTTTATCGTAGAACAGCATTTAGGCGAATCCGGAATTTTACTACCTCATGCTTTTGGTGGTCTTACGATG
GGGGCCGATCCGATTTGTTATGGAATCAGTTTGGAATTTAGAAAACAAAATAAAAACGTATATCCCTTGATTGTACGCAA
ACTTTCCAAGGATCATGGGACGAAAAAATTGGTGGAAGGTTCGGCTCATTTAGTGAAACAATGTGTCGTGATAGACGACG
TGATTACCACGGGTGGTTCTACGATTCAAGCAATTCGTAGTTTAAGAGATTGTGGAATCGAAGTCGTCCAAGGTGTTTGT
ATCTTAGATCGTCAAGAAGGTGGGAAAGACGCGATTCTTGCGGAAGGTGTGGAAATGTTTCCTATATTCAAAAAAAGTGA
TTTTGGTAATTTGGAACATGAGTGA

Upstream 100 bases:

>100_bases
TGCATGAATTACAGGATTCATGTCGGAATCCGTTTTGAAAGTTTTTTTTATTTTGAAAACGGGTTTCCGGATTCTTTCCT
GGAAATTCACTGGTTAAAAA

Downstream 100 bases:

>100_bases
GTTCCAGTACGATTCAGCCAAGTTTACAAGAAATCTGATTTTTCGTTCAACGGCGATTATTCTTCTGTATTGTGCTTTTA
TTGTCTGGAATTTTTTTAAA

Product: uridine 5-monophosphate synthase

Products: NA

Alternate protein names: OPRT; OPRTase [H]

Number of amino acids: Translated: 194; Mature: 194

Protein sequence:

>194_residues
MLKKELSMKQELLELIRTHVYRYSEQPFTLASGRKSRHYFNCKEITLVPDRLELLCKFIVEQHLGESGILLPHAFGGLTM
GADPICYGISLEFRKQNKNVYPLIVRKLSKDHGTKKLVEGSAHLVKQCVVIDDVITTGGSTIQAIRSLRDCGIEVVQGVC
ILDRQEGGKDAILAEGVEMFPIFKKSDFGNLEHE

Sequences:

>Translated_194_residues
MLKKELSMKQELLELIRTHVYRYSEQPFTLASGRKSRHYFNCKEITLVPDRLELLCKFIVEQHLGESGILLPHAFGGLTM
GADPICYGISLEFRKQNKNVYPLIVRKLSKDHGTKKLVEGSAHLVKQCVVIDDVITTGGSTIQAIRSLRDCGIEVVQGVC
ILDRQEGGKDAILAEGVEMFPIFKKSDFGNLEHE
>Mature_194_residues
MLKKELSMKQELLELIRTHVYRYSEQPFTLASGRKSRHYFNCKEITLVPDRLELLCKFIVEQHLGESGILLPHAFGGLTM
GADPICYGISLEFRKQNKNVYPLIVRKLSKDHGTKKLVEGSAHLVKQCVVIDDVITTGGSTIQAIRSLRDCGIEVVQGVC
ILDRQEGGKDAILAEGVEMFPIFKKSDFGNLEHE

Specific function: Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP) [H]

COG id: COG0461

COG function: function code F; Orotate phosphoribosyltransferase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the purine/pyrimidine phosphoribosyltransferase family. PyrE subfamily [H]

Homologues:

Organism=Homo sapiens, GI4507835, Length=156, Percent_Identity=31.4102564102564, Blast_Score=76, Evalue=2e-14,
Organism=Caenorhabditis elegans, GI17554964, Length=183, Percent_Identity=30.0546448087432, Blast_Score=71, Evalue=3e-13,
Organism=Drosophila melanogaster, GI17933654, Length=187, Percent_Identity=29.9465240641711, Blast_Score=75, Evalue=3e-14,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004467
- InterPro:   IPR023031
- InterPro:   IPR000836 [H]

Pfam domain/function: PF00156 Pribosyltran [H]

EC number: =2.4.2.10 [H]

Molecular weight: Translated: 21816; Mature: 21816

Theoretical pI: Translated: 7.85; Mature: 7.85

Prosite motif: PS00103 PUR_PYR_PR_TRANSFER

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

3.1 %Cys     (Translated Protein)
2.1 %Met     (Translated Protein)
5.2 %Cys+Met (Translated Protein)
3.1 %Cys     (Mature Protein)
2.1 %Met     (Mature Protein)
5.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLKKELSMKQELLELIRTHVYRYSEQPFTLASGRKSRHYFNCKEITLVPDRLELLCKFIV
CCCHHHHHHHHHHHHHHHHHHHCCCCCEEECCCCCCCCEECCCEEEECHHHHHHHHHHHH
EQHLGESGILLPHAFGGLTMGADPICYGISLEFRKQNKNVYPLIVRKLSKDHGTKKLVEG
HHHCCCCCCCCCCCCCCCCCCCCCEEEECEEEEECCCCCCHHHHHHHHHHCCCHHHHHCC
SAHLVKQCVVIDDVITTGGSTIQAIRSLRDCGIEVVQGVCILDRQEGGKDAILAEGVEMF
HHHHHHHHHHHHHHHHCCCHHHHHHHHHHHCCHHHHCCHHEEECCCCCCCCHHHCCCHHC
PIFKKSDFGNLEHE
EEECCCCCCCCCCC
>Mature Secondary Structure
MLKKELSMKQELLELIRTHVYRYSEQPFTLASGRKSRHYFNCKEITLVPDRLELLCKFIV
CCCHHHHHHHHHHHHHHHHHHHCCCCCEEECCCCCCCCEECCCEEEECHHHHHHHHHHHH
EQHLGESGILLPHAFGGLTMGADPICYGISLEFRKQNKNVYPLIVRKLSKDHGTKKLVEG
HHHCCCCCCCCCCCCCCCCCCCCCEEEECEEEEECCCCCCHHHHHHHHHHCCCHHHHHCC
SAHLVKQCVVIDDVITTGGSTIQAIRSLRDCGIEVVQGVCILDRQEGGKDAILAEGVEMF
HHHHHHHHHHHHHHHHCCCHHHHHHHHHHHCCHHHHCCHHEEECCCCCCCCHHHCCCHHC
PIFKKSDFGNLEHE
EEECCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA