| Definition | Leptospira interrogans serovar Copenhageni str. Fiocruz L1-130 chromosome chromosome I, complete sequence. |
|---|---|
| Accession | NC_005823 |
| Length | 4,277,185 |
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The map label for this gene is relA [H]
Identifier: 45656898
GI number: 45656898
Start: 1233953
End: 1235977
Strand: Direct
Name: relA [H]
Synonym: LIC11012
Alternate gene names: 45656898
Gene position: 1233953-1235977 (Clockwise)
Preceding gene: 45656897
Following gene: 45656899
Centisome position: 28.85
GC content: 38.27
Gene sequence:
>2025_bases ATGGGATTTGTAAAAGCTCCTGTTACCAAAGATATACTTCTCGAAGGAGTTTGCCAAAAACTTGGAGATCACGCGTATGA ATCCGTTCAAAAGGCGTATGACGTTTCGGAACGAGCGCATCAAGGTCAGTTTCGTCTTTCAGGAGAACCTTACATAGTTC ATCCTCTTCAAGTGGGATTTATTCTTTACGAGTTAGGTCTTGACGAAAAGGTAATCTGCGCCGGTCTTCTTCATGACGTC ATTGAAGATACGGAATATTCTAGAGAGGATATGATTCGAGACTTTGGAGAAGACATCACAGATCTAGTTGAAGGTGTCAC TAAAATTTCCAAAATTAAAAGTCAGTCTAAAGAAACCGAAGCCGCGGAGAATATTCGAAAGATCATTGTTGCAACAATCA AAGATATCCGAGTCATTCTTATTAAACTCGCAGATAAAACTCATAACCTTCGAACTCTTTCCTTTCAACCACCGGAAAAA CAAAGAAGAATCGCTCAAGAAACTCTTTCTTTATACGCGCCGATTGCGGGTCGTTTGGGGATTTACAAAATCAAATCCGA GTTGGAAGATCTTGCATTTCAGATTTTAAATCCAGATGAATATCAAGAAGTAAAGAAGAACATCAATTCTAAAAAATCGG AAAGAGAAGGTTTTATTGAAACTTTGAAGATCATCCTTCTCCAAAGACTTTCTGAAATTCAGATTGAAGCGGATGTGGAC GGTAGGGCGAAACATTTTTATTCTATCTATCGTAAGATGAAACTCAAAGAAAAAACTTTTAACGAAATTTTTGACCTTAG GGCGATCCGTATTATTACGAATGAAGTAAAGGATTGTTATGGAGTATTAGGAATTGTGCATACTCTTTGGAATCCCGTTC CAGGTCGTTTTAAGGATTATATTGCAACTCCTAAAACGAACATGTATCAATCTCTTCATACGACTGTGATTGGACCTGAT GGAAAACCTTTGGAAGTACAGATTCGTACAAGGGATATGAACGACATCGCAGAATACGGAATCGCAGCACATTGGATTTA TAAGGAAGGTAAACCTTCAGCTTCGGAAAAAAATGTAAAAGTGAAGTGGTTGGAACTTCTCAGTTCCTGGCAGGATTCCG CTTTAGATCCAAAGGAATTTGTAGAAGAACTCAAATACGATCTTCACGAAGACGAAGTCTTCGTATTTACTCCAAAAGGT GAAATTCTTCAGCTTCCCAAGGGTGCTACCATTTTAGACTTCGCGTTTCGAATTCATACCGATGTAGGTTTAAAAGCGAA AGGCGGAAGAATCAACGGTCGAATGCTTCCTCTTCGTACTGAACTTCGTTCCGGAGATCAAATCGAAATCATTACCGATA AAAGAACAAAACCTTCTCCAATTTGGTTACGTATTGTTAGGACTCCCTCCGCTAGACAAAAATTAAGAAGTTATTTTAAG AAGTTAAGAGAAGAAAACAAAAAAGATCTTCAACAAGAAGCCGAGTTTGCAGCGGAGATTACGCTTAACGTTGATGTTTT AGAAGAACTAAAGAAGAAACCTTCTTCTAAACCGACTAAACAAATCGATCTGGCTGCTGGTAAAGTAATTGTTGCAGGTC TTCGTGGAATTCCTGTTAGACTTTCCGGTTGTTGTTCTCCTTTGCCAGGAGATGGTATTATTGGATTTGTGACTCGAGGT AGGGGGGTAAGCATTCATAAAAAAGGATGTGTTACCGCCAAACAACAGGAACAAGAAGAATCCATGCGAGTTATTACAGT CGAATGGGACTATGGTCAGAGTGAATCTATTCCTGTGCTTATCGAAGTAAAGTCAAAAGATAGACAAGGTATTTTTATGG AAATTGTAAAATCGATTTCTAATACACAAACCAACATTCGAGAATCTAAAGCAAGCACGGATCAAAGAGGAAACTTGGTC GCTAGTTTTGAAGTCGACGTAGAACATTTGGATCAACTCAAAGAGATTTTAAGTAATCTCAAACAAATTCCGGATGTATA TCAAGCGCATAGAATTAAAAATTAA
Upstream 100 bases:
>100_bases GCCCTTTCTGAATTTTCTGGAGCCGGAGTTAGTATGGGTTATCTTACACATACGACCCGTTTTTTGGACTTGGGTTTGGA TATTGAACGGCACTAAAATT
Downstream 100 bases:
>100_bases AAGAGGTAATTACTTGAAGAAAATATTATATTCTGTTTTTTGTATTTTGTTTTTTTGTCTTCTTCCCGTTAATTGTGGGG ATAAAGAAGAAGTCGAGTCC
Product: guanosine polyphosphate pyrophosphohydrolase/synthetase
Products: NA
Alternate protein names: (p)ppGpp synthase; ATP:GTP 3'-pyrophosphotransferase; ppGpp synthase I [H]
Number of amino acids: Translated: 674; Mature: 673
Protein sequence:
>674_residues MGFVKAPVTKDILLEGVCQKLGDHAYESVQKAYDVSERAHQGQFRLSGEPYIVHPLQVGFILYELGLDEKVICAGLLHDV IEDTEYSREDMIRDFGEDITDLVEGVTKISKIKSQSKETEAAENIRKIIVATIKDIRVILIKLADKTHNLRTLSFQPPEK QRRIAQETLSLYAPIAGRLGIYKIKSELEDLAFQILNPDEYQEVKKNINSKKSEREGFIETLKIILLQRLSEIQIEADVD GRAKHFYSIYRKMKLKEKTFNEIFDLRAIRIITNEVKDCYGVLGIVHTLWNPVPGRFKDYIATPKTNMYQSLHTTVIGPD GKPLEVQIRTRDMNDIAEYGIAAHWIYKEGKPSASEKNVKVKWLELLSSWQDSALDPKEFVEELKYDLHEDEVFVFTPKG EILQLPKGATILDFAFRIHTDVGLKAKGGRINGRMLPLRTELRSGDQIEIITDKRTKPSPIWLRIVRTPSARQKLRSYFK KLREENKKDLQQEAEFAAEITLNVDVLEELKKKPSSKPTKQIDLAAGKVIVAGLRGIPVRLSGCCSPLPGDGIIGFVTRG RGVSIHKKGCVTAKQQEQEESMRVITVEWDYGQSESIPVLIEVKSKDRQGIFMEIVKSISNTQTNIRESKASTDQRGNLV ASFEVDVEHLDQLKEILSNLKQIPDVYQAHRIKN
Sequences:
>Translated_674_residues MGFVKAPVTKDILLEGVCQKLGDHAYESVQKAYDVSERAHQGQFRLSGEPYIVHPLQVGFILYELGLDEKVICAGLLHDV IEDTEYSREDMIRDFGEDITDLVEGVTKISKIKSQSKETEAAENIRKIIVATIKDIRVILIKLADKTHNLRTLSFQPPEK QRRIAQETLSLYAPIAGRLGIYKIKSELEDLAFQILNPDEYQEVKKNINSKKSEREGFIETLKIILLQRLSEIQIEADVD GRAKHFYSIYRKMKLKEKTFNEIFDLRAIRIITNEVKDCYGVLGIVHTLWNPVPGRFKDYIATPKTNMYQSLHTTVIGPD GKPLEVQIRTRDMNDIAEYGIAAHWIYKEGKPSASEKNVKVKWLELLSSWQDSALDPKEFVEELKYDLHEDEVFVFTPKG EILQLPKGATILDFAFRIHTDVGLKAKGGRINGRMLPLRTELRSGDQIEIITDKRTKPSPIWLRIVRTPSARQKLRSYFK KLREENKKDLQQEAEFAAEITLNVDVLEELKKKPSSKPTKQIDLAAGKVIVAGLRGIPVRLSGCCSPLPGDGIIGFVTRG RGVSIHKKGCVTAKQQEQEESMRVITVEWDYGQSESIPVLIEVKSKDRQGIFMEIVKSISNTQTNIRESKASTDQRGNLV ASFEVDVEHLDQLKEILSNLKQIPDVYQAHRIKN >Mature_673_residues GFVKAPVTKDILLEGVCQKLGDHAYESVQKAYDVSERAHQGQFRLSGEPYIVHPLQVGFILYELGLDEKVICAGLLHDVI EDTEYSREDMIRDFGEDITDLVEGVTKISKIKSQSKETEAAENIRKIIVATIKDIRVILIKLADKTHNLRTLSFQPPEKQ RRIAQETLSLYAPIAGRLGIYKIKSELEDLAFQILNPDEYQEVKKNINSKKSEREGFIETLKIILLQRLSEIQIEADVDG RAKHFYSIYRKMKLKEKTFNEIFDLRAIRIITNEVKDCYGVLGIVHTLWNPVPGRFKDYIATPKTNMYQSLHTTVIGPDG KPLEVQIRTRDMNDIAEYGIAAHWIYKEGKPSASEKNVKVKWLELLSSWQDSALDPKEFVEELKYDLHEDEVFVFTPKGE ILQLPKGATILDFAFRIHTDVGLKAKGGRINGRMLPLRTELRSGDQIEIITDKRTKPSPIWLRIVRTPSARQKLRSYFKK LREENKKDLQQEAEFAAEITLNVDVLEELKKKPSSKPTKQIDLAAGKVIVAGLRGIPVRLSGCCSPLPGDGIIGFVTRGR GVSIHKKGCVTAKQQEQEESMRVITVEWDYGQSESIPVLIEVKSKDRQGIFMEIVKSISNTQTNIRESKASTDQRGNLVA SFEVDVEHLDQLKEILSNLKQIPDVYQAHRIKN
Specific function: In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance. This enzyme catalyzes the formation of pppGpp which i
COG id: COG0317
COG function: function code TK; Guanosine polyphosphate pyrophosphohydrolases/synthetases
Gene ontology:
Cell location: Cytoplasm [C]
Metaboloic importance: Essential [C]
Operon status: Not Known
Operon components: None
Similarity: Contains 1 HD domain [H]
Homologues:
Organism=Escherichia coli, GI1790082, Length=684, Percent_Identity=39.9122807017544, Blast_Score=514, Evalue=1e-147, Organism=Escherichia coli, GI1789147, Length=678, Percent_Identity=34.2182890855457, Blast_Score=420, Evalue=1e-118, Organism=Drosophila melanogaster, GI24650996, Length=111, Percent_Identity=40.5405405405405, Blast_Score=69, Evalue=2e-11,
Paralogues:
None
Copy number: NA
Swissprot (AC and ID): NA
Other databases:
- InterPro: IPR002912 - InterPro: IPR012675 - InterPro: IPR003607 - InterPro: IPR007685 - InterPro: IPR004811 - InterPro: IPR004095 - InterPro: IPR012676 [H]
Pfam domain/function: PF01842 ACT; PF04607 RelA_SpoT; PF02824 TGS [H]
EC number: =2.7.6.5 [H]
Molecular weight: Translated: 76671; Mature: 76540
Theoretical pI: Translated: 8.49; Mature: 8.49
Prosite motif: NA
Important sites: NA
Signals:
None
Transmembrane regions:
None
Cys/Met content:
0.9 %Cys (Translated Protein) 1.2 %Met (Translated Protein) 2.1 %Cys+Met (Translated Protein) 0.9 %Cys (Mature Protein) 1.0 %Met (Mature Protein) 1.9 %Cys+Met (Mature Protein)
Secondary structure:
>Translated Secondary Structure MGFVKAPVTKDILLEGVCQKLGDHAYESVQKAYDVSERAHQGQFRLSGEPYIVHPLQVGF CCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEECCCCEEEEHHHHHH ILYELGLDEKVICAGLLHDVIEDTEYSREDMIRDFGEDITDLVEGVTKISKIKSQSKETE HHHCCCCCCHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH AAENIRKIIVATIKDIRVILIKLADKTHNLRTLSFQPPEKQRRIAQETLSLYAPIAGRLG HHHHHHHHHHHHHHHHHHHHHEECCCCCCEEEEECCCCHHHHHHHHHHHHHHHCHHHCCH IYKIKSELEDLAFQILNPDEYQEVKKNINSKKSEREGFIETLKIILLQRLSEIQIEADVD HHHHHHHHHHHHHHHCCCHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHCEEEECCC GRAKHFYSIYRKMKLKEKTFNEIFDLRAIRIITNEVKDCYGVLGIVHTLWNPVPGRFKDY CHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHH IATPKTNMYQSLHTTVIGPDGKPLEVQIRTRDMNDIAEYGIAAHWIYKEGKPSASEKNVK HCCCCHHHHHHHHHEEECCCCCEEEEEEEECCHHHHHHHCCEEEEEEECCCCCCCCCCCH VKWLELLSSWQDSALDPKEFVEELKYDLHEDEVFVFTPKGEILQLPKGATILDFAFRIHT HHHHHHHHHHCCCCCCHHHHHHHHHHCCCCCCEEEECCCCCEEECCCCCCHHHHHHHHCC DVGLKAKGGRINGRMLPLRTELRSGDQIEIITDKRTKPSPIWLRIVRTPSARQKLRSYFK CCCCEECCCCCCCEEEEEEHHHCCCCEEEEEECCCCCCCCEEEEEEECCHHHHHHHHHHH KLREENKKDLQQEAEFAAEITLNVDVLEELKKKPSSKPTKQIDLAAGKVIVAGLRGIPVR HHHHHHHHHHHHHHHHHHHEEECHHHHHHHHHCCCCCCCCHHHHHCCCEEEECCCCCCEE LSGCCSPLPGDGIIGFVTRGRGVSIHKKGCVTAKQQEQEESMRVITVEWDYGQSESIPVL ECCCCCCCCCCCEEEEEECCCCCEEECCCCCCCHHHHHCCCCEEEEEEECCCCCCCCEEE IEVKSKDRQGIFMEIVKSISNTQTNIRESKASTDQRGNLVASFEVDVEHLDQLKEILSNL EEECCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCCCEEEEEECCHHHHHHHHHHHHHH KQIPDVYQAHRIKN HHCHHHHHHHCCCC >Mature Secondary Structure GFVKAPVTKDILLEGVCQKLGDHAYESVQKAYDVSERAHQGQFRLSGEPYIVHPLQVGF CCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEECCCCEEEEHHHHHH ILYELGLDEKVICAGLLHDVIEDTEYSREDMIRDFGEDITDLVEGVTKISKIKSQSKETE HHHCCCCCCHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH AAENIRKIIVATIKDIRVILIKLADKTHNLRTLSFQPPEKQRRIAQETLSLYAPIAGRLG HHHHHHHHHHHHHHHHHHHHHEECCCCCCEEEEECCCCHHHHHHHHHHHHHHHCHHHCCH IYKIKSELEDLAFQILNPDEYQEVKKNINSKKSEREGFIETLKIILLQRLSEIQIEADVD HHHHHHHHHHHHHHHCCCHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHCEEEECCC GRAKHFYSIYRKMKLKEKTFNEIFDLRAIRIITNEVKDCYGVLGIVHTLWNPVPGRFKDY CHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHH IATPKTNMYQSLHTTVIGPDGKPLEVQIRTRDMNDIAEYGIAAHWIYKEGKPSASEKNVK HCCCCHHHHHHHHHEEECCCCCEEEEEEEECCHHHHHHHCCEEEEEEECCCCCCCCCCCH VKWLELLSSWQDSALDPKEFVEELKYDLHEDEVFVFTPKGEILQLPKGATILDFAFRIHT HHHHHHHHHHCCCCCCHHHHHHHHHHCCCCCCEEEECCCCCEEECCCCCCHHHHHHHHCC DVGLKAKGGRINGRMLPLRTELRSGDQIEIITDKRTKPSPIWLRIVRTPSARQKLRSYFK CCCCEECCCCCCCEEEEEEHHHCCCCEEEEEECCCCCCCCEEEEEEECCHHHHHHHHHHH KLREENKKDLQQEAEFAAEITLNVDVLEELKKKPSSKPTKQIDLAAGKVIVAGLRGIPVR HHHHHHHHHHHHHHHHHHHEEECHHHHHHHHHCCCCCCCCHHHHHCCCEEEECCCCCCEE LSGCCSPLPGDGIIGFVTRGRGVSIHKKGCVTAKQQEQEESMRVITVEWDYGQSESIPVL ECCCCCCCCCCCEEEEEECCCCCEEECCCCCCCHHHHHCCCCEEEEEEECCCCCCCCEEE IEVKSKDRQGIFMEIVKSISNTQTNIRESKASTDQRGNLVASFEVDVEHLDQLKEILSNL EEECCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCCCEEEEEECCHHHHHHHHHHHHHH KQIPDVYQAHRIKN HHCHHHHHHHCCCC
PDB accession: NA
Resolution: NA
Structure class: Alpha Beta
Cofactors: NA
Metal ions: NA
Kcat value (1/min): NA
Specific activity: NA
Km value (mM): NA
Substrates: NA
Specific reaction: NA
General reaction: NA
Inhibitor: NA
Structure determination priority: 9.0
TargetDB status: NA
Availability: NA
References: 9383190; 9384377 [H]