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The map label for this gene is nadC

Identifier: 45656897

GI number: 45656897

Start: 1233034

End: 1233948

Strand: Direct

Name: nadC

Synonym: LIC11011

Alternate gene names: 45656897

Gene position: 1233034-1233948 (Clockwise)

Preceding gene: 45656895

Following gene: 45656898

Centisome position: 28.83

GC content: 38.14

Gene sequence:

>915_bases
TTGTGGCTTTCTAAGGATAAAACTTTCTTTTGCAGCCAGATGAAACGTGCTTATACTCATCCGATTTCGTCAGTAAACTT
TCAAGATTATGAACTCCTGGCTAAACTCGCCTGGGAAGAAGATTGCCCTGAGGAAGATATCACTTCTGTTTCTCTTTTTT
CTATCGACCAAAATGCTACCGCTAATCTGAATTCGAGAGAACCTGGAATTCTATGCGGAACTGGTGTATTAGAAGTTTTG
AATACACTTTCGGGAAATAAAATTCGGTCGGAACTTTTTAAAAAGGATTCGGAAAGTTTTCAGGCGGGGGAAACACTTTT
AAAGATAGAAGGAAGTCTCGTTCAAATTCTAAGGATAGAAAGGATTTTACTAAATTTTATTCAGTATCTTTCTGGAATTT
CGACTACCACTGGAGAAGTAGTTAAAAAGTACGGACAAAAAGGTTTGATGATCTTGGATACCCGTAAGACACTTCCCGGT
TATCGCAAACTTGCTAAGTATGCTGTCTATTGTGGAGGTGGAAGTAATCATAGACTGAATCTTTCCGAAATGGCTATGAT
CAAAGACAATCATCTTGCGATGTATTCTTCCGCTCGCGAGCCTGTCGAAAAAATCAAATTAAGTTTTCCTAATAAACTGG
TCGAAGTGGAAATTGATTCTATTTTACAACTTGAAGACGCCATAAGTTCTGGGGCAGAGGTTATTCTTTTAGATAATTTT
TCTCTGGAAGATTCTAAAACAGCGTATTCCATTTTGAAACAAAAGGCGCCTAACGTTCTAATAGAATTTTCTGGTGGAAT
TACTCCTGAAAAACTAGAAGCCCTTTCTGAATTTTCTGGAGCCGGAGTTAGTATGGGTTATCTTACACATACGACCCGTT
TTTTGGACTTGGGTTTGGATATTGAACGGCACTAA

Upstream 100 bases:

>100_bases
GGAATTTATGGTTTTTTTGAGAGAATCTTACATTGTGGACGGAACTCCGCCGCAAATGAAAGGGGAGTTTATTTTTAGAT
TCTCACTGAAATTCACTTGA

Downstream 100 bases:

>100_bases
AATTATGGGATTTGTAAAAGCTCCTGTTACCAAAGATATACTTCTCGAAGGAGTTTGCCAAAAACTTGGAGATCACGCGT
ATGAATCCGTTCAAAAGGCG

Product: nicotinate-nucleotide pyrophosphorylase

Products: NA

Alternate protein names: Quinolinate phosphoribosyltransferase [decarboxylating]; QAPRTase [H]

Number of amino acids: Translated: 304; Mature: 304

Protein sequence:

>304_residues
MWLSKDKTFFCSQMKRAYTHPISSVNFQDYELLAKLAWEEDCPEEDITSVSLFSIDQNATANLNSREPGILCGTGVLEVL
NTLSGNKIRSELFKKDSESFQAGETLLKIEGSLVQILRIERILLNFIQYLSGISTTTGEVVKKYGQKGLMILDTRKTLPG
YRKLAKYAVYCGGGSNHRLNLSEMAMIKDNHLAMYSSAREPVEKIKLSFPNKLVEVEIDSILQLEDAISSGAEVILLDNF
SLEDSKTAYSILKQKAPNVLIEFSGGITPEKLEALSEFSGAGVSMGYLTHTTRFLDLGLDIERH

Sequences:

>Translated_304_residues
MWLSKDKTFFCSQMKRAYTHPISSVNFQDYELLAKLAWEEDCPEEDITSVSLFSIDQNATANLNSREPGILCGTGVLEVL
NTLSGNKIRSELFKKDSESFQAGETLLKIEGSLVQILRIERILLNFIQYLSGISTTTGEVVKKYGQKGLMILDTRKTLPG
YRKLAKYAVYCGGGSNHRLNLSEMAMIKDNHLAMYSSAREPVEKIKLSFPNKLVEVEIDSILQLEDAISSGAEVILLDNF
SLEDSKTAYSILKQKAPNVLIEFSGGITPEKLEALSEFSGAGVSMGYLTHTTRFLDLGLDIERH
>Mature_304_residues
MWLSKDKTFFCSQMKRAYTHPISSVNFQDYELLAKLAWEEDCPEEDITSVSLFSIDQNATANLNSREPGILCGTGVLEVL
NTLSGNKIRSELFKKDSESFQAGETLLKIEGSLVQILRIERILLNFIQYLSGISTTTGEVVKKYGQKGLMILDTRKTLPG
YRKLAKYAVYCGGGSNHRLNLSEMAMIKDNHLAMYSSAREPVEKIKLSFPNKLVEVEIDSILQLEDAISSGAEVILLDNF
SLEDSKTAYSILKQKAPNVLIEFSGGITPEKLEALSEFSGAGVSMGYLTHTTRFLDLGLDIERH

Specific function: Involved in the catabolism of quinolinic acid (QA) [H]

COG id: COG0157

COG function: function code H; Nicotinate-nucleotide pyrophosphorylase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the nadC/modD family [H]

Homologues:

Organism=Homo sapiens, GI45269149, Length=269, Percent_Identity=30.4832713754647, Blast_Score=117, Evalue=2e-26,
Organism=Escherichia coli, GI1786299, Length=255, Percent_Identity=37.6470588235294, Blast_Score=147, Evalue=7e-37,
Organism=Saccharomyces cerevisiae, GI6321162, Length=258, Percent_Identity=34.8837209302326, Blast_Score=105, Evalue=7e-24,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013785
- InterPro:   IPR004393
- InterPro:   IPR002638
- InterPro:   IPR022412 [H]

Pfam domain/function: PF01729 QRPTase_C; PF02749 QRPTase_N [H]

EC number: =2.4.2.19 [H]

Molecular weight: Translated: 33866; Mature: 33866

Theoretical pI: Translated: 5.26; Mature: 5.26

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
3.6 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
2.3 %Met     (Mature Protein)
3.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MWLSKDKTFFCSQMKRAYTHPISSVNFQDYELLAKLAWEEDCPEEDITSVSLFSIDQNAT
CCCCCCCHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHCCCCCHHHCCEEEEEEECCCCC
ANLNSREPGILCGTGVLEVLNTLSGNKIRSELFKKDSESFQAGETLLKIEGSLVQILRIE
CCCCCCCCCEEECHHHHHHHHHCCCCHHHHHHHHCCCHHHHHCCCCEEECHHHHHHHHHH
RILLNFIQYLSGISTTTGEVVKKYGQKGLMILDTRKTLPGYRKLAKYAVYCGGGSNHRLN
HHHHHHHHHHCCCCCCHHHHHHHHCCCCEEEEECCCCCCHHHHHHHHEEEECCCCCCEEC
LSEMAMIKDNHLAMYSSAREPVEKIKLSFPNKLVEVEIDSILQLEDAISSGAEVILLDNF
HHHHHEECCCCEEEHHHHHHHHHHHHHCCCCEEEEEEHHHHHHHHHHHCCCCEEEEEECC
SLEDSKTAYSILKQKAPNVLIEFSGGITPEKLEALSEFSGAGVSMGYLTHTTRFLDLGLD
CCCCHHHHHHHHHHCCCCEEEEECCCCCHHHHHHHHHHCCCCCEEHHHHHHHHHHEECCC
IERH
CCCC
>Mature Secondary Structure
MWLSKDKTFFCSQMKRAYTHPISSVNFQDYELLAKLAWEEDCPEEDITSVSLFSIDQNAT
CCCCCCCHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHCCCCCHHHCCEEEEEEECCCCC
ANLNSREPGILCGTGVLEVLNTLSGNKIRSELFKKDSESFQAGETLLKIEGSLVQILRIE
CCCCCCCCCEEECHHHHHHHHHCCCCHHHHHHHHCCCHHHHHCCCCEEECHHHHHHHHHH
RILLNFIQYLSGISTTTGEVVKKYGQKGLMILDTRKTLPGYRKLAKYAVYCGGGSNHRLN
HHHHHHHHHHCCCCCCHHHHHHHHCCCCEEEEECCCCCCHHHHHHHHEEEECCCCCCEEC
LSEMAMIKDNHLAMYSSAREPVEKIKLSFPNKLVEVEIDSILQLEDAISSGAEVILLDNF
HHHHHEECCCCEEEHHHHHHHHHHHHHCCCCEEEEEEHHHHHHHHHHHCCCCEEEEEECC
SLEDSKTAYSILKQKAPNVLIEFSGGITPEKLEALSEFSGAGVSMGYLTHTTRFLDLGLD
CCCCHHHHHHHHHHCCCCEEEEECCCCCHHHHHHHHHHCCCCCEEHHHHHHHHHHEECCC
IERH
CCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11234002 [H]