Click here to switch to the map view.

The map label for this gene is pyrH

Identifier: 45656743

GI number: 45656743

Start: 1027999

End: 1028745

Strand: Direct

Name: pyrH

Synonym: LIC10852

Alternate gene names: 45656743

Gene position: 1027999-1028745 (Clockwise)

Preceding gene: 45656742

Following gene: 45656744

Centisome position: 24.03

GC content: 44.85

Gene sequence:

>747_bases
TTGGCTACGGAAGCGAAGTATAATAGAATTCTAATTAAGCTTTCCGGCGAGGCTCTCGCTGGAGAGGGTGAATTTGGGAT
CGATACAAATAAGGCCCACTCTCTCGCGGAAGAAATCAAAGAAGTTCACGATTTAGGAGTGGAGATCGCTCTTGTCGTTG
GCGGTGGTAACATCATCCGAGGCACAAACCTTGCCAAGGCGGGAATCGACCGCGCCACCGCGGATTATATGGGAATGCTC
GCCACGATTCAAAACGCTTTGGCCCTCCAAGACGCTTGCGAAAAAAAAGGCCTTTATACAAGGGTTCAATCCGCGATCGA
AATCAATTCTATTGCAGAAAGTTATATCCGTCGTCGGGCCGTTAGACATCTCGAAAAAAGAAGAATCGTGATTTTTGCCG
GTGGAACGGGTAATCCTTATTTTACCACGGATACAACTGCAAGTCTCAGAGCCGTAGAAGTGGGTTGTGATGTGATTCTC
AAAGCTACCAAAGTGGACGGGGTTTATACCGCGGATCCTAAAAAAGACAATGGTGCCAAACGTTATTCTCAGATTTCTTT
TATGGAATCTATCAATCGTAGGCTTAAGGTTATGGATTCTACCGCCCTAAGTTTGTGTATGGAAAATAATATGTCGATTA
TAGTGTTCGACATCTTCAAACGTGGAAATCTCAAAGACCTGGTTACCGGTAAAAACATCGGCACATTGATCTCTAATTCG
GAGGACATTCAAATCGATGGCAAGTGA

Upstream 100 bases:

>100_bases
TAAAACCATAGACGACTTAGTAAAGGAAGCGATCGCGAAATTTGGCGAGAACATTACTATCGCCCGTTTTATCCGCTTTC
AGGTGGGTGGACTCTAAGTT

Downstream 100 bases:

>100_bases
TGCAATCATTTCTGGAATGAAAACTAAGATGGATAAAACCATCGATCTTGTAAAAAAGGATTTCGGAACCATTCGTACTG
GACGCGCTAATCCCTCTCTT

Product: uridylate kinase

Products: NA

Alternate protein names: UK; Uridine monophosphate kinase; UMP kinase; UMPK

Number of amino acids: Translated: 248; Mature: 247

Protein sequence:

>248_residues
MATEAKYNRILIKLSGEALAGEGEFGIDTNKAHSLAEEIKEVHDLGVEIALVVGGGNIIRGTNLAKAGIDRATADYMGML
ATIQNALALQDACEKKGLYTRVQSAIEINSIAESYIRRRAVRHLEKRRIVIFAGGTGNPYFTTDTTASLRAVEVGCDVIL
KATKVDGVYTADPKKDNGAKRYSQISFMESINRRLKVMDSTALSLCMENNMSIIVFDIFKRGNLKDLVTGKNIGTLISNS
EDIQIDGK

Sequences:

>Translated_248_residues
MATEAKYNRILIKLSGEALAGEGEFGIDTNKAHSLAEEIKEVHDLGVEIALVVGGGNIIRGTNLAKAGIDRATADYMGML
ATIQNALALQDACEKKGLYTRVQSAIEINSIAESYIRRRAVRHLEKRRIVIFAGGTGNPYFTTDTTASLRAVEVGCDVIL
KATKVDGVYTADPKKDNGAKRYSQISFMESINRRLKVMDSTALSLCMENNMSIIVFDIFKRGNLKDLVTGKNIGTLISNS
EDIQIDGK
>Mature_247_residues
ATEAKYNRILIKLSGEALAGEGEFGIDTNKAHSLAEEIKEVHDLGVEIALVVGGGNIIRGTNLAKAGIDRATADYMGMLA
TIQNALALQDACEKKGLYTRVQSAIEINSIAESYIRRRAVRHLEKRRIVIFAGGTGNPYFTTDTTASLRAVEVGCDVILK
ATKVDGVYTADPKKDNGAKRYSQISFMESINRRLKVMDSTALSLCMENNMSIIVFDIFKRGNLKDLVTGKNIGTLISNSE
DIQIDGK

Specific function: Catalyzes the reversible phosphorylation of UMP to UDP

COG id: COG0528

COG function: function code F; Uridylate kinase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the UMP kinase family

Homologues:

Organism=Escherichia coli, GI1786367, Length=240, Percent_Identity=49.1666666666667, Blast_Score=239, Evalue=2e-64,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): PYRH_LEPIC (Q72U12)

Other databases:

- EMBL:   AE016823
- RefSeq:   YP_000829.1
- ProteinModelPortal:   Q72U12
- SMR:   Q72U12
- GeneID:   2770216
- GenomeReviews:   AE016823_GR
- KEGG:   lic:LIC10852
- HOGENOM:   HBG497552
- OMA:   RHMEKGR
- ProtClustDB:   PRK00358
- BioCyc:   LINT267671:LIC_10852-MONOMER
- GO:   GO:0005737
- HAMAP:   MF_01220_B
- InterPro:   IPR001048
- InterPro:   IPR011817
- InterPro:   IPR015963
- Gene3D:   G3DSA:3.40.1160.10
- PIRSF:   PIRSF005650
- TIGRFAMs:   TIGR02075

Pfam domain/function: PF00696 AA_kinase; SSF53633 Aa_kinase

EC number: =2.7.4.22

Molecular weight: Translated: 27005; Mature: 26874

Theoretical pI: Translated: 8.44; Mature: 8.44

Prosite motif: NA

Important sites: BINDING 55-55 BINDING 56-56 BINDING 60-60 BINDING 75-75 BINDING 163-163 BINDING 169-169 BINDING 172-172

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
2.8 %Met     (Translated Protein)
4.0 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
2.4 %Met     (Mature Protein)
3.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MATEAKYNRILIKLSGEALAGEGEFGIDTNKAHSLAEEIKEVHDLGVEIALVVGGGNIIR
CCCCCCCCEEEEEECCCEEECCCCCCCCCCHHHHHHHHHHHHHHCCEEEEEEEECCCEEE
GTNLAKAGIDRATADYMGMLATIQNALALQDACEKKGLYTRVQSAIEINSIAESYIRRRA
CCCHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHH
VRHLEKRRIVIFAGGTGNPYFTTDTTASLRAVEVGCDVILKATKVDGVYTADPKKDNGAK
HHHHHHCEEEEEECCCCCCCEECCCCCCEEEEEECCEEEEEEEECCCEEECCCCCCCCHH
RYSQISFMESINRRLKVMDSTALSLCMENNMSIIVFDIFKRGNLKDLVTGKNIGTLISNS
HHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEEEEECCCCCHHHHCCCCCHHEECCC
EDIQIDGK
CCEEECCC
>Mature Secondary Structure 
ATEAKYNRILIKLSGEALAGEGEFGIDTNKAHSLAEEIKEVHDLGVEIALVVGGGNIIR
CCCCCCCEEEEEECCCEEECCCCCCCCCCHHHHHHHHHHHHHHCCEEEEEEEECCCEEE
GTNLAKAGIDRATADYMGMLATIQNALALQDACEKKGLYTRVQSAIEINSIAESYIRRRA
CCCHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHH
VRHLEKRRIVIFAGGTGNPYFTTDTTASLRAVEVGCDVILKATKVDGVYTADPKKDNGAK
HHHHHHCEEEEEECCCCCCCEECCCCCCEEEEEECCEEEEEEEECCCEEECCCCCCCCHH
RYSQISFMESINRRLKVMDSTALSLCMENNMSIIVFDIFKRGNLKDLVTGKNIGTLISNS
HHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEEEEECCCCCHHHHCCCCCHHEECCC
EDIQIDGK
CCEEECCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA