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The map label for this gene is 45358944

Identifier: 45358944

GI number: 45358944

Start: 1360985

End: 1362253

Strand: Direct

Name: 45358944

Synonym: MMP1381

Alternate gene names: NA

Gene position: 1360985-1362253 (Clockwise)

Preceding gene: 45358943

Following gene: 45358945

Centisome position: 81.93

GC content: 35.38

Gene sequence:

>1269_bases
ATGACAATTGCTAAGTTTCACGGTGGATGCCACCAAATCGGAAAATCTTGCGTAGAGATAAACACTAAAAAATCAAAAAT
ATTAATTGATTGTGGAATGGACCCATCAGACAACGGTCTTCCAGATATTAACGACTCAGACGTTGATGCGGTTGTAGTTT
CACACGCACACTTGGACCACTGCGGTGCAATACCTTACTTTAACTTCAAAAAAATATTCTGTAATCCCCCTACTGCTGAT
TTAATGTACAATGTATGGAAAGATACAGTAAGCCTTTCAAAAACGTACAAAGAAGAAGATATCAAAAAATCAATGGACGT
AATCAAAACTGTAAACTATAGAGAAGAAAAACAGGTTACTTCAGACATTAAGATGAAAATGTACGATGCTGGGCACATTT
TAGGAAGTTCTTCTCTTTATTTAGATATCGATGGAAAAAAATTACTCTATACGGGAGATATTAACGAAATTGAAACTAGA
ACTCTTCGTGCAGCTGACACTGACTTTGATGAAATTGATACAATAATTATTGAATCTACTTACGGTTCACCATTAGATAT
AAAGCCTGCAAGAAAAGTTTTAGAAAAACAGCTTATTGATGAAATCTCTGAAACTATCGACAACGGTGGAAAAGTAATTA
TTCCAGTTTTTGCAGTTGGAAGATCCCAAGAAATCATTGTCGTAATCAATAACTACATGAAAAGCGGTGCTTTAAAAGAA
GTTCCAATTTACATTAACGGATCATTGACACACACTACCGGAATGTACATGGGATATTCTGACTGGTTAAATCCAAAAAT
AAAAAATGCAATTGAAAACAGGATCAACCCATTTGGAAATCTAATAAAAGGTGGAGATGAAGTTTTCAGTAGGGAACCAT
GTATCATTATTTCAACATCAGGAATGGTTCAGGGAGGCCCAGTACTTCAATATCTTTCACTATTGAAAAATCCAAGAAAT
AAAATTATATTAACCGGATATCAAGCTGAAGGAACAATTGGAAGAAGCCTTGAAGAAGGTGCTACAGAAGTAAAACCATT
TAAAAGAGCGATTCCGGTAAATGGAAAAGTAGTGAAAATCGAGTTTTCTGCCCACGCTGATTACAATTCACTTCTTAGAT
TTATGAAGAAAATACCGCAGCCAGATAAAGCAATTGTAATGCACGGGGAAAGATATCAGGCACTATCCCTTGCAATGACG
ATCTGGAAAACCTTAAAAATTCCAGCACTTGCTCCAAGTATTGGCAGTGTTTTGCCTTTATTTGATTAA

Upstream 100 bases:

>100_bases
GGAAAATGGAGACGTTGATTCAAAGTTTTTAGTTTGCTAATTTAATGTTTAATTATTATTTAATTTAAAAAACTGTAATA
TATTAAATTTATGTGATATA

Downstream 100 bases:

>100_bases
TTATCCCACATATTCTCTTTTTTAATATTTTAAATTTTGATAACCGATATAATATTTACTTTTCTAATGTCTATTACAAA
AATAAGTAATTTAAACGGGC

Product: beta-lactamase-like protein

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 422; Mature: 421

Protein sequence:

>422_residues
MTIAKFHGGCHQIGKSCVEINTKKSKILIDCGMDPSDNGLPDINDSDVDAVVVSHAHLDHCGAIPYFNFKKIFCNPPTAD
LMYNVWKDTVSLSKTYKEEDIKKSMDVIKTVNYREEKQVTSDIKMKMYDAGHILGSSSLYLDIDGKKLLYTGDINEIETR
TLRAADTDFDEIDTIIIESTYGSPLDIKPARKVLEKQLIDEISETIDNGGKVIIPVFAVGRSQEIIVVINNYMKSGALKE
VPIYINGSLTHTTGMYMGYSDWLNPKIKNAIENRINPFGNLIKGGDEVFSREPCIIISTSGMVQGGPVLQYLSLLKNPRN
KIILTGYQAEGTIGRSLEEGATEVKPFKRAIPVNGKVVKIEFSAHADYNSLLRFMKKIPQPDKAIVMHGERYQALSLAMT
IWKTLKIPALAPSIGSVLPLFD

Sequences:

>Translated_422_residues
MTIAKFHGGCHQIGKSCVEINTKKSKILIDCGMDPSDNGLPDINDSDVDAVVVSHAHLDHCGAIPYFNFKKIFCNPPTAD
LMYNVWKDTVSLSKTYKEEDIKKSMDVIKTVNYREEKQVTSDIKMKMYDAGHILGSSSLYLDIDGKKLLYTGDINEIETR
TLRAADTDFDEIDTIIIESTYGSPLDIKPARKVLEKQLIDEISETIDNGGKVIIPVFAVGRSQEIIVVINNYMKSGALKE
VPIYINGSLTHTTGMYMGYSDWLNPKIKNAIENRINPFGNLIKGGDEVFSREPCIIISTSGMVQGGPVLQYLSLLKNPRN
KIILTGYQAEGTIGRSLEEGATEVKPFKRAIPVNGKVVKIEFSAHADYNSLLRFMKKIPQPDKAIVMHGERYQALSLAMT
IWKTLKIPALAPSIGSVLPLFD
>Mature_421_residues
TIAKFHGGCHQIGKSCVEINTKKSKILIDCGMDPSDNGLPDINDSDVDAVVVSHAHLDHCGAIPYFNFKKIFCNPPTADL
MYNVWKDTVSLSKTYKEEDIKKSMDVIKTVNYREEKQVTSDIKMKMYDAGHILGSSSLYLDIDGKKLLYTGDINEIETRT
LRAADTDFDEIDTIIIESTYGSPLDIKPARKVLEKQLIDEISETIDNGGKVIIPVFAVGRSQEIIVVINNYMKSGALKEV
PIYINGSLTHTTGMYMGYSDWLNPKIKNAIENRINPFGNLIKGGDEVFSREPCIIISTSGMVQGGPVLQYLSLLKNPRNK
IILTGYQAEGTIGRSLEEGATEVKPFKRAIPVNGKVVKIEFSAHADYNSLLRFMKKIPQPDKAIVMHGERYQALSLAMTI
WKTLKIPALAPSIGSVLPLFD

Specific function: Unknown

COG id: COG1236

COG function: function code J; Predicted exonuclease of the beta-lactamase fold involved in RNA processing

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the metallo-beta-lactamase superfamily. RNA-metabolizing metallo-beta-lactamase-like family [H]

Homologues:

Organism=Homo sapiens, GI7706427, Length=416, Percent_Identity=33.6538461538462, Blast_Score=224, Evalue=1e-58,
Organism=Homo sapiens, GI33300633, Length=441, Percent_Identity=29.0249433106576, Blast_Score=203, Evalue=3e-52,
Organism=Homo sapiens, GI34101288, Length=377, Percent_Identity=22.5464190981432, Blast_Score=74, Evalue=3e-13,
Organism=Caenorhabditis elegans, GI32566029, Length=426, Percent_Identity=30.0469483568075, Blast_Score=209, Evalue=3e-54,
Organism=Caenorhabditis elegans, GI32564696, Length=441, Percent_Identity=28.1179138321995, Blast_Score=179, Evalue=3e-45,
Organism=Caenorhabditis elegans, GI17559452, Length=367, Percent_Identity=23.1607629427793, Blast_Score=71, Evalue=1e-12,
Organism=Saccharomyces cerevisiae, GI6323307, Length=422, Percent_Identity=27.9620853080569, Blast_Score=176, Evalue=8e-45,
Organism=Drosophila melanogaster, GI24648013, Length=428, Percent_Identity=32.2429906542056, Blast_Score=226, Evalue=3e-59,
Organism=Drosophila melanogaster, GI21358523, Length=412, Percent_Identity=30.5825242718447, Blast_Score=189, Evalue=2e-48,
Organism=Drosophila melanogaster, GI21358013, Length=374, Percent_Identity=22.7272727272727, Blast_Score=74, Evalue=1e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR022712
- InterPro:   IPR001279
- InterPro:   IPR011108 [H]

Pfam domain/function: PF10996 Beta-Casp; PF00753 Lactamase_B; PF07521 RMMBL [H]

EC number: NA

Molecular weight: Translated: 46854; Mature: 46723

Theoretical pI: Translated: 7.00; Mature: 7.00

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.4 %Cys     (Translated Protein)
3.1 %Met     (Translated Protein)
4.5 %Cys+Met (Translated Protein)
1.4 %Cys     (Mature Protein)
2.9 %Met     (Mature Protein)
4.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTIAKFHGGCHQIGKSCVEINTKKSKILIDCGMDPSDNGLPDINDSDVDAVVVSHAHLDH
CEEEECCCCHHHHCHHHEEECCCCCEEEEECCCCCCCCCCCCCCCCCCCEEEEECCCHHH
CGAIPYFNFKKIFCNPPTADLMYNVWKDTVSLSKTYKEEDIKKSMDVIKTVNYREEKQVT
CCCCCCCCCEEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHH
SDIKMKMYDAGHILGSSSLYLDIDGKKLLYTGDINEIETRTLRAADTDFDEIDTIIIEST
HHHEEEEEECCEEECCCEEEEEECCCEEEEECCCCHHHHHEEEECCCCHHHCCEEEEECC
YGSPLDIKPARKVLEKQLIDEISETIDNGGKVIIPVFAVGRSQEIIVVINNYMKSGALKE
CCCCCCCHHHHHHHHHHHHHHHHHHHCCCCEEEEEEEECCCCCEEEEEEECHHCCCCCEE
VPIYINGSLTHTTGMYMGYSDWLNPKIKNAIENRINPFGNLIKGGDEVFSREPCIIISTS
CCEEEECCEEECCCEEECHHHHCCHHHHHHHHHHCCHHHHHHCCCHHHHCCCCEEEEECC
GMVQGGPVLQYLSLLKNPRNKIILTGYQAEGTIGRSLEEGATEVKPFKRAIPVNGKVVKI
CCCCCCHHHHHHHHHCCCCCCEEEEEEECCCCCCCCHHHCCHHHCHHHHCCCCCCEEEEE
EFSAHADYNSLLRFMKKIPQPDKAIVMHGERYQALSLAMTIWKTLKIPALAPSIGSVLPL
EEECCCCHHHHHHHHHHCCCCCCEEEEECCCHHHHHHHHHHHHHHCCCCCCCCHHCCCCC
FD
CC
>Mature Secondary Structure 
TIAKFHGGCHQIGKSCVEINTKKSKILIDCGMDPSDNGLPDINDSDVDAVVVSHAHLDH
EEEECCCCHHHHCHHHEEECCCCCEEEEECCCCCCCCCCCCCCCCCCCEEEEECCCHHH
CGAIPYFNFKKIFCNPPTADLMYNVWKDTVSLSKTYKEEDIKKSMDVIKTVNYREEKQVT
CCCCCCCCCEEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHH
SDIKMKMYDAGHILGSSSLYLDIDGKKLLYTGDINEIETRTLRAADTDFDEIDTIIIEST
HHHEEEEEECCEEECCCEEEEEECCCEEEEECCCCHHHHHEEEECCCCHHHCCEEEEECC
YGSPLDIKPARKVLEKQLIDEISETIDNGGKVIIPVFAVGRSQEIIVVINNYMKSGALKE
CCCCCCCHHHHHHHHHHHHHHHHHHHCCCCEEEEEEEECCCCCEEEEEEECHHCCCCCEE
VPIYINGSLTHTTGMYMGYSDWLNPKIKNAIENRINPFGNLIKGGDEVFSREPCIIISTS
CCEEEECCEEECCCEEECHHHHCCHHHHHHHHHHCCHHHHHHCCCHHHHCCCCEEEEECC
GMVQGGPVLQYLSLLKNPRNKIILTGYQAEGTIGRSLEEGATEVKPFKRAIPVNGKVVKI
CCCCCCHHHHHHHHHCCCCCCEEEEEEECCCCCCCCHHHCCHHHCHHHHCCCCCCEEEEE
EFSAHADYNSLLRFMKKIPQPDKAIVMHGERYQALSLAMTIWKTLKIPALAPSIGSVLPL
EEECCCCHHHHHHHHHHCCCCCCEEEEECCCHHHHHHHHHHHHHHCCCCCCCCHHCCCCC
FD
CC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8688087 [H]