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The map label for this gene is appB [H]

Identifier: 37680919

GI number: 37680919

Start: 2779377

End: 2780363

Strand: Direct

Name: appB [H]

Synonym: VV2735

Alternate gene names: 37680919

Gene position: 2779377-2780363 (Clockwise)

Preceding gene: 37680918

Following gene: 37680920

Centisome position: 82.86

GC content: 46.0

Gene sequence:

>987_bases
ATGGGTTATTTTTTAAGACGTTTGTCGTTCTATATGGTCGCGCTGCTAGTCGCGGCAACATTAAACTTTATTATTCCTCG
AGCAATGCCTGGCGATCCAGTTACCATGATGTTTGCGAATGCAACCACACAGGTAACGCCAGAACGTATTGAGGCAATGA
AGAAACTGCTAGGTTTTGTCGATGGTCCCCTTTATGTTCAGTATTTCACTTACATTAAGAGCATTCTAAGCTGGGAACTT
GGTACTTCTATTAAATTCTACCCACTGAGTGTTAATGACCTATTAGGCAGCGCATTTGGTTGGTCCCTCTTCCTAGCTGG
TACTGCGGTTATTCTTTCATTCTCAATCGGCTCTATTCTGGGTATTTTCGCAGCATGGCGTCGTGGTAGTAAATACGATG
CATTCATCACACCAGGTATGTTGATTATTCAAGCTGTACCTCAGGTGGTTATCGCAATGCTAGCCCTATTTATCTTTGCA
ATCGGTCTTGGTTGGTTCCCGACGGGCTATGCATACACGCCTGGTACCATTCCAGATTGGACGAGCTGGGCCTACTTCAA
GGATGTTGCTTATCACGCCGTCCTACCTCTCTTCTGTGCGTCTATCGTTCAAATTGGTGGCTTCTTGGTGAACATGCGTA
ACAACATGATCAACCTGCTAGCAGAAGACTACATCACTATGGCGAAAGGCAAAGGCTTAAGCGAAAACCGCGTGGTGTTC
AACTACGCAGCGCGTAACGCACTGCTACCAAGTGTAACCGCCCTATCCATGTCACTCGGTATGGCCATCGGTGGTCAGCT
GATTGTTGAAATCATCTTCAACTACCCAGGTTTGGGTAAAGTCCTGCTTGATGCGATCAATGCACGTGACTACCAAGTAC
TACAAGGCCAATTGTTAATCATGACTCTGTTTATGCTGTCATTTAACCTGATTGCCGACATGCTGTATGTCGTACTCGAT
CCTCGCCTACGCAAGGGAGGCAAATAA

Upstream 100 bases:

>100_bases
TTATGGCGCCAGTCGTCAGGGGATTTTTCGCTCTGAATTTGGTCACGAGCGACCTGAAACCAGAAACAGGGAAAAAGTCT
GGGTGAGTAAGGTGTGAGTT

Downstream 100 bases:

>100_bases
TCATGAACAACTTATTTAAGCTGATTCTAGGTAATGCGATTGCTCGCGTTGGTTTGGTCATTGTTTGTCTGTTTATCTTT
ATGGCGGTCGCAGCGCCACT

Product: peptide ABC transporter, permease protein

Products: ADP; phosphate; dipeptides [Cytoplasm] [C]

Alternate protein names: NA

Number of amino acids: Translated: 328; Mature: 327

Protein sequence:

>328_residues
MGYFLRRLSFYMVALLVAATLNFIIPRAMPGDPVTMMFANATTQVTPERIEAMKKLLGFVDGPLYVQYFTYIKSILSWEL
GTSIKFYPLSVNDLLGSAFGWSLFLAGTAVILSFSIGSILGIFAAWRRGSKYDAFITPGMLIIQAVPQVVIAMLALFIFA
IGLGWFPTGYAYTPGTIPDWTSWAYFKDVAYHAVLPLFCASIVQIGGFLVNMRNNMINLLAEDYITMAKGKGLSENRVVF
NYAARNALLPSVTALSMSLGMAIGGQLIVEIIFNYPGLGKVLLDAINARDYQVLQGQLLIMTLFMLSFNLIADMLYVVLD
PRLRKGGK

Sequences:

>Translated_328_residues
MGYFLRRLSFYMVALLVAATLNFIIPRAMPGDPVTMMFANATTQVTPERIEAMKKLLGFVDGPLYVQYFTYIKSILSWEL
GTSIKFYPLSVNDLLGSAFGWSLFLAGTAVILSFSIGSILGIFAAWRRGSKYDAFITPGMLIIQAVPQVVIAMLALFIFA
IGLGWFPTGYAYTPGTIPDWTSWAYFKDVAYHAVLPLFCASIVQIGGFLVNMRNNMINLLAEDYITMAKGKGLSENRVVF
NYAARNALLPSVTALSMSLGMAIGGQLIVEIIFNYPGLGKVLLDAINARDYQVLQGQLLIMTLFMLSFNLIADMLYVVLD
PRLRKGGK
>Mature_327_residues
GYFLRRLSFYMVALLVAATLNFIIPRAMPGDPVTMMFANATTQVTPERIEAMKKLLGFVDGPLYVQYFTYIKSILSWELG
TSIKFYPLSVNDLLGSAFGWSLFLAGTAVILSFSIGSILGIFAAWRRGSKYDAFITPGMLIIQAVPQVVIAMLALFIFAI
GLGWFPTGYAYTPGTIPDWTSWAYFKDVAYHAVLPLFCASIVQIGGFLVNMRNNMINLLAEDYITMAKGKGLSENRVVFN
YAARNALLPSVTALSMSLGMAIGGQLIVEIIFNYPGLGKVLLDAINARDYQVLQGQLLIMTLFMLSFNLIADMLYVVLDP
RLRKGGK

Specific function: This protein is a component of an oligopeptide permease, a binding protein-dependent transport system. This APP system can completely substitute for the OPP system in both sporulation and genetic competence, though, unlike OPP, is incapable of transportin

COG id: COG0601

COG function: function code EP; ABC-type dipeptide/oligopeptide/nickel transport systems, permease components

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 ABC transmembrane type-1 domain [H]

Homologues:

Organism=Escherichia coli, GI1789965, Length=340, Percent_Identity=30.2941176470588, Blast_Score=157, Evalue=1e-39,
Organism=Escherichia coli, GI1787053, Length=325, Percent_Identity=30.4615384615385, Blast_Score=154, Evalue=1e-38,
Organism=Escherichia coli, GI1787497, Length=327, Percent_Identity=29.3577981651376, Blast_Score=142, Evalue=3e-35,
Organism=Escherichia coli, GI1789888, Length=324, Percent_Identity=30.5555555555556, Blast_Score=136, Evalue=2e-33,
Organism=Escherichia coli, GI1788504, Length=364, Percent_Identity=25.5494505494505, Blast_Score=108, Evalue=4e-25,
Organism=Escherichia coli, GI1787761, Length=341, Percent_Identity=28.7390029325513, Blast_Score=108, Evalue=6e-25,
Organism=Escherichia coli, GI1787550, Length=280, Percent_Identity=23.5714285714286, Blast_Score=84, Evalue=1e-17,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000515 [H]

Pfam domain/function: PF00528 BPD_transp_1 [H]

EC number: NA

Molecular weight: Translated: 36227; Mature: 36095

Theoretical pI: Translated: 9.56; Mature: 9.56

Prosite motif: PS50928 ABC_TM1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
4.9 %Met     (Translated Protein)
5.2 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
4.6 %Met     (Mature Protein)
4.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MGYFLRRLSFYMVALLVAATLNFIIPRAMPGDPVTMMFANATTQVTPERIEAMKKLLGFV
CCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCEEEEEECCCCCCCHHHHHHHHHHHHHH
DGPLYVQYFTYIKSILSWELGTSIKFYPLSVNDLLGSAFGWSLFLAGTAVILSFSIGSIL
CCHHHHHHHHHHHHHHHHHCCCCEEEEECCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
GIFAAWRRGSKYDAFITPGMLIIQAVPQVVIAMLALFIFAIGLGWFPTGYAYTPGTIPDW
HHHHHHHCCCCCCCHHCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCC
TSWAYFKDVAYHAVLPLFCASIVQIGGFLVNMRNNMINLLAEDYITMAKGKGLSENRVVF
CCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCEEE
NYAARNALLPSVTALSMSLGMAIGGQLIVEIIFNYPGLGKVLLDAINARDYQVLQGQLLI
EEHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHCCCCHHHHHHHHHH
MTLFMLSFNLIADMLYVVLDPRLRKGGK
HHHHHHHHHHHHHHHHHHHCHHHHCCCC
>Mature Secondary Structure 
GYFLRRLSFYMVALLVAATLNFIIPRAMPGDPVTMMFANATTQVTPERIEAMKKLLGFV
CHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCEEEEEECCCCCCCHHHHHHHHHHHHHH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HHHHHHHHHHHHHHHHHHHCHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: ATP; dipeptides [Periplasm]; H2O [C]

Specific reaction: ATP + dipeptides [Periplasm] + H2O = ADP + phosphate + dipeptides [Cytoplasm] [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: 7997159; 9384377 [H]