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The map label for this gene is panE [H]

Identifier: 37680786

GI number: 37680786

Start: 2627565

End: 2628458

Strand: Direct

Name: panE [H]

Synonym: VV2602

Alternate gene names: 37680786

Gene position: 2627565-2628458 (Clockwise)

Preceding gene: 37680785

Following gene: 37680787

Centisome position: 78.33

GC content: 48.43

Gene sequence:

>894_bases
TTGGTGAATATCCTCATTTTAGGTCCGGGGGCCGTTGGCTCACTTTGGGCGACAAAACTCAAACTCGCAGGGCACAATGT
CGCATTGTGGGGAAGAAGCGATGCATCTGAGCAACCCTTGCAACTTGATGACTCATCAGCCATGACGTTTAAACATCGTC
ACCTACCCTCTTTGCAAAGCGCTGATCTCATTTTGGTCACAGTGAAAGCATGGCAGGTGATGGCGGCGATTGAGCCTTTA
TTGCCACACATCCACTCAGATACCATCATCCTGCTGATGCACAACGGCATGGGAACCGCATCTCAGGTTGAAGAGAAGCT
CACGCACAACCCAATCATTGTGGCAACCACCACACATGGCGCGTATAAACCCCATTCGCAGCAGGTCTTGCACACCGGAC
AAGGCATCACGCAGTTGGGTGGCTTTAATGCACAAGGTGCACAATGTGAGTTCCTGCAAGCGGTGCTCGATCACGCCTTA
CCGTCTGTCACATGGAATCCCAATATCCAACAGGCGCTTTGGACCAAACTGGCCATCAACTGTGCCATCAACCCGTTAAC
AGCGATTCATCAATGTAAAAATGGTGAGCTAGACGATGAGAGGTTTCATCAACTGCTTGAGCGCATCACTCAAGAGTTGG
TCGACGTTATGGTCGAAGAAGGGATCGAGGTTACTTTCGATACCTTGCAGCAAACCATCATGAACGTGATTCATGCAACG
GCAGAAAATTATTCCTCGATGCGACAAGATGTTTTCCATCAACGCCGCACTGAAATCGACTATATCACTGGATATTTGTT
GCAAGCGGCGCATAAACACCAGATTGATGCAGCGGAAAACGCTAAACTTTATCAACACATCAAACAGATTGAACAAAGCT
GGACAGAACAATGA

Upstream 100 bases:

>100_bases
TTGTAAATTATCGCTTCAAATGGCGCCTGTTGGCGCCATTTTTATTTGCTTTCCTTATTTCCCTCATTATCCTTGCAGCA
AACCTTTTTACTGAGAGTGT

Downstream 100 bases:

>100_bases
AGAAAAAAATCTTAGTGCCTATTGCTTGCGGTACCGAGGAGATGGAAGCAGTGACCGCCATCGATATGATGGCTCGTGCT
GGCTACGACGTCACAGTCGC

Product: 2-dehydropantoate 2-reductase

Products: NA

Alternate protein names: Ketopantoate reductase; KPA reductase; KPR [H]

Number of amino acids: Translated: 297; Mature: 297

Protein sequence:

>297_residues
MVNILILGPGAVGSLWATKLKLAGHNVALWGRSDASEQPLQLDDSSAMTFKHRHLPSLQSADLILVTVKAWQVMAAIEPL
LPHIHSDTIILLMHNGMGTASQVEEKLTHNPIIVATTTHGAYKPHSQQVLHTGQGITQLGGFNAQGAQCEFLQAVLDHAL
PSVTWNPNIQQALWTKLAINCAINPLTAIHQCKNGELDDERFHQLLERITQELVDVMVEEGIEVTFDTLQQTIMNVIHAT
AENYSSMRQDVFHQRRTEIDYITGYLLQAAHKHQIDAAENAKLYQHIKQIEQSWTEQ

Sequences:

>Translated_297_residues
MVNILILGPGAVGSLWATKLKLAGHNVALWGRSDASEQPLQLDDSSAMTFKHRHLPSLQSADLILVTVKAWQVMAAIEPL
LPHIHSDTIILLMHNGMGTASQVEEKLTHNPIIVATTTHGAYKPHSQQVLHTGQGITQLGGFNAQGAQCEFLQAVLDHAL
PSVTWNPNIQQALWTKLAINCAINPLTAIHQCKNGELDDERFHQLLERITQELVDVMVEEGIEVTFDTLQQTIMNVIHAT
AENYSSMRQDVFHQRRTEIDYITGYLLQAAHKHQIDAAENAKLYQHIKQIEQSWTEQ
>Mature_297_residues
MVNILILGPGAVGSLWATKLKLAGHNVALWGRSDASEQPLQLDDSSAMTFKHRHLPSLQSADLILVTVKAWQVMAAIEPL
LPHIHSDTIILLMHNGMGTASQVEEKLTHNPIIVATTTHGAYKPHSQQVLHTGQGITQLGGFNAQGAQCEFLQAVLDHAL
PSVTWNPNIQQALWTKLAINCAINPLTAIHQCKNGELDDERFHQLLERITQELVDVMVEEGIEVTFDTLQQTIMNVIHAT
AENYSSMRQDVFHQRRTEIDYITGYLLQAAHKHQIDAAENAKLYQHIKQIEQSWTEQ

Specific function: Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid [H]

COG id: COG1893

COG function: function code H; Ketopantoate reductase

Gene ontology:

Cell location: Cytoplasm (Potential) [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ketopantoate reductase family [H]

Homologues:

Organism=Escherichia coli, GI1786627, Length=298, Percent_Identity=39.9328859060403, Blast_Score=202, Evalue=2e-53,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR008927
- InterPro:   IPR003710
- InterPro:   IPR013752
- InterPro:   IPR013332
- InterPro:   IPR013328
- InterPro:   IPR016040 [H]

Pfam domain/function: PF02558 ApbA; PF08546 ApbA_C [H]

EC number: =1.1.1.169 [H]

Molecular weight: Translated: 33139; Mature: 33139

Theoretical pI: Translated: 6.22; Mature: 6.22

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
2.7 %Met     (Translated Protein)
3.7 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
2.7 %Met     (Mature Protein)
3.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MVNILILGPGAVGSLWATKLKLAGHNVALWGRSDASEQPLQLDDSSAMTFKHRHLPSLQS
CEEEEEECCCCHHHHHHHHHEECCCEEEEECCCCCCCCCCCCCCCCCCEEHHHCCCCCCC
ADLILVTVKAWQVMAAIEPLLPHIHSDTIILLMHNGMGTASQVEEKLTHNPIIVATTTHG
CCEEEEEHHHHHHHHHHHHHHHCCCCCEEEEEEECCCCCHHHHHHHHCCCCEEEEEECCC
AYKPHSQQVLHTGQGITQLGGFNAQGAQCEFLQAVLDHALPSVTWNPNIQQALWTKLAIN
CCCCCHHHHHHCCCCHHHHCCCCCCCCHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHH
CAINPLTAIHQCKNGELDDERFHQLLERITQELVDVMVEEGIEVTFDTLQQTIMNVIHAT
HCCCHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHH
AENYSSMRQDVFHQRRTEIDYITGYLLQAAHKHQIDAAENAKLYQHIKQIEQSWTEQ
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHCCC
>Mature Secondary Structure
MVNILILGPGAVGSLWATKLKLAGHNVALWGRSDASEQPLQLDDSSAMTFKHRHLPSLQS
CEEEEEECCCCHHHHHHHHHEECCCEEEEECCCCCCCCCCCCCCCCCCEEHHHCCCCCCC
ADLILVTVKAWQVMAAIEPLLPHIHSDTIILLMHNGMGTASQVEEKLTHNPIIVATTTHG
CCEEEEEHHHHHHHHHHHHHHHCCCCCEEEEEEECCCCCHHHHHHHHCCCCEEEEEECCC
AYKPHSQQVLHTGQGITQLGGFNAQGAQCEFLQAVLDHALPSVTWNPNIQQALWTKLAIN
CCCCCHHHHHHCCCCHHHHCCCCCCCCHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHH
CAINPLTAIHQCKNGELDDERFHQLLERITQELVDVMVEEGIEVTFDTLQQTIMNVIHAT
HCCCHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHH
AENYSSMRQDVFHQRRTEIDYITGYLLQAAHKHQIDAAENAKLYQHIKQIEQSWTEQ
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 10952301 [H]