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The map label for this gene is pncB [H]

Identifier: 37680153

GI number: 37680153

Start: 1959885

End: 1961198

Strand: Direct

Name: pncB [H]

Synonym: VV1969

Alternate gene names: 37680153

Gene position: 1959885-1961198 (Clockwise)

Preceding gene: 37680149

Following gene: 37680161

Centisome position: 58.43

GC content: 46.65

Gene sequence:

>1314_bases
ATGTGCGCGCCACTTTTTCAACCAGCCATTATTCAAAGTGTTCTTGATTTAGATGTGTATAAAATCAATATGATGCAAGC
CGCGTATCGATTTTATCCTCAAACACAAGTGCGCTACGAACTGATCGTTCGCTCTGATGATAACTTGTCTGATTTAGTGG
AAGAGGTTCGTGAGGAAATCAACCGCCTCGCAGAGCTTCGCTTTGATGCTGCCCAGCTGGCTTACTTGGCAGAGAAAGCG
CCCTATTTAACGGCAGAGTTTCTCTCCTATTTAGAAACCTTCCGCTTCCACCCTCAGCAACAAGTCTCTGTCGGTATTTT
CCGCACCGCACAGGGCGACTGCCAGCTCAGAGTCACCATAAATGGCATTTGGCACGAAACCATTCTCTACGAAACCTTAG
TGATGAGTATTATCTCAGAGCTGCGCAATCGTCGTTATTGGGCACAAATACCCCAATCTCAACTGCACAAGGTATTAGAG
GACAAACTGGACTTTTTAGATTCGGAACTTAAACGCCGTAATATTACTAATTTCCGCTTCTCTGAGATGGGGACACGACG
CCGATTTAGCTTTGCTGCGCAAAAAACGATGCTTGACGTATTGCGTGCACGAGTGCCAGAACTGCTCTTAGGCACCAGTA
ATTATCACCTTGCTCAAGAGTTCAATTTAACGCCAATTGGCACGGTCGCACATGAATGGACCATGGCACATCAAGCGCTT
GTCGCTGTTCAACACTCTCAGTGTGTCGCATTAGACAAATGGCTTGAGGCGTTTAATGGCAGCCTTGGTATCGCTCTAAC
CGACACCATCGGTATTGATGCGTTTCTTAGCGATTTTGACCTAGAGAAAGCCACTGCCTATGCAGGCGTGAGACACGATT
CCGGCAGTCCATTTGTTTGGGGAGATAAAATCATTGCCCATTACGAAAGTCTAGGCATCGATCCAAGCACTAAAACCTTG
ATTTTTACCGATGGACTGGATTTTGCGCGTGCGCTTGATATTTGCGAGTATTTCGCCGGACGCGCACAGATAAGTTTTGG
CATTGGCACTTTCCTCGCCAATGATATGGGGAATTGGACCAATGACAAAGGCATCCGTTACCAACCGATATCAATGGTGG
TCAAGATGGCGGAATGTAATGGCTCCCCGGTGGCAAAAATCAGCGACGAGCCAGAGAAAGCTATGTGTGAAGACATCTTC
TTCTTGATGAACCTCAAGCAACGCTTTGGCTTAGAAGTGGACCTTGATAAAGCGATCGAAACGCTAAAGCAGATGAAACG
TCAGCAGAAAAAGCGCATTCAAAGCGTCGCTTAA

Upstream 100 bases:

>100_bases
GGTGTTAGTAACAAAAATTGACAAACCATACTCTCTCATTTAGAGTTCAGCACATTAACGAACAAAATGTTCTTAACCTA
AACAGGGTGAAAACAGACAC

Downstream 100 bases:

>100_bases
AACAAATTAGCCCCTGTCCTCTCATGGCGCCTTTCGTGGCGATTAACGACAGACGTAAAAAAACCTGCCAACTGGCAGGT
TTTTTGTCTTCGATGTTTAA

Product: nicotinate phosphoribosyltransferase

Products: NA

Alternate protein names: NAPRTase [H]

Number of amino acids: Translated: 437; Mature: 437

Protein sequence:

>437_residues
MCAPLFQPAIIQSVLDLDVYKINMMQAAYRFYPQTQVRYELIVRSDDNLSDLVEEVREEINRLAELRFDAAQLAYLAEKA
PYLTAEFLSYLETFRFHPQQQVSVGIFRTAQGDCQLRVTINGIWHETILYETLVMSIISELRNRRYWAQIPQSQLHKVLE
DKLDFLDSELKRRNITNFRFSEMGTRRRFSFAAQKTMLDVLRARVPELLLGTSNYHLAQEFNLTPIGTVAHEWTMAHQAL
VAVQHSQCVALDKWLEAFNGSLGIALTDTIGIDAFLSDFDLEKATAYAGVRHDSGSPFVWGDKIIAHYESLGIDPSTKTL
IFTDGLDFARALDICEYFAGRAQISFGIGTFLANDMGNWTNDKGIRYQPISMVVKMAECNGSPVAKISDEPEKAMCEDIF
FLMNLKQRFGLEVDLDKAIETLKQMKRQQKKRIQSVA

Sequences:

>Translated_437_residues
MCAPLFQPAIIQSVLDLDVYKINMMQAAYRFYPQTQVRYELIVRSDDNLSDLVEEVREEINRLAELRFDAAQLAYLAEKA
PYLTAEFLSYLETFRFHPQQQVSVGIFRTAQGDCQLRVTINGIWHETILYETLVMSIISELRNRRYWAQIPQSQLHKVLE
DKLDFLDSELKRRNITNFRFSEMGTRRRFSFAAQKTMLDVLRARVPELLLGTSNYHLAQEFNLTPIGTVAHEWTMAHQAL
VAVQHSQCVALDKWLEAFNGSLGIALTDTIGIDAFLSDFDLEKATAYAGVRHDSGSPFVWGDKIIAHYESLGIDPSTKTL
IFTDGLDFARALDICEYFAGRAQISFGIGTFLANDMGNWTNDKGIRYQPISMVVKMAECNGSPVAKISDEPEKAMCEDIF
FLMNLKQRFGLEVDLDKAIETLKQMKRQQKKRIQSVA
>Mature_437_residues
MCAPLFQPAIIQSVLDLDVYKINMMQAAYRFYPQTQVRYELIVRSDDNLSDLVEEVREEINRLAELRFDAAQLAYLAEKA
PYLTAEFLSYLETFRFHPQQQVSVGIFRTAQGDCQLRVTINGIWHETILYETLVMSIISELRNRRYWAQIPQSQLHKVLE
DKLDFLDSELKRRNITNFRFSEMGTRRRFSFAAQKTMLDVLRARVPELLLGTSNYHLAQEFNLTPIGTVAHEWTMAHQAL
VAVQHSQCVALDKWLEAFNGSLGIALTDTIGIDAFLSDFDLEKATAYAGVRHDSGSPFVWGDKIIAHYESLGIDPSTKTL
IFTDGLDFARALDICEYFAGRAQISFGIGTFLANDMGNWTNDKGIRYQPISMVVKMAECNGSPVAKISDEPEKAMCEDIF
FLMNLKQRFGLEVDLDKAIETLKQMKRQQKKRIQSVA

Specific function: NAD biosynthesis; nicotinamide to NaMN; second step. [C]

COG id: COG1488

COG function: function code H; Nicotinic acid phosphoribosyltransferase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the NAPRTase family [H]

Homologues:

Organism=Escherichia coli, GI1787162, Length=407, Percent_Identity=40.5405405405405, Blast_Score=308, Evalue=4e-85,
Organism=Saccharomyces cerevisiae, GI6324783, Length=405, Percent_Identity=32.3456790123457, Blast_Score=206, Evalue=7e-54,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006406
- InterPro:   IPR015977
- InterPro:   IPR007229
- InterPro:   IPR002638 [H]

Pfam domain/function: PF04095 NAPRTase [H]

EC number: =2.4.2.11 [H]

Molecular weight: Translated: 49947; Mature: 49947

Theoretical pI: Translated: 5.68; Mature: 5.68

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.4 %Cys     (Translated Protein)
3.0 %Met     (Translated Protein)
4.3 %Cys+Met (Translated Protein)
1.4 %Cys     (Mature Protein)
3.0 %Met     (Mature Protein)
4.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MCAPLFQPAIIQSVLDLDVYKINMMQAAYRFYPQTQVRYELIVRSDDNLSDLVEEVREEI
CCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEEEEECCCCHHHHHHHHHHHH
NRLAELRFDAAQLAYLAEKAPYLTAEFLSYLETFRFHPQQQVSVGIFRTAQGDCQLRVTI
HHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHCCCCHHCEEEEEEECCCCEEEEEEE
NGIWHETILYETLVMSIISELRNRRYWAQIPQSQLHKVLEDKLDFLDSELKRRNITNFRF
ECHHHHHHHHHHHHHHHHHHHHCCHHHHHCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCH
SEMGTRRRFSFAAQKTMLDVLRARVPELLLGTSNYHLAQEFNLTPIGTVAHEWTMAHQAL
HHHCCHHHHHHHHHHHHHHHHHHHCHHHHCCCCCCEEHEECCCCCCHHHHHHHHHHHHHH
VAVQHSQCVALDKWLEAFNGSLGIALTDTIGIDAFLSDFDLEKATAYAGVRHDSGSPFVW
HHHHCCHHHHHHHHHHHHCCCCEEEEECCCCHHHHHHHCCHHHHHHHHCCEECCCCCEEE
GDKIIAHYESLGIDPSTKTLIFTDGLDFARALDICEYFAGRAQISFGIGTFLANDMGNWT
CCHHHHHHHHCCCCCCCCEEEEECCCHHHHHHHHHHHHCCCCEEEHHHHHHHHHCCCCCC
NDKGIRYQPISMVVKMAECNGSPVAKISDEPEKAMCEDIFFLMNLKQRFGLEVDLDKAIE
CCCCCEEEHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHCCCCEEHHHHHH
TLKQMKRQQKKRIQSVA
HHHHHHHHHHHHHHCCC
>Mature Secondary Structure
MCAPLFQPAIIQSVLDLDVYKINMMQAAYRFYPQTQVRYELIVRSDDNLSDLVEEVREEI
CCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEEEEECCCCHHHHHHHHHHHH
NRLAELRFDAAQLAYLAEKAPYLTAEFLSYLETFRFHPQQQVSVGIFRTAQGDCQLRVTI
HHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHCCCCHHCEEEEEEECCCCEEEEEEE
NGIWHETILYETLVMSIISELRNRRYWAQIPQSQLHKVLEDKLDFLDSELKRRNITNFRF
ECHHHHHHHHHHHHHHHHHHHHCCHHHHHCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCH
SEMGTRRRFSFAAQKTMLDVLRARVPELLLGTSNYHLAQEFNLTPIGTVAHEWTMAHQAL
HHHCCHHHHHHHHHHHHHHHHHHHCHHHHCCCCCCEEHEECCCCCCHHHHHHHHHHHHHH
VAVQHSQCVALDKWLEAFNGSLGIALTDTIGIDAFLSDFDLEKATAYAGVRHDSGSPFVW
HHHHCCHHHHHHHHHHHHCCCCEEEEECCCCHHHHHHHCCHHHHHHHHCCEECCCCCEEE
GDKIIAHYESLGIDPSTKTLIFTDGLDFARALDICEYFAGRAQISFGIGTFLANDMGNWT
CCHHHHHHHHCCCCCCCCEEEEECCCHHHHHHHHHHHHCCCCEEEHHHHHHHHHCCCCCC
NDKGIRYQPISMVVKMAECNGSPVAKISDEPEKAMCEDIFFLMNLKQRFGLEVDLDKAIE
CCCCCEEEHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHCCCCEEHHHHHH
TLKQMKRQQKKRIQSVA
HHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA