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The map label for this gene is cmaA2 [H]

Identifier: 37521508

GI number: 37521508

Start: 2061878

End: 2063887

Strand: Reverse

Name: cmaA2 [H]

Synonym: gll1939

Alternate gene names: 37521508

Gene position: 2063887-2061878 (Counterclockwise)

Preceding gene: 37521509

Following gene: 37521507

Centisome position: 44.3

GC content: 62.69

Gene sequence:

>2010_bases
ATGAATACCGCTGCGACGGCCCAGGCTTGCGCCTCGGCGCAGGCCATTCAATACCACTACGACCTGGGAAACGAATTTTA
CCGGCTGTGGCTCGACAGCAGCATGACCTATTCCTGCGGTCTTTGGGAAGCAGACGGCACGCTGGAGGAGGCCCAGGCCC
GCAAGATCGACCATCACATCCGCGAAGCCCGGGCCGCGGGGGGCGGCCGGGTCCTGGACATCGGCTGCGGCTGGGGGGGA
ACACTGCGGTCGCTGGTCGGGGCGCACGGTGTCACCCGGGCCGTCGGACTCACCCTGAGCCAAACCCAGGCCACCTGGAT
CGCCGCTTTTGGCCATCCCCGCATCGAAGTCCGGCTCGAAAGCTGGCAGGACCATGCGCCGGCAGAACCTTACGACGCGA
TCATCTCCGTGGGCGCTTTCGAGCACTTCGCCAGACCGGAGCTCACCGGTGCGCAAAAAGTGCAAGTCTACCGCGAGTTT
TTCGAACGTTGCCACGGTTGGCTGCCGCCCGGCGGGCGGCTTTCGCTGCAGACGATCGCCTACGGCAACGTCCCCAAGCA
GCAGATGCATCCATTTTTCTCCAGCGAGATCTTCCCCGAATCGGACTTGCCGACCCTGACGGAGATCGCCCAAGCGAGCG
CGCGCACGTTCGAAGTGATCGCTTTGCGCAACGACGCGGAGGATTACCGGCTCACCTGCCAAAGCTGGCTGACGCGCTTG
AAATCGCACCGGGCGCAGGCCGTGGCCCTGGTCGGGGAGGCGGCGGTCAGCCGATACGAGAAGTATCTGGCGCTGTTTGT
GCTCAGCTTTCGCACCAGGGCTATGCACCTGCTGCGCATCACCCTGCGCCGCAACGACCGGCTTTTTGACCAGCAAGGCG
ACCACCAGACGACGCACGGGCAGAGTTCAGATACCAGGGCAAGGTCGGCGGCCTCTCCCGGCATGAAGGGGGAAGGTTTC
TACGACGCACACTCTGACTCTCAAAAGCTCGCTCTAGTCTCGGCGCAGGCGCTGATTGCCGGAGCGGTCCGCCGCATCCC
GCCGCTTACGGACAGCCGACCGTTTACGATCGTCGATTACGGCTGCTCCGAAGGCCGGAACTCCCTGATGGCCGTCCAGT
GGGCTCTCGATGCCCTTGCCGGCCAAGAAGATCTCCAACCGACCATTTGTGTTGTCCACAACGACCTGCCCACCAACAAT
TTCAACGGGTTGTTCCGCAACCTGGGCTCAACCGGGTGCTGCCTGGAGACGGCCAACGGGTGTCCAATCTATGTCTTCGC
CGCCGGCCGTTCGTTCTACCGCCAGATCCTCCCCAGCGGCTCAGCCAGTTTCGGCCTCTCGTCGACCGCTTTGCACTGGT
TAAGCCGTCCGCCTGTTGTGCACTTTCCGGAGCACACCTACTCCGGATGGGCCAGGGGGTCGGTGCGCGAAGCTTTCGCC
GCACAATCCCGACAGGATCTGACCACTTTTTTGTCCTGCCGAGCTCAAGAAACCCGGCCCGGCGGACGGCTGGTGCTGTT
GATGCTCGGGCGGGCGGATGCCGGTGAATTGGCAGGGATCGACGGCGAGAAAATCAGTGGGTTGATGACGACCGAACTGA
TGAACCAGGTGCTCATCGAAATGGTGGAAGACGGCACCCTCGATCGCCAGGAATACCACGACTTTTTCTATCCCACCTAC
TGCCCGTCTCTGGCGGAGGTGCTTGCCCCGCTCCAGGAACCCGGCTCGCCGTTGGTAGAGCAATTTACCGTCGAGCATGC
CGAGGTGCAGGCTCTGCCCTGTCCTCTCTACACCCGCTACCGGCAGAGCGGCAATCTCCAGGAGTACGCGCAGGCGTACA
CGGCCTTCATCCGGGCATTCAGCGAACCGCTGTTTGCCCAAACCCTTTTTCGCGGCCGAGCGCGCTTGCTGGAGAATTAC
TACGCCGGAGTACACAGCCGCATCGCCCGCAGTCCGCAAGCGTTTGTCCACGAACAAGTGCAGTTGCAGCTTGTCCTGGC
CAGAAATTGA

Upstream 100 bases:

>100_bases
ACCCGAGCGGCTGGTGCATTCGGCTGCTCGCTGCTGTCGGCCTGGTCTGGGAGGTAAAGATTCCGAACCAAGCAACGATC
GCCGCCAGGAGGCAAGTCCG

Downstream 100 bases:

>100_bases
TCCGGCCCGTCTTCTTACCCATCAGGATATCCTCCACCATGTCAGAGCCTGCCGAGCAGCCCGAGTCCGTCAAGGGCTGG
ACCCGTTTGACCCGACGGCG

Product: cyclopropane-fatty-acyl-phospholipid synthase

Products: NA

Alternate protein names: CMAS; Cyclopropane-fatty-acyl-phospholipid synthase; CFA synthase; Cyclopropane fatty acid synthase; Mycolic acid methyltransferase; MA-MT; S-adenosylmethionine-dependent methyltransferase; AdoMet-MT; SAM-MT [H]

Number of amino acids: Translated: 669; Mature: 669

Protein sequence:

>669_residues
MNTAATAQACASAQAIQYHYDLGNEFYRLWLDSSMTYSCGLWEADGTLEEAQARKIDHHIREARAAGGGRVLDIGCGWGG
TLRSLVGAHGVTRAVGLTLSQTQATWIAAFGHPRIEVRLESWQDHAPAEPYDAIISVGAFEHFARPELTGAQKVQVYREF
FERCHGWLPPGGRLSLQTIAYGNVPKQQMHPFFSSEIFPESDLPTLTEIAQASARTFEVIALRNDAEDYRLTCQSWLTRL
KSHRAQAVALVGEAAVSRYEKYLALFVLSFRTRAMHLLRITLRRNDRLFDQQGDHQTTHGQSSDTRARSAASPGMKGEGF
YDAHSDSQKLALVSAQALIAGAVRRIPPLTDSRPFTIVDYGCSEGRNSLMAVQWALDALAGQEDLQPTICVVHNDLPTNN
FNGLFRNLGSTGCCLETANGCPIYVFAAGRSFYRQILPSGSASFGLSSTALHWLSRPPVVHFPEHTYSGWARGSVREAFA
AQSRQDLTTFLSCRAQETRPGGRLVLLMLGRADAGELAGIDGEKISGLMTTELMNQVLIEMVEDGTLDRQEYHDFFYPTY
CPSLAEVLAPLQEPGSPLVEQFTVEHAEVQALPCPLYTRYRQSGNLQEYAQAYTAFIRAFSEPLFAQTLFRGRARLLENY
YAGVHSRIARSPQAFVHEQVQLQLVLARN

Sequences:

>Translated_669_residues
MNTAATAQACASAQAIQYHYDLGNEFYRLWLDSSMTYSCGLWEADGTLEEAQARKIDHHIREARAAGGGRVLDIGCGWGG
TLRSLVGAHGVTRAVGLTLSQTQATWIAAFGHPRIEVRLESWQDHAPAEPYDAIISVGAFEHFARPELTGAQKVQVYREF
FERCHGWLPPGGRLSLQTIAYGNVPKQQMHPFFSSEIFPESDLPTLTEIAQASARTFEVIALRNDAEDYRLTCQSWLTRL
KSHRAQAVALVGEAAVSRYEKYLALFVLSFRTRAMHLLRITLRRNDRLFDQQGDHQTTHGQSSDTRARSAASPGMKGEGF
YDAHSDSQKLALVSAQALIAGAVRRIPPLTDSRPFTIVDYGCSEGRNSLMAVQWALDALAGQEDLQPTICVVHNDLPTNN
FNGLFRNLGSTGCCLETANGCPIYVFAAGRSFYRQILPSGSASFGLSSTALHWLSRPPVVHFPEHTYSGWARGSVREAFA
AQSRQDLTTFLSCRAQETRPGGRLVLLMLGRADAGELAGIDGEKISGLMTTELMNQVLIEMVEDGTLDRQEYHDFFYPTY
CPSLAEVLAPLQEPGSPLVEQFTVEHAEVQALPCPLYTRYRQSGNLQEYAQAYTAFIRAFSEPLFAQTLFRGRARLLENY
YAGVHSRIARSPQAFVHEQVQLQLVLARN
>Mature_669_residues
MNTAATAQACASAQAIQYHYDLGNEFYRLWLDSSMTYSCGLWEADGTLEEAQARKIDHHIREARAAGGGRVLDIGCGWGG
TLRSLVGAHGVTRAVGLTLSQTQATWIAAFGHPRIEVRLESWQDHAPAEPYDAIISVGAFEHFARPELTGAQKVQVYREF
FERCHGWLPPGGRLSLQTIAYGNVPKQQMHPFFSSEIFPESDLPTLTEIAQASARTFEVIALRNDAEDYRLTCQSWLTRL
KSHRAQAVALVGEAAVSRYEKYLALFVLSFRTRAMHLLRITLRRNDRLFDQQGDHQTTHGQSSDTRARSAASPGMKGEGF
YDAHSDSQKLALVSAQALIAGAVRRIPPLTDSRPFTIVDYGCSEGRNSLMAVQWALDALAGQEDLQPTICVVHNDLPTNN
FNGLFRNLGSTGCCLETANGCPIYVFAAGRSFYRQILPSGSASFGLSSTALHWLSRPPVVHFPEHTYSGWARGSVREAFA
AQSRQDLTTFLSCRAQETRPGGRLVLLMLGRADAGELAGIDGEKISGLMTTELMNQVLIEMVEDGTLDRQEYHDFFYPTY
CPSLAEVLAPLQEPGSPLVEQFTVEHAEVQALPCPLYTRYRQSGNLQEYAQAYTAFIRAFSEPLFAQTLFRGRARLLENY
YAGVHSRIARSPQAFVHEQVQLQLVLARN

Specific function: Catalyzes the formation of trans cyclopropanated ketomycolate or methoxymycolate through the conversion of a double bond to a cyclopropane ring at the proximal position of an oxygenated mycolic acid via the transfers of a methylene group from S-adenosyl-L

COG id: COG2230

COG function: function code M; Cyclopropane fatty acid synthase and related methyltransferases

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the CFA/CMAS family [H]

Homologues:

Organism=Escherichia coli, GI1787951, Length=271, Percent_Identity=30.2583025830258, Blast_Score=114, Evalue=3e-26,
Organism=Caenorhabditis elegans, GI133904226, Length=291, Percent_Identity=27.4914089347079, Blast_Score=102, Evalue=8e-22,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003333 [H]

Pfam domain/function: PF02353 CMAS [H]

EC number: =2.1.1.79 [H]

Molecular weight: Translated: 74206; Mature: 74206

Theoretical pI: Translated: 6.73; Mature: 6.73

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.9 %Cys     (Translated Protein)
1.5 %Met     (Translated Protein)
3.4 %Cys+Met (Translated Protein)
1.9 %Cys     (Mature Protein)
1.5 %Met     (Mature Protein)
3.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNTAATAQACASAQAIQYHYDLGNEFYRLWLDSSMTYSCGLWEADGTLEEAQARKIDHHI
CCCCHHHHHHHHHHHEEEEHHCCHHHEEEEECCCCEEECEEECCCCCHHHHHHHHHHHHH
REARAAGGGRVLDIGCGWGGTLRSLVGAHGVTRAVGLTLSQTQATWIAAFGHPRIEVRLE
HHHHHCCCCEEEEEECCCCHHHHHHHHHCHHHHHHCCEEECCCCEEEEECCCCEEEEEEE
SWQDHAPAEPYDAIISVGAFEHFARPELTGAQKVQVYREFFERCHGWLPPGGRLSLQTIA
CCCCCCCCCHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHCCCCCCCCCEEEEEEE
YGNVPKQQMHPFFSSEIFPESDLPTLTEIAQASARTFEVIALRNDAEDYRLTCQSWLTRL
ECCCCHHHHCCHHHCCCCCCCCCCHHHHHHHHCCCEEEEEEEECCCHHHHHHHHHHHHHH
KSHRAQAVALVGEAAVSRYEKYLALFVLSFRTRAMHLLRITLRRNDRLFDQQGDHQTTHG
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCC
QSSDTRARSAASPGMKGEGFYDAHSDSQKLALVSAQALIAGAVRRIPPLTDSRPFTIVDY
CCCCHHHHHHCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHCCCCCCCCCEEEEEC
GCSEGRNSLMAVQWALDALAGQEDLQPTICVVHNDLPTNNFNGLFRNLGSTGCCLETANG
CCCCCCCCHHHHHHHHHHHCCCCCCCCEEEEEECCCCCCCHHHHHHHCCCCCCEEECCCC
CPIYVFAAGRSFYRQILPSGSASFGLSSTALHWLSRPPVVHFPEHTYSGWARGSVREAFA
CEEEEEECCHHHHHHHCCCCCCCCCCHHHHHHHHCCCCEEECCCCCCCCCCCCHHHHHHH
AQSRQDLTTFLSCRAQETRPGGRLVLLMLGRADAGELAGIDGEKISGLMTTELMNQVLIE
HHHHHHHHHHHHHCCCCCCCCCEEEEEEECCCCCCCCCCCCCHHHHHHHHHHHHHHHHHH
MVEDGTLDRQEYHDFFYPTYCPSLAEVLAPLQEPGSPLVEQFTVEHAEVQALPCPLYTRY
HHHCCCCCHHHHHCCCCCHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHEECCCCHHHHH
RQSGNLQEYAQAYTAFIRAFSEPLFAQTLFRGRARLLENYYAGVHSRIARSPQAFVHEQV
HCCCCHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHCE
QLQLVLARN
EEEEEEECC
>Mature Secondary Structure
MNTAATAQACASAQAIQYHYDLGNEFYRLWLDSSMTYSCGLWEADGTLEEAQARKIDHHI
CCCCHHHHHHHHHHHEEEEHHCCHHHEEEEECCCCEEECEEECCCCCHHHHHHHHHHHHH
REARAAGGGRVLDIGCGWGGTLRSLVGAHGVTRAVGLTLSQTQATWIAAFGHPRIEVRLE
HHHHHCCCCEEEEEECCCCHHHHHHHHHCHHHHHHCCEEECCCCEEEEECCCCEEEEEEE
SWQDHAPAEPYDAIISVGAFEHFARPELTGAQKVQVYREFFERCHGWLPPGGRLSLQTIA
CCCCCCCCCHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHCCCCCCCCCEEEEEEE
YGNVPKQQMHPFFSSEIFPESDLPTLTEIAQASARTFEVIALRNDAEDYRLTCQSWLTRL
ECCCCHHHHCCHHHCCCCCCCCCCHHHHHHHHCCCEEEEEEEECCCHHHHHHHHHHHHHH
KSHRAQAVALVGEAAVSRYEKYLALFVLSFRTRAMHLLRITLRRNDRLFDQQGDHQTTHG
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCC
QSSDTRARSAASPGMKGEGFYDAHSDSQKLALVSAQALIAGAVRRIPPLTDSRPFTIVDY
CCCCHHHHHHCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHCCCCCCCCCEEEEEC
GCSEGRNSLMAVQWALDALAGQEDLQPTICVVHNDLPTNNFNGLFRNLGSTGCCLETANG
CCCCCCCCHHHHHHHHHHHCCCCCCCCEEEEEECCCCCCCHHHHHHHCCCCCCEEECCCC
CPIYVFAAGRSFYRQILPSGSASFGLSSTALHWLSRPPVVHFPEHTYSGWARGSVREAFA
CEEEEEECCHHHHHHHCCCCCCCCCCHHHHHHHHCCCCEEECCCCCCCCCCCCHHHHHHH
AQSRQDLTTFLSCRAQETRPGGRLVLLMLGRADAGELAGIDGEKISGLMTTELMNQVLIE
HHHHHHHHHHHHHCCCCCCCCCEEEEEEECCCCCCCCCCCCCHHHHHHHHHHHHHHHHHH
MVEDGTLDRQEYHDFFYPTYCPSLAEVLAPLQEPGSPLVEQFTVEHAEVQALPCPLYTRY
HHHCCCCCHHHHHCCCCCHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHEECCCCHHHHH
RQSGNLQEYAQAYTAFIRAFSEPLFAQTLFRGRARLLENYYAGVHSRIARSPQAFVHEQV
HCCCCHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHCE
QLQLVLARN
EEEEEEECC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 11234002 [H]