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The map label for this gene is hik2 [H]

Identifier: 34497953

GI number: 34497953

Start: 2688875

End: 2691091

Strand: Reverse

Name: hik2 [H]

Synonym: CV_2498

Alternate gene names: 34497953

Gene position: 2691091-2688875 (Counterclockwise)

Preceding gene: 34497954

Following gene: 34497952

Centisome position: 56.64

GC content: 64.55

Gene sequence:

>2217_bases
TTGCGCGAGGCCAAGCAGATGGCCGAGCAGGCCACCCGCGCCAAGTCGCTGTTCCTGGCCAACATGAGCCACGAGATACG
CACGCCAATGAACGCCATCATCGGCATGTCTTACCTGGCGCTGCGCACCGATCTCGACGACCAGCAGCGCAACTACATCG
GCAAGATCCACAATGCAGGCACTTCGCTGCTGGGCATCATCAACGACATCCTCGATTTTTCCAAGGTGGAGGCCGGCAAG
CTGGAGCTGGAGGCACAGCCTTTCTGGCTGGACGATGTGCTGGACGGCGTGTCGGCGCTGGTTGCGCAGAAGGCGGCGGA
CAAGGGGCTGGAGCTGTTGTTCGAAACCGCGGGCGACGTGCCGCAGGGGCTGGTCGGCGATGCGCTGAGGCTGGGGCAGG
TGCTGACCAATCTGGCCGGCAACGCGATCAAGTTCACAGAGACGGGGCAGGTGTCCATCATCATCGGCCAGGTCGAACGC
ATAGGCGACAAGGTCCAGCTGAAGTTCTGCGTCCACGATACCGGGATAGGCATGAGCGAGGAGCAGCAAAGCCGGCTGTT
CCAGGCCTTCAGCCAGGCGGATGGTTCGACGACGCGCCGCTTTGGCGGCACCGGCCTGGGCCTGACCATCGCGAAAAGGC
TGGTGGAGCTGATGGGCGGCAGCATGTTGGTGGAATCGGCTCCAGGCTGGGGCAGCTCTTTCATCTTCAGCTGCTGGCTG
GGCGTGTCGGCCGAAACGGATTCGCGCCGGCAGTCGCTGCCCAAGGAAATTCGCGGCTTGCGCGTGCTGGTGGTGGACGA
CAACCAGTCGGCCGTCGACGTCCTGTGCGCGCAACTGAAACAGCTGGGTTTCGAGGTGCAGGGATGCTTGAACGGCCACG
AGGCCTTGTCGAAAGTGCGGCAGGATTGCCTGCAAAAGCCGTTCGACGTCGCCTTCGTCGACTGGATGATGCCGGAAATG
GACGGCCTGGAAGCGGTGCGCAGAATGCGGCAGGTCAGCCGCAAGATGCGCATCGTGATGGTGACGGCCTTCGGGCGCGA
CGAAATCCGGGTCAAGGCCCGCGCCGCCGGCTGCGATGCTTTCATGGTCAAGCCAGTCAATCTGTCCCAACTGTACGATG
TGCTGCTGGAGGTGTTCGGTTTCGGGCGCAGCGGCGGCTTGTCGCTGTTCGATGAGACGGACCAGCTTCCCCGCTTCGAT
GGCGCGCACCTGCTGCTGGTGGAGGACAATCGCATCAATCAGCAGATCGCGATCGAGCTGCTGGAAGGCACGGGCGCGAC
CATTACGGTGGCCGCGAACGGGCAGGCGGCGCTGGACAAGCTGCTGGCTTATGGTCCCAAGGCTTTCGATGCGGTGCTGA
TGGACGTGCAGATGCCGGTGATGGACGGGATAGAGGCCACCGGACGCATACGTTCCCAGCCGGGATTCATCGATCTGCCT
GTCATCGCGATGACGGCGGACGCGCTGGTGGAGGAGCGGGAGCGCTGTCTGGCGGCGGGCATGGTGGACCATATCGCGAA
GCCCATCGACCCGCATATTCTATTCTCCACCCTGGCGCGCTGGGTGCGGCGAAGCGGGGCGCCGCAGGGGCGCGAAGCCG
AAACTGCCGCCGACCAGACGCCGCTGCCGCAGATCGACGGCTTGGACCAGCTGGCGGGTCTGCGCCGCGTAGCCGGCAAT
CGACAGCTCTACCTGCATCTGCTCAGACAGTTCGTCGATGAGGAGGCCGGCGCGGCCACCCGTTTGGGCCTTGCTTTGGG
CGAGCGTGACTTCCAGACGGCGGAGCGCATCGCGCACACGCTGAAGGGCGCGGCCGGGAGCATAGGTTTCGTCGATCTGC
AAAGCGCGGCGATGCGATTGGAAATGGCGCTCCGGGCGCGCGAAAGCTGGCAAGATTTGCTGGTGGAGCTGGAAATGGAG
TTGGGGCAAGTGGTGGGCGCCCTGCGGGCCGGTTTGGCGGAACTGGGGCAGCCCGCGTCCGGCGCCAGGCCGGATGACGC
GCTGCTCGAACGCCTGGCCGCGTTGCTGGCGGTTGGGGACGGCGACGCGCTGGGATATTTTCTTGAGCATGCGCCGCGCA
TCCGGGCCTGCTTTCCGGAGGGAGCATGCGCTGATTTCGAGCAAGCGCTGAACCGTTTCGATTTCGTTTCCGCGTTGGGC
GCGCTGCGCGAGCTGGCGAGAGCTTGCGGCAAAAAGCTGCCGGAGGACACGAGATGA

Upstream 100 bases:

>100_bases
CGGTCGTATTTACGGCTTGATGGCTGCCAGCTTCGTGTTGATGGTGCTGCTGCTGGAGTATGGCTTGCTGTACGCGCGGC
TGGTCGAGAATTCCGCGCAA

Downstream 100 bases:

>100_bases
GCGATGCGAACGCAGCCGGGCGTCAGACCGTGCTGCTGGTGGACGACAGCCCAGAGAGCCTGACCCAGATGTACGGTTTG
CTGAAGGCGGACTATCGGAC

Product: hybrid sensory kinase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 738; Mature: 738

Protein sequence:

>738_residues
MREAKQMAEQATRAKSLFLANMSHEIRTPMNAIIGMSYLALRTDLDDQQRNYIGKIHNAGTSLLGIINDILDFSKVEAGK
LELEAQPFWLDDVLDGVSALVAQKAADKGLELLFETAGDVPQGLVGDALRLGQVLTNLAGNAIKFTETGQVSIIIGQVER
IGDKVQLKFCVHDTGIGMSEEQQSRLFQAFSQADGSTTRRFGGTGLGLTIAKRLVELMGGSMLVESAPGWGSSFIFSCWL
GVSAETDSRRQSLPKEIRGLRVLVVDDNQSAVDVLCAQLKQLGFEVQGCLNGHEALSKVRQDCLQKPFDVAFVDWMMPEM
DGLEAVRRMRQVSRKMRIVMVTAFGRDEIRVKARAAGCDAFMVKPVNLSQLYDVLLEVFGFGRSGGLSLFDETDQLPRFD
GAHLLLVEDNRINQQIAIELLEGTGATITVAANGQAALDKLLAYGPKAFDAVLMDVQMPVMDGIEATGRIRSQPGFIDLP
VIAMTADALVEERERCLAAGMVDHIAKPIDPHILFSTLARWVRRSGAPQGREAETAADQTPLPQIDGLDQLAGLRRVAGN
RQLYLHLLRQFVDEEAGAATRLGLALGERDFQTAERIAHTLKGAAGSIGFVDLQSAAMRLEMALRARESWQDLLVELEME
LGQVVGALRAGLAELGQPASGARPDDALLERLAALLAVGDGDALGYFLEHAPRIRACFPEGACADFEQALNRFDFVSALG
ALRELARACGKKLPEDTR

Sequences:

>Translated_738_residues
MREAKQMAEQATRAKSLFLANMSHEIRTPMNAIIGMSYLALRTDLDDQQRNYIGKIHNAGTSLLGIINDILDFSKVEAGK
LELEAQPFWLDDVLDGVSALVAQKAADKGLELLFETAGDVPQGLVGDALRLGQVLTNLAGNAIKFTETGQVSIIIGQVER
IGDKVQLKFCVHDTGIGMSEEQQSRLFQAFSQADGSTTRRFGGTGLGLTIAKRLVELMGGSMLVESAPGWGSSFIFSCWL
GVSAETDSRRQSLPKEIRGLRVLVVDDNQSAVDVLCAQLKQLGFEVQGCLNGHEALSKVRQDCLQKPFDVAFVDWMMPEM
DGLEAVRRMRQVSRKMRIVMVTAFGRDEIRVKARAAGCDAFMVKPVNLSQLYDVLLEVFGFGRSGGLSLFDETDQLPRFD
GAHLLLVEDNRINQQIAIELLEGTGATITVAANGQAALDKLLAYGPKAFDAVLMDVQMPVMDGIEATGRIRSQPGFIDLP
VIAMTADALVEERERCLAAGMVDHIAKPIDPHILFSTLARWVRRSGAPQGREAETAADQTPLPQIDGLDQLAGLRRVAGN
RQLYLHLLRQFVDEEAGAATRLGLALGERDFQTAERIAHTLKGAAGSIGFVDLQSAAMRLEMALRARESWQDLLVELEME
LGQVVGALRAGLAELGQPASGARPDDALLERLAALLAVGDGDALGYFLEHAPRIRACFPEGACADFEQALNRFDFVSALG
ALRELARACGKKLPEDTR
>Mature_738_residues
MREAKQMAEQATRAKSLFLANMSHEIRTPMNAIIGMSYLALRTDLDDQQRNYIGKIHNAGTSLLGIINDILDFSKVEAGK
LELEAQPFWLDDVLDGVSALVAQKAADKGLELLFETAGDVPQGLVGDALRLGQVLTNLAGNAIKFTETGQVSIIIGQVER
IGDKVQLKFCVHDTGIGMSEEQQSRLFQAFSQADGSTTRRFGGTGLGLTIAKRLVELMGGSMLVESAPGWGSSFIFSCWL
GVSAETDSRRQSLPKEIRGLRVLVVDDNQSAVDVLCAQLKQLGFEVQGCLNGHEALSKVRQDCLQKPFDVAFVDWMMPEM
DGLEAVRRMRQVSRKMRIVMVTAFGRDEIRVKARAAGCDAFMVKPVNLSQLYDVLLEVFGFGRSGGLSLFDETDQLPRFD
GAHLLLVEDNRINQQIAIELLEGTGATITVAANGQAALDKLLAYGPKAFDAVLMDVQMPVMDGIEATGRIRSQPGFIDLP
VIAMTADALVEERERCLAAGMVDHIAKPIDPHILFSTLARWVRRSGAPQGREAETAADQTPLPQIDGLDQLAGLRRVAGN
RQLYLHLLRQFVDEEAGAATRLGLALGERDFQTAERIAHTLKGAAGSIGFVDLQSAAMRLEMALRARESWQDLLVELEME
LGQVVGALRAGLAELGQPASGARPDDALLERLAALLAVGDGDALGYFLEHAPRIRACFPEGACADFEQALNRFDFVSALG
ALRELARACGKKLPEDTR

Specific function: Member of the two-component regulatory system UvrY/BarA involved in the regulation of carbon metabolism via the CsrA/CsrB regulatory system. Phosphorylates UvrY, probably via a four-step phosphorelay [H]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 response regulatory domain [H]

Homologues:

Organism=Escherichia coli, GI1789149, Length=623, Percent_Identity=34.991974317817, Blast_Score=325, Evalue=5e-90,
Organism=Escherichia coli, GI145693157, Length=530, Percent_Identity=33.5849056603774, Blast_Score=221, Evalue=2e-58,
Organism=Escherichia coli, GI87081816, Length=412, Percent_Identity=32.2815533980583, Blast_Score=185, Evalue=1e-47,
Organism=Escherichia coli, GI48994928, Length=369, Percent_Identity=32.2493224932249, Blast_Score=184, Evalue=1e-47,
Organism=Escherichia coli, GI1788713, Length=387, Percent_Identity=33.8501291989664, Blast_Score=174, Evalue=2e-44,
Organism=Escherichia coli, GI1788393, Length=226, Percent_Identity=27.8761061946903, Blast_Score=88, Evalue=2e-18,
Organism=Escherichia coli, GI1786783, Length=228, Percent_Identity=29.8245614035088, Blast_Score=86, Evalue=1e-17,
Organism=Escherichia coli, GI1786600, Length=241, Percent_Identity=28.2157676348548, Blast_Score=79, Evalue=8e-16,
Organism=Escherichia coli, GI1790436, Length=225, Percent_Identity=30.6666666666667, Blast_Score=78, Evalue=2e-15,
Organism=Escherichia coli, GI1786912, Length=236, Percent_Identity=26.271186440678, Blast_Score=72, Evalue=1e-13,
Organism=Escherichia coli, GI1790346, Length=238, Percent_Identity=26.890756302521, Blast_Score=70, Evalue=3e-13,
Organism=Escherichia coli, GI1788549, Length=236, Percent_Identity=25, Blast_Score=70, Evalue=7e-13,
Organism=Escherichia coli, GI1787894, Length=257, Percent_Identity=24.9027237354086, Blast_Score=64, Evalue=3e-11,
Organism=Saccharomyces cerevisiae, GI6322044, Length=382, Percent_Identity=26.7015706806283, Blast_Score=110, Evalue=7e-25,
Organism=Saccharomyces cerevisiae, GI6322000, Length=153, Percent_Identity=32.6797385620915, Blast_Score=79, Evalue=3e-15,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003594
- InterPro:   IPR011006
- InterPro:   IPR019247
- InterPro:   IPR003660
- InterPro:   IPR004358
- InterPro:   IPR008207
- InterPro:   IPR003661
- InterPro:   IPR005467
- InterPro:   IPR009082
- InterPro:   IPR001789 [H]

Pfam domain/function: PF09984 DUF2222; PF00672 HAMP; PF02518 HATPase_c; PF00512 HisKA; PF01627 Hpt; PF00072 Response_reg [H]

EC number: =2.7.13.3 [H]

Molecular weight: Translated: 80240; Mature: 80240

Theoretical pI: Translated: 4.90; Mature: 4.90

Prosite motif: PS50894 HPT ; PS50110 RESPONSE_REGULATORY ; PS50109 HIS_KIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.4 %Cys     (Translated Protein)
3.1 %Met     (Translated Protein)
4.5 %Cys+Met (Translated Protein)
1.4 %Cys     (Mature Protein)
3.1 %Met     (Mature Protein)
4.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MREAKQMAEQATRAKSLFLANMSHEIRTPMNAIIGMSYLALRTDLDDQQRNYIGKIHNAG
CCHHHHHHHHHHHHHHHHHHHCCHHHHCHHHHHHHHHHHHHHCCCCHHHHHHHHHHHCCC
TSLLGIINDILDFSKVEAGKLELEAQPFWLDDVLDGVSALVAQKAADKGLELLFETAGDV
HHHHHHHHHHHHHHHCCCCCEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCC
PQGLVGDALRLGQVLTNLAGNAIKFTETGQVSIIIGQVERIGDKVQLKFCVHDTGIGMSE
CCHHHHHHHHHHHHHHHHCCCEEEEECCCCEEEEEECHHHCCCEEEEEEEEEECCCCCCH
EQQSRLFQAFSQADGSTTRRFGGTGLGLTIAKRLVELMGGSMLVESAPGWGSSFIFSCWL
HHHHHHHHHHHHCCCCCHHHCCCCCHHHHHHHHHHHHHCCCEEEECCCCCCHHHHHHHHH
GVSAETDSRRQSLPKEIRGLRVLVVDDNQSAVDVLCAQLKQLGFEVQGCLNGHEALSKVR
CCCCCCCHHHHHCHHHHCCCEEEEEECCCHHHHHHHHHHHHCCCHHHHHCCHHHHHHHHH
QDCLQKPFDVAFVDWMMPEMDGLEAVRRMRQVSRKMRIVMVTAFGRDEIRVKARAAGCDA
HHHHCCCCCCHHHHHHCCCCCHHHHHHHHHHHHHCEEEEEEEECCCCCEEEEEECCCCCE
FMVKPVNLSQLYDVLLEVFGFGRSGGLSLFDETDQLPRFDGAHLLLVEDNRINQQIAIEL
EEECCCCHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCEEEEEECCCCCHHHHHHH
LEGTGATITVAANGQAALDKLLAYGPKAFDAVLMDVQMPVMDGIEATGRIRSQPGFIDLP
HCCCCCEEEEECCCHHHHHHHHHCCCHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCEECH
VIAMTADALVEERERCLAAGMVDHIAKPIDPHILFSTLARWVRRSGAPQGREAETAADQT
HHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHCCCCCCCCCHHCCCCC
PLPQIDGLDQLAGLRRVAGNRQLYLHLLRQFVDEEAGAATRLGLALGERDFQTAERIAHT
CCCCCCCHHHHHHHHHHHCCHHHHHHHHHHHHHHHCCCHHHHHHHHCCHHHHHHHHHHHH
LKGAAGSIGFVDLQSAAMRLEMALRARESWQDLLVELEMELGQVVGALRAGLAELGQPAS
HCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCC
GARPDDALLERLAALLAVGDGDALGYFLEHAPRIRACFPEGACADFEQALNRFDFVSALG
CCCCHHHHHHHHHHHHHCCCCHHHHHHHHCCCCCEEECCCCCCHHHHHHHHHHHHHHHHH
ALRELARACGKKLPEDTR
HHHHHHHHHHHCCCCCCC
>Mature Secondary Structure
MREAKQMAEQATRAKSLFLANMSHEIRTPMNAIIGMSYLALRTDLDDQQRNYIGKIHNAG
CCHHHHHHHHHHHHHHHHHHHCCHHHHCHHHHHHHHHHHHHHCCCCHHHHHHHHHHHCCC
TSLLGIINDILDFSKVEAGKLELEAQPFWLDDVLDGVSALVAQKAADKGLELLFETAGDV
HHHHHHHHHHHHHHHCCCCCEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCC
PQGLVGDALRLGQVLTNLAGNAIKFTETGQVSIIIGQVERIGDKVQLKFCVHDTGIGMSE
CCHHHHHHHHHHHHHHHHCCCEEEEECCCCEEEEEECHHHCCCEEEEEEEEEECCCCCCH
EQQSRLFQAFSQADGSTTRRFGGTGLGLTIAKRLVELMGGSMLVESAPGWGSSFIFSCWL
HHHHHHHHHHHHCCCCCHHHCCCCCHHHHHHHHHHHHHCCCEEEECCCCCCHHHHHHHHH
GVSAETDSRRQSLPKEIRGLRVLVVDDNQSAVDVLCAQLKQLGFEVQGCLNGHEALSKVR
CCCCCCCHHHHHCHHHHCCCEEEEEECCCHHHHHHHHHHHHCCCHHHHHCCHHHHHHHHH
QDCLQKPFDVAFVDWMMPEMDGLEAVRRMRQVSRKMRIVMVTAFGRDEIRVKARAAGCDA
HHHHCCCCCCHHHHHHCCCCCHHHHHHHHHHHHHCEEEEEEEECCCCCEEEEEECCCCCE
FMVKPVNLSQLYDVLLEVFGFGRSGGLSLFDETDQLPRFDGAHLLLVEDNRINQQIAIEL
EEECCCCHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCEEEEEECCCCCHHHHHHH
LEGTGATITVAANGQAALDKLLAYGPKAFDAVLMDVQMPVMDGIEATGRIRSQPGFIDLP
HCCCCCEEEEECCCHHHHHHHHHCCCHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCEECH
VIAMTADALVEERERCLAAGMVDHIAKPIDPHILFSTLARWVRRSGAPQGREAETAADQT
HHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHCCCCCCCCCHHCCCCC
PLPQIDGLDQLAGLRRVAGNRQLYLHLLRQFVDEEAGAATRLGLALGERDFQTAERIAHT
CCCCCCCHHHHHHHHHHHCCHHHHHHHHHHHHHHHCCCHHHHHHHHCCHHHHHHHHHHHH
LKGAAGSIGFVDLQSAAMRLEMALRARESWQDLLVELEMELGQVVGALRAGLAELGQPAS
HCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCC
GARPDDALLERLAALLAVGDGDALGYFLEHAPRIRACFPEGACADFEQALNRFDFVSALG
CCCCHHHHHHHHHHHHHCCCCHHHHHHHHCCCCCEEECCCCCCHHHHHHHHHHHHHHHHH
ALRELARACGKKLPEDTR
HHHHHHHHHHHCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]