Click here to switch to the map view.

The map label for this gene is lysA [H]

Identifier: 33863330

GI number: 33863330

Start: 1141671

End: 1143038

Strand: Reverse

Name: lysA [H]

Synonym: PMT1059

Alternate gene names: 33863330

Gene position: 1143038-1141671 (Counterclockwise)

Preceding gene: 33863336

Following gene: 33863329

Centisome position: 47.41

GC content: 53.0

Gene sequence:

>1368_bases
ATGATGTCATCCAGCCCCTATGAGCCTGGGCGGGATCCCCTTAGCCCCAATTGCAACCTCGCGCCGATTACAACCGAACT
TGATGCGCAATCACGCTTGATCGTTGGAGGCTGTCAACTGAGCGAATTGGCGGAGTGTTATGGCACCCCTCTCTATGTGC
TTGACGAAGCCACCTTGAGGGCAGCTTGTCAGTCATACCGTGGGGCATTACAGCGTCACTATCCAGGGCCATCTCTTCCT
ATCTATGCCTCTAAGGCCAATAGCTCATTGATGATGAGCAGCCTGGTGGCTTCAGAAGGTTTTGGGCTGGATGTGGTCTC
AGCAGGTGAGTTGCTTACCGCTTTGAAGGGAGGTGTGCCGGGCGATTGCATTGTGCTTCATGGCAACAACAAATCTGATC
AGGAGCTGCTGCTTGCCTATCGCAATGGCGTCACAATCGTTGCTGATAATCAGCATGATCTGGATCGCCTCTCACAACTG
GTGCCTGTTGGAGCAGATCCTGCAAAGTTGATGTTGCGTTTCACTCCGGGTATCGAATGCCATACCCATGAGTACATCCG
CACCGGCCATCTTGATAGCAAGTTTGGTTTTGATCCAGATCAGCTGGAATCGGTTCTGAATCAGTTACTCGGCTGTCGCT
GGGCACGCTTAACGGGACTCCACGCTCATATTGGATCGCAGATCTTTGAATTGGAACCTCATCAGGATCTGGCAGATGTG
ATGGCTGGTGCTCTGCAACTGGCTAGGCGCCTGGGTCATCCAGTCATGGATCTCAACGTTGGAGGAGGTCTAGGTGTCAG
ATATGTCAGTTCTGATGATCCACCTTCAATTGATAACTGGGTCAAGGTGGTTGCCGAGGCAGTGAATCAAGCCTGTCGTT
CTCGTAACCTGGATTTGCCCCGGTTGATGTGTGAGCCGGGTCGCTCTCTGGTCGCTGCTGCCGGAGTCACCCTTTATCGG
GTTGGATCACGCAAGACCATCCCAGGGCTGCGCACCTATCTTTCTGTCGATGGAGGGATGAGTGATAACCCCCGCCCAAT
CACGTATCAATCTCTCTATACGGCTTGCCTTGCTGACCGACCGTTGGCCTCGCCAGACGAGACGATCACTCTGGTTGGCA
AGCATTGTGAATCTGGGGATGTTCTGCTTAAGGACCTTGCTTTGCCATATGCCAGCAGTGGAGACGTCTTGGTGGTTTTT
GCGACAGGGGCTTATAACGTCTCTATGAGTTCTAACTACAACCGCATCCCACGACCTGCAGCGGTCCTTGTTCATTCAGG
CCACTCGGAGTTGGTGCAGAGGCGGGAGCAGCCAGAAGATCTTCTGCGATATGACGTTATGCCGGAACGATTTTTAGCGT
TAGGCTGA

Upstream 100 bases:

>100_bases
CTTCCATTGCTTGGATGTCGTGCTTCAACATGCCTAACCCCTTCCTTGGGGGGATTGATCTCTACATTGATCCCTCTAAC
TAATTTCCTCGTCCATCGCC

Downstream 100 bases:

>100_bases
GCAAGCAAGGCTGGGGAGTGGGAGTGAACTTGTGGGGGGTGGTAGATCCGCGCCTGCTCGATGTTTTGTTTGCTTCGGCC
CTTGGCGTCTTGCTTTTTTC

Product: diaminopimelate decarboxylase

Products: NA

Alternate protein names: DAP decarboxylase [H]

Number of amino acids: Translated: 455; Mature: 455

Protein sequence:

>455_residues
MMSSSPYEPGRDPLSPNCNLAPITTELDAQSRLIVGGCQLSELAECYGTPLYVLDEATLRAACQSYRGALQRHYPGPSLP
IYASKANSSLMMSSLVASEGFGLDVVSAGELLTALKGGVPGDCIVLHGNNKSDQELLLAYRNGVTIVADNQHDLDRLSQL
VPVGADPAKLMLRFTPGIECHTHEYIRTGHLDSKFGFDPDQLESVLNQLLGCRWARLTGLHAHIGSQIFELEPHQDLADV
MAGALQLARRLGHPVMDLNVGGGLGVRYVSSDDPPSIDNWVKVVAEAVNQACRSRNLDLPRLMCEPGRSLVAAAGVTLYR
VGSRKTIPGLRTYLSVDGGMSDNPRPITYQSLYTACLADRPLASPDETITLVGKHCESGDVLLKDLALPYASSGDVLVVF
ATGAYNVSMSSNYNRIPRPAAVLVHSGHSELVQRREQPEDLLRYDVMPERFLALG

Sequences:

>Translated_455_residues
MMSSSPYEPGRDPLSPNCNLAPITTELDAQSRLIVGGCQLSELAECYGTPLYVLDEATLRAACQSYRGALQRHYPGPSLP
IYASKANSSLMMSSLVASEGFGLDVVSAGELLTALKGGVPGDCIVLHGNNKSDQELLLAYRNGVTIVADNQHDLDRLSQL
VPVGADPAKLMLRFTPGIECHTHEYIRTGHLDSKFGFDPDQLESVLNQLLGCRWARLTGLHAHIGSQIFELEPHQDLADV
MAGALQLARRLGHPVMDLNVGGGLGVRYVSSDDPPSIDNWVKVVAEAVNQACRSRNLDLPRLMCEPGRSLVAAAGVTLYR
VGSRKTIPGLRTYLSVDGGMSDNPRPITYQSLYTACLADRPLASPDETITLVGKHCESGDVLLKDLALPYASSGDVLVVF
ATGAYNVSMSSNYNRIPRPAAVLVHSGHSELVQRREQPEDLLRYDVMPERFLALG
>Mature_455_residues
MMSSSPYEPGRDPLSPNCNLAPITTELDAQSRLIVGGCQLSELAECYGTPLYVLDEATLRAACQSYRGALQRHYPGPSLP
IYASKANSSLMMSSLVASEGFGLDVVSAGELLTALKGGVPGDCIVLHGNNKSDQELLLAYRNGVTIVADNQHDLDRLSQL
VPVGADPAKLMLRFTPGIECHTHEYIRTGHLDSKFGFDPDQLESVLNQLLGCRWARLTGLHAHIGSQIFELEPHQDLADV
MAGALQLARRLGHPVMDLNVGGGLGVRYVSSDDPPSIDNWVKVVAEAVNQACRSRNLDLPRLMCEPGRSLVAAAGVTLYR
VGSRKTIPGLRTYLSVDGGMSDNPRPITYQSLYTACLADRPLASPDETITLVGKHCESGDVLLKDLALPYASSGDVLVVF
ATGAYNVSMSSNYNRIPRPAAVLVHSGHSELVQRREQPEDLLRYDVMPERFLALG

Specific function: Lysine biosynthesis; last step. [C]

COG id: COG0019

COG function: function code E; Diaminopimelate decarboxylase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the Orn/Lys/Arg decarboxylase class-II family [H]

Homologues:

Organism=Escherichia coli, GI1789203, Length=409, Percent_Identity=30.3178484107579, Blast_Score=131, Evalue=1e-31,
Organism=Drosophila melanogaster, GI24586472, Length=410, Percent_Identity=23.4146341463415, Blast_Score=78, Evalue=1e-14,
Organism=Drosophila melanogaster, GI24586474, Length=356, Percent_Identity=25.2808988764045, Blast_Score=73, Evalue=5e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR009006
- InterPro:   IPR002986
- InterPro:   IPR022643
- InterPro:   IPR022644
- InterPro:   IPR022653
- InterPro:   IPR000183 [H]

Pfam domain/function: PF02784 Orn_Arg_deC_N; PF00278 Orn_DAP_Arg_deC [H]

EC number: =4.1.1.20 [H]

Molecular weight: Translated: 49202; Mature: 49202

Theoretical pI: Translated: 5.73; Mature: 5.73

Prosite motif: PS00879 ODR_DC_2_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.4 %Cys     (Translated Protein)
2.4 %Met     (Translated Protein)
4.8 %Cys+Met (Translated Protein)
2.4 %Cys     (Mature Protein)
2.4 %Met     (Mature Protein)
4.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MMSSSPYEPGRDPLSPNCNLAPITTELDAQSRLIVGGCQLSELAECYGTPLYVLDEATLR
CCCCCCCCCCCCCCCCCCCEEEEEECCCCCCEEEEECCCHHHHHHHHCCCEEEECHHHHH
AACQSYRGALQRHYPGPSLPIYASKANSSLMMSSLVASEGFGLDVVSAGELLTALKGGVP
HHHHHHHHHHHHCCCCCCCCEEECCCCCHHHHHHHHHCCCCCEEEECHHHHHHHHHCCCC
GDCIVLHGNNKSDQELLLAYRNGVTIVADNQHDLDRLSQLVPVGADPAKLMLRFTPGIEC
CCEEEEECCCCCCHHHEEEEECCEEEEECCCHHHHHHHHHCCCCCCHHHEEEEECCCCCC
HTHEYIRTGHLDSKFGFDPDQLESVLNQLLGCRWARLTGLHAHIGSQIFELEPHQDLADV
CCHHHHHHCCCCCCCCCCHHHHHHHHHHHHCCHHHHHHHHHHHHCCCEEECCCCHHHHHH
MAGALQLARRLGHPVMDLNVGGGLGVRYVSSDDPPSIDNWVKVVAEAVNQACRSRNLDLP
HHHHHHHHHHHCCCEEEEECCCCCEEEEECCCCCCCHHHHHHHHHHHHHHHHHHCCCCCC
RLMCEPGRSLVAAAGVTLYRVGSRKTIPGLRTYLSVDGGMSDNPRPITYQSLYTACLADR
HHHHCCCCHHHHHCCEEEEEECCCCCCCCHHHEEEECCCCCCCCCCEEHHHHHHHHHCCC
PLASPDETITLVGKHCESGDVLLKDLALPYASSGDVLVVFATGAYNVSMSSNYNRIPRPA
CCCCCCCEEEEEECCCCCCCEEHHHHCCCCCCCCCEEEEEECCCEEEEECCCCCCCCCCE
AVLVHSGHSELVQRREQPEDLLRYDVMPERFLALG
EEEEECCHHHHHHHHCCHHHHHHHCCCHHHHHHCC
>Mature Secondary Structure
MMSSSPYEPGRDPLSPNCNLAPITTELDAQSRLIVGGCQLSELAECYGTPLYVLDEATLR
CCCCCCCCCCCCCCCCCCCEEEEEECCCCCCEEEEECCCHHHHHHHHCCCEEEECHHHHH
AACQSYRGALQRHYPGPSLPIYASKANSSLMMSSLVASEGFGLDVVSAGELLTALKGGVP
HHHHHHHHHHHHCCCCCCCCEEECCCCCHHHHHHHHHCCCCCEEEECHHHHHHHHHCCCC
GDCIVLHGNNKSDQELLLAYRNGVTIVADNQHDLDRLSQLVPVGADPAKLMLRFTPGIEC
CCEEEEECCCCCCHHHEEEEECCEEEEECCCHHHHHHHHHCCCCCCHHHEEEEECCCCCC
HTHEYIRTGHLDSKFGFDPDQLESVLNQLLGCRWARLTGLHAHIGSQIFELEPHQDLADV
CCHHHHHHCCCCCCCCCCHHHHHHHHHHHHCCHHHHHHHHHHHHCCCEEECCCCHHHHHH
MAGALQLARRLGHPVMDLNVGGGLGVRYVSSDDPPSIDNWVKVVAEAVNQACRSRNLDLP
HHHHHHHHHHHCCCEEEEECCCCCEEEEECCCCCCCHHHHHHHHHHHHHHHHHHCCCCCC
RLMCEPGRSLVAAAGVTLYRVGSRKTIPGLRTYLSVDGGMSDNPRPITYQSLYTACLADR
HHHHCCCCHHHHHCCEEEEEECCCCCCCCHHHEEEECCCCCCCCCCEEHHHHHHHHHCCC
PLASPDETITLVGKHCESGDVLLKDLALPYASSGDVLVVFATGAYNVSMSSNYNRIPRPA
CCCCCCCEEEEEECCCCCCCEEHHHHCCCCCCCCCEEEEEECCCEEEEECCCCCCCCCCE
AVLVHSGHSELVQRREQPEDLLRYDVMPERFLALG
EEEEECCHHHHHHHHCCHHHHHHHCCCHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8590279; 8905231 [H]