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The map label for this gene is uppS

Identifier: 33863328

GI number: 33863328

Start: 1139972

End: 1140769

Strand: Reverse

Name: uppS

Synonym: PMT1057

Alternate gene names: 33863328

Gene position: 1140769-1139972 (Counterclockwise)

Preceding gene: 33863329

Following gene: 33863327

Centisome position: 47.32

GC content: 52.88

Gene sequence:

>798_bases
TTGAGCCGCCGTTCGGCCACTAGTTCAGGCCATCCAAAGGTCTGTGCATGTCCCTCGGGGCTTGATCCCTATCGGCTACC
TAACCATGTGGCTGTGATTATGGATGGGAACGGACGCTGGGCCAAGGCCAGAGGCCTGCCTAGGATGGTTGGCCATCGCG
CTGGCGTAGAAGCTCTCAAGAGAACCCTTCGTCTTTGCAGTGACTGGGGCATTGGCGCCCTTACGGCTTATGCCTTTTCT
ACGGAGAATTGGTCTCGCCCTGGAGATGAGGTGAATTTCTTGATGACTCTGTTTGAGCGTGTGCTGCAGAGGGAGTTGGA
GTCACTTGAACGTGAAAAGGTACGGATTCGTTTCCTGGGAGACCTTGAGGGTCTCCCATCAGGTCTGCAGGAGTTGATCA
GTGAGGCCACCGAGCTCACTGTTAGGAACAATGGCATTCACTTCAATGTCTGCACCAATTACGGTGGTCGCCGTGAACTG
GTGCTTGCGGCACAGAAACTTGCACAACGCGCTGCAAGAGGGGATCTTGATCCAACTTTGATTGATGAGAACAGTTTCGA
GGCTGAGTTACTCACGGCTGGTGAGGTTGATCCAGACCTGCTGATCCGCACCAGTGGTGAGCGACGGATCAGTAATTTTC
TGCTCTGGCAACTCGCCTATGCAGAAATTCACGTCACCGATGTGTGCTGGCCTGATTTTGATGAAGTAGCTTTGACAAAA
GCTCTTTTTGATTACCAGTCACGCTGTCGTCGTTTCGGCGGTTTGGATCCAATCGCAGCGAATCATCTGGGATCTTGA

Upstream 100 bases:

>100_bases
CAGCTACGAAGGGGGCCTCTAGTCCAGTCAAAGCTTCGGCTGTTGCTACACAAGCTTCATCCAGGCTTAGCGTGAGCAGC
TCTATCGAGGAACCACTCCC

Downstream 100 bases:

>100_bases
CCGTTGGCTCCAGTCGTTCCATGACCGTGCTTATTGCCAAGGATCTCACTTTTGAACCCGTTGTTCATCGTTATGACTGG
ACAGTGGATGAGGTGCGGGA

Product: undecaprenyl pyrophosphate synthase

Products: NA

Alternate protein names: UPP synthase; Di-trans,poly-cis-decaprenylcistransferase; Undecaprenyl diphosphate synthase; UDS

Number of amino acids: Translated: 265; Mature: 264

Protein sequence:

>265_residues
MSRRSATSSGHPKVCACPSGLDPYRLPNHVAVIMDGNGRWAKARGLPRMVGHRAGVEALKRTLRLCSDWGIGALTAYAFS
TENWSRPGDEVNFLMTLFERVLQRELESLEREKVRIRFLGDLEGLPSGLQELISEATELTVRNNGIHFNVCTNYGGRREL
VLAAQKLAQRAARGDLDPTLIDENSFEAELLTAGEVDPDLLIRTSGERRISNFLLWQLAYAEIHVTDVCWPDFDEVALTK
ALFDYQSRCRRFGGLDPIAANHLGS

Sequences:

>Translated_265_residues
MSRRSATSSGHPKVCACPSGLDPYRLPNHVAVIMDGNGRWAKARGLPRMVGHRAGVEALKRTLRLCSDWGIGALTAYAFS
TENWSRPGDEVNFLMTLFERVLQRELESLEREKVRIRFLGDLEGLPSGLQELISEATELTVRNNGIHFNVCTNYGGRREL
VLAAQKLAQRAARGDLDPTLIDENSFEAELLTAGEVDPDLLIRTSGERRISNFLLWQLAYAEIHVTDVCWPDFDEVALTK
ALFDYQSRCRRFGGLDPIAANHLGS
>Mature_264_residues
SRRSATSSGHPKVCACPSGLDPYRLPNHVAVIMDGNGRWAKARGLPRMVGHRAGVEALKRTLRLCSDWGIGALTAYAFST
ENWSRPGDEVNFLMTLFERVLQRELESLEREKVRIRFLGDLEGLPSGLQELISEATELTVRNNGIHFNVCTNYGGRRELV
LAAQKLAQRAARGDLDPTLIDENSFEAELLTAGEVDPDLLIRTSGERRISNFLLWQLAYAEIHVTDVCWPDFDEVALTKA
LFDYQSRCRRFGGLDPIAANHLGS

Specific function: Generates undecaprenyl pyrophosphate (UPP) from isopentenyl pyrophosphate (IPP). UPP is the precursor of glycosyl carrier lipid in the biosynthesis of bacterial cell wall polysaccharide components such as peptidoglycan and lipopolysaccharide

COG id: COG0020

COG function: function code I; Undecaprenyl pyrophosphate synthase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the UPP synthase family

Homologues:

Organism=Homo sapiens, GI45580742, Length=234, Percent_Identity=41.025641025641, Blast_Score=167, Evalue=9e-42,
Organism=Homo sapiens, GI45580738, Length=234, Percent_Identity=41.025641025641, Blast_Score=167, Evalue=1e-41,
Organism=Escherichia coli, GI1786371, Length=229, Percent_Identity=48.9082969432314, Blast_Score=228, Evalue=2e-61,
Organism=Caenorhabditis elegans, GI71993029, Length=226, Percent_Identity=38.0530973451327, Blast_Score=154, Evalue=6e-38,
Organism=Saccharomyces cerevisiae, GI6319474, Length=225, Percent_Identity=36.8888888888889, Blast_Score=130, Evalue=2e-31,
Organism=Saccharomyces cerevisiae, GI6323748, Length=225, Percent_Identity=32.8888888888889, Blast_Score=114, Evalue=2e-26,
Organism=Drosophila melanogaster, GI18857969, Length=225, Percent_Identity=36.4444444444444, Blast_Score=146, Evalue=1e-35,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): UPPS_PROMM (Q7V6T7)

Other databases:

- EMBL:   BX548175
- RefSeq:   NP_894888.1
- ProteinModelPortal:   Q7V6T7
- SMR:   Q7V6T7
- STRING:   Q7V6T7
- GeneID:   1728358
- GenomeReviews:   BX548175_GR
- KEGG:   pmt:PMT1057
- NMPDR:   fig|74547.1.peg.1055
- eggNOG:   COG0020
- HOGENOM:   HBG627837
- OMA:   RVRWAGR
- ProtClustDB:   PRK14831
- BioCyc:   PMAR74547:PMT1057-MONOMER
- HAMAP:   MF_01139
- InterPro:   IPR001441
- InterPro:   IPR018520
- Gene3D:   G3DSA:3.40.1180.10
- PANTHER:   PTHR10291
- TIGRFAMs:   TIGR00055

Pfam domain/function: PF01255 Prenyltransf; SSF64005 UPP_synth

EC number: =2.5.1.31

Molecular weight: Translated: 29569; Mature: 29438

Theoretical pI: Translated: 6.51; Mature: 6.51

Prosite motif: PS01066 UPP_SYNTHASE

Important sites: ACT_SITE 35-35

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.3 %Cys     (Translated Protein)
1.5 %Met     (Translated Protein)
3.8 %Cys+Met (Translated Protein)
2.3 %Cys     (Mature Protein)
1.1 %Met     (Mature Protein)
3.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSRRSATSSGHPKVCACPSGLDPYRLPNHVAVIMDGNGRWAKARGLPRMVGHRAGVEALK
CCCCCCCCCCCCCEEECCCCCCCCCCCCEEEEEECCCCCEEHHCCCHHHHHHHHHHHHHH
RTLRLCSDWGIGALTAYAFSTENWSRPGDEVNFLMTLFERVLQRELESLEREKVRIRFLG
HHHHHHHCCCCHHHHHEEECCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHEEEEEEC
DLEGLPSGLQELISEATELTVRNNGIHFNVCTNYGGRRELVLAAQKLAQRAARGDLDPTL
CCCCCHHHHHHHHHHHHHEEEECCCEEEEEECCCCCCHHHHHHHHHHHHHHHCCCCCCEE
IDENSFEAELLTAGEVDPDLLIRTSGERRISNFLLWQLAYAEIHVTDVCWPDFDEVALTK
ECCCCCCEEEEECCCCCCCEEEECCCHHHHHHHHHHHHHHHEEEEEECCCCCHHHHHHHH
ALFDYQSRCRRFGGLDPIAANHLGS
HHHHHHHHHHHCCCCCCHHHHCCCC
>Mature Secondary Structure 
SRRSATSSGHPKVCACPSGLDPYRLPNHVAVIMDGNGRWAKARGLPRMVGHRAGVEALK
CCCCCCCCCCCCEEECCCCCCCCCCCCEEEEEECCCCCEEHHCCCHHHHHHHHHHHHHH
RTLRLCSDWGIGALTAYAFSTENWSRPGDEVNFLMTLFERVLQRELESLEREKVRIRFLG
HHHHHHHCCCCHHHHHEEECCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHEEEEEEC
DLEGLPSGLQELISEATELTVRNNGIHFNVCTNYGGRRELVLAAQKLAQRAARGDLDPTL
CCCCCHHHHHHHHHHHHHEEEECCCEEEEEECCCCCCHHHHHHHHHHHHHHHCCCCCCEE
IDENSFEAELLTAGEVDPDLLIRTSGERRISNFLLWQLAYAEIHVTDVCWPDFDEVALTK
ECCCCCCEEEEECCCCCCCEEEECCCHHHHHHHHHHHHHHHEEEEEECCCCCHHHHHHHH
ALFDYQSRCRRFGGLDPIAANHLGS
HHHHHHHHHHHCCCCCCHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 12917642