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The map label for this gene is fmt [H]

Identifier: 33863044

GI number: 33863044

Start: 842133

End: 843161

Strand: Direct

Name: fmt [H]

Synonym: PMT0772

Alternate gene names: 33863044

Gene position: 842133-843161 (Clockwise)

Preceding gene: 33863043

Following gene: 33863045

Centisome position: 34.93

GC content: 48.4

Gene sequence:

>1029_bases
GTGCTGTTCTGGGGTACCCCCAGCTATGCAGTGCCAACTCTGGATGCCTTAAATGACTCAGGCTATGAAATTGTTGGCGT
GGTGAGTCAGCCTGATCGTCGTCGTGGGCGTGGTAATCAGCAAATGGCGTCACCCGTCAAACAACGAGCAATGGATCAGG
GGTTGCGTTTATTCACCCCTGAACGGATTAGGGATGAGGGCGACATTCAAGCAGAATTAAAATCACTAAAGGCTGATATC
TCTGTTGTAGTCGCCTTTGGGCAGCTTCTTCCTTCAACAGTTCTCAATCAACCTCCTCTCGGTTGCTGGAACGGTCACGC
TTCACTGCTACCCCGCTGGCGAGGAGCAGGACCGATTCAATGGAGTTTGCTAAGTGGTGACAGCGTGACAGGCGTTGGAA
TCATGGCAATGGAAGAGGGGCTTGATACAGGCCCTGTTTTAGTCCAGGAAAGGGTTGCTATCGGCTTACTCGAAAATGCG
AATCAGCTGTCTAATCGTTTGAGCTCTATAACAGCAAAATTGTTTTTAGAATCAATGCCAAGGATTGCAGCAGCAGGCCC
TGGAATCGAATCGGAACGTTGGAAACAATTGGAAGTCATCAAACAGGAAGAGATTGAAGGTGACCCGACATATGCCCGAA
TGCTCTCGAAAAAAGACCACATTCTTGATTGGAATCAATCTGCAATGGATTTGCATCGCAGGGTTATGGGCCTTTATCCA
AACGCATTCAGCAGCTGGAATAACAAAAGGCTGAAAGTACAAGCCACTGAGCCACTTGATGAGGAATTGAAATCCAAGCT
TTCGGAAGAAGTAAGGCCACTGCTTGGACGATGGCAAGATGGAGAACATGAACCAGGAAAGATCCTGGCTTGCGAATCCG
ATCTGGGCCTAGTCGTAAGTACAAAAACGTGCCCTTTACTCATTCGACAAGGCCAATTGGAAGGCAAAAGCAAGGCACTT
GGAGAGGTGTTAATACAACAATTGCAAGCGACTGTTGGCCAGGGTCTTGGGGTGGGGTTCAACATCTAA

Upstream 100 bases:

>100_bases
ATAGCATTGTGAATATGGAAGCTGAACAGGTAATCACACCTGGTGGGGTATCTCCTCATGTGTGGGTCGAAGGCTTATCA
ATTACTGGTGAAGCATGAGG

Downstream 100 bases:

>100_bases
CACAAGGGTTATCTTTGCCAGATGTCCTCCTTTAGCGAGTTTCAAAAATTGTCATAGGTTCAAACCAGACTTGACCAATC
CTGACAGGAGCATGCTTAGA

Product: methionyl-tRNA formyltransferase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 342; Mature: 342

Protein sequence:

>342_residues
MLFWGTPSYAVPTLDALNDSGYEIVGVVSQPDRRRGRGNQQMASPVKQRAMDQGLRLFTPERIRDEGDIQAELKSLKADI
SVVVAFGQLLPSTVLNQPPLGCWNGHASLLPRWRGAGPIQWSLLSGDSVTGVGIMAMEEGLDTGPVLVQERVAIGLLENA
NQLSNRLSSITAKLFLESMPRIAAAGPGIESERWKQLEVIKQEEIEGDPTYARMLSKKDHILDWNQSAMDLHRRVMGLYP
NAFSSWNNKRLKVQATEPLDEELKSKLSEEVRPLLGRWQDGEHEPGKILACESDLGLVVSTKTCPLLIRQGQLEGKSKAL
GEVLIQQLQATVGQGLGVGFNI

Sequences:

>Translated_342_residues
MLFWGTPSYAVPTLDALNDSGYEIVGVVSQPDRRRGRGNQQMASPVKQRAMDQGLRLFTPERIRDEGDIQAELKSLKADI
SVVVAFGQLLPSTVLNQPPLGCWNGHASLLPRWRGAGPIQWSLLSGDSVTGVGIMAMEEGLDTGPVLVQERVAIGLLENA
NQLSNRLSSITAKLFLESMPRIAAAGPGIESERWKQLEVIKQEEIEGDPTYARMLSKKDHILDWNQSAMDLHRRVMGLYP
NAFSSWNNKRLKVQATEPLDEELKSKLSEEVRPLLGRWQDGEHEPGKILACESDLGLVVSTKTCPLLIRQGQLEGKSKAL
GEVLIQQLQATVGQGLGVGFNI
>Mature_342_residues
MLFWGTPSYAVPTLDALNDSGYEIVGVVSQPDRRRGRGNQQMASPVKQRAMDQGLRLFTPERIRDEGDIQAELKSLKADI
SVVVAFGQLLPSTVLNQPPLGCWNGHASLLPRWRGAGPIQWSLLSGDSVTGVGIMAMEEGLDTGPVLVQERVAIGLLENA
NQLSNRLSSITAKLFLESMPRIAAAGPGIESERWKQLEVIKQEEIEGDPTYARMLSKKDHILDWNQSAMDLHRRVMGLYP
NAFSSWNNKRLKVQATEPLDEELKSKLSEEVRPLLGRWQDGEHEPGKILACESDLGLVVSTKTCPLLIRQGQLEGKSKAL
GEVLIQQLQATVGQGLGVGFNI

Specific function: Modifies the free amino group of the aminoacyl moiety of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by:(I) promoting its recognition by IF2 and (II) impairing its binding to EFTu-

COG id: COG0223

COG function: function code J; Methionyl-tRNA formyltransferase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the fmt family [H]

Homologues:

Organism=Homo sapiens, GI21614513, Length=225, Percent_Identity=29.3333333333333, Blast_Score=89, Evalue=5e-18,
Organism=Homo sapiens, GI238814322, Length=253, Percent_Identity=28.0632411067194, Blast_Score=87, Evalue=2e-17,
Organism=Homo sapiens, GI164663775, Length=255, Percent_Identity=28.6274509803922, Blast_Score=83, Evalue=3e-16,
Organism=Escherichia coli, GI1789683, Length=256, Percent_Identity=39.84375, Blast_Score=170, Evalue=1e-43,
Organism=Escherichia coli, GI1788589, Length=276, Percent_Identity=25.7246376811594, Blast_Score=97, Evalue=2e-21,
Organism=Caenorhabditis elegans, GI133930964, Length=262, Percent_Identity=25.1908396946565, Blast_Score=77, Evalue=1e-14,
Organism=Saccharomyces cerevisiae, GI6319458, Length=351, Percent_Identity=25.6410256410256, Blast_Score=74, Evalue=3e-14,
Organism=Drosophila melanogaster, GI45550868, Length=241, Percent_Identity=29.8755186721992, Blast_Score=99, Evalue=6e-21,
Organism=Drosophila melanogaster, GI28571984, Length=163, Percent_Identity=34.3558282208589, Blast_Score=91, Evalue=1e-18,
Organism=Drosophila melanogaster, GI24585660, Length=168, Percent_Identity=30.952380952381, Blast_Score=76, Evalue=4e-14,

Paralogues:

None

Copy number: 400 Molecules/Cell In: Glucose minimal media [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005794
- InterPro:   IPR005793
- InterPro:   IPR002376
- InterPro:   IPR011034
- InterPro:   IPR015518 [H]

Pfam domain/function: PF02911 Formyl_trans_C; PF00551 Formyl_trans_N [H]

EC number: =2.1.2.9 [H]

Molecular weight: Translated: 37607; Mature: 37607

Theoretical pI: Translated: 5.81; Mature: 5.81

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
2.6 %Met     (Translated Protein)
3.5 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
2.6 %Met     (Mature Protein)
3.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLFWGTPSYAVPTLDALNDSGYEIVGVVSQPDRRRGRGNQQMASPVKQRAMDQGLRLFTP
CCEECCCCCCCCCHHHCCCCCCEEEEECCCCHHHCCCCCHHHHHHHHHHHHHCCCEECCH
ERIRDEGDIQAELKSLKADISVVVAFGQLLPSTVLNQPPLGCWNGHASLLPRWRGAGPIQ
HHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCHHHCCCCCCCCCEE
WSLLSGDSVTGVGIMAMEEGLDTGPVLVQERVAIGLLENANQLSNRLSSITAKLFLESMP
EEEECCCCCCCEEEEEHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCC
RIAAAGPGIESERWKQLEVIKQEEIEGDPTYARMLSKKDHILDWNQSAMDLHRRVMGLYP
HHHHCCCCCCHHHHHHHHHHHHHHCCCCHHHHHHHCCCCCCCCCCHHHHHHHHHHHHCCC
NAFSSWNNKRLKVQATEPLDEELKSKLSEEVRPLLGRWQDGEHEPGKILACESDLGLVVS
CHHCCCCCCEEEEEECCCHHHHHHHHHHHHHHHHHCCCCCCCCCCCEEEEECCCCCEEEE
TKTCPLLIRQGQLEGKSKALGEVLIQQLQATVGQGLGVGFNI
CCCCEEEEECCCCCCHHHHHHHHHHHHHHHHHCCCCCCCCCC
>Mature Secondary Structure
MLFWGTPSYAVPTLDALNDSGYEIVGVVSQPDRRRGRGNQQMASPVKQRAMDQGLRLFTP
CCEECCCCCCCCCHHHCCCCCCEEEEECCCCHHHCCCCCHHHHHHHHHHHHHCCCEECCH
ERIRDEGDIQAELKSLKADISVVVAFGQLLPSTVLNQPPLGCWNGHASLLPRWRGAGPIQ
HHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCHHHCCCCCCCCCEE
WSLLSGDSVTGVGIMAMEEGLDTGPVLVQERVAIGLLENANQLSNRLSSITAKLFLESMP
EEEECCCCCCCEEEEEHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCC
RIAAAGPGIESERWKQLEVIKQEEIEGDPTYARMLSKKDHILDWNQSAMDLHRRVMGLYP
HHHHCCCCCCHHHHHHHHHHHHHHCCCCHHHHHHHCCCCCCCCCCHHHHHHHHHHHHCCC
NAFSSWNNKRLKVQATEPLDEELKSKLSEEVRPLLGRWQDGEHEPGKILACESDLGLVVS
CHHCCCCCCEEEEEECCCHHHHHHHHHHHHHHHHHCCCCCCCCCCCEEEEECCCCCEEEE
TKTCPLLIRQGQLEGKSKALGEVLIQQLQATVGQGLGVGFNI
CCCCEEEEECCCCCCHHHHHHHHHHHHHHHHHCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA