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The map label for this gene is cbbA [H]

Identifier: 33862810

GI number: 33862810

Start: 585077

End: 586150

Strand: Direct

Name: cbbA [H]

Synonym: PMT0537

Alternate gene names: 33862810

Gene position: 585077-586150 (Clockwise)

Preceding gene: 33862809

Following gene: 33862815

Centisome position: 24.27

GC content: 52.33

Gene sequence:

>1074_bases
ATGGCCCTCGTTCCGCTAAGGCTTCTGCTTGACCATGCCGCAGAAAACGGCTATGGCATCCCTGCTTTCAATGTGAACAA
CCTCGAGCAGGTGCAGTCCATCATGGAAGCGGCTTACGAGACTGATAGCCCCGTGATCCTGCAGGCCTCCCGCGGTGCTC
GAAGCTACGCAGGTGAAATCTTTTTAAGACATCTGATCATCGCCGCCGTTGAGACTTATCCAGACATCCCGGTTGTGATG
CATCAAGACCACGGGAATAGCCCCTCAACATGCTTTGGTGCTGCAGCCAACGGGTTCACCTCTGTGATGATGGATGGTTC
TCTTGAGGCAGACGCCAAGACACCTGCCAGCTACGAGTACAACGTTGCTGTCACAAAAGAAGTCGTAGGCGTGGCCCATG
CCATTGGCGTAAGCGTGGAGGGTGAACTGGGCTGCCTGGGCTCCTTGGAAACAGGTATGGGTGAAGCCGAAGACGGCCAC
GGATTTGAAGGCAAGCTCGACCACAGCCAACTGCTCACCGACCCAGCTGAGGCCTCCGACTTCGTCGCTAAAACCAAAGT
TGACGCTTTAGCAATCGCGATTGGAACCAGCCACGGCGCCTACAAATTCACGCGCAAACCCACTGGTGAAGTATTAGCGA
TCAGTCGAATTGCAGAAATCCATAAGGCCATCCCTAACACTCATTTAGTGATGCACGGTTCCTCTTCCGTTCCCCAGGAA
TGGCTGCAAATGATCAATAAATACGGAGGTGCAATCCCTGAGACCTATGGCGTTCCTGTCGAAGAGATCCAAGAAGGGAT
TCGCAATGGCGTGCGTAAGGTCAATATCGACACCGACAATCGCCTGGCTTTCACCGCTGCTGTGCGTGAAGCTTCTGTCG
CTGATCCTGCCAACTTTGATCCACGCCACTTCAACAAACCTGCGCGTAAATATATGAAGCAGGTCTGTCTTGATCGCTAT
CAGCAGTTTTGGTGTGCCGGCAATGCCAGTAAAATTAAGCAACGTGATATCAACTATTACTCAGCCCTTTATGAGAAAGG
GCAGCTTGATCCAAAAAACGCTGTTGCTGCATGA

Upstream 100 bases:

>100_bases
GATAGGTGACAGTTCTGACCATCGTCTTATAAAGTCCGGGGCCGCAGGTCCAGGACTCTTTGCTTGAGAACTGGCCCCTA
CTGACACTACGGAGATCTCT

Downstream 100 bases:

>100_bases
TTAAGGCCAAATGAATCGCTGAGGGGGGCTGCGAGGCCTCCCTTTTTAATGAATATGGCTTAGGACAACAACATTAGAGA
TCCATTGCGTCCGTCGAGGC

Product: fructose-1,6-bisphosphate aldolase

Products: NA

Alternate protein names: FBP aldolase; FBPA; Fructose-1,6-bisphosphate aldolase; Fructose-bisphosphate aldolase class II [H]

Number of amino acids: Translated: 357; Mature: 356

Protein sequence:

>357_residues
MALVPLRLLLDHAAENGYGIPAFNVNNLEQVQSIMEAAYETDSPVILQASRGARSYAGEIFLRHLIIAAVETYPDIPVVM
HQDHGNSPSTCFGAAANGFTSVMMDGSLEADAKTPASYEYNVAVTKEVVGVAHAIGVSVEGELGCLGSLETGMGEAEDGH
GFEGKLDHSQLLTDPAEASDFVAKTKVDALAIAIGTSHGAYKFTRKPTGEVLAISRIAEIHKAIPNTHLVMHGSSSVPQE
WLQMINKYGGAIPETYGVPVEEIQEGIRNGVRKVNIDTDNRLAFTAAVREASVADPANFDPRHFNKPARKYMKQVCLDRY
QQFWCAGNASKIKQRDINYYSALYEKGQLDPKNAVAA

Sequences:

>Translated_357_residues
MALVPLRLLLDHAAENGYGIPAFNVNNLEQVQSIMEAAYETDSPVILQASRGARSYAGEIFLRHLIIAAVETYPDIPVVM
HQDHGNSPSTCFGAAANGFTSVMMDGSLEADAKTPASYEYNVAVTKEVVGVAHAIGVSVEGELGCLGSLETGMGEAEDGH
GFEGKLDHSQLLTDPAEASDFVAKTKVDALAIAIGTSHGAYKFTRKPTGEVLAISRIAEIHKAIPNTHLVMHGSSSVPQE
WLQMINKYGGAIPETYGVPVEEIQEGIRNGVRKVNIDTDNRLAFTAAVREASVADPANFDPRHFNKPARKYMKQVCLDRY
QQFWCAGNASKIKQRDINYYSALYEKGQLDPKNAVAA
>Mature_356_residues
ALVPLRLLLDHAAENGYGIPAFNVNNLEQVQSIMEAAYETDSPVILQASRGARSYAGEIFLRHLIIAAVETYPDIPVVMH
QDHGNSPSTCFGAAANGFTSVMMDGSLEADAKTPASYEYNVAVTKEVVGVAHAIGVSVEGELGCLGSLETGMGEAEDGHG
FEGKLDHSQLLTDPAEASDFVAKTKVDALAIAIGTSHGAYKFTRKPTGEVLAISRIAEIHKAIPNTHLVMHGSSSVPQEW
LQMINKYGGAIPETYGVPVEEIQEGIRNGVRKVNIDTDNRLAFTAAVREASVADPANFDPRHFNKPARKYMKQVCLDRYQ
QFWCAGNASKIKQRDINYYSALYEKGQLDPKNAVAA

Specific function: Catalyzes the aldol condensation of dihydroxyacetone phosphate (DHAP or glycerone-phosphate) with glyceraldehyde 3- phosphate (G3P) to form fructose 1,6-bisphosphate (FBP) in gluconeogenesis and the reverse reaction in glycolysis [H]

COG id: COG0191

COG function: function code G; Fructose/tagatose bisphosphate aldolase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class II fructose-bisphosphate aldolase family [H]

Homologues:

Organism=Escherichia coli, GI1789526, Length=335, Percent_Identity=33.4328358208955, Blast_Score=156, Evalue=2e-39,
Organism=Escherichia coli, GI87082041, Length=329, Percent_Identity=31.306990881459, Blast_Score=142, Evalue=3e-35,
Organism=Escherichia coli, GI1788072, Length=329, Percent_Identity=29.7872340425532, Blast_Score=120, Evalue=2e-28,
Organism=Escherichia coli, GI1789293, Length=337, Percent_Identity=25.2225519287834, Blast_Score=78, Evalue=7e-16,
Organism=Saccharomyces cerevisiae, GI6322790, Length=358, Percent_Identity=25.9776536312849, Blast_Score=72, Evalue=2e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013785
- InterPro:   IPR006412
- InterPro:   IPR000771 [H]

Pfam domain/function: PF01116 F_bP_aldolase [H]

EC number: =4.1.2.13 [H]

Molecular weight: Translated: 38622; Mature: 38491

Theoretical pI: Translated: 5.56; Mature: 5.56

Prosite motif: PS00602 ALDOLASE_CLASS_II_1 ; PS00806 ALDOLASE_CLASS_II_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
2.5 %Met     (Translated Protein)
3.6 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
2.2 %Met     (Mature Protein)
3.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MALVPLRLLLDHAAENGYGIPAFNVNNLEQVQSIMEAAYETDSPVILQASRGARSYAGEI
CCCCHHHHHHHHHCCCCCCCCCCCCCCHHHHHHHHHHHHCCCCCEEEEECCCCHHHHHHH
FLRHLIIAAVETYPDIPVVMHQDHGNSPSTCFGAAANGFTSVMMDGSLEADAKTPASYEY
HHHHHHHHHHHHCCCCCEEEECCCCCCCCCHHHHHHCCHHHEEECCCCCCCCCCCCCEEE
NVAVTKEVVGVAHAIGVSVEGELGCLGSLETGMGEAEDGHGFEGKLDHSQLLTDPAEASD
EEEEHHHHHHHHHHHCCCCCCCCCCCCCHHCCCCCCCCCCCCCCCCCHHHHHCCCCHHHH
FVAKTKVDALAIAIGTSHGAYKFTRKPTGEVLAISRIAEIHKAIPNTHLVMHGSSSVPQE
HHHHHHHCEEEEEEECCCCCEEECCCCCCCHHHHHHHHHHHHHCCCCEEEEECCCCCHHH
WLQMINKYGGAIPETYGVPVEEIQEGIRNGVRKVNIDTDNRLAFTAAVREASVADPANFD
HHHHHHHHCCCCCCCCCCCHHHHHHHHHCCCEEEECCCCCCEEEEHHHHHHCCCCCCCCC
PRHFNKPARKYMKQVCLDRYQQFWCAGNASKIKQRDINYYSALYEKGQLDPKNAVAA
HHHCCHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHCCCCCCHHCCCC
>Mature Secondary Structure 
ALVPLRLLLDHAAENGYGIPAFNVNNLEQVQSIMEAAYETDSPVILQASRGARSYAGEI
CCCHHHHHHHHHCCCCCCCCCCCCCCHHHHHHHHHHHHCCCCCEEEEECCCCHHHHHHH
FLRHLIIAAVETYPDIPVVMHQDHGNSPSTCFGAAANGFTSVMMDGSLEADAKTPASYEY
HHHHHHHHHHHHCCCCCEEEECCCCCCCCCHHHHHHCCHHHEEECCCCCCCCCCCCCEEE
NVAVTKEVVGVAHAIGVSVEGELGCLGSLETGMGEAEDGHGFEGKLDHSQLLTDPAEASD
EEEEHHHHHHHHHHHCCCCCCCCCCCCCHHCCCCCCCCCCCCCCCCCHHHHHCCCCHHHH
FVAKTKVDALAIAIGTSHGAYKFTRKPTGEVLAISRIAEIHKAIPNTHLVMHGSSSVPQE
HHHHHHHCEEEEEEECCCCCEEECCCCCCCHHHHHHHHHHHHHCCCCEEEEECCCCCHHH
WLQMINKYGGAIPETYGVPVEEIQEGIRNGVRKVNIDTDNRLAFTAAVREASVADPANFD
HHHHHHHHCCCCCCCCCCCHHHHHHHHHCCCEEEECCCCCCEEEEHHHHHHCCCCCCCCC
PRHFNKPARKYMKQVCLDRYQQFWCAGNASKIKQRDINYYSALYEKGQLDPKNAVAA
HHHCCHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHCCCCCCHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8590279; 8905231; 9298645 [H]