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The map label for this gene is prlC [H]

Identifier: 33862701

GI number: 33862701

Start: 480328

End: 482475

Strand: Direct

Name: prlC [H]

Synonym: PMT0428

Alternate gene names: 33862701

Gene position: 480328-482475 (Clockwise)

Preceding gene: 161350045

Following gene: 33862702

Centisome position: 19.92

GC content: 54.1

Gene sequence:

>2148_bases
ATGCCTGTTGCTGTGAACGAAATAAAGTCATCAGCCCTCCTCCAGGGTGAAGGAATCCCAAACTTCACTGCCATTACTGC
TCAACAAGTTCAGGATCACATGCCTGAACTTCTCTGTGCTCTTAACAAACAATTCAGCCGGCTGGAACAAGACATAGACA
AAGTTTTGGTGTCTGGCAAGAGCATTAATTGGGAACAAGTCATGTCTCCTCTGCATCGGCTGCAAGAGCAATTGCGTTGG
AGCTGGGGAGTCGTATCCCATCTCAACGGCGTCTGCAATACCTCCGAATTACGGCAAGCTCACGCTGCACAAGAACCAGA
GGTGGTGCGCTTTGGAAACCTTATGGGCCAAAGCCAAACACTTCATCGTGCCCTGCGCCGGCTTAAAGACCAGACCTCAA
GGCCATTGCTGGATTCGACTCAACAGCGGATTTTGAACGCGGAATTACTCTCCATGGATCAACGAGGCGTGGGTCTCGAT
GACGACGCACAGCAGGCTTTTAATACAACCAGTGAACAACTGGCCGAGCTGTCGACCTGCTTCAGCAATCACGTCCTGGA
TGCAACCCAGGGATGGAGCCTGCTCCTCAATCGATCAGCACAAGTTGAAGGACTGCCGCAGAGGGCCTTGGAGGTTTTGT
CCTTAGCAGCCAAGCAAGCCGGAGATCACCGAGAAGACGGTGGAGAACCTACAGCGGAGCAGGGTCCCTGGCGATTAGGT
CTAGATATGCCCCGCTACATCCCCTTCATCACCCATGCAAAAGATCGAGGGCTACGTGAAACGCTCTACAAGGCTCATGT
GAGTAGAGCGAGTGCAGGTGAGTTAAACAATCAACCATTGATTGAAGAGCTGCTAAGCCTTCGGCTTGAGCAAGCTCAAA
GGCTTGGCTACAGGAACTGGGCTGAACTCAGCCTGGCCAGCAAAATGGCCGAGGGCGTTGAGGCCGTCGAGCAGTTGCTT
GATGAGTTGCGTGCTGCCGCTTTACCCGCAGCCCAAAAGGAGTTAATTGAGCTCGAGGCCTGTGCCAAAAAACATGGAGC
TCCAGAGGCCAGCCAGCTCAAACCATGGGATGTGAACTTCTGGGCTGAACGGCTGAGGCAAGAGCGCTTTGACCTTGATC
AAGAAGCGCTGCGCCCTTGGTTTCCCCTGCCACAGGTTTTGGAAGGTTTGTTCGGACTTTGTGAACGTCTTTTTGGCATT
CGCATTCAAAGTGCCGACGGCGAGGCTCCGATCTGGCATCAAGACGTGCGTTATTTCCGGGTGTTGAATGCCAATGGTTC
TGACCTGGCAGCGTTCTACCTCGATCCCTATAGCCGACCAGCCAGCAAGCGAGGGGGGGCATGGATGGACGAATGCCTGA
CACGCAGCAAAAGCCTCGAGGGCCAATCGATTCTTCCTGTGGCCTATTTGATTTGTAACCAGACTCCACCGCAAGCAGAG
ACGCCAAGTCTGATGAGCTTCGATGAGGTGGAGACTTTGTTCCATGAGTTCGGCCATGGCCTTCAGCACATGCTCACGAC
CGTTGAGTATCCACAGGCTGCAGGAATCAACAACGTGGAATGGGACGCAGTGGAACTGCCTAGCCAGTTCATGGAGAACT
GGTGCCTCGATCGCACCACGTTGATGGGGATGGCACGTCACTGGCGTACTGGCGAACCGCTTCCGGAGGAGGAGTTCGCA
AAATTGCGCTCCAGCCGCACCTTTAATGCCGGTTTGGCAACTCTGCGCCAGGTGCATTTCGCTCTCACTGATCTGCGTTT
GCATAGTTGCTGGACACCAGATCTCGGCGTGACCCCAGATCAGCTGCGCCGTCAGATTGCTCAGACCACCACGGTGATGC
TTCCGATCGCCGAAGATCAATTCCTCTGTAGCTTTGGCCACATCTTCGCCGGTGGTTATTCCGCCGGGTACTACTCCTAC
AAGTGGGCAGAAGTTCTTAGTGCTGATGCCTTTGCTGCCTTTGAGGAAGCTGGTCTGGAACTTGAAGATCAAGTTCGACT
CACTGGCGCTCGCTTTCGCGACACAGTTCTCAGTTTGGGAGGTAGCCATTCCCCAGCAGACGTCTATGAGCAATTCCGTG
GACGACCAGCGACCACTGAGGCATTGATTCGCCATTCCGGCTTAGCCGCAAGCGCTGCGGATCAGTGA

Upstream 100 bases:

>100_bases
CGCCATCGATCTCTATGAGGCTTCAACCAATGCTCTCGCTGATCGACTGATTAGCCATAGCTTGGCAGCCCAAGGTTCCC
TGCTACCCCTTGGCTGAATA

Downstream 100 bases:

>100_bases
GGAGATGGCTGAAGAGATACCGCACTCTCTGAACCCCCTAGCGTTATCACAAAGCTGGGGCCAAGACGAGCATGACGATA
TCCACACGGCACCACTGATT

Product: phosphofructokinase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 715; Mature: 714

Protein sequence:

>715_residues
MPVAVNEIKSSALLQGEGIPNFTAITAQQVQDHMPELLCALNKQFSRLEQDIDKVLVSGKSINWEQVMSPLHRLQEQLRW
SWGVVSHLNGVCNTSELRQAHAAQEPEVVRFGNLMGQSQTLHRALRRLKDQTSRPLLDSTQQRILNAELLSMDQRGVGLD
DDAQQAFNTTSEQLAELSTCFSNHVLDATQGWSLLLNRSAQVEGLPQRALEVLSLAAKQAGDHREDGGEPTAEQGPWRLG
LDMPRYIPFITHAKDRGLRETLYKAHVSRASAGELNNQPLIEELLSLRLEQAQRLGYRNWAELSLASKMAEGVEAVEQLL
DELRAAALPAAQKELIELEACAKKHGAPEASQLKPWDVNFWAERLRQERFDLDQEALRPWFPLPQVLEGLFGLCERLFGI
RIQSADGEAPIWHQDVRYFRVLNANGSDLAAFYLDPYSRPASKRGGAWMDECLTRSKSLEGQSILPVAYLICNQTPPQAE
TPSLMSFDEVETLFHEFGHGLQHMLTTVEYPQAAGINNVEWDAVELPSQFMENWCLDRTTLMGMARHWRTGEPLPEEEFA
KLRSSRTFNAGLATLRQVHFALTDLRLHSCWTPDLGVTPDQLRRQIAQTTTVMLPIAEDQFLCSFGHIFAGGYSAGYYSY
KWAEVLSADAFAAFEEAGLELEDQVRLTGARFRDTVLSLGGSHSPADVYEQFRGRPATTEALIRHSGLAASAADQ

Sequences:

>Translated_715_residues
MPVAVNEIKSSALLQGEGIPNFTAITAQQVQDHMPELLCALNKQFSRLEQDIDKVLVSGKSINWEQVMSPLHRLQEQLRW
SWGVVSHLNGVCNTSELRQAHAAQEPEVVRFGNLMGQSQTLHRALRRLKDQTSRPLLDSTQQRILNAELLSMDQRGVGLD
DDAQQAFNTTSEQLAELSTCFSNHVLDATQGWSLLLNRSAQVEGLPQRALEVLSLAAKQAGDHREDGGEPTAEQGPWRLG
LDMPRYIPFITHAKDRGLRETLYKAHVSRASAGELNNQPLIEELLSLRLEQAQRLGYRNWAELSLASKMAEGVEAVEQLL
DELRAAALPAAQKELIELEACAKKHGAPEASQLKPWDVNFWAERLRQERFDLDQEALRPWFPLPQVLEGLFGLCERLFGI
RIQSADGEAPIWHQDVRYFRVLNANGSDLAAFYLDPYSRPASKRGGAWMDECLTRSKSLEGQSILPVAYLICNQTPPQAE
TPSLMSFDEVETLFHEFGHGLQHMLTTVEYPQAAGINNVEWDAVELPSQFMENWCLDRTTLMGMARHWRTGEPLPEEEFA
KLRSSRTFNAGLATLRQVHFALTDLRLHSCWTPDLGVTPDQLRRQIAQTTTVMLPIAEDQFLCSFGHIFAGGYSAGYYSY
KWAEVLSADAFAAFEEAGLELEDQVRLTGARFRDTVLSLGGSHSPADVYEQFRGRPATTEALIRHSGLAASAADQ
>Mature_714_residues
PVAVNEIKSSALLQGEGIPNFTAITAQQVQDHMPELLCALNKQFSRLEQDIDKVLVSGKSINWEQVMSPLHRLQEQLRWS
WGVVSHLNGVCNTSELRQAHAAQEPEVVRFGNLMGQSQTLHRALRRLKDQTSRPLLDSTQQRILNAELLSMDQRGVGLDD
DAQQAFNTTSEQLAELSTCFSNHVLDATQGWSLLLNRSAQVEGLPQRALEVLSLAAKQAGDHREDGGEPTAEQGPWRLGL
DMPRYIPFITHAKDRGLRETLYKAHVSRASAGELNNQPLIEELLSLRLEQAQRLGYRNWAELSLASKMAEGVEAVEQLLD
ELRAAALPAAQKELIELEACAKKHGAPEASQLKPWDVNFWAERLRQERFDLDQEALRPWFPLPQVLEGLFGLCERLFGIR
IQSADGEAPIWHQDVRYFRVLNANGSDLAAFYLDPYSRPASKRGGAWMDECLTRSKSLEGQSILPVAYLICNQTPPQAET
PSLMSFDEVETLFHEFGHGLQHMLTTVEYPQAAGINNVEWDAVELPSQFMENWCLDRTTLMGMARHWRTGEPLPEEEFAK
LRSSRTFNAGLATLRQVHFALTDLRLHSCWTPDLGVTPDQLRRQIAQTTTVMLPIAEDQFLCSFGHIFAGGYSAGYYSYK
WAEVLSADAFAAFEEAGLELEDQVRLTGARFRDTVLSLGGSHSPADVYEQFRGRPATTEALIRHSGLAASAADQ

Specific function: May play a specific role in the degradation of signal peptides after they are released from precursor forms of secreted proteins. Can cleave N-acetyl-L-Ala(4) [H]

COG id: COG0339

COG function: function code E; Zn-dependent oligopeptidases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the peptidase M3 family [H]

Homologues:

Organism=Homo sapiens, GI4507491, Length=701, Percent_Identity=26.9614835948645, Blast_Score=249, Evalue=6e-66,
Organism=Homo sapiens, GI14149738, Length=633, Percent_Identity=26.8562401263823, Blast_Score=209, Evalue=6e-54,
Organism=Homo sapiens, GI156105687, Length=441, Percent_Identity=29.9319727891156, Blast_Score=150, Evalue=4e-36,
Organism=Escherichia coli, GI1789913, Length=704, Percent_Identity=38.3522727272727, Blast_Score=497, Evalue=1e-141,
Organism=Escherichia coli, GI1787819, Length=617, Percent_Identity=31.7666126418152, Blast_Score=258, Evalue=8e-70,
Organism=Caenorhabditis elegans, GI71999758, Length=592, Percent_Identity=23.8175675675676, Blast_Score=125, Evalue=9e-29,
Organism=Caenorhabditis elegans, GI32565901, Length=659, Percent_Identity=25.1896813353566, Blast_Score=106, Evalue=4e-23,
Organism=Saccharomyces cerevisiae, GI6319793, Length=531, Percent_Identity=29.1902071563089, Blast_Score=229, Evalue=2e-60,
Organism=Saccharomyces cerevisiae, GI6322715, Length=371, Percent_Identity=25.6064690026954, Blast_Score=108, Evalue=3e-24,
Organism=Drosophila melanogaster, GI21356111, Length=708, Percent_Identity=29.9435028248588, Blast_Score=285, Evalue=7e-77,
Organism=Drosophila melanogaster, GI20129717, Length=464, Percent_Identity=26.0775862068966, Blast_Score=145, Evalue=1e-34,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001567 [H]

Pfam domain/function: PF01432 Peptidase_M3 [H]

EC number: =3.4.24.70 [H]

Molecular weight: Translated: 80044; Mature: 79913

Theoretical pI: Translated: 5.03; Mature: 5.03

Prosite motif: PS00142 ZINC_PROTEASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.4 %Cys     (Translated Protein)
2.0 %Met     (Translated Protein)
3.4 %Cys+Met (Translated Protein)
1.4 %Cys     (Mature Protein)
1.8 %Met     (Mature Protein)
3.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPVAVNEIKSSALLQGEGIPNFTAITAQQVQDHMPELLCALNKQFSRLEQDIDKVLVSGK
CCCCHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCC
SINWEQVMSPLHRLQEQLRWSWGVVSHLNGVCNTSELRQAHAAQEPEVVRFGNLMGQSQT
CCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHCCCCCCHHHHHHHHCCHHH
LHRALRRLKDQTSRPLLDSTQQRILNAELLSMDQRGVGLDDDAQQAFNTTSEQLAELSTC
HHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHCCHHHHHHHHHHH
FSNHVLDATQGWSLLLNRSAQVEGLPQRALEVLSLAAKQAGDHREDGGEPTAEQGPWRLG
HHHCCCCCCCCHHHHHCCCCCCCCCHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCEEEC
LDMPRYIPFITHAKDRGLRETLYKAHVSRASAGELNNQPLIEELLSLRLEQAQRLGYRNW
CCCHHHHHHHHCHHCCCHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHCCCCCH
AELSLASKMAEGVEAVEQLLDELRAAALPAAQKELIELEACAKKHGAPEASQLKPWDVNF
HHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHCCCCCCCCCCCCCHHH
WAERLRQERFDLDQEALRPWFPLPQVLEGLFGLCERLFGIRIQSADGEAPIWHQDVRYFR
HHHHHHHHHCCCCHHHCCCCCCHHHHHHHHHHHHHHHHCCEEECCCCCCCCHHHHHHHHE
VLNANGSDLAAFYLDPYSRPASKRGGAWMDECLTRSKSLEGQSILPVAYLICNQTPPQAE
EECCCCCCEEEEEECCCCCCCCCCCCCHHHHHHHHHCCCCCCCHHHHHHHHHCCCCCCCC
TPSLMSFDEVETLFHEFGHGLQHMLTTVEYPQAAGINNVEWDAVELPSQFMENWCLDRTT
CCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHH
LMGMARHWRTGEPLPEEEFAKLRSSRTFNAGLATLRQVHFALTDLRLHSCWTPDLGVTPD
HHHHHHHCCCCCCCCHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHH
QLRRQIAQTTTVMLPIAEDQFLCSFGHIFAGGYSAGYYSYKWAEVLSADAFAAFEEAGLE
HHHHHHHHHHEEEEECCCCHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHCCC
LEDQVRLTGARFRDTVLSLGGSHSPADVYEQFRGRPATTEALIRHSGLAASAADQ
CHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHCCCCCHHHHHHHHCCCCCCCCCC
>Mature Secondary Structure 
PVAVNEIKSSALLQGEGIPNFTAITAQQVQDHMPELLCALNKQFSRLEQDIDKVLVSGK
CCCHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCC
SINWEQVMSPLHRLQEQLRWSWGVVSHLNGVCNTSELRQAHAAQEPEVVRFGNLMGQSQT
CCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHCCCCCCHHHHHHHHCCHHH
LHRALRRLKDQTSRPLLDSTQQRILNAELLSMDQRGVGLDDDAQQAFNTTSEQLAELSTC
HHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHCCHHHHHHHHHHH
FSNHVLDATQGWSLLLNRSAQVEGLPQRALEVLSLAAKQAGDHREDGGEPTAEQGPWRLG
HHHCCCCCCCCHHHHHCCCCCCCCCHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCEEEC
LDMPRYIPFITHAKDRGLRETLYKAHVSRASAGELNNQPLIEELLSLRLEQAQRLGYRNW
CCCHHHHHHHHCHHCCCHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHCCCCCH
AELSLASKMAEGVEAVEQLLDELRAAALPAAQKELIELEACAKKHGAPEASQLKPWDVNF
HHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHCCCCCCCCCCCCCHHH
WAERLRQERFDLDQEALRPWFPLPQVLEGLFGLCERLFGIRIQSADGEAPIWHQDVRYFR
HHHHHHHHHCCCCHHHCCCCCCHHHHHHHHHHHHHHHHCCEEECCCCCCCCHHHHHHHHE
VLNANGSDLAAFYLDPYSRPASKRGGAWMDECLTRSKSLEGQSILPVAYLICNQTPPQAE
EECCCCCCEEEEEECCCCCCCCCCCCCHHHHHHHHHCCCCCCCHHHHHHHHHCCCCCCCC
TPSLMSFDEVETLFHEFGHGLQHMLTTVEYPQAAGINNVEWDAVELPSQFMENWCLDRTT
CCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHH
LMGMARHWRTGEPLPEEEFAKLRSSRTFNAGLATLRQVHFALTDLRLHSCWTPDLGVTPD
HHHHHHHCCCCCCCCHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHH
QLRRQIAQTTTVMLPIAEDQFLCSFGHIFAGGYSAGYYSYKWAEVLSADAFAAFEEAGLE
HHHHHHHHHHEEEEECCCCHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHCCC
LEDQVRLTGARFRDTVLSLGGSHSPADVYEQFRGRPATTEALIRHSGLAASAADQ
CHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHCCCCCHHHHHHHHCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 7542800 [H]