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The map label for this gene is creB

Identifier: 30065634

GI number: 30065634

Start: 4593710

End: 4594399

Strand: Direct

Name: creB

Synonym: S4701

Alternate gene names: 30065634

Gene position: 4593710-4594399 (Clockwise)

Preceding gene: 30065633

Following gene: 30065635

Centisome position: 99.88

GC content: 54.93

Gene sequence:

>690_bases
ATGCAACGGGAAACGGTCTGGTTAGTGGAAGATGAGCAAGGGATAGCCGACACGCTGGTCTACATGTTGCAGCAGGAAGG
TTTTGCCGTCGAGGTCTTTGAGCGAGGTTTGCCGGTGCTGGATAAAGCTCGCCAGCAGGTTCCCGACGTCATGATTCTCG
ACGTTGGTTTGCCTGATATCAGTGGCTTTGAATTGTGCCGCCAGTTACTGGCGCTCCATCCGGCGTTACCTGTACTGTTC
CTGACGGCCCGAAGTGAAGAGGTCGATCGCCTGCTTGGGCTGGAAATTGGCGCTGACGACTATGTGGCTAAACCGTTTTC
ACCCCGCGAAGTGTGCGCCAGGGTGCGCACCTTACTGCGTCGGGTGAAGAAGTTCTCGACGCCGTCTCCCGTCATCCGTA
TTGGTCATTTTGAATTGAATGAACCCGCGGCGCAGATCAGCTGGTTTGACACGCCATTAACGCTGACGCGGTATGAGTTT
TTATTGCTGAAGACGTTACTCAAGTCGCCAGGCCGCGTCTGGTCCCGCCAGCAACTAATGGATAGCGTGTGGGAAGATGC
GCAGGACACCTACGATCGCACCGTCGATATCCACATTAAAACGCTGCGTGCCAAGCTGCGCGCCATCAACCCCGATCTTT
CACCGATTAATACTCATCGCGGCATGGGATATAGCCTGAGGGGCTTGTAA

Upstream 100 bases:

>100_bases
CGCTTATCTGGCTTACTCCGACAAAGTTGTAGAAGGTTCGCCGAAAAACGCGATTAGCGCGGTTCCTGTCATGCCGTGGC
GGCAATAACAGAGGCGATTT

Downstream 100 bases:

>100_bases
TGCGTATCGGCATGCGGTTGCTGCTGGGCTATTTTTTACTGGTGGCGGTGGCGGCCTGGTTCGTACTGGCTATTTTTGTC
AAAGAAGTTAAACCGGGCGT

Product: DNA-binding response regulator CreB

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 229; Mature: 229

Protein sequence:

>229_residues
MQRETVWLVEDEQGIADTLVYMLQQEGFAVEVFERGLPVLDKARQQVPDVMILDVGLPDISGFELCRQLLALHPALPVLF
LTARSEEVDRLLGLEIGADDYVAKPFSPREVCARVRTLLRRVKKFSTPSPVIRIGHFELNEPAAQISWFDTPLTLTRYEF
LLLKTLLKSPGRVWSRQQLMDSVWEDAQDTYDRTVDIHIKTLRAKLRAINPDLSPINTHRGMGYSLRGL

Sequences:

>Translated_229_residues
MQRETVWLVEDEQGIADTLVYMLQQEGFAVEVFERGLPVLDKARQQVPDVMILDVGLPDISGFELCRQLLALHPALPVLF
LTARSEEVDRLLGLEIGADDYVAKPFSPREVCARVRTLLRRVKKFSTPSPVIRIGHFELNEPAAQISWFDTPLTLTRYEF
LLLKTLLKSPGRVWSRQQLMDSVWEDAQDTYDRTVDIHIKTLRAKLRAINPDLSPINTHRGMGYSLRGL
>Mature_229_residues
MQRETVWLVEDEQGIADTLVYMLQQEGFAVEVFERGLPVLDKARQQVPDVMILDVGLPDISGFELCRQLLALHPALPVLF
LTARSEEVDRLLGLEIGADDYVAKPFSPREVCARVRTLLRRVKKFSTPSPVIRIGHFELNEPAAQISWFDTPLTLTRYEF
LLLKTLLKSPGRVWSRQQLMDSVWEDAQDTYDRTVDIHIKTLRAKLRAINPDLSPINTHRGMGYSLRGL

Specific function: Member of the two-component regulatory system CreC/CreB involved in catabolic regulation [H]

COG id: COG0745

COG function: function code TK; Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain

Gene ontology:

Cell location: Cytoplasmic [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 response regulatory domain [H]

Homologues:

Organism=Escherichia coli, GI1790860, Length=229, Percent_Identity=98.6899563318777, Blast_Score=461, Evalue=1e-131,
Organism=Escherichia coli, GI1788394, Length=225, Percent_Identity=42.6666666666667, Blast_Score=168, Evalue=2e-43,
Organism=Escherichia coli, GI1786599, Length=221, Percent_Identity=36.6515837104072, Blast_Score=139, Evalue=2e-34,
Organism=Escherichia coli, GI1786784, Length=221, Percent_Identity=36.1990950226244, Blast_Score=129, Evalue=1e-31,
Organism=Escherichia coli, GI1786911, Length=223, Percent_Identity=37.219730941704, Blast_Score=127, Evalue=6e-31,
Organism=Escherichia coli, GI1789809, Length=224, Percent_Identity=33.9285714285714, Blast_Score=125, Evalue=3e-30,
Organism=Escherichia coli, GI1787375, Length=219, Percent_Identity=34.703196347032, Blast_Score=120, Evalue=8e-29,
Organism=Escherichia coli, GI2367329, Length=226, Percent_Identity=36.7256637168142, Blast_Score=113, Evalue=1e-26,
Organism=Escherichia coli, GI1787229, Length=227, Percent_Identity=34.3612334801762, Blast_Score=112, Evalue=1e-26,
Organism=Escherichia coli, GI1790863, Length=235, Percent_Identity=31.9148936170213, Blast_Score=112, Evalue=2e-26,
Organism=Escherichia coli, GI1789402, Length=222, Percent_Identity=34.2342342342342, Blast_Score=111, Evalue=3e-26,
Organism=Escherichia coli, GI87082012, Length=221, Percent_Identity=33.4841628959276, Blast_Score=106, Evalue=1e-24,
Organism=Escherichia coli, GI1790552, Length=221, Percent_Identity=31.2217194570136, Blast_Score=103, Evalue=7e-24,
Organism=Escherichia coli, GI145693140, Length=231, Percent_Identity=28.1385281385281, Blast_Score=82, Evalue=4e-17,
Organism=Escherichia coli, GI1790299, Length=146, Percent_Identity=32.8767123287671, Blast_Score=80, Evalue=1e-16,
Organism=Escherichia coli, GI1790437, Length=142, Percent_Identity=27.4647887323944, Blast_Score=64, Evalue=1e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011006
- InterPro:   IPR001867
- InterPro:   IPR001789
- InterPro:   IPR011991 [H]

Pfam domain/function: PF00072 Response_reg; PF00486 Trans_reg_C [H]

EC number: NA

Molecular weight: Translated: 26168; Mature: 26168

Theoretical pI: Translated: 6.14; Mature: 6.14

Prosite motif: PS50110 RESPONSE_REGULATORY

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
2.2 %Met     (Translated Protein)
3.1 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
2.2 %Met     (Mature Protein)
3.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MQRETVWLVEDEQGIADTLVYMLQQEGFAVEVFERGLPVLDKARQQVPDVMILDVGLPDI
CCCCEEEEEECCCCHHHHHHHHHHHCCCEEEHHHCCCCHHHHHHHHCCCEEEEECCCCCC
SGFELCRQLLALHPALPVLFLTARSEEVDRLLGLEIGADDYVAKPFSPREVCARVRTLLR
CHHHHHHHHHHHCCCHHHEEEECCHHHHHHHHCCEECCCCCCCCCCCHHHHHHHHHHHHH
RVKKFSTPSPVIRIGHFELNEPAAQISWFDTPLTLTRYEFLLLKTLLKSPGRVWSRQQLM
HHHHCCCCCCEEEECCEECCCCHHHEEECCCCCHHHHHHHHHHHHHHCCCCCHHHHHHHH
DSVWEDAQDTYDRTVDIHIKTLRAKLRAINPDLSPINTHRGMGYSLRGL
HHHHHHHHHHHCCEEEEEHHHHHHHHHHCCCCCCCCCCCCCCCEECCCC
>Mature Secondary Structure
MQRETVWLVEDEQGIADTLVYMLQQEGFAVEVFERGLPVLDKARQQVPDVMILDVGLPDI
CCCCEEEEEECCCCHHHHHHHHHHHCCCEEEHHHCCCCHHHHHHHHCCCEEEEECCCCCC
SGFELCRQLLALHPALPVLFLTARSEEVDRLLGLEIGADDYVAKPFSPREVCARVRTLLR
CHHHHHHHHHHHCCCHHHEEEECCHHHHHHHHCCEECCCCCCCCCCCHHHHHHHHHHHHH
RVKKFSTPSPVIRIGHFELNEPAAQISWFDTPLTLTRYEFLLLKTLLKSPGRVWSRQQLM
HHHHCCCCCCEEEECCEECCCCHHHEEECCCCCHHHHHHHHHHHHHHCCCCCHHHHHHHH
DSVWEDAQDTYDRTVDIHIKTLRAKLRAINPDLSPINTHRGMGYSLRGL
HHHHHHHHHHHCCEEEEEHHHHHHHHHHCCCCCCCCCCCCCCCEECCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 3531171; 7610040; 9278503 [H]