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The map label for this gene is creC

Identifier: 30065635

GI number: 30065635

Start: 4594399

End: 4595823

Strand: Direct

Name: creC

Synonym: S4702

Alternate gene names: 30065635

Gene position: 4594399-4595823 (Clockwise)

Preceding gene: 30065634

Following gene: 30065636

Centisome position: 99.89

GC content: 53.89

Gene sequence:

>1425_bases
ATGCGTATCGGCATGCGGTTGCTGCTGGGCTATTTTTTACTGGTGGCGGTGGCGGCCTGGTTCGTACTGGCTATTTTTGT
CAAAGAAGTTAAACCGGGCGTGCGAAGAGCAACGGAGGGGACGTTGATCGACACGGCAACGTTACTTGCGGAGCTGGCGC
GTCCCGATTTGCTCTCTGGGGACCCAACGCATGGGCAACTGGCGCAGGCGTTTAATCAGCTACAACATCGCCCGTTTCGC
GCCAATATTGGTGGCATTAACAAAGTGCGCAATGAATATCATGTCTATATGACCGATGCGCATGGCAAAGTATTGTTCGA
TTCGGCAAATAAAGCCGTTGGACAGGATTATTCGCGCTGGAATGACGTCTGGCTAACGTTGCGTGGTCAGTATGGTGCGC
GCAGCACGTTGCAAAATCCTGCCGATCCCGAAAGTTCGGTGATGTATGTTGCCGCGCCGATTATGGGCGGCTCGCGGCTT
ATTGGCGTTTTGAGCGTAGGCAAACCGAACGCGGCGATGGCTCCGGTCATTAAACGCAGCGAGCGGCGAATTTTATGGGC
CAGCGCCATTTTGTTGGGGATTGCACTGGTGATTGGCGCAGGCATGGTTTGGTGGATCAACCGCTCCATTGCCCGGCTCA
CTCGCTATGCTGATTCCGTCACTGACAATAAGCCCGTTCCTCTTCCCGATCTCGGTAGTAGCGAGCTGCGTAAACTCGCG
CAGGCGCTGGAAAGTATGCGCGTGAAGCTGGAAGGGAAAAACTATATTGAGCAGTATGTTTATGCGTTAACCCATGAGCT
AAAAAGCCCACTGGCGGCGATTCGTGGCGCGGCGGAAATTTTACGCGAAGGTCCGCCGCCTGAAGTAGTGGCTCGTTTTA
CTGACAACATTCTGACACAAAATGCGCGAATGCAGGCGCTGGTGGAAACGTTACTACGCCAGGCAAGACTGGAGAATCGT
CAGGAAGTCGTTCTGACTGCTGTTGATGTGGCGGCATTATTTCGCCGCGTCAGCGAAGCGCGCACCGTGCAGTTGGCAGA
AAAAAACATCACTTTGCATGTTATGCCCACCGAGGTTAATGTTGCTGCTGAACCGGCGTTACTGGATCAGGCGCTGGGGA
ATTTACTGGATAACGCCATCGATTTTACTCCCGAGAGCGGTTGCATAACGCTAAGCGCCGAAGTGGATCAGGAACACGTC
ACGCTTAAGGTGCTGGATACCGGTAGTGGTATTCCTGACTACGCGCTGTCACGTATTTTTGAACGCTTTTACTCTTTGCC
GCGTGCAAATGGGCAAAAAAGCAGCGGTCTGGGGTTGGCGTTCGTCAGTGAGGTCGCCCGTTTGTTTAACGGCGAAGTCA
CGCTGCGCAACGTGCAGGAAGGTGGCGTGCTGGCCTCGCTACGACTTCACCGTCACTTCACATAG

Upstream 100 bases:

>100_bases
TCCACATTAAAACGCTGCGTGCCAAGCTGCGCGCCATCAACCCCGATCTTTCACCGATTAATACTCATCGCGGCATGGGA
TATAGCCTGAGGGGCTTGTA

Downstream 100 bases:

>100_bases
CTTCAAATTCTTCCCACATAGCCTTCGTATCCTGCTGCCATTGCAAAGGAGAAGACTATGTTGAAATCCCCCCTGTTCTG
GAAAATGACCACCTTGTTTG

Product: sensory histidine kinase CreC

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 474; Mature: 474

Protein sequence:

>474_residues
MRIGMRLLLGYFLLVAVAAWFVLAIFVKEVKPGVRRATEGTLIDTATLLAELARPDLLSGDPTHGQLAQAFNQLQHRPFR
ANIGGINKVRNEYHVYMTDAHGKVLFDSANKAVGQDYSRWNDVWLTLRGQYGARSTLQNPADPESSVMYVAAPIMGGSRL
IGVLSVGKPNAAMAPVIKRSERRILWASAILLGIALVIGAGMVWWINRSIARLTRYADSVTDNKPVPLPDLGSSELRKLA
QALESMRVKLEGKNYIEQYVYALTHELKSPLAAIRGAAEILREGPPPEVVARFTDNILTQNARMQALVETLLRQARLENR
QEVVLTAVDVAALFRRVSEARTVQLAEKNITLHVMPTEVNVAAEPALLDQALGNLLDNAIDFTPESGCITLSAEVDQEHV
TLKVLDTGSGIPDYALSRIFERFYSLPRANGQKSSGLGLAFVSEVARLFNGEVTLRNVQEGGVLASLRLHRHFT

Sequences:

>Translated_474_residues
MRIGMRLLLGYFLLVAVAAWFVLAIFVKEVKPGVRRATEGTLIDTATLLAELARPDLLSGDPTHGQLAQAFNQLQHRPFR
ANIGGINKVRNEYHVYMTDAHGKVLFDSANKAVGQDYSRWNDVWLTLRGQYGARSTLQNPADPESSVMYVAAPIMGGSRL
IGVLSVGKPNAAMAPVIKRSERRILWASAILLGIALVIGAGMVWWINRSIARLTRYADSVTDNKPVPLPDLGSSELRKLA
QALESMRVKLEGKNYIEQYVYALTHELKSPLAAIRGAAEILREGPPPEVVARFTDNILTQNARMQALVETLLRQARLENR
QEVVLTAVDVAALFRRVSEARTVQLAEKNITLHVMPTEVNVAAEPALLDQALGNLLDNAIDFTPESGCITLSAEVDQEHV
TLKVLDTGSGIPDYALSRIFERFYSLPRANGQKSSGLGLAFVSEVARLFNGEVTLRNVQEGGVLASLRLHRHFT
>Mature_474_residues
MRIGMRLLLGYFLLVAVAAWFVLAIFVKEVKPGVRRATEGTLIDTATLLAELARPDLLSGDPTHGQLAQAFNQLQHRPFR
ANIGGINKVRNEYHVYMTDAHGKVLFDSANKAVGQDYSRWNDVWLTLRGQYGARSTLQNPADPESSVMYVAAPIMGGSRL
IGVLSVGKPNAAMAPVIKRSERRILWASAILLGIALVIGAGMVWWINRSIARLTRYADSVTDNKPVPLPDLGSSELRKLA
QALESMRVKLEGKNYIEQYVYALTHELKSPLAAIRGAAEILREGPPPEVVARFTDNILTQNARMQALVETLLRQARLENR
QEVVLTAVDVAALFRRVSEARTVQLAEKNITLHVMPTEVNVAAEPALLDQALGNLLDNAIDFTPESGCITLSAEVDQEHV
TLKVLDTGSGIPDYALSRIFERFYSLPRANGQKSSGLGLAFVSEVARLFNGEVTLRNVQEGGVLASLRLHRHFT

Specific function: Member of the two-component regulatory system CreC/CreB involved in catabolic regulation. CreC may function as a membrane- associated protein kinase that phosphorylates CreB in response to environmental signals. CreC can also phosphorylate PhoB [H]

COG id: COG0642

COG function: function code T; Signal transduction histidine kinase

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 histidine kinase domain [H]

Homologues:

Organism=Escherichia coli, GI1790861, Length=474, Percent_Identity=98.9451476793249, Blast_Score=951, Evalue=0.0,
Organism=Escherichia coli, GI87082128, Length=294, Percent_Identity=30.2721088435374, Blast_Score=97, Evalue=2e-21,
Organism=Escherichia coli, GI1788393, Length=250, Percent_Identity=29.6, Blast_Score=87, Evalue=3e-18,
Organism=Escherichia coli, GI145693157, Length=226, Percent_Identity=24.7787610619469, Blast_Score=80, Evalue=2e-16,
Organism=Escherichia coli, GI1786600, Length=201, Percent_Identity=30.3482587064677, Blast_Score=79, Evalue=5e-16,
Organism=Escherichia coli, GI1789403, Length=477, Percent_Identity=24.7379454926625, Blast_Score=75, Evalue=1e-14,
Organism=Escherichia coli, GI48994928, Length=220, Percent_Identity=24.5454545454545, Blast_Score=74, Evalue=2e-14,
Organism=Escherichia coli, GI1788713, Length=234, Percent_Identity=26.0683760683761, Blast_Score=73, Evalue=5e-14,
Organism=Escherichia coli, GI1786912, Length=240, Percent_Identity=28.3333333333333, Blast_Score=70, Evalue=2e-13,
Organism=Escherichia coli, GI1786783, Length=298, Percent_Identity=25.1677852348993, Blast_Score=68, Evalue=1e-12,
Organism=Escherichia coli, GI1789808, Length=240, Percent_Identity=25, Blast_Score=67, Evalue=2e-12,
Organism=Escherichia coli, GI1790346, Length=261, Percent_Identity=24.5210727969349, Blast_Score=64, Evalue=1e-11,
Organism=Escherichia coli, GI1790436, Length=203, Percent_Identity=28.0788177339901, Blast_Score=64, Evalue=3e-11,
Organism=Escherichia coli, GI1787374, Length=287, Percent_Identity=26.4808362369338, Blast_Score=62, Evalue=7e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003594
- InterPro:   IPR003660
- InterPro:   IPR004358
- InterPro:   IPR003661
- InterPro:   IPR005467
- InterPro:   IPR009082 [H]

Pfam domain/function: PF00672 HAMP; PF02518 HATPase_c; PF00512 HisKA [H]

EC number: =2.7.13.3 [H]

Molecular weight: Translated: 52130; Mature: 52130

Theoretical pI: Translated: 9.51; Mature: 9.51

Prosite motif: PS50885 HAMP ; PS50109 HIS_KIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.2 %Cys     (Translated Protein)
2.1 %Met     (Translated Protein)
2.3 %Cys+Met (Translated Protein)
0.2 %Cys     (Mature Protein)
2.1 %Met     (Mature Protein)
2.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRIGMRLLLGYFLLVAVAAWFVLAIFVKEVKPGVRRATEGTLIDTATLLAELARPDLLSG
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCHHHHHCCCCCHHHHHHHHHHHHCCCCCCC
DPTHGQLAQAFNQLQHRPFRANIGGINKVRNEYHVYMTDAHGKVLFDSANKAVGQDYSRW
CCCCHHHHHHHHHHHCCCCCCCCCCHHHHCCCEEEEEECCCCEEEEECCCHHHCCCHHCC
NDVWLTLRGQYGARSTLQNPADPESSVMYVAAPIMGGSRLIGVLSVGKPNAAMAPVIKRS
CCEEEEEECCCCCHHCCCCCCCCCCCEEEEEECCCCCCCEEEEEECCCCCCHHHHHHHHC
ERRILWASAILLGIALVIGAGMVWWINRSIARLTRYADSVTDNKPVPLPDLGSSELRKLA
CCHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCHHHHHHHH
QALESMRVKLEGKNYIEQYVYALTHELKSPLAAIRGAAEILREGPPPEVVARFTDNILTQ
HHHHHHEEEECCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHCC
NARMQALVETLLRQARLENRQEVVLTAVDVAALFRRVSEARTVQLAEKNITLHVMPTEVN
CHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHEEEECCEEEEEEECCCC
VAAEPALLDQALGNLLDNAIDFTPESGCITLSAEVDQEHVTLKVLDTGSGIPDYALSRIF
CCCCHHHHHHHHHHHHHHHHCCCCCCCCEEEEECCCCCEEEEEEEECCCCCHHHHHHHHH
ERFYSLPRANGQKSSGLGLAFVSEVARLFNGEVTLRNVQEGGVLASLRLHRHFT
HHHHCCCCCCCCCCCCCHHHHHHHHHHHHCCCEEEEECCCCCEEEEEHHHHCCC
>Mature Secondary Structure
MRIGMRLLLGYFLLVAVAAWFVLAIFVKEVKPGVRRATEGTLIDTATLLAELARPDLLSG
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCHHHHHCCCCCHHHHHHHHHHHHCCCCCCC
DPTHGQLAQAFNQLQHRPFRANIGGINKVRNEYHVYMTDAHGKVLFDSANKAVGQDYSRW
CCCCHHHHHHHHHHHCCCCCCCCCCHHHHCCCEEEEEECCCCEEEEECCCHHHCCCHHCC
NDVWLTLRGQYGARSTLQNPADPESSVMYVAAPIMGGSRLIGVLSVGKPNAAMAPVIKRS
CCEEEEEECCCCCHHCCCCCCCCCCCEEEEEECCCCCCCEEEEEECCCCCCHHHHHHHHC
ERRILWASAILLGIALVIGAGMVWWINRSIARLTRYADSVTDNKPVPLPDLGSSELRKLA
CCHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCHHHHHHHH
QALESMRVKLEGKNYIEQYVYALTHELKSPLAAIRGAAEILREGPPPEVVARFTDNILTQ
HHHHHHEEEECCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHCC
NARMQALVETLLRQARLENRQEVVLTAVDVAALFRRVSEARTVQLAEKNITLHVMPTEVN
CHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHEEEECCEEEEEEECCCC
VAAEPALLDQALGNLLDNAIDFTPESGCITLSAEVDQEHVTLKVLDTGSGIPDYALSRIF
CCCCHHHHHHHHHHHHHHHHCCCCCCCCEEEEECCCCCEEEEEEEECCCCCHHHHHHHHH
ERFYSLPRANGQKSSGLGLAFVSEVARLFNGEVTLRNVQEGGVLASLRLHRHFT
HHHHCCCCCCCCCCCCCHHHHHHHHHHHHCCCEEEEECCCCCEEEEEHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 3531171; 7610040; 9278503; 2835585; 2228961 [H]